Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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6482
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Gene name
Gene Name - the full gene name approved by the HGNC.
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ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ST3GAL1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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Gal-NAc6S, SIAT4A, SIATFL, ST3GalA, ST3GalA.1, ST3GalIA, ST3GalIA,1, ST3O |
Chromosome
Chromosome number
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8 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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8q24.22 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a |
UniProt ID |
Q11201
|
Protein name |
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) |
Protein function |
A beta-galactoside alpha2->3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:31784620, PubMed:8027041). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide suga |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00777
|
Glyco_transf_29 |
83 → 338 |
Glycosyltransferase family 29 (sialyltransferase) |
Family |
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Tissue specificity |
TISSUE SPECIFICITY: Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta. {ECO:0000269|PubMed:8027041}. |
Sequence |
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Sequence length |
340 |
Interactions |
View interactions
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Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
18180429 |
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Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Frontal Fibrosing Alopecia |
Frontal Fibrosing Alopecia |
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GWAS |
Carcinoma |
Carcinoma |
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GWAS |
Glioblastoma |
Glioblastoma |
CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 |
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GWAS, CBGDA |
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