DEPTOR (DEP domain containing MTOR interacting protein)

Gene

• Entrez ID: 64798
• Gene name: DEP domain containing MTOR interacting protein
• Gene symbol: DEPTOR
• Synonyms (NCBI Gene): DEP.6, DEPDC6, hDEPTOR
• Chromosome: 8
• Chromosome location: 8q24.12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT518506	hsa-miR-4803	HITS-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518503	hsa-miR-654-3p	HITS-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518503	hsa-miR-654-3p	HITS-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT641359	hsa-miR-365a-3p	HITS-CLIP	23824327
MIRT641358	hsa-miR-365b-3p	HITS-CLIP	23824327
MIRT641357	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT641356	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT659077	hsa-miR-4457	HITS-CLIP	23824327
MIRT641355	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT641354	hsa-miR-3685	HITS-CLIP	23824327
MIRT641353	hsa-miR-384	HITS-CLIP	23824327
MIRT659076	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT659075	hsa-miR-3145-5p	HITS-CLIP	23824327
MIRT659074	hsa-miR-8063	HITS-CLIP	23824327
MIRT659073	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT659072	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT659071	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT659070	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT659069	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT659068	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT659067	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT659066	hsa-miR-3921	HITS-CLIP	23824327
MIRT659065	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT659064	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT659063	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT659062	hsa-miR-668-3p	HITS-CLIP	23824327
MIRT659061	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT641359	hsa-miR-365a-3p	HITS-CLIP	23824327
MIRT641358	hsa-miR-365b-3p	HITS-CLIP	23824327
MIRT641357	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT641356	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT641355	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT641354	hsa-miR-3685	HITS-CLIP	23824327
MIRT641353	hsa-miR-384	HITS-CLIP	23824327
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518503	hsa-miR-654-3p	HITS-CLIP	23824327
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	23824327
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518506	hsa-miR-4803	PAR-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518503	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518503	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518506	hsa-miR-4803	PAR-CLIP	23446348
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518503	hsa-miR-654-3p	PAR-CLIP	23446348
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	23446348
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT518506	hsa-miR-4803	HITS-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518503	hsa-miR-654-3p	HITS-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518503	hsa-miR-654-3p	HITS-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT641359	hsa-miR-365a-3p	HITS-CLIP	23824327
MIRT641358	hsa-miR-365b-3p	HITS-CLIP	23824327
MIRT641357	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT641356	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT659077	hsa-miR-4457	HITS-CLIP	23824327
MIRT641355	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT641354	hsa-miR-3685	HITS-CLIP	23824327
MIRT641353	hsa-miR-384	HITS-CLIP	23824327
MIRT659076	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT659075	hsa-miR-3145-5p	HITS-CLIP	23824327
MIRT659074	hsa-miR-8063	HITS-CLIP	23824327
MIRT659073	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT659072	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT659071	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT659070	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT659069	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT659068	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT659067	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT659066	hsa-miR-3921	HITS-CLIP	23824327
MIRT659065	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT659064	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT659063	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT659062	hsa-miR-668-3p	HITS-CLIP	23824327
MIRT659061	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT641359	hsa-miR-365a-3p	HITS-CLIP	23824327
MIRT641358	hsa-miR-365b-3p	HITS-CLIP	23824327
MIRT641357	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT641356	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT641355	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT641354	hsa-miR-3685	HITS-CLIP	23824327
MIRT641353	hsa-miR-384	HITS-CLIP	23824327
MIRT518504	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518503	hsa-miR-654-3p	HITS-CLIP	23824327
MIRT518502	hsa-miR-4796-5p	HITS-CLIP	23824327
MIRT518501	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518505	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518506	hsa-miR-4803	PAR-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518503	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518503	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	21572407
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518506	hsa-miR-4803	PAR-CLIP	23446348
MIRT518505	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT518504	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518503	hsa-miR-654-3p	PAR-CLIP	23446348
MIRT518502	hsa-miR-4796-5p	PAR-CLIP	23446348
MIRT518501	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT933012	hsa-miR-1	CLIP-seq
MIRT933013	hsa-miR-103a	CLIP-seq
MIRT933014	hsa-miR-107	CLIP-seq
MIRT933015	hsa-miR-1253	CLIP-seq
MIRT933016	hsa-miR-1270	CLIP-seq
MIRT933017	hsa-miR-147b	CLIP-seq
MIRT933018	hsa-miR-15a	CLIP-seq
MIRT933019	hsa-miR-15b	CLIP-seq
MIRT933020	hsa-miR-16	CLIP-seq
MIRT933021	hsa-miR-195	CLIP-seq
MIRT933022	hsa-miR-206	CLIP-seq
MIRT933023	hsa-miR-297	CLIP-seq
MIRT933024	hsa-miR-3155	CLIP-seq
MIRT933025	hsa-miR-3155b	CLIP-seq
MIRT933026	hsa-miR-3173-3p	CLIP-seq
MIRT933027	hsa-miR-3185	CLIP-seq
MIRT933028	hsa-miR-3612	CLIP-seq
MIRT933029	hsa-miR-3673	CLIP-seq
MIRT933030	hsa-miR-424	CLIP-seq
MIRT933031	hsa-miR-4428	CLIP-seq
MIRT933032	hsa-miR-4432	CLIP-seq
MIRT933033	hsa-miR-4434	CLIP-seq
MIRT933034	hsa-miR-4516	CLIP-seq
MIRT933035	hsa-miR-4521	CLIP-seq
MIRT933036	hsa-miR-4531	CLIP-seq
MIRT933037	hsa-miR-455-5p	CLIP-seq
MIRT933038	hsa-miR-4695-5p	CLIP-seq
MIRT933039	hsa-miR-4704-5p	CLIP-seq
MIRT933040	hsa-miR-4731-3p	CLIP-seq
MIRT933041	hsa-miR-4735-5p	CLIP-seq
MIRT933042	hsa-miR-4775	CLIP-seq
MIRT933043	hsa-miR-4801	CLIP-seq
MIRT933044	hsa-miR-484	CLIP-seq
MIRT933045	hsa-miR-497	CLIP-seq
MIRT933046	hsa-miR-548aa	CLIP-seq
MIRT933047	hsa-miR-548c-3p	CLIP-seq
MIRT933048	hsa-miR-548k	CLIP-seq
MIRT933049	hsa-miR-567	CLIP-seq
MIRT933050	hsa-miR-590-3p	CLIP-seq
MIRT933051	hsa-miR-613	CLIP-seq
MIRT933052	hsa-miR-620	CLIP-seq
MIRT933053	hsa-miR-628-3p	CLIP-seq
MIRT933054	hsa-miR-650	CLIP-seq
MIRT933055	hsa-miR-658	CLIP-seq
MIRT933056	hsa-miR-885-5p	CLIP-seq
MIRT1547950	hsa-miR-1587	CLIP-seq
MIRT1547951	hsa-miR-3123	CLIP-seq
MIRT1547952	hsa-miR-3154	CLIP-seq
MIRT1547953	hsa-miR-3163	CLIP-seq
MIRT1547954	hsa-miR-3925-5p	CLIP-seq
MIRT1547955	hsa-miR-4674	CLIP-seq
MIRT1976228	hsa-miR-181a	CLIP-seq
MIRT1976229	hsa-miR-181b	CLIP-seq
MIRT1976230	hsa-miR-181c	CLIP-seq
MIRT1976231	hsa-miR-181d	CLIP-seq
MIRT1976232	hsa-miR-3143	CLIP-seq
MIRT1976233	hsa-miR-3159	CLIP-seq
MIRT1547953	hsa-miR-3163	CLIP-seq
MIRT1976234	hsa-miR-421	CLIP-seq
MIRT1976235	hsa-miR-4262	CLIP-seq
MIRT1976236	hsa-miR-4272	CLIP-seq
MIRT1976237	hsa-miR-4276	CLIP-seq
MIRT1976238	hsa-miR-4302	CLIP-seq
MIRT1976239	hsa-miR-543	CLIP-seq
MIRT933015	hsa-miR-1253	CLIP-seq
MIRT2211660	hsa-miR-1297	CLIP-seq
MIRT2211661	hsa-miR-1303	CLIP-seq
MIRT933017	hsa-miR-147b	CLIP-seq
MIRT1976228	hsa-miR-181a	CLIP-seq
MIRT1976229	hsa-miR-181b	CLIP-seq
MIRT1976230	hsa-miR-181c	CLIP-seq
MIRT1976231	hsa-miR-181d	CLIP-seq
MIRT2211662	hsa-miR-26a	CLIP-seq
MIRT2211663	hsa-miR-26b	CLIP-seq
MIRT933023	hsa-miR-297	CLIP-seq
MIRT933024	hsa-miR-3155	CLIP-seq
MIRT933025	hsa-miR-3155b	CLIP-seq
MIRT1547953	hsa-miR-3163	CLIP-seq
MIRT933026	hsa-miR-3173-3p	CLIP-seq
MIRT933028	hsa-miR-3612	CLIP-seq
MIRT2211664	hsa-miR-3692	CLIP-seq
MIRT2211665	hsa-miR-3714	CLIP-seq
MIRT1976235	hsa-miR-4262	CLIP-seq
MIRT1976237	hsa-miR-4276	CLIP-seq
MIRT1976238	hsa-miR-4302	CLIP-seq
MIRT933031	hsa-miR-4428	CLIP-seq
MIRT933032	hsa-miR-4432	CLIP-seq
MIRT933033	hsa-miR-4434	CLIP-seq
MIRT2211666	hsa-miR-4465	CLIP-seq
MIRT933034	hsa-miR-4516	CLIP-seq
MIRT933035	hsa-miR-4521	CLIP-seq
MIRT933037	hsa-miR-455-5p	CLIP-seq
MIRT933038	hsa-miR-4695-5p	CLIP-seq
MIRT2211667	hsa-miR-4698	CLIP-seq
MIRT933040	hsa-miR-4731-3p	CLIP-seq
MIRT933043	hsa-miR-4801	CLIP-seq
MIRT933044	hsa-miR-484	CLIP-seq
MIRT2211668	hsa-miR-548a-3p	CLIP-seq
MIRT2211669	hsa-miR-548e	CLIP-seq
MIRT2211670	hsa-miR-548f	CLIP-seq
MIRT933049	hsa-miR-567	CLIP-seq
MIRT2211671	hsa-miR-568	CLIP-seq
MIRT933054	hsa-miR-650	CLIP-seq
MIRT933055	hsa-miR-658	CLIP-seq
MIRT2211672	hsa-miR-671-3p	CLIP-seq
MIRT2211673	hsa-miR-941	CLIP-seq
MIRT933033	hsa-miR-4434	CLIP-seq
MIRT933034	hsa-miR-4516	CLIP-seq
MIRT2679194	hsa-miR-135a	CLIP-seq
MIRT2679195	hsa-miR-135b	CLIP-seq
MIRT2679196	hsa-miR-3117-5p	CLIP-seq
MIRT2679197	hsa-miR-3119	CLIP-seq
MIRT2679198	hsa-miR-3146	CLIP-seq
MIRT2679199	hsa-miR-3606	CLIP-seq
MIRT2679200	hsa-miR-3647-3p	CLIP-seq
MIRT2679201	hsa-miR-3653	CLIP-seq
MIRT2679202	hsa-miR-3658	CLIP-seq
MIRT2211665	hsa-miR-3714	CLIP-seq
MIRT2679203	hsa-miR-4484	CLIP-seq
MIRT2679204	hsa-miR-4503	CLIP-seq
MIRT2679205	hsa-miR-4509	CLIP-seq
MIRT2679206	hsa-miR-4640-3p	CLIP-seq
MIRT2679207	hsa-miR-4780	CLIP-seq
MIRT2679208	hsa-miR-548an	CLIP-seq
MIRT2679209	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000045	Process	Autophagosome assembly	IDA	28890335
GO:0004860	Function	Protein kinase inhibitor activity	IDA	22017875, 22017876, 22017877, 25936805, 34519268, 34519269
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005515	Function	Protein binding	IPI	19446321, 25416956, 30080879, 30232230, 32296183
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	25936805
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0006469	Process	Negative regulation of protein kinase activity	IMP	19446321
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0008289	Function	Lipid binding	IEA
GO:0010507	Process	Negative regulation of autophagy	IDA	32561715
GO:0010508	Process	Positive regulation of autophagy	IDA	22017875, 22017876, 22017877
GO:0016020	Component	Membrane	IEA
GO:0030291	Function	Protein serine/threonine kinase inhibitor activity	IBA
GO:0030291	Function	Protein serine/threonine kinase inhibitor activity	IDA	22017875, 22017876
GO:0031669	Process	Cellular response to nutrient levels	IDA	32561715
GO:0032007	Process	Negative regulation of TOR signaling	IEA
GO:0032007	Process	Negative regulation of TOR signaling	IMP	19446321
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0038202	Process	TORC1 signaling	IDA	12087098
GO:0045792	Process	Negative regulation of cell size	IMP	19446321
GO:0070300	Function	Phosphatidic acid binding	IDA	25936805, 33865870
GO:1903940	Process	Negative regulation of TORC2 signaling	IBA
GO:1903940	Process	Negative regulation of TORC2 signaling	IDA	25936805, 33865870, 34519268, 34634301
GO:1903940	Process	Negative regulation of TORC2 signaling	IGI	33110214
GO:1904262	Process	Negative regulation of TORC1 signaling	IBA
GO:1904262	Process	Negative regulation of TORC1 signaling	IDA	22017875, 22017876, 22017877, 25936805, 33865870, 34519268, 34519269, 34634301
GO:1904262	Process	Negative regulation of TORC1 signaling	IGI	33110214
GO:2001236	Process	Regulation of extrinsic apoptotic signaling pathway	IMP	19446321

Other IDs

• MIM: 612974
• HGNC: 22953
• e!Ensembl: ENSG00000155792

Protein

• UniProt ID: Q8TB45
• Protein name: DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6)
• Protein function: Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMe
• PDB: 7DKL, 7OWG, 7PE7, 7PE8, 7PE9, 7PEA, 7PEB, 7PEC, 7PED
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00610	DEP	48 → 117	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain
  PF00610	DEP	148 → 217	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain

• Sequence:

  MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTY
  PNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKD
  DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEA
  TTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQE
  THDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSP
  PVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGP
  AAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC

• Sequence length: 409

Pathways

KEGG:

Autophagy - animal
mTOR signaling pathway