CYP3A43 (cytochrome P450 family 3 subfamily A member 43)

Gene

• Entrez ID: 64816
• Gene name: Cytochrome P450 family 3 subfamily A member 43
• Gene symbol: CYP3A43
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7q22.1
• Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protei

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT921536	hsa-miR-1276	CLIP-seq
MIRT921537	hsa-miR-4311	CLIP-seq
MIRT921538	hsa-miR-583	CLIP-seq
MIRT921539	hsa-miR-636	CLIP-seq
MIRT921540	hsa-miR-653	CLIP-seq
MIRT921541	hsa-miR-1286	CLIP-seq
MIRT921542	hsa-miR-200b	CLIP-seq
MIRT921543	hsa-miR-200c	CLIP-seq
MIRT921544	hsa-miR-3617	CLIP-seq
MIRT921545	hsa-miR-369-3p	CLIP-seq
MIRT921546	hsa-miR-374a	CLIP-seq
MIRT921547	hsa-miR-374b	CLIP-seq
MIRT921548	hsa-miR-3913-3p	CLIP-seq
MIRT921549	hsa-miR-429	CLIP-seq
MIRT921550	hsa-miR-4517	CLIP-seq
MIRT921551	hsa-miR-4722-5p	CLIP-seq
MIRT921552	hsa-miR-4793-5p	CLIP-seq
MIRT921553	hsa-miR-4795-3p	CLIP-seq
MIRT921554	hsa-miR-641	CLIP-seq
MIRT921555	hsa-miR-7	CLIP-seq
MIRT921556	hsa-miR-889	CLIP-seq
MIRT2436753	hsa-miR-4457	CLIP-seq
MIRT2436754	hsa-miR-4775	CLIP-seq
MIRT2436755	hsa-miR-513b	CLIP-seq
MIRT2436756	hsa-miR-590-3p	CLIP-seq
MIRT2436753	hsa-miR-4457	CLIP-seq
MIRT2436754	hsa-miR-4775	CLIP-seq
MIRT2436755	hsa-miR-513b	CLIP-seq
MIRT2436756	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004497	Function	Monooxygenase activity	ISS
GO:0004497	Function	Monooxygenase activity	TAS
GO:0005506	Function	Iron ion binding	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0008202	Process	Steroid metabolic process	IBA	21873635
GO:0008395	Function	Steroid hydroxylase activity	IBA	21873635
GO:0020037	Function	Heme binding	IEA
GO:0050649	Function	Testosterone 6-beta-hydroxylase activity	IBA	21873635
GO:0070330	Function	Aromatase activity	IEA
GO:0070989	Process	Oxidative demethylation	IBA	21873635
GO:0101020	Function	Estrogen 16-alpha-hydroxylase activity	IBA	21873635

Other IDs

• MIM: 606534
• HGNC: 17450
• e!Ensembl: ENSG00000021461

Protein

• UniProt ID: Q9HB55
• Protein name: Cytochrome P450 3A43 (EC 1.14.14.1)
• Protein function: Exhibits low testosterone 6-beta-hydroxylase activity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00067	p450	38 → 493	Cytochrome P450	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle. {ECO:0000269|PubMed:11160876, ECO:0000269|PubMed:11243885}.
• Sequence:

  MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
  AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
  MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
  FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
  IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
  NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS
  KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL
  PILQPEKPIVLKVHLRDGITSGP

• Sequence length: 503

Pathways

KEGG:

Chemical carcinogenesis - DNA adducts

Reactome:

Miscellaneous substrates
Xenobiotics

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	15894682

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Inhibit	36613552
Breast Neoplasms	Associate	20715157
Carcinoma Hepatocellular	Associate	36613552
Cholangiocarcinoma	Associate	38181271
Epilepsy Familial Mesial Temporal Lobe	Associate	28276448
Lymphatic Metastasis	Inhibit	36613552
Neoplasms	Associate	18566991, 20715157, 36613552
Ovarian Neoplasms	Associate	36613552
Personality Disorders	Associate	25337833
Prostatic Hyperplasia	Associate	18566991, 21493872
Prostatic Neoplasms	Associate	18566991, 21493872, 25111073, 25337833, 27164191