Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64798
Gene name Gene Name - the full gene name approved by the HGNC.	DEP domain containing MTOR interacting protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DEPTOR
Synonyms (NCBI Gene) Gene synonyms aliases	DEP.6, DEPDC6, hDEPTOR
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8q24.12

Show/Hide all(253)

miRTarBase ID	miRNA	Experiments	Reference
MIRT518506	hsa-miR-4803	HITS-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518503	hsa-miR-654-3p	HITS-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518503	hsa-miR-654-3p	HITS-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT641359	hsa-miR-365a-3p	HITS-CLIP	23824327
MIRT641358	hsa-miR-365b-3p	HITS-CLIP	23824327
MIRT641357	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT641356	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT659077	hsa-miR-4457	HITS-CLIP	23824327
MIRT641355	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT641354	hsa-miR-3685	HITS-CLIP	23824327
MIRT641353	hsa-miR-384	HITS-CLIP	23824327
MIRT659076	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT659075	hsa-miR-3145-5p	HITS-CLIP	23824327
MIRT659074	hsa-miR-8063	HITS-CLIP	23824327
MIRT659073	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT659072	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT659071	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT659070	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT659069	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT659068	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT659067	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT659066	hsa-miR-3921	HITS-CLIP	23824327
MIRT659065	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT659064	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT659063	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT659062	hsa-miR-668-3p	HITS-CLIP	23824327
MIRT659061	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT641359	hsa-miR-365a-3p	HITS-CLIP	23824327
MIRT641358	hsa-miR-365b-3p	HITS-CLIP	23824327
MIRT641357	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT641356	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT641355	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT641354	hsa-miR-3685	HITS-CLIP	23824327
MIRT641353	hsa-miR-384	HITS-CLIP	23824327
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518503	hsa-miR-654-3p	HITS-CLIP	23824327
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	23824327
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518506	hsa-miR-4803	PAR-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518503	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518503	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518506	hsa-miR-4803	PAR-CLIP	23446348
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518503	hsa-miR-654-3p	PAR-CLIP	23446348
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	23446348
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT518506	hsa-miR-4803	HITS-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518503	hsa-miR-654-3p	HITS-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518503	hsa-miR-654-3p	HITS-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT641359	hsa-miR-365a-3p	HITS-CLIP	23824327
MIRT641358	hsa-miR-365b-3p	HITS-CLIP	23824327
MIRT641357	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT641356	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT659077	hsa-miR-4457	HITS-CLIP	23824327
MIRT641355	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT641354	hsa-miR-3685	HITS-CLIP	23824327
MIRT641353	hsa-miR-384	HITS-CLIP	23824327
MIRT659076	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT659075	hsa-miR-3145-5p	HITS-CLIP	23824327
MIRT659074	hsa-miR-8063	HITS-CLIP	23824327
MIRT659073	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT659072	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT659071	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT659070	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT659069	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT659068	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT659067	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT659066	hsa-miR-3921	HITS-CLIP	23824327
MIRT659065	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT659064	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT659063	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT659062	hsa-miR-668-3p	HITS-CLIP	23824327
MIRT659061	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT641359	hsa-miR-365a-3p	HITS-CLIP	23824327
MIRT641358	hsa-miR-365b-3p	HITS-CLIP	23824327
MIRT641357	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT641356	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT641355	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT641354	hsa-miR-3685	HITS-CLIP	23824327
MIRT641353	hsa-miR-384	HITS-CLIP	23824327
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518503	hsa-miR-654-3p	HITS-CLIP	23824327
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	23824327
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518506	hsa-miR-4803	PAR-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518503	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518503	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518506	hsa-miR-4803	PAR-CLIP	23446348
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518503	hsa-miR-654-3p	PAR-CLIP	23446348
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	23446348
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT933012	hsa-miR-1	CLIP-seq
MIRT933013	hsa-miR-103a	CLIP-seq
MIRT933014	hsa-miR-107	CLIP-seq
MIRT933015	hsa-miR-1253	CLIP-seq
MIRT933016	hsa-miR-1270	CLIP-seq
MIRT933017	hsa-miR-147b	CLIP-seq
MIRT933018	hsa-miR-15a	CLIP-seq
MIRT933019	hsa-miR-15b	CLIP-seq
MIRT933020	hsa-miR-16	CLIP-seq
MIRT933021	hsa-miR-195	CLIP-seq
MIRT933022	hsa-miR-206	CLIP-seq
MIRT933023	hsa-miR-297	CLIP-seq
MIRT933024	hsa-miR-3155	CLIP-seq
MIRT933025	hsa-miR-3155b	CLIP-seq
MIRT933026	hsa-miR-3173-3p	CLIP-seq
MIRT933027	hsa-miR-3185	CLIP-seq
MIRT933028	hsa-miR-3612	CLIP-seq
MIRT933029	hsa-miR-3673	CLIP-seq
MIRT933030	hsa-miR-424	CLIP-seq
MIRT933031	hsa-miR-4428	CLIP-seq
MIRT933032	hsa-miR-4432	CLIP-seq
MIRT933033	hsa-miR-4434	CLIP-seq
MIRT933034	hsa-miR-4516	CLIP-seq
MIRT933035	hsa-miR-4521	CLIP-seq
MIRT933036	hsa-miR-4531	CLIP-seq
MIRT933037	hsa-miR-455-5p	CLIP-seq
MIRT933038	hsa-miR-4695-5p	CLIP-seq
MIRT933039	hsa-miR-4704-5p	CLIP-seq
MIRT933040	hsa-miR-4731-3p	CLIP-seq
MIRT933041	hsa-miR-4735-5p	CLIP-seq
MIRT933042	hsa-miR-4775	CLIP-seq
MIRT933043	hsa-miR-4801	CLIP-seq
MIRT933044	hsa-miR-484	CLIP-seq
MIRT933045	hsa-miR-497	CLIP-seq
MIRT933046	hsa-miR-548aa	CLIP-seq
MIRT933047	hsa-miR-548c-3p	CLIP-seq
MIRT933048	hsa-miR-548k	CLIP-seq
MIRT933049	hsa-miR-567	CLIP-seq
MIRT933050	hsa-miR-590-3p	CLIP-seq
MIRT933051	hsa-miR-613	CLIP-seq
MIRT933052	hsa-miR-620	CLIP-seq
MIRT933053	hsa-miR-628-3p	CLIP-seq
MIRT933054	hsa-miR-650	CLIP-seq
MIRT933055	hsa-miR-658	CLIP-seq
MIRT933056	hsa-miR-885-5p	CLIP-seq
MIRT1547950	hsa-miR-1587	CLIP-seq
MIRT1547951	hsa-miR-3123	CLIP-seq
MIRT1547952	hsa-miR-3154	CLIP-seq
MIRT1547953	hsa-miR-3163	CLIP-seq
MIRT1547954	hsa-miR-3925-5p	CLIP-seq
MIRT1547955	hsa-miR-4674	CLIP-seq
MIRT1976228	hsa-miR-181a	CLIP-seq
MIRT1976229	hsa-miR-181b	CLIP-seq
MIRT1976230	hsa-miR-181c	CLIP-seq
MIRT1976231	hsa-miR-181d	CLIP-seq
MIRT1976232	hsa-miR-3143	CLIP-seq
MIRT1976233	hsa-miR-3159	CLIP-seq
MIRT1547953	hsa-miR-3163	CLIP-seq
MIRT1976234	hsa-miR-421	CLIP-seq
MIRT1976235	hsa-miR-4262	CLIP-seq
MIRT1976236	hsa-miR-4272	CLIP-seq
MIRT1976237	hsa-miR-4276	CLIP-seq
MIRT1976238	hsa-miR-4302	CLIP-seq
MIRT1976239	hsa-miR-543	CLIP-seq
MIRT933015	hsa-miR-1253	CLIP-seq
MIRT2211660	hsa-miR-1297	CLIP-seq
MIRT2211661	hsa-miR-1303	CLIP-seq
MIRT933017	hsa-miR-147b	CLIP-seq
MIRT1976228	hsa-miR-181a	CLIP-seq
MIRT1976229	hsa-miR-181b	CLIP-seq
MIRT1976230	hsa-miR-181c	CLIP-seq
MIRT1976231	hsa-miR-181d	CLIP-seq
MIRT2211662	hsa-miR-26a	CLIP-seq
MIRT2211663	hsa-miR-26b	CLIP-seq
MIRT933023	hsa-miR-297	CLIP-seq
MIRT933024	hsa-miR-3155	CLIP-seq
MIRT933025	hsa-miR-3155b	CLIP-seq
MIRT1547953	hsa-miR-3163	CLIP-seq
MIRT933026	hsa-miR-3173-3p	CLIP-seq
MIRT933028	hsa-miR-3612	CLIP-seq
MIRT2211664	hsa-miR-3692	CLIP-seq
MIRT2211665	hsa-miR-3714	CLIP-seq
MIRT1976235	hsa-miR-4262	CLIP-seq
MIRT1976237	hsa-miR-4276	CLIP-seq
MIRT1976238	hsa-miR-4302	CLIP-seq
MIRT933031	hsa-miR-4428	CLIP-seq
MIRT933032	hsa-miR-4432	CLIP-seq
MIRT933033	hsa-miR-4434	CLIP-seq
MIRT2211666	hsa-miR-4465	CLIP-seq
MIRT933034	hsa-miR-4516	CLIP-seq
MIRT933035	hsa-miR-4521	CLIP-seq
MIRT933037	hsa-miR-455-5p	CLIP-seq
MIRT933038	hsa-miR-4695-5p	CLIP-seq
MIRT2211667	hsa-miR-4698	CLIP-seq
MIRT933040	hsa-miR-4731-3p	CLIP-seq
MIRT933043	hsa-miR-4801	CLIP-seq
MIRT933044	hsa-miR-484	CLIP-seq
MIRT2211668	hsa-miR-548a-3p	CLIP-seq
MIRT2211669	hsa-miR-548e	CLIP-seq
MIRT2211670	hsa-miR-548f	CLIP-seq
MIRT933049	hsa-miR-567	CLIP-seq
MIRT2211671	hsa-miR-568	CLIP-seq
MIRT933054	hsa-miR-650	CLIP-seq
MIRT933055	hsa-miR-658	CLIP-seq
MIRT2211672	hsa-miR-671-3p	CLIP-seq
MIRT2211673	hsa-miR-941	CLIP-seq
MIRT933033	hsa-miR-4434	CLIP-seq
MIRT933034	hsa-miR-4516	CLIP-seq
MIRT2679194	hsa-miR-135a	CLIP-seq
MIRT2679195	hsa-miR-135b	CLIP-seq
MIRT2679196	hsa-miR-3117-5p	CLIP-seq
MIRT2679197	hsa-miR-3119	CLIP-seq
MIRT2679198	hsa-miR-3146	CLIP-seq
MIRT2679199	hsa-miR-3606	CLIP-seq
MIRT2679200	hsa-miR-3647-3p	CLIP-seq
MIRT2679201	hsa-miR-3653	CLIP-seq
MIRT2679202	hsa-miR-3658	CLIP-seq
MIRT2211665	hsa-miR-3714	CLIP-seq
MIRT2679203	hsa-miR-4484	CLIP-seq
MIRT2679204	hsa-miR-4503	CLIP-seq
MIRT2679205	hsa-miR-4509	CLIP-seq
MIRT2679206	hsa-miR-4640-3p	CLIP-seq
MIRT2679207	hsa-miR-4780	CLIP-seq
MIRT2679208	hsa-miR-548an	CLIP-seq
MIRT2679209	hsa-miR-940	CLIP-seq

Show/Hide all(6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19446321, 25416956, 30080879, 30232230, 32296183
GO:0006469	Process	Negative regulation of protein kinase activity	IMP	19446321
GO:0032007	Process	Negative regulation of TOR signaling	IMP	19446321
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0045792	Process	Negative regulation of cell size	IMP	19446321
GO:2001236	Process	Regulation of extrinsic apoptotic signaling pathway	IMP	19446321

MIM	HGNC	e!Ensembl
612974	22953	ENSG00000155792

Protein

UniProt ID

Q8TB45

Protein name

DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6)

Protein function

Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMe

PDB

7DKL , 7OWG , 7PE7 , 7PE8 , 7PE9 , 7PEA , 7PEB , 7PEC , 7PED

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00610	DEP	48 → 117	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain
PF00610	DEP	148 → 217	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain

Sequence

MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTY
PNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKD
DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEA
TTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQE
THDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSP
PVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGP
AAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC

Sequence length

409

Interactions

View interactions

	KEGG
	Autophagy - animal mTOR signaling pathway

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Pulmonary Fibrosis	Pulmonary Fibrosis	GWAS
Oligodendroglioma	Oligodendroglioma	GWAS

Show/Hide Text Mining Associations (39)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	32998690
Alzheimer Disease	Inhibit	25119265
Alzheimer disease type 1	Inhibit	25119265
Autoimmune Diseases	Associate	28349073, 29940800
Breast Neoplasms	Associate	33995662
Breast Neoplasms	Inhibit	39945739
Carcinogenesis	Associate	26992219
Carcinoma Endometrioid	Inhibit	28358054
Carcinoma Hepatocellular	Associate	34634301
Carcinoma Pancreatic Ductal	Inhibit	25544749
Carcinoma Renal Cell	Associate	37328520
Carcinoma Squamous Cell	Associate	26992219
Colorectal Neoplasms	Associate	24969890, 35923131
Diabetes Mellitus Type 2	Associate	37140276
Endometrial Neoplasms	Associate	28358054
Fibrosis	Associate	31710517
HEM dysplasia	Stimulate	30232230
Idiopathic Pulmonary Fibrosis	Associate	31710517, 36413936
Inflammation	Associate	28349073, 32702393
Jansen type metaphyseal chondrodysplasia	Stimulate	30232230
Kashin Beck Disease	Associate	29242531
Lymphoma Large B Cell Diffuse	Associate	32702393
Mitochondrial Diseases	Associate	30692212
Multiple Myeloma	Associate	19446321, 23613505, 28420429, 33416146, 35216969
Neoplasm Metastasis	Inhibit	24969890
Neoplasms	Associate	23260012, 24969890, 26992219, 28546520, 29382726, 33184290, 37902189
Neoplasms	Inhibit	28358054, 30387804, 35095893
Ovarian Diseases	Associate	35295989
Ovarian Neoplasms	Stimulate	27211906
Ovarian Neoplasms	Inhibit	30387804
Pancreatic Neoplasms	Associate	25544749
Pancreatitis	Associate	25544749
Plaque Amyloid	Inhibit	25119265
Polycystic Ovary Syndrome	Associate	37140276
Prostatic Neoplasms	Associate	26558456
Pulmonary Disease Chronic Obstructive	Associate	29799805
Pulmonary Disease Chronic Obstructive	Inhibit	30692212
Spondylitis Ankylosing	Associate	29940800
Stomach Neoplasms	Associate	37469018

DEPTOR (DEP domain containing MTOR interacting protein)