Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6480
Gene name Gene Name - the full gene name approved by the HGNC.	ST6 beta-galactoside alpha-2,6-sialyltransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ST6GAL1
Synonyms (NCBI Gene) Gene synonyms aliases	CDw75, SIAT1, ST6GalI, ST6N
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q27.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006076	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT006076	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT006076	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT017979	hsa-miR-335-5p	Microarray	18185580
MIRT030941	hsa-miR-21-5p	Microarray	18591254
MIRT040947	hsa-miR-18a-3p	CLASH	23622248
MIRT448173	hsa-miR-5009-3p	PAR-CLIP	22100165
MIRT448172	hsa-miR-924	PAR-CLIP	22100165
MIRT448171	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT448170	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT448169	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT448168	hsa-miR-3685	PAR-CLIP	22100165
MIRT448167	hsa-miR-384	PAR-CLIP	22100165
MIRT448165	hsa-miR-8081	PAR-CLIP	22100165
MIRT448173	hsa-miR-5009-3p	PAR-CLIP	22100165
MIRT448172	hsa-miR-924	PAR-CLIP	22100165
MIRT448171	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT448170	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT448169	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT448168	hsa-miR-3685	PAR-CLIP	22100165
MIRT448167	hsa-miR-384	PAR-CLIP	22100165
MIRT448165	hsa-miR-8081	PAR-CLIP	22100165
MIRT030941	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT439531	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT030941	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT439531	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT448173	hsa-miR-5009-3p	PAR-CLIP	22100165
MIRT448172	hsa-miR-924	PAR-CLIP	22100165
MIRT448171	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT448170	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT448169	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT448168	hsa-miR-3685	PAR-CLIP	22100165
MIRT448167	hsa-miR-384	PAR-CLIP	22100165
MIRT448165	hsa-miR-8081	PAR-CLIP	22100165
MIRT448173	hsa-miR-5009-3p	PAR-CLIP	22100165
MIRT448172	hsa-miR-924	PAR-CLIP	22100165
MIRT448171	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT448170	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT448169	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT448168	hsa-miR-3685	PAR-CLIP	22100165
MIRT448167	hsa-miR-384	PAR-CLIP	22100165
MIRT448165	hsa-miR-8081	PAR-CLIP	22100165
MIRT1393652	hsa-miR-1252	CLIP-seq
MIRT1393653	hsa-miR-140-3p	CLIP-seq
MIRT1393654	hsa-miR-148a	CLIP-seq
MIRT1393655	hsa-miR-148b	CLIP-seq
MIRT1393656	hsa-miR-152	CLIP-seq
MIRT1393657	hsa-miR-1825	CLIP-seq
MIRT1393658	hsa-miR-21	CLIP-seq
MIRT1393659	hsa-miR-2355-5p	CLIP-seq
MIRT1393660	hsa-miR-3155	CLIP-seq
MIRT1393661	hsa-miR-3155b	CLIP-seq
MIRT1393662	hsa-miR-3173-3p	CLIP-seq
MIRT1393663	hsa-miR-338-3p	CLIP-seq
MIRT1393664	hsa-miR-3616-5p	CLIP-seq
MIRT1393665	hsa-miR-3647-5p	CLIP-seq
MIRT1393666	hsa-miR-3714	CLIP-seq
MIRT1393667	hsa-miR-3908	CLIP-seq
MIRT1393668	hsa-miR-3942-5p	CLIP-seq
MIRT1393669	hsa-miR-4302	CLIP-seq
MIRT1393670	hsa-miR-4438	CLIP-seq
MIRT1393671	hsa-miR-4476	CLIP-seq
MIRT1393672	hsa-miR-4484	CLIP-seq
MIRT1393673	hsa-miR-4496	CLIP-seq
MIRT1393674	hsa-miR-4509	CLIP-seq
MIRT1393675	hsa-miR-4533	CLIP-seq
MIRT1393676	hsa-miR-4635	CLIP-seq
MIRT1393677	hsa-miR-4703-5p	CLIP-seq
MIRT1393678	hsa-miR-4762-5p	CLIP-seq
MIRT1393679	hsa-miR-4766-3p	CLIP-seq
MIRT1393680	hsa-miR-4803	CLIP-seq
MIRT1393681	hsa-miR-484	CLIP-seq
MIRT1393682	hsa-miR-515-5p	CLIP-seq
MIRT1393683	hsa-miR-548an	CLIP-seq
MIRT1393684	hsa-miR-573	CLIP-seq
MIRT1393685	hsa-miR-590-5p	CLIP-seq
MIRT1393686	hsa-miR-592	CLIP-seq
MIRT1393687	hsa-miR-597	CLIP-seq
MIRT1393688	hsa-miR-605	CLIP-seq
MIRT1393689	hsa-miR-634	CLIP-seq
MIRT1393690	hsa-miR-940	CLIP-seq
MIRT1557147	hsa-miR-3620	CLIP-seq
MIRT2340126	hsa-miR-1284	CLIP-seq
MIRT2340127	hsa-miR-2278	CLIP-seq
MIRT2340128	hsa-miR-2355-3p	CLIP-seq
MIRT2340129	hsa-miR-3120-3p	CLIP-seq
MIRT2340130	hsa-miR-337-3p	CLIP-seq
MIRT2340131	hsa-miR-3936	CLIP-seq
MIRT1393668	hsa-miR-3942-5p	CLIP-seq
MIRT2340132	hsa-miR-3976	CLIP-seq
MIRT2340133	hsa-miR-4503	CLIP-seq
MIRT2340134	hsa-miR-4690-3p	CLIP-seq
MIRT1393677	hsa-miR-4703-5p	CLIP-seq
MIRT2340135	hsa-miR-4765	CLIP-seq
MIRT2340136	hsa-miR-4771	CLIP-seq
MIRT2340137	hsa-miR-498	CLIP-seq
MIRT2340138	hsa-miR-499a-5p	CLIP-seq
MIRT2340139	hsa-miR-580	CLIP-seq
MIRT2340140	hsa-miR-662	CLIP-seq
MIRT2340141	hsa-miR-676	CLIP-seq
MIRT2340142	hsa-miR-758	CLIP-seq
MIRT2340143	hsa-miR-759	CLIP-seq
MIRT2395245	hsa-miR-1271	CLIP-seq
MIRT2395246	hsa-miR-182	CLIP-seq
MIRT2395247	hsa-miR-185	CLIP-seq
MIRT2395248	hsa-miR-342-5p	CLIP-seq
MIRT2395249	hsa-miR-3926	CLIP-seq
MIRT2395250	hsa-miR-4306	CLIP-seq
MIRT2395251	hsa-miR-4644	CLIP-seq
MIRT2395252	hsa-miR-4651	CLIP-seq
MIRT2395253	hsa-miR-4664-5p	CLIP-seq
MIRT2395254	hsa-miR-4729	CLIP-seq
MIRT2395255	hsa-miR-4786-5p	CLIP-seq
MIRT2395256	hsa-miR-548s	CLIP-seq
MIRT2395257	hsa-miR-579	CLIP-seq
MIRT2395258	hsa-miR-608	CLIP-seq
MIRT2395259	hsa-miR-664	CLIP-seq
MIRT2395260	hsa-miR-885-3p	CLIP-seq
MIRT2395261	hsa-miR-96	CLIP-seq
MIRT2460612	hsa-miR-3199	CLIP-seq
MIRT2460613	hsa-miR-4515	CLIP-seq
MIRT2460614	hsa-miR-4774-5p	CLIP-seq
MIRT1393652	hsa-miR-1252	CLIP-seq
MIRT2634053	hsa-miR-1915	CLIP-seq
MIRT2634054	hsa-miR-2116	CLIP-seq
MIRT2395248	hsa-miR-342-5p	CLIP-seq
MIRT1393666	hsa-miR-3714	CLIP-seq
MIRT1393671	hsa-miR-4476	CLIP-seq
MIRT1393672	hsa-miR-4484	CLIP-seq
MIRT1393673	hsa-miR-4496	CLIP-seq
MIRT2634055	hsa-miR-4505	CLIP-seq
MIRT1393674	hsa-miR-4509	CLIP-seq
MIRT1393675	hsa-miR-4533	CLIP-seq
MIRT2395252	hsa-miR-4651	CLIP-seq
MIRT2395253	hsa-miR-4664-5p	CLIP-seq
MIRT2634056	hsa-miR-4677-5p	CLIP-seq
MIRT2634057	hsa-miR-4726-3p	CLIP-seq
MIRT2634058	hsa-miR-4731-5p	CLIP-seq
MIRT1393683	hsa-miR-548an	CLIP-seq
MIRT2395258	hsa-miR-608	CLIP-seq
MIRT1393690	hsa-miR-940	CLIP-seq
MIRT1393652	hsa-miR-1252	CLIP-seq
MIRT2634053	hsa-miR-1915	CLIP-seq
MIRT2634054	hsa-miR-2116	CLIP-seq
MIRT2395248	hsa-miR-342-5p	CLIP-seq
MIRT1393666	hsa-miR-3714	CLIP-seq
MIRT1393671	hsa-miR-4476	CLIP-seq
MIRT1393672	hsa-miR-4484	CLIP-seq
MIRT1393673	hsa-miR-4496	CLIP-seq
MIRT2634055	hsa-miR-4505	CLIP-seq
MIRT1393674	hsa-miR-4509	CLIP-seq
MIRT1393675	hsa-miR-4533	CLIP-seq
MIRT2395252	hsa-miR-4651	CLIP-seq
MIRT2395253	hsa-miR-4664-5p	CLIP-seq
MIRT2634056	hsa-miR-4677-5p	CLIP-seq
MIRT2634057	hsa-miR-4726-3p	CLIP-seq
MIRT2634058	hsa-miR-4731-5p	CLIP-seq
MIRT1393683	hsa-miR-548an	CLIP-seq
MIRT2395258	hsa-miR-608	CLIP-seq
MIRT1393689	hsa-miR-634	CLIP-seq
MIRT1393690	hsa-miR-940	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
POU2F1	Unknown	10814704
SP1	Unknown	10814704

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	20378551
GO:0000139	Component	Golgi membrane	TAS
GO:0003835	Function	Beta-galactoside alpha-2,6-sialyltransferase activity	IBA
GO:0003835	Function	Beta-galactoside alpha-2,6-sialyltransferase activity	IDA	23999306
GO:0003835	Function	Beta-galactoside alpha-2,6-sialyltransferase activity	IEA
GO:0003835	Function	Beta-galactoside alpha-2,6-sialyltransferase activity	TAS
GO:0005515	Function	Protein binding	IPI	16237761
GO:0005576	Component	Extracellular region	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IEA
GO:0006054	Process	N-acetylneuraminate metabolic process	IDA	23999306
GO:0006486	Process	Protein glycosylation	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0008373	Function	Sialyltransferase activity	IDA	21081508
GO:0008373	Function	Sialyltransferase activity	IEA
GO:0008373	Function	Sialyltransferase activity	TAS
GO:0016020	Component	Membrane	IEA
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0018279	Process	Protein N-linked glycosylation via asparagine	IBA
GO:0018279	Process	Protein N-linked glycosylation via asparagine	IDA	23999306
GO:0018279	Process	Protein N-linked glycosylation via asparagine	IEA
GO:0019082	Process	Viral protein processing	TAS
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	20378551
GO:0097503	Process	Sialylation	IBA
GO:0097503	Process	Sialylation	IDA	23999306

MIM	HGNC	e!Ensembl
109675	10860	ENSG00000073849

Protein

UniProt ID

P15907

Protein name

Beta-galactoside alpha-2,6-sialyltransferase 1 (Alpha 2,6-ST 1) (EC 2.4.3.1) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1) (ST6Gal I) (ST6GalI) (Sialyltransferase 1)

Protein function

Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. In B lymphocytes, generates neuraminidase-sensitive lymphocyte cell-surface differentiation antigens, such as CDw75, HB-6 and CD76 (PubMed:1730763). {ECO:000

PDB

4JS1 , 4JS2 , 6QVS , 6QVT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00777	Glyco_transf_29	157 → 386	Glycosyltransferase family 29 (sialyltransferase)	Family

Sequence

MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKEFQVLKSLGKLAMGSDS
QSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSSKNLIPRLQKIWKNYLSMN
KYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGP
WGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTE
KRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQM
PWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFF
DSACTMGAYHPLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC

Sequence length

406

Interactions

View interactions

	KEGG		Reactome
	N-Glycan biosynthesis Other types of O-glycan biosynthesis Metabolic pathways		Sialic acid metabolism N-Glycan antennae elongation Termination of O-glycan biosynthesis

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Eosinophilia	Eosinophilic esophagitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (67)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	14507929
Asthma	Associate	30730306
Astrocytoma	Associate	33836687
Breast Neoplasms	Associate	12841680, 25344606, 35676533
Breast Neoplasms	Stimulate	27588482
Carcinogenesis	Associate	23358684, 25465919
Carcinoma	Stimulate	23358684
Carcinoma Basal Cell	Associate	23549466
Carcinoma Hepatocellular	Associate	12429811, 24255131, 27340870, 34559939
Carcinoma Hepatocellular	Stimulate	27588482
Carcinoma Pancreatic Ductal	Associate	29191829, 39260693
Carcinoma Papillary	Stimulate	25465919
Carcinoma Renal Cell	Associate	25556450
Carcinoma Squamous Cell	Associate	23549466
Cataract Age Related Nuclear	Associate	34954695
Colonic Neoplasms	Associate	12515997
Colonic Neoplasms	Stimulate	23358684
Colorectal Neoplasms	Associate	10673297, 20003255, 22449099, 32945502
Colorectal Neoplasms	Stimulate	11406350
Coronary Artery Disease	Associate	22216278
Diabetes Mellitus Type 1	Associate	36907892
Diabetes Mellitus Type 2	Stimulate	21874001
Diabetes Mellitus Type 2	Associate	26395551, 35467766
Drug Related Side Effects and Adverse Reactions	Associate	33947960
Esophageal Neoplasms	Associate	35704638
Glomerulonephritis IGA	Associate	26028593, 30042224
Glomerulonephritis IGA	Stimulate	32677771
Hand Foot Syndrome	Associate	35467766
Heart Failure	Stimulate	35945262
Hypoxia	Associate	29475939, 37364046
Hypoxia Brain	Associate	29475939
Inflammation	Associate	24324693, 30730306, 34290711
Inflammation	Stimulate	39260693
Influenza Human	Associate	34198852
Keratoacanthoma	Associate	23549466
Keratosis Actinic	Associate	23549466
Leukemia	Associate	24454800
Lupus Erythematosus Systemic	Associate	31509989
Lymphatic Metastasis	Stimulate	38003522
Lymphoma Large Cell Anaplastic	Associate	25573487
Meningioma	Associate	34943806
Mucocutaneous Lymph Node Syndrome	Associate	24324693
Neoplasm Metastasis	Associate	22449099, 23549466, 25556450
Neoplasms	Associate	12235148, 12515997, 22449099, 23549466, 25556450, 27340870, 28154177, 29402301, 29475939, 31610800, 32763973, 34943806, 35676533, 37364046
Neoplasms	Stimulate	20003255, 23358684, 25344606, 37660914
Non Muscle Invasive Bladder Neoplasms	Inhibit	25465919
Obesity	Associate	26395551, 30021629
Obesity	Stimulate	30021629
Ovarian Neoplasms	Associate	24855066, 29402301, 31610800, 32016470
Ovarian Neoplasms	Stimulate	27588482, 37660914
Pancreatic Neoplasms	Associate	29402301, 33148698, 39260693
Prostatic Neoplasms	Associate	27428423
Prostatic Neoplasms	Stimulate	27588482
Prostatitis	Associate	27428423
Proteinuria	Stimulate	32677771
Pulmonary Disease Chronic Obstructive	Associate	34290711
Skin Neoplasms	Associate	23549466
Stomach Neoplasms	Associate	20003255, 32763973, 33947960
Supranuclear Palsy Progressive	Associate	33635380
Thyroid cancer follicular	Associate	38003522
Thyroid Cancer Papillary	Stimulate	38003522
Thyroid Neoplasms	Associate	38003522
Tuberculosis Multidrug Resistant	Associate	24454800
Urinary Bladder Neoplasms	Inhibit	25465919
Uterine Cervical Diseases	Associate	24606438
Uterine Cervical Neoplasms	Associate	24606438
Uterine Cervicitis	Associate	24606438

ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1)