Gene Gene information from NCBI Gene database.
Entrez ID 6482
Gene name ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Gene symbol ST3GAL1
Synonyms (NCBI Gene)
Gal-NAc6SSIAT4ASIATFLST3GalAST3GalA.1ST3GalIAST3GalIA1ST3O
Chromosome 8
Chromosome location 8q24.22
Summary The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a
miRNA miRNA information provided by mirtarbase database.
985
miRTarBase ID miRNA Experiments Reference
MIRT047012 hsa-miR-204-5p CLASH 23622248
MIRT047012 hsa-miR-204-5p CLASH 23622248
MIRT706904 hsa-miR-3664-5p HITS-CLIP 21572407
MIRT706903 hsa-miR-4639-3p HITS-CLIP 21572407
MIRT706902 hsa-miR-1304-3p HITS-CLIP 21572407
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
MYC Activation 22547830
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
39
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0002319 Process Memory B cell differentiation IEA
GO:0003836 Function Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
GO:0003836 Function Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA 8027041, 14722111
GO:0003836 Function Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607187 10862 ENSG00000008513
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q11201
Protein name CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase)
Protein function A beta-galactoside alpha2->3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:31784620, PubMed:8027041). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide suga
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00777 Glyco_transf_29 83 338 Glycosyltransferase family 29 (sialyltransferase) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta. {ECO:0000269|PubMed:8027041}.
Sequence
Sequence length 340
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Mucin type O-glycan biosynthesis
Glycosaminoglycan biosynthesis - keratan sulfate
Glycosphingolipid biosynthesis - globo and isoglobo series
Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways
  Keratan sulfate biosynthesis
Sialic acid metabolism
Termination of O-glycan biosynthesis