Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
648
Gene name Gene Name - the full gene name approved by the HGNC.
BMI1 proto-oncogene, polycomb ring finger
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BMI1
Synonyms (NCBI Gene) Gene synonyms aliases
FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p12.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000197 hsa-miR-200c-3p Review 20026422
MIRT004645 hsa-miR-128-3p Review 20029422
MIRT004645 hsa-miR-128-3p Immunohistochemistry, In situ hybridization, Microarray, qRT-PCR, Western blot 19010882
MIRT000197 hsa-miR-200c-3p Luciferase reporter assay, Western blot 19665978
MIRT000197 hsa-miR-200c-3p Luciferase reporter assay, Western blot 19665978
Transcription factors
Transcription factor Regulation Reference
E2F1 Unknown 17360938
MYC Activation 21856782
MYCN Activation 21856782
TWIST1 Activation 21876555
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 19636380
GO:0000151 Component Ubiquitin ligase complex IDA 16714294
GO:0005515 Function Protein binding IPI 15386022, 16710298, 17332741, 19233177, 19636380, 19903340, 20543829, 20601937, 21282530, 21772249, 22078878, 22493164, 22897849, 22902369, 23523425, 24981860, 25185265, 25416956, 26496610, 27705803, 28514442, 32296183
GO:0005634 Component Nucleus IDA 9367786, 10445843, 21282530
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
164831 1066 ENSG00000168283
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Polycomb repressive complex
Signaling pathways regulating pluripotency of stem cells
Transcriptional misregulation in cancer
MicroRNAs in cancer
  Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Glioblastoma Glioblastoma, Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 19823589
Glioma Glioma, mixed gliomas, Malignant Glioma rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499
View all (13 more)
23383216
Hirschsprung disease Hirschsprung Disease rs76262710, rs75996173, rs77316810, rs75076352, rs76534745, rs76764689, rs76449634, rs377767412, rs193922699, rs75030001, rs606231342, rs1553540620, rs759944122, rs1057519322, rs1057519323
View all (4 more)
29429387
Myelodysplastic syndrome MYELODYSPLASTIC SYNDROME rs193303018, rs387906631, rs1576745225, rs373145711, rs752746786, rs377023736, rs373221034, rs1576749014, rs1600586587 24571310
Associations from Text Mining
Disease Name Relationship Type References
3 Hydroxy 3 Methylglutaryl CoA Lyase Deficiency Associate 14982841
Adenocarcinoma Associate 23078618
Adenocarcinoma of Lung Associate 22529186, 23990442
Adenoma Oxyphilic Stimulate 18347933
Adenoma Pleomorphic Associate 26166073
Adenomatous Polyposis Coli Inhibit 22094874
Alzheimer Disease Inhibit 29847796, 34610832
Anemia Refractory Associate 16160010
Anemia Refractory with Excess of Blasts Stimulate 16160010
Arthropathy progressive pseudorheumatoid of childhood Associate 26166073