Gene Gene information from NCBI Gene database.
Entrez ID 64782
Gene name Apoptosis enhancing nuclease
Gene symbol AEN
Synonyms (NCBI Gene)
ISG20L1pp12744
Chromosome 15
Chromosome location 15q26.1
miRNA miRNA information provided by mirtarbase database.
688
miRTarBase ID miRNA Experiments Reference
MIRT021177 hsa-miR-186-5p Sequencing 20371350
MIRT029335 hsa-miR-26b-5p Microarray 19088304
MIRT038005 hsa-miR-193b-5p CLASH 23622248
MIRT705875 hsa-miR-6771-3p HITS-CLIP 23313552
MIRT395183 hsa-miR-665 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0004518 Function Nuclease activity IEA
GO:0004527 Function Exonuclease activity IBA
GO:0004527 Function Exonuclease activity IDA 16171785
GO:0004527 Function Exonuclease activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610177 25722 ENSG00000181026
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WTP8
Protein name Apoptosis-enhancing nuclease (EC 3.1.-.-) (Interferon-stimulated 20 kDa exonuclease-like 1)
Protein function Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leadin
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00929 RNase_T 111 266 Exonuclease Family
Sequence
MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPG
SSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGT
GPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKE
ILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQ
LLHKKIQVGQHGHSSVEDATTAMELY
RLVEVQWEQQEARSLWTCPEDREPDSSTDMEQYM
EDQYWPDDLAHGSRGGAREAQDRRN
Sequence length 325
Interactions View interactions