Gene Gene information from NCBI Gene database.
Entrez ID 64778
Gene name Fibronectin type III domain containing 3B
Gene symbol FNDC3B
Synonyms (NCBI Gene)
FAD104PRO4979YVTM2421
Chromosome 3
Chromosome location 3q26.31
miRNA miRNA information provided by mirtarbase database.
1018
miRTarBase ID miRNA Experiments Reference
MIRT003060 hsa-miR-143-3p Luciferase reporter assayqRT-PCRWestern blot 19472311
MIRT003060 hsa-miR-143-3p Review 19935707
MIRT003060 hsa-miR-143-3p Luciferase reporter assay 19472311
MIRT003060 hsa-miR-143-3p Review 20026422
MIRT001467 hsa-miR-16-5p pSILAC 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005737 Component Cytoplasm IEA
GO:0012505 Component Endomembrane system IEA
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611909 24670 ENSG00000075420
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q53EP0
Protein name Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37)
Protein function May be a positive regulator of adipogenesis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00041 fn3 277 367 Fibronectin type III domain Domain
PF00041 fn3 381 463 Fibronectin type III domain Domain
PF00041 fn3 476 560 Fibronectin type III domain Domain
PF00041 fn3 573 659 Fibronectin type III domain Domain
PF00041 fn3 674 755 Fibronectin type III domain Domain
PF00041 fn3 777 849 Fibronectin type III domain Domain
PF00041 fn3 881 947 Fibronectin type III domain Domain
PF00041 fn3 959 1042 Fibronectin type III domain Domain
PF00041 fn3 1055 1135 Fibronectin type III domain Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3. Expression increased in the early stage
Sequence
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQC
IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT
HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY
ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGS
GPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPV
GLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYN
SVKGSCS
EPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGK
RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYS
QEVVCYTLGNIPQMPSA
PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKR
STQYKFRLTASNTEGKSCPS
EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG
GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCS
E
SLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV
YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS
DVSEITTAAGPPGQCKAPCISCTPD
GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAF
NQAGAGPYS
ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEI
LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFS
QFIKAKTRPLPPL
PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL
TEFTCYSFRIQAASEAGEGPFS
ETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM
KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTS
QELSG
AFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY
FLMK
Sequence length 1204
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
12
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
FNDC3B-related disorder Likely benign; Benign rs139505585, rs2270568, rs35366330, rs7652177, rs143064249, rs35409041, rs34553291, rs113522210, rs113685139, rs36032820, rs61734221, rs112342266 RCV003938992
RCV003974492
RCV003973899
RCV003977343
RCV003941796
RCV003931376
RCV003939426
RCV003922202
RCV003949182
RCV003915830
RCV003930809
RCV003978412
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Spontaneous Associate 39684334
Adenocarcinoma Clear Cell Associate 24389164
Barrett Esophagus Associate 29417867
Breast Neoplasms Inhibit 29180690
Carcinoma Hepatocellular Associate 22510613, 30945699
Esophageal Squamous Cell Carcinoma Stimulate 35703190, 37667251
Glaucoma Associate 29452408
Glaucoma Open Angle Associate 25173106, 25414181, 29452408, 30352225, 36980976
Glioma Associate 34603558, 36275754
Heart Failure Associate 32852391