Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64834
Gene name Gene Name - the full gene name approved by the HGNC.	ELOVL fatty acid elongase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ELOVL1
Synonyms (NCBI Gene) Gene synonyms aliases	CGI-88, IKSHD, Ssc1
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p34.2

Show/Hide all(260)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002696	hsa-miR-124-3p	Microarray	15685193
MIRT002696	hsa-miR-124-3p	Microarray	18668037
MIRT002696	hsa-miR-124-3p	Microarray	15685193
MIRT024485	hsa-miR-215-5p	Microarray	19074876
MIRT026598	hsa-miR-192-5p	Microarray	19074876
MIRT031693	hsa-miR-16-5p	Proteomics	18668040
MIRT032337	hsa-let-7b-5p	Proteomics	18668040
MIRT042165	hsa-miR-484	CLASH	23622248
MIRT039565	hsa-miR-652-3p	CLASH	23622248
MIRT037904	hsa-miR-455-3p	CLASH	23622248
MIRT477456	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT477455	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT477454	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT477453	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT477452	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT477451	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT477450	hsa-miR-4306	PAR-CLIP	23592263
MIRT477449	hsa-miR-4644	PAR-CLIP	23592263
MIRT477448	hsa-miR-5192	PAR-CLIP	23592263
MIRT477447	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT477446	hsa-miR-6802-5p	PAR-CLIP	23592263
MIRT477445	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT477444	hsa-miR-5587-5p	PAR-CLIP	23592263
MIRT477456	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT477455	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT477454	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT477453	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT477452	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT477451	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT477450	hsa-miR-4306	PAR-CLIP	23592263
MIRT477449	hsa-miR-4644	PAR-CLIP	23592263
MIRT477448	hsa-miR-5192	PAR-CLIP	23592263
MIRT477447	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT477446	hsa-miR-6802-5p	PAR-CLIP	23592263
MIRT477445	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT477444	hsa-miR-5587-5p	PAR-CLIP	23592263
MIRT961141	hsa-miR-1207-5p	CLIP-seq
MIRT961142	hsa-miR-122	CLIP-seq
MIRT961143	hsa-miR-129-3p	CLIP-seq
MIRT961144	hsa-miR-1321	CLIP-seq
MIRT961145	hsa-miR-1324	CLIP-seq
MIRT961146	hsa-miR-185	CLIP-seq
MIRT961147	hsa-miR-3120-3p	CLIP-seq
MIRT961148	hsa-miR-3150a-3p	CLIP-seq
MIRT961149	hsa-miR-3166	CLIP-seq
MIRT961150	hsa-miR-3175	CLIP-seq
MIRT961151	hsa-miR-331-3p	CLIP-seq
MIRT961152	hsa-miR-361-3p	CLIP-seq
MIRT961153	hsa-miR-3908	CLIP-seq
MIRT961154	hsa-miR-3943	CLIP-seq
MIRT961155	hsa-miR-4254	CLIP-seq
MIRT961156	hsa-miR-4267	CLIP-seq
MIRT961157	hsa-miR-4270	CLIP-seq
MIRT961158	hsa-miR-4292	CLIP-seq
MIRT961159	hsa-miR-4308	CLIP-seq
MIRT961160	hsa-miR-4323	CLIP-seq
MIRT961161	hsa-miR-4441	CLIP-seq
MIRT961162	hsa-miR-4633-3p	CLIP-seq
MIRT961163	hsa-miR-4640-5p	CLIP-seq
MIRT961164	hsa-miR-4716-3p	CLIP-seq
MIRT961165	hsa-miR-4717-5p	CLIP-seq
MIRT961166	hsa-miR-4726-5p	CLIP-seq
MIRT961167	hsa-miR-4728-5p	CLIP-seq
MIRT961168	hsa-miR-4739	CLIP-seq
MIRT961169	hsa-miR-4756-5p	CLIP-seq
MIRT961170	hsa-miR-4763-3p	CLIP-seq
MIRT961171	hsa-miR-491-5p	CLIP-seq
MIRT961172	hsa-miR-516b	CLIP-seq
MIRT961173	hsa-miR-625	CLIP-seq
MIRT961174	hsa-miR-939	CLIP-seq
MIRT961175	hsa-miR-940	CLIP-seq
MIRT1984806	hsa-miR-147	CLIP-seq
MIRT1984807	hsa-miR-1910	CLIP-seq
MIRT1984808	hsa-miR-1915	CLIP-seq
MIRT1984809	hsa-miR-3151	CLIP-seq
MIRT1984810	hsa-miR-342-5p	CLIP-seq
MIRT1984811	hsa-miR-3911	CLIP-seq
MIRT1984812	hsa-miR-3977	CLIP-seq
MIRT1984813	hsa-miR-4276	CLIP-seq
MIRT1984814	hsa-miR-4302	CLIP-seq
MIRT1984815	hsa-miR-4447	CLIP-seq
MIRT1984816	hsa-miR-4472	CLIP-seq
MIRT1984817	hsa-miR-4651	CLIP-seq
MIRT1984818	hsa-miR-4664-5p	CLIP-seq
MIRT1984819	hsa-miR-4726-3p	CLIP-seq
MIRT961171	hsa-miR-491-5p	CLIP-seq
MIRT1984820	hsa-miR-608	CLIP-seq
MIRT1984821	hsa-miR-644	CLIP-seq
MIRT1984822	hsa-miR-765	CLIP-seq
MIRT2219689	hsa-miR-1200	CLIP-seq
MIRT2219690	hsa-miR-128	CLIP-seq
MIRT1984806	hsa-miR-147	CLIP-seq
MIRT2219691	hsa-miR-1827	CLIP-seq
MIRT2219692	hsa-miR-18a	CLIP-seq
MIRT2219693	hsa-miR-18b	CLIP-seq
MIRT1984807	hsa-miR-1910	CLIP-seq
MIRT2219694	hsa-miR-208a	CLIP-seq
MIRT2219695	hsa-miR-208b	CLIP-seq
MIRT1984809	hsa-miR-3151	CLIP-seq
MIRT2219696	hsa-miR-3157-3p	CLIP-seq
MIRT2219697	hsa-miR-3178	CLIP-seq
MIRT1984810	hsa-miR-342-5p	CLIP-seq
MIRT2219698	hsa-miR-3617	CLIP-seq
MIRT2219699	hsa-miR-3672	CLIP-seq
MIRT1984811	hsa-miR-3911	CLIP-seq
MIRT1984813	hsa-miR-4276	CLIP-seq
MIRT1984814	hsa-miR-4302	CLIP-seq
MIRT2219700	hsa-miR-4324	CLIP-seq
MIRT1984815	hsa-miR-4447	CLIP-seq
MIRT2219701	hsa-miR-4463	CLIP-seq
MIRT1984816	hsa-miR-4472	CLIP-seq
MIRT2219702	hsa-miR-4649-3p	CLIP-seq
MIRT1984817	hsa-miR-4651	CLIP-seq
MIRT1984818	hsa-miR-4664-5p	CLIP-seq
MIRT2219703	hsa-miR-4731-3p	CLIP-seq
MIRT2219704	hsa-miR-4735-3p	CLIP-seq
MIRT2219705	hsa-miR-4801	CLIP-seq
MIRT961171	hsa-miR-491-5p	CLIP-seq
MIRT2219706	hsa-miR-499-5p	CLIP-seq
MIRT2219707	hsa-miR-541	CLIP-seq
MIRT2219708	hsa-miR-544b	CLIP-seq
MIRT2219709	hsa-miR-566	CLIP-seq
MIRT1984820	hsa-miR-608	CLIP-seq
MIRT2219710	hsa-miR-641	CLIP-seq
MIRT1984821	hsa-miR-644	CLIP-seq
MIRT2219711	hsa-miR-654-5p	CLIP-seq
MIRT1984822	hsa-miR-765	CLIP-seq
MIRT961173	hsa-miR-625	CLIP-seq
MIRT2219689	hsa-miR-1200	CLIP-seq
MIRT2523234	hsa-miR-125a-5p	CLIP-seq
MIRT2523235	hsa-miR-125b	CLIP-seq
MIRT2219690	hsa-miR-128	CLIP-seq
MIRT2523236	hsa-miR-1294	CLIP-seq
MIRT2523237	hsa-miR-137	CLIP-seq
MIRT2523238	hsa-miR-150	CLIP-seq
MIRT2219691	hsa-miR-1827	CLIP-seq
MIRT2219692	hsa-miR-18a	CLIP-seq
MIRT2219693	hsa-miR-18b	CLIP-seq
MIRT1984807	hsa-miR-1910	CLIP-seq
MIRT2523239	hsa-miR-22	CLIP-seq
MIRT961147	hsa-miR-3120-3p	CLIP-seq
MIRT2523240	hsa-miR-3148	CLIP-seq
MIRT1984809	hsa-miR-3151	CLIP-seq
MIRT2219696	hsa-miR-3157-3p	CLIP-seq
MIRT2219697	hsa-miR-3178	CLIP-seq
MIRT2523241	hsa-miR-3182	CLIP-seq
MIRT2523242	hsa-miR-3183	CLIP-seq
MIRT2523243	hsa-miR-3194-5p	CLIP-seq
MIRT2219699	hsa-miR-3672	CLIP-seq
MIRT961153	hsa-miR-3908	CLIP-seq
MIRT2523244	hsa-miR-3915	CLIP-seq
MIRT2523245	hsa-miR-3928	CLIP-seq
MIRT961155	hsa-miR-4254	CLIP-seq
MIRT2523246	hsa-miR-4265	CLIP-seq
MIRT2523247	hsa-miR-4268	CLIP-seq
MIRT2523248	hsa-miR-4271	CLIP-seq
MIRT961158	hsa-miR-4292	CLIP-seq
MIRT2523249	hsa-miR-4296	CLIP-seq
MIRT961159	hsa-miR-4308	CLIP-seq
MIRT2523250	hsa-miR-4316	CLIP-seq
MIRT2523251	hsa-miR-4319	CLIP-seq
MIRT2523252	hsa-miR-4322	CLIP-seq
MIRT2219700	hsa-miR-4324	CLIP-seq
MIRT1984815	hsa-miR-4447	CLIP-seq
MIRT2523253	hsa-miR-4448	CLIP-seq
MIRT2219701	hsa-miR-4463	CLIP-seq
MIRT1984816	hsa-miR-4472	CLIP-seq
MIRT2523254	hsa-miR-4532	CLIP-seq
MIRT961162	hsa-miR-4633-3p	CLIP-seq
MIRT961163	hsa-miR-4640-5p	CLIP-seq
MIRT2219702	hsa-miR-4649-3p	CLIP-seq
MIRT2523255	hsa-miR-4713-5p	CLIP-seq
MIRT961165	hsa-miR-4717-5p	CLIP-seq
MIRT2523256	hsa-miR-4723-3p	CLIP-seq
MIRT2523257	hsa-miR-4725-3p	CLIP-seq
MIRT961166	hsa-miR-4726-5p	CLIP-seq
MIRT2219704	hsa-miR-4735-3p	CLIP-seq
MIRT2523258	hsa-miR-4753-5p	CLIP-seq
MIRT2523259	hsa-miR-4795-5p	CLIP-seq
MIRT961171	hsa-miR-491-5p	CLIP-seq
MIRT2523260	hsa-miR-532-3p	CLIP-seq
MIRT2219707	hsa-miR-541	CLIP-seq
MIRT2219708	hsa-miR-544b	CLIP-seq
MIRT2523261	hsa-miR-558	CLIP-seq
MIRT2219709	hsa-miR-566	CLIP-seq
MIRT961173	hsa-miR-625	CLIP-seq
MIRT2523262	hsa-miR-628-5p	CLIP-seq
MIRT2219711	hsa-miR-654-5p	CLIP-seq
MIRT2219689	hsa-miR-1200	CLIP-seq
MIRT961141	hsa-miR-1207-5p	CLIP-seq
MIRT2679948	hsa-miR-124	CLIP-seq
MIRT2523234	hsa-miR-125a-5p	CLIP-seq
MIRT2523235	hsa-miR-125b	CLIP-seq
MIRT2219690	hsa-miR-128	CLIP-seq
MIRT2523236	hsa-miR-1294	CLIP-seq
MIRT961144	hsa-miR-1321	CLIP-seq
MIRT2523237	hsa-miR-137	CLIP-seq
MIRT2523238	hsa-miR-150	CLIP-seq
MIRT2219691	hsa-miR-1827	CLIP-seq
MIRT2219692	hsa-miR-18a	CLIP-seq
MIRT2219693	hsa-miR-18b	CLIP-seq
MIRT1984807	hsa-miR-1910	CLIP-seq
MIRT2523239	hsa-miR-22	CLIP-seq
MIRT961147	hsa-miR-3120-3p	CLIP-seq
MIRT2523240	hsa-miR-3148	CLIP-seq
MIRT1984809	hsa-miR-3151	CLIP-seq
MIRT2219696	hsa-miR-3157-3p	CLIP-seq
MIRT2219697	hsa-miR-3178	CLIP-seq
MIRT2523241	hsa-miR-3182	CLIP-seq
MIRT2523242	hsa-miR-3183	CLIP-seq
MIRT2523243	hsa-miR-3194-5p	CLIP-seq
MIRT2219699	hsa-miR-3672	CLIP-seq
MIRT2679949	hsa-miR-3714	CLIP-seq
MIRT961153	hsa-miR-3908	CLIP-seq
MIRT2679950	hsa-miR-3910	CLIP-seq
MIRT2523244	hsa-miR-3915	CLIP-seq
MIRT2523245	hsa-miR-3928	CLIP-seq
MIRT961155	hsa-miR-4254	CLIP-seq
MIRT2523246	hsa-miR-4265	CLIP-seq
MIRT2523247	hsa-miR-4268	CLIP-seq
MIRT961157	hsa-miR-4270	CLIP-seq
MIRT961158	hsa-miR-4292	CLIP-seq
MIRT2523249	hsa-miR-4296	CLIP-seq
MIRT961159	hsa-miR-4308	CLIP-seq
MIRT2523250	hsa-miR-4316	CLIP-seq
MIRT2523251	hsa-miR-4319	CLIP-seq
MIRT2523252	hsa-miR-4322	CLIP-seq
MIRT2219700	hsa-miR-4324	CLIP-seq
MIRT961161	hsa-miR-4441	CLIP-seq
MIRT1984815	hsa-miR-4447	CLIP-seq
MIRT2523253	hsa-miR-4448	CLIP-seq
MIRT2219701	hsa-miR-4463	CLIP-seq
MIRT1984816	hsa-miR-4472	CLIP-seq
MIRT2679951	hsa-miR-4477b	CLIP-seq
MIRT961162	hsa-miR-4633-3p	CLIP-seq
MIRT961163	hsa-miR-4640-5p	CLIP-seq
MIRT2219702	hsa-miR-4649-3p	CLIP-seq
MIRT2523255	hsa-miR-4713-5p	CLIP-seq
MIRT961164	hsa-miR-4716-3p	CLIP-seq
MIRT961165	hsa-miR-4717-5p	CLIP-seq
MIRT2523256	hsa-miR-4723-3p	CLIP-seq
MIRT961166	hsa-miR-4726-5p	CLIP-seq
MIRT961167	hsa-miR-4728-5p	CLIP-seq
MIRT2219704	hsa-miR-4735-3p	CLIP-seq
MIRT961168	hsa-miR-4739	CLIP-seq
MIRT2523258	hsa-miR-4753-5p	CLIP-seq
MIRT961169	hsa-miR-4756-5p	CLIP-seq
MIRT961170	hsa-miR-4763-3p	CLIP-seq
MIRT961171	hsa-miR-491-5p	CLIP-seq
MIRT2679952	hsa-miR-506	CLIP-seq
MIRT2523260	hsa-miR-532-3p	CLIP-seq
MIRT2219707	hsa-miR-541	CLIP-seq
MIRT2219708	hsa-miR-544b	CLIP-seq
MIRT2523261	hsa-miR-558	CLIP-seq
MIRT2219709	hsa-miR-566	CLIP-seq
MIRT961173	hsa-miR-625	CLIP-seq
MIRT2523262	hsa-miR-628-5p	CLIP-seq
MIRT2679953	hsa-miR-645	CLIP-seq
MIRT2219711	hsa-miR-654-5p	CLIP-seq
MIRT961175	hsa-miR-940	CLIP-seq

Show/Hide all(38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	20937905, 38422897
GO:0005783	Component	Endoplasmic reticulum	IDA	20937905
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	NAS	20166112
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IEA
GO:0006636	Process	Unsaturated fatty acid biosynthetic process	IEA
GO:0009922	Function	Fatty acid elongase activity	EXP	10970790
GO:0009922	Function	Fatty acid elongase activity	IBA
GO:0009922	Function	Fatty acid elongase activity	IDA	20166112
GO:0009922	Function	Fatty acid elongase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019367	Process	Fatty acid elongation, saturated fatty acid	IBA
GO:0019367	Process	Fatty acid elongation, saturated fatty acid	IDA	20166112, 20937905
GO:0019367	Process	Fatty acid elongation, saturated fatty acid	IEA
GO:0030148	Process	Sphingolipid biosynthetic process	IBA
GO:0030148	Process	Sphingolipid biosynthetic process	IEA
GO:0030148	Process	Sphingolipid biosynthetic process	IMP	20937905
GO:0030497	Process	Fatty acid elongation	IEA
GO:0034625	Process	Fatty acid elongation, monounsaturated fatty acid	IBA
GO:0034625	Process	Fatty acid elongation, monounsaturated fatty acid	IDA	20166112
GO:0034625	Process	Fatty acid elongation, monounsaturated fatty acid	IEA
GO:0034626	Process	Fatty acid elongation, polyunsaturated fatty acid	IBA
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	IEA
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0036109	Process	Alpha-linolenic acid metabolic process	TAS
GO:0042761	Process	Very long-chain fatty acid biosynthetic process	IBA
GO:0042761	Process	Very long-chain fatty acid biosynthetic process	IDA	20166112, 20937905
GO:0042761	Process	Very long-chain fatty acid biosynthetic process	IEA
GO:0043651	Process	Linoleic acid metabolic process	TAS
GO:0046513	Process	Ceramide biosynthetic process	IEA
GO:0061436	Process	Establishment of skin barrier	IEA

MIM	HGNC	e!Ensembl
611813	14418	ENSG00000066322

Protein

UniProt ID

Q9BW60

Protein name

Very long chain fatty acid elongase 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Elongation of very long chain fatty acids protein 1) (Very long chain 3-ketoacyl-CoA synthase 1) (Very long chain 3

Protein function

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carb

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01151	ELO	23 → 262	GNS1/SUR4 family	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:30487246}.

Sequence

MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRG
FMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFI
ELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYL
YYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYG
TIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN

Sequence length

279

Interactions

View interactions

	KEGG		Reactome
	Fatty acid elongation Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism		Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs

ELOVL1 (ELOVL fatty acid elongase 1)