RBM15 (RNA binding motif protein 15)

Gene

• Entrez ID: 64783
• Gene name: RNA binding motif protein 15
• Gene symbol: RBM15
• Synonyms (NCBI Gene): OTT, OTT1, SPEN
• Chromosome: 1
• Chromosome location: 1p13.3
• Summary: Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1294975	hsa-miR-1236	CLIP-seq
MIRT1294976	hsa-miR-1256	CLIP-seq
MIRT1294977	hsa-miR-3177-5p	CLIP-seq
MIRT1294978	hsa-miR-339-3p	CLIP-seq
MIRT1294979	hsa-miR-3692	CLIP-seq
MIRT1294980	hsa-miR-4436b-5p	CLIP-seq
MIRT1294981	hsa-miR-4642	CLIP-seq
MIRT1294982	hsa-miR-4660	CLIP-seq
MIRT1294983	hsa-miR-4672	CLIP-seq
MIRT1294984	hsa-miR-4677-3p	CLIP-seq
MIRT1294985	hsa-miR-4719	CLIP-seq
MIRT1294986	hsa-miR-4731-3p	CLIP-seq
MIRT1294987	hsa-miR-4753-3p	CLIP-seq
MIRT1294988	hsa-miR-4801	CLIP-seq
MIRT1294989	hsa-miR-581	CLIP-seq
MIRT1294990	hsa-miR-583	CLIP-seq
MIRT1294991	hsa-miR-942	CLIP-seq
MIRT1294985	hsa-miR-4719	CLIP-seq
MIRT2312463	hsa-miR-22	CLIP-seq
MIRT2312464	hsa-miR-30a	CLIP-seq
MIRT2312465	hsa-miR-30b	CLIP-seq
MIRT2312466	hsa-miR-30c	CLIP-seq
MIRT2312467	hsa-miR-30d	CLIP-seq
MIRT2312468	hsa-miR-30e	CLIP-seq
MIRT2312469	hsa-miR-3160-5p	CLIP-seq
MIRT1294977	hsa-miR-3177-5p	CLIP-seq
MIRT2312470	hsa-miR-320e	CLIP-seq
MIRT2312471	hsa-miR-4257	CLIP-seq
MIRT2312472	hsa-miR-4495	CLIP-seq
MIRT2312473	hsa-miR-4503	CLIP-seq
MIRT2312474	hsa-miR-4641	CLIP-seq
MIRT2312475	hsa-miR-4659a-3p	CLIP-seq
MIRT2312476	hsa-miR-4659b-3p	CLIP-seq
MIRT1294983	hsa-miR-4672	CLIP-seq
MIRT1294985	hsa-miR-4719	CLIP-seq
MIRT1294986	hsa-miR-4731-3p	CLIP-seq
MIRT2312477	hsa-miR-4769-3p	CLIP-seq
MIRT1294988	hsa-miR-4801	CLIP-seq
MIRT1294989	hsa-miR-581	CLIP-seq
MIRT1294977	hsa-miR-3177-5p	CLIP-seq
MIRT1294979	hsa-miR-3692	CLIP-seq
MIRT1294980	hsa-miR-4436b-5p	CLIP-seq
MIRT1294983	hsa-miR-4672	CLIP-seq
MIRT1294985	hsa-miR-4719	CLIP-seq
MIRT1294990	hsa-miR-583	CLIP-seq
MIRT1294979	hsa-miR-3692	CLIP-seq
MIRT1294980	hsa-miR-4436b-5p	CLIP-seq
MIRT1294990	hsa-miR-583	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IBA
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IDA	26575292
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IEA
GO:0001510	Process	RNA methylation	IDA	27602518
GO:0001510	Process	RNA methylation	IEA
GO:0001569	Process	Branching involved in blood vessel morphogenesis	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IDA	27602518
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0003729	Function	MRNA binding	IDA	26575292
GO:0005515	Function	Protein binding	IPI	16129689, 25416956, 26575292, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IEA
GO:0005654	Component	Nucleoplasm	IDA	24100041
GO:0005654	Component	Nucleoplasm	IEA
GO:0007221	Process	Positive regulation of transcription of Notch receptor target	IEA
GO:0009048	Process	Dosage compensation by inactivation of X chromosome	IDA	27602518
GO:0009048	Process	Dosage compensation by inactivation of X chromosome	IEA
GO:0016020	Component	Membrane	IEA
GO:0016607	Component	Nuclear speck	IDA	24100041
GO:0016607	Component	Nuclear speck	IEA
GO:0031965	Component	Nuclear membrane	IEA
GO:0036396	Component	RNA N6-methyladenosine methyltransferase complex	IDA	27602518
GO:0036396	Component	RNA N6-methyladenosine methyltransferase complex	IEA
GO:0038163	Process	Thrombopoietin-mediated signaling pathway	IEA
GO:0038163	Process	Thrombopoietin-mediated signaling pathway	ISS
GO:0045637	Process	Regulation of myeloid cell differentiation	IEA
GO:0045638	Process	Negative regulation of myeloid cell differentiation	IEA
GO:0045652	Process	Regulation of megakaryocyte differentiation	IDA	26575292
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	16129689
GO:0048536	Process	Spleen development	IEA
GO:0060412	Process	Ventricular septum morphogenesis	IEA
GO:0060674	Process	Placenta blood vessel development	IEA

Other IDs

• MIM: 606077
• HGNC: 14959
• e!Ensembl: ENSG00000162775

Protein

• UniProt ID: Q96T37
• Protein name: RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15)
• Protein function: RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediate
• PDB: 7Z27
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	179 → 246	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	376 → 445	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF07744	SPOC	778 → 955	SPOC domain	Domain

• Sequence:

  MRTAGRDPVPRRSPRWRRAVPLCETSAGRRVTQLRGDDLRRPATMKGKERSPVKAKRSRG
  GEDSTSRGERSKKLGGSGGSNGSSSGKTDSGGGSRRSLHLDKSSSRGGSREYDTGGGSSS
  SRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDGAEYKTLKISELGSQ
  LSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLVL
  YDRPLKIEAVYVSRRRSRSPLDKDTYPPSASVVGASVGGHRHPPGGGGGQRSLSPGGAAL
  GYRDYRLQQLALGRLPPPPPPPLPRDLERERDYPFYERVRPAYSLEPRVGAGAGAAPFRE
  VDEISPEDDQRANRTLFLGNLDITVTESDLRRAFDRFGVITEVDIKRPSRGQTSTYGFLK
  FENLDMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGT
  IRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQYLQP
  LPLTHYELVTDAFGHRAPDPLRGARDRTPPLLYRDRDRDLYPDSDWVPPPPPVRERSTRT
  AATSVPAYEPLDSLDRRRDGWSLDRDRGDRDLPSSRDQPRKRRLPEESGGRHLDRSPESD
  RPRKRHCAPSPDRSPELSSSRDRYNSDNDRSSRLLLERPSPIRDRRGSLEKSQGDKRDRK
  NSASAERDRKHRTTAPTEGKSPLKKEDRSDGSAPSTSTASSKLKSPSQKQDGGTAPVASA
  SPKLCLAWQGMLLLKNSNFPSNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQRLRLDQP
  KLDEVTRRIKVAGPNGYAILLAVPGSSDSRSSSSSAASDTATSTQRPLRNLVSYLKQKQA
  AGVISLPVGGNKDKENTGVLHAFPPCEFSQQFLDSPAKALAKSEEDYLVMIIVRGFGFQI
  GVRYENKKRENLALTLL

• Sequence length: 977

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Neuroblastoma	other	rs1553224979	RCV000505538

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Stimulate	32086933
Adenocarcinoma of Lung	Associate	32398949, 37047493
Adrenocortical Carcinoma	Associate	33725886
Asthma	Associate	35606385
Carcinogenesis	Associate	37474926
Carcinoma Hepatocellular	Stimulate	32631107, 34221187
Carcinoma Non Small Cell Lung	Associate	34812534, 37013777
Carcinoma Renal Cell	Associate	38164857
Cardiomyopathies	Associate	37041267
Colonic Neoplasms	Associate	31823961
Colorectal Neoplasms	Associate	33415160
COVID 19	Associate	34301919, 36460278
Crohn Disease	Associate	36595818
Glioma	Associate	34432221
Huntington Disease	Associate	33049985
Hypoxia	Associate	40682199
Inflammation	Associate	34301919
Leukemia	Associate	18667423
Leukemia Megakaryoblastic Acute	Associate	15849773, 18667423, 19724058, 26215111, 26575292, 27114462, 27118388, 28412998, 28420865
Leukemia Myeloid Acute	Associate	15849773
Leukemia T Cell	Associate	37640841
Male Infertility with Large Headed Multiflagellar Polyploid Spermatozoa	Associate	24803180
Myasthenia Gravis	Stimulate	36864526
Myocardial Infarction	Associate	36061306
Myocardial Infarction	Stimulate	40682199
Neoplasm Metastasis	Associate	33225598
Neoplasms	Associate	35047056, 35211628, 36389678, 37474926
Neoplasms	Inhibit	37594126
Osteoporosis	Associate	36967763
Osteosarcoma	Associate	36181462, 37002245
Ovarian Diseases	Associate	37594126
Ovarian Neoplasms	Associate	33225598, 37594126
Phyllodes Tumor	Associate	29315289
Polycystic Ovary Syndrome	Associate	37046273
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	36567510
Sarcoma	Associate	33370249
Sarcoma Kaposi	Associate	20828777
Thyroid Neoplasms	Associate	36389678
Uterine Cervical Neoplasms	Associate	37474926