Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	64779
Gene name	Methenyltetrahydrofolate synthetase domain containing
Gene symbol	MTHFSD
Synonyms (NCBI Gene)	-
Chromosome	16
Chromosome location	16q24.1

120

Show/Hide all (120)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022160	hsa-miR-124-3p	Microarray	18668037
MIRT049525	hsa-miR-92a-3p	CLASH	23622248
MIRT456788	hsa-miR-3154	PAR-CLIP	23592263
MIRT456786	hsa-miR-4270	PAR-CLIP	23592263
MIRT456787	hsa-miR-4441	PAR-CLIP	23592263
MIRT456785	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT456784	hsa-miR-3179	PAR-CLIP	23592263
MIRT456783	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT456782	hsa-miR-4434	PAR-CLIP	23592263
MIRT456781	hsa-miR-4516	PAR-CLIP	23592263
MIRT456780	hsa-miR-5703	PAR-CLIP	23592263
MIRT456779	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT456778	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT456776	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT456777	hsa-miR-4656	PAR-CLIP	23592263
MIRT456775	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT456774	hsa-miR-185-3p	PAR-CLIP	23592263
MIRT456773	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT456772	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT456771	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT456770	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT456769	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT456768	hsa-miR-4531	PAR-CLIP	23592263
MIRT456788	hsa-miR-3154	PAR-CLIP	23592263
MIRT456786	hsa-miR-4270	PAR-CLIP	23592263
MIRT456787	hsa-miR-4441	PAR-CLIP	23592263
MIRT456785	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT456784	hsa-miR-3179	PAR-CLIP	23592263
MIRT456783	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT456782	hsa-miR-4434	PAR-CLIP	23592263
MIRT456781	hsa-miR-4516	PAR-CLIP	23592263
MIRT456780	hsa-miR-5703	PAR-CLIP	23592263
MIRT456779	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT456778	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT456776	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT456777	hsa-miR-4656	PAR-CLIP	23592263
MIRT456775	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT456774	hsa-miR-185-3p	PAR-CLIP	23592263
MIRT456773	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT456772	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT456771	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT456770	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT456769	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT456768	hsa-miR-4531	PAR-CLIP	23592263
MIRT1163482	hsa-miR-1197	CLIP-seq
MIRT1163483	hsa-miR-1252	CLIP-seq
MIRT1163484	hsa-miR-1273	CLIP-seq
MIRT1163485	hsa-miR-3151	CLIP-seq
MIRT1163486	hsa-miR-3922-5p	CLIP-seq
MIRT1163487	hsa-miR-4533	CLIP-seq
MIRT1163488	hsa-miR-4708-3p	CLIP-seq
MIRT1163489	hsa-miR-4747-5p	CLIP-seq
MIRT1163490	hsa-miR-4753-5p	CLIP-seq
MIRT1163491	hsa-miR-1267	CLIP-seq
MIRT1163492	hsa-miR-3182	CLIP-seq
MIRT1163493	hsa-miR-4652-3p	CLIP-seq
MIRT1163494	hsa-miR-518a-3p	CLIP-seq
MIRT1163495	hsa-miR-518a-5p	CLIP-seq
MIRT1163496	hsa-miR-518b	CLIP-seq
MIRT1163497	hsa-miR-518c	CLIP-seq
MIRT1163498	hsa-miR-518d-3p	CLIP-seq
MIRT1163499	hsa-miR-518e	CLIP-seq
MIRT1163500	hsa-miR-518f	CLIP-seq
MIRT1163501	hsa-miR-527	CLIP-seq
MIRT1163502	hsa-miR-3157-5p	CLIP-seq
MIRT1163503	hsa-miR-3177-3p	CLIP-seq
MIRT1163504	hsa-miR-3622b-5p	CLIP-seq
MIRT1163505	hsa-miR-3652	CLIP-seq
MIRT1163506	hsa-miR-4269	CLIP-seq
MIRT1163507	hsa-miR-4430	CLIP-seq
MIRT1163508	hsa-miR-4433	CLIP-seq
MIRT1163509	hsa-miR-4505	CLIP-seq
MIRT1163510	hsa-miR-4514	CLIP-seq
MIRT1163511	hsa-miR-4632	CLIP-seq
MIRT1163512	hsa-miR-4638-3p	CLIP-seq
MIRT1163513	hsa-miR-4691-3p	CLIP-seq
MIRT1163514	hsa-miR-4692	CLIP-seq
MIRT1163515	hsa-miR-4742-5p	CLIP-seq
MIRT1163516	hsa-miR-516a-5p	CLIP-seq
MIRT1163517	hsa-miR-539	CLIP-seq
MIRT1163518	hsa-miR-541	CLIP-seq
MIRT1163519	hsa-miR-580	CLIP-seq
MIRT1163520	hsa-miR-615-5p	CLIP-seq
MIRT1163521	hsa-miR-654-5p	CLIP-seq
MIRT2276032	hsa-miR-2115	CLIP-seq
MIRT2276033	hsa-miR-3180-5p	CLIP-seq
MIRT2276034	hsa-miR-3934	CLIP-seq
MIRT2276035	hsa-miR-3937	CLIP-seq
MIRT1163508	hsa-miR-4433	CLIP-seq
MIRT1163509	hsa-miR-4505	CLIP-seq
MIRT2276036	hsa-miR-4660	CLIP-seq
MIRT2276037	hsa-miR-4786-5p	CLIP-seq
MIRT2276038	hsa-miR-520a-5p	CLIP-seq
MIRT2276039	hsa-miR-525-5p	CLIP-seq
MIRT1163518	hsa-miR-541	CLIP-seq
MIRT2276040	hsa-miR-548aa	CLIP-seq
MIRT2276041	hsa-miR-548c-3p	CLIP-seq
MIRT1163520	hsa-miR-615-5p	CLIP-seq
MIRT2276042	hsa-miR-644	CLIP-seq
MIRT2276043	hsa-miR-646	CLIP-seq
MIRT1163521	hsa-miR-654-5p	CLIP-seq
MIRT2276044	hsa-miR-769-5p	CLIP-seq
MIRT1163508	hsa-miR-4433	CLIP-seq
MIRT1163518	hsa-miR-541	CLIP-seq
MIRT1163520	hsa-miR-615-5p	CLIP-seq
MIRT1163521	hsa-miR-654-5p	CLIP-seq
MIRT2454548	hsa-miR-124	CLIP-seq
MIRT2454549	hsa-miR-1285	CLIP-seq
MIRT2454550	hsa-miR-3187-5p	CLIP-seq
MIRT2454551	hsa-miR-4501	CLIP-seq
MIRT2454552	hsa-miR-506	CLIP-seq
MIRT1163494	hsa-miR-518a-3p	CLIP-seq
MIRT1163495	hsa-miR-518a-5p	CLIP-seq
MIRT1163496	hsa-miR-518b	CLIP-seq
MIRT1163497	hsa-miR-518c	CLIP-seq
MIRT1163498	hsa-miR-518d-3p	CLIP-seq
MIRT1163499	hsa-miR-518e	CLIP-seq
MIRT1163500	hsa-miR-518f	CLIP-seq
MIRT1163501	hsa-miR-527	CLIP-seq
MIRT2454553	hsa-miR-612	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005737	Component	Cytoplasm	IBA

MIM	HGNC	e!Ensembl
616820	25778	ENSG00000103248

Q2M296

Protein name

Methenyltetrahydrofolate synthase domain-containing protein

PDB

2E5J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01812	5-FTHF_cyc-lig	10 → 207	5-formyltetrahydrofolate cyclo-ligase family	Family
PF00076	RRM_1	308 → 373	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Sequence

MEPRAVGVSKQDIREQIWGYMESQNLADFPRPVHHRIPNFKGSYLACQNIKDLDVFARTQ
EVKVDPDKPLEGVRLLVLQSKKTLLVPTPRLRTGLFNKITPPPGATKDILRKCATSQGVR
NYSVPIGLDSRVLVDLVVVGSVAVSEKGWRIGKGEGYADLEYAMMVSMGAVSKETPVVTI
VHDCQVVDIPEELVEEHDITVDYILTPTRVIATGCKRPKPMGITWFKISLEMMEKIPILR
SLRAREQQAGKDVTLQGEHQHLPEPGCQQTVPLSVGRRPPDTPGPETNSMEAAPGSPPGE
GAPLAADVYVGNLPGDARVSDLKRALRELGSVPLRLTWQGPRRRAFLHYPDSAAAQQAVS
CLQGLRLGTDTLRVALARQQRDK

Sequence length

383

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Bipolar Disorder	Associate	40142297	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	24419231	★★★★★ ★☆☆☆☆ Found in Text Mining only

MTHFSD (methenyltetrahydrofolate synthetase domain containing)