Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64783
Gene name Gene Name - the full gene name approved by the HGNC.	RNA binding motif protein 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RBM15
Synonyms (NCBI Gene) Gene synonyms aliases	OTT, OTT1, SPEN
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb

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miRTarBase ID	miRNA	Experiments
MIRT1294975	hsa-miR-1236	CLIP-seq
MIRT1294976	hsa-miR-1256	CLIP-seq
MIRT1294977	hsa-miR-3177-5p	CLIP-seq
MIRT1294978	hsa-miR-339-3p	CLIP-seq
MIRT1294979	hsa-miR-3692	CLIP-seq
MIRT1294980	hsa-miR-4436b-5p	CLIP-seq
MIRT1294981	hsa-miR-4642	CLIP-seq
MIRT1294982	hsa-miR-4660	CLIP-seq
MIRT1294983	hsa-miR-4672	CLIP-seq
MIRT1294984	hsa-miR-4677-3p	CLIP-seq
MIRT1294985	hsa-miR-4719	CLIP-seq
MIRT1294986	hsa-miR-4731-3p	CLIP-seq
MIRT1294987	hsa-miR-4753-3p	CLIP-seq
MIRT1294988	hsa-miR-4801	CLIP-seq
MIRT1294989	hsa-miR-581	CLIP-seq
MIRT1294990	hsa-miR-583	CLIP-seq
MIRT1294991	hsa-miR-942	CLIP-seq
MIRT1294985	hsa-miR-4719	CLIP-seq
MIRT2312463	hsa-miR-22	CLIP-seq
MIRT2312464	hsa-miR-30a	CLIP-seq
MIRT2312465	hsa-miR-30b	CLIP-seq
MIRT2312466	hsa-miR-30c	CLIP-seq
MIRT2312467	hsa-miR-30d	CLIP-seq
MIRT2312468	hsa-miR-30e	CLIP-seq
MIRT2312469	hsa-miR-3160-5p	CLIP-seq
MIRT1294977	hsa-miR-3177-5p	CLIP-seq
MIRT2312470	hsa-miR-320e	CLIP-seq
MIRT2312471	hsa-miR-4257	CLIP-seq
MIRT2312472	hsa-miR-4495	CLIP-seq
MIRT2312473	hsa-miR-4503	CLIP-seq
MIRT2312474	hsa-miR-4641	CLIP-seq
MIRT2312475	hsa-miR-4659a-3p	CLIP-seq
MIRT2312476	hsa-miR-4659b-3p	CLIP-seq
MIRT1294983	hsa-miR-4672	CLIP-seq
MIRT1294985	hsa-miR-4719	CLIP-seq
MIRT1294986	hsa-miR-4731-3p	CLIP-seq
MIRT2312477	hsa-miR-4769-3p	CLIP-seq
MIRT1294988	hsa-miR-4801	CLIP-seq
MIRT1294989	hsa-miR-581	CLIP-seq
MIRT1294977	hsa-miR-3177-5p	CLIP-seq
MIRT1294979	hsa-miR-3692	CLIP-seq
MIRT1294980	hsa-miR-4436b-5p	CLIP-seq
MIRT1294983	hsa-miR-4672	CLIP-seq
MIRT1294985	hsa-miR-4719	CLIP-seq
MIRT1294990	hsa-miR-583	CLIP-seq
MIRT1294979	hsa-miR-3692	CLIP-seq
MIRT1294980	hsa-miR-4436b-5p	CLIP-seq
MIRT1294990	hsa-miR-583	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IDA	26575292
GO:0000398	Process	MRNA splicing, via spliceosome	IBA	21873635
GO:0001510	Process	RNA methylation	IDA	27602518
GO:0001569	Process	Branching involved in blood vessel morphogenesis	IEA
GO:0003676	Function	Nucleic acid binding	IBA	21873635
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IDA	27602518
GO:0003729	Function	MRNA binding	IDA	26575292
GO:0005515	Function	Protein binding	IPI	16129689, 25416956, 26575292
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA	24100041
GO:0007221	Process	Positive regulation of transcription of Notch receptor target	IEA
GO:0009048	Process	Dosage compensation by inactivation of X chromosome	IDA	27602518
GO:0016032	Process	Viral process	IEA
GO:0016607	Component	Nuclear speck	IDA	24100041
GO:0031965	Component	Nuclear membrane	IEA
GO:0036396	Component	RNA N6-methyladenosine methyltransferase complex	IDA	27602518
GO:0038163	Process	Thrombopoietin-mediated signaling pathway	ISS
GO:0045638	Process	Negative regulation of myeloid cell differentiation	IEA
GO:0045652	Process	Regulation of megakaryocyte differentiation	IDA	26575292
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IDA	16129689
GO:0048536	Process	Spleen development	IEA
GO:0060412	Process	Ventricular septum morphogenesis	IEA
GO:0060674	Process	Placenta blood vessel development	IEA

MIM	HGNC	e!Ensembl
606077	14959	ENSG00000162775

Protein

UniProt ID

Q96T37

Protein name

RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15)

Protein function

RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediate

PDB

7Z27

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	179 → 246	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	376 → 445	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF07744	SPOC	778 → 955	SPOC domain	Domain

Sequence

MRTAGRDPVPRRSPRWRRAVPLCETSAGRRVTQLRGDDLRRPATMKGKERSPVKAKRSRG
GEDSTSRGERSKKLGGSGGSNGSSSGKTDSGGGSRRSLHLDKSSSRGGSREYDTGGGSSS
SRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDGAEYKTLKISELGSQ
LSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLVL
YDRPLKIEAVYVSRRRSRSPLDKDTYPPSASVVGASVGGHRHPPGGGGGQRSLSPGGAAL
GYRDYRLQQLALGRLPPPPPPPLPRDLERERDYPFYERVRPAYSLEPRVGAGAGAAPFRE
VDEISPEDDQRANRTLFLGNLDITVTESDLRRAFDRFGVITEVDIKRPSRGQTSTYGFLK
FENLDMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGT
IRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQYLQP
LPLTHYELVTDAFGHRAPDPLRGARDRTPPLLYRDRDRDLYPDSDWVPPPPPVRERSTRT
AATSVPAYEPLDSLDRRRDGWSLDRDRGDRDLPSSRDQPRKRRLPEESGGRHLDRSPESD
RPRKRHCAPSPDRSPELSSSRDRYNSDNDRSSRLLLERPSPIRDRRGSLEKSQGDKRDRK
NSASAERDRKHRTTAPTEGKSPLKKEDRSDGSAPSTSTASSKLKSPSQKQDGGTAPVASA
SPKLCLAWQGMLLLKNSNFPSNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQRLRLDQP
KLDEVTRRIKVAGPNGYAILLAVPGSSDSRSSSSSAASDTATSTQRPLRNLVSYLKQKQA
AGVISLPVGGNKDKENTGVLHAFPPCEFSQQFLDSPAKALAKSEEDYLVMIIVRGFGFQI
GVRYENKKRENLALTLL

Sequence length

977

Interactions

View interactions

RBM15 (RNA binding motif protein 15)