Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6482
Gene name Gene Name - the full gene name approved by the HGNC.
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ST3GAL1
Synonyms (NCBI Gene) Gene synonyms aliases
Gal-NAc6S, SIAT4A, SIATFL, ST3GalA, ST3GalA.1, ST3GalIA, ST3GalIA,1, ST3O
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q24.22
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047012 hsa-miR-204-5p CLASH 23622248
MIRT047012 hsa-miR-204-5p CLASH 23622248
MIRT706904 hsa-miR-3664-5p HITS-CLIP 21572407
MIRT706903 hsa-miR-4639-3p HITS-CLIP 21572407
MIRT706902 hsa-miR-1304-3p HITS-CLIP 21572407
Transcription factors
Transcription factor Regulation Reference
MYC Activation 22547830
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0002319 Process Memory B cell differentiation IEA
GO:0003836 Function Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA 21873635
GO:0003836 Function Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA 8027041, 14722111
GO:0003836 Function Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607187 10862 ENSG00000008513
Protein
UniProt ID Q11201
Protein name CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase)
Protein function A beta-galactoside alpha2->3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:31784620, PubMed:8027041). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide suga
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00777 Glyco_transf_29 83 338 Glycosyltransferase family 29 (sialyltransferase) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta. {ECO:0000269|PubMed:8027041}.
Sequence
Sequence length 340
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Mucin type O-glycan biosynthesis
Glycosaminoglycan biosynthesis - keratan sulfate
Glycosphingolipid biosynthesis - globo and isoglobo series
Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways
  Keratan sulfate biosynthesis
Sialic acid metabolism
Termination of O-glycan biosynthesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
18180429
Unknown
Disease term Disease name Evidence References Source
Frontal Fibrosing Alopecia Frontal Fibrosing Alopecia GWAS
Carcinoma Carcinoma GWAS
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Bipolar Disorder Associate 18163389, 21176025
Breast Neoplasms Stimulate 11118434
Breast Neoplasms Associate 23275522
Carcinoma Basal Cell Associate 23549466
Carcinoma Renal Cell Associate 26552809
Carcinoma Squamous Cell Stimulate 23549466
Carcinoma Squamous Cell Associate 26908436
Death Associate 26436774
Hypoxia Brain Stimulate 15141079
Influenza Human Associate 26436774