Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
64778
Gene name Gene Name - the full gene name approved by the HGNC.
Fibronectin type III domain containing 3B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FNDC3B
Synonyms (NCBI Gene) Gene synonyms aliases
FAD104, PRO4979, YVTM2421
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q26.31
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003060 hsa-miR-143-3p Luciferase reporter assay, qRT-PCR, Western blot 19472311
MIRT003060 hsa-miR-143-3p Review 19935707
MIRT003060 hsa-miR-143-3p Luciferase reporter assay 19472311
MIRT003060 hsa-miR-143-3p Review 20026422
MIRT001467 hsa-miR-16-5p pSILAC 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0016021 Component Integral component of membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611909 24670 ENSG00000075420
Protein
UniProt ID Q53EP0
Protein name Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37)
Protein function May be a positive regulator of adipogenesis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00041 fn3 277 367 Fibronectin type III domain Domain
PF00041 fn3 381 463 Fibronectin type III domain Domain
PF00041 fn3 476 560 Fibronectin type III domain Domain
PF00041 fn3 573 659 Fibronectin type III domain Domain
PF00041 fn3 674 755 Fibronectin type III domain Domain
PF00041 fn3 777 849 Fibronectin type III domain Domain
PF00041 fn3 881 947 Fibronectin type III domain Domain
PF00041 fn3 959 1042 Fibronectin type III domain Domain
PF00041 fn3 1055 1135 Fibronectin type III domain Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3. Expression increased in the early stage
Sequence
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQC
IQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPT
HHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY
ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGS
GPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPPV
GLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYN
SVKGSCS
EPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGK
RNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYS
QEVVCYTLGNIPQMPSA
PRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKR
STQYKFRLTASNTEGKSCPS
EVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNG
GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCS
E
SLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV
YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS
DVSEITTAAGPPGQCKAPCISCTPD
GCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAF
NQAGAGPYS
ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEI
LAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFS
QFIKAKTRPLPPL
PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL
TEFTCYSFRIQAASEAGEGPFS
ETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSM
KGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTS
QELSG
AFSPSAAFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQY
FLMK
Sequence length 1204
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 29212778
Glaucoma Glaucoma, Open-Angle, Glaucoma, Primary Open Angle rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328
View all (29 more)
23291589
Keratoconus Keratoconus rs273585637, rs273585632, rs273585616, rs273585618, rs281865144, rs281865150, rs1553500862, rs756938019 23291589
Unknown
Disease term Disease name Evidence References Source
Myocardial Infarction Myocardial Infarction GWAS
Hypertrophic cardiomyopathy Hypertrophic cardiomyopathy GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Associate 39684334
Adenocarcinoma Clear Cell Associate 24389164
Barrett Esophagus Associate 29417867
Breast Neoplasms Inhibit 29180690
Carcinoma Hepatocellular Associate 22510613, 30945699
Esophageal Squamous Cell Carcinoma Stimulate 35703190, 37667251
Glaucoma Associate 29452408
Glaucoma Open Angle Associate 25173106, 25414181, 29452408, 30352225, 36980976
Glioma Associate 34603558, 36275754
Heart Failure Associate 32852391