Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	64761
Gene name	Poly(ADP-ribose) polymerase family member 12
Gene symbol	PARP12
Synonyms (NCBI Gene)	ARTD12MST109MSTP109ZC3H1ZC3HDC1
Chromosome	7
Chromosome location	7q34

235

Show/Hide all (235)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027561	hsa-miR-98-5p	Microarray	19088304
MIRT1214444	hsa-miR-1323	CLIP-seq
MIRT1214445	hsa-miR-3654	CLIP-seq
MIRT1214446	hsa-miR-4477a	CLIP-seq
MIRT1214447	hsa-miR-548a-3p	CLIP-seq
MIRT1214448	hsa-miR-548e	CLIP-seq
MIRT1214449	hsa-miR-548f	CLIP-seq
MIRT1214450	hsa-miR-548o	CLIP-seq
MIRT1214451	hsa-miR-548p	CLIP-seq
MIRT2061690	hsa-miR-134	CLIP-seq
MIRT2061691	hsa-miR-147	CLIP-seq
MIRT2061692	hsa-miR-2113	CLIP-seq
MIRT2061693	hsa-miR-298	CLIP-seq
MIRT2061694	hsa-miR-3118	CLIP-seq
MIRT2061695	hsa-miR-34b	CLIP-seq
MIRT2061696	hsa-miR-3688-5p	CLIP-seq
MIRT2061697	hsa-miR-3911	CLIP-seq
MIRT2061698	hsa-miR-4504	CLIP-seq
MIRT2061699	hsa-miR-4514	CLIP-seq
MIRT2061700	hsa-miR-4632	CLIP-seq
MIRT2061701	hsa-miR-4692	CLIP-seq
MIRT2061702	hsa-miR-542-3p	CLIP-seq
MIRT2061703	hsa-miR-644	CLIP-seq
MIRT2061704	hsa-miR-758	CLIP-seq
MIRT2061705	hsa-miR-943	CLIP-seq
MIRT2290058	hsa-miR-15a	CLIP-seq
MIRT2290059	hsa-miR-15b	CLIP-seq
MIRT2290060	hsa-miR-16	CLIP-seq
MIRT2290061	hsa-miR-1825	CLIP-seq
MIRT2290062	hsa-miR-183	CLIP-seq
MIRT2290063	hsa-miR-195	CLIP-seq
MIRT2290064	hsa-miR-198	CLIP-seq
MIRT2290065	hsa-miR-199a-5p	CLIP-seq
MIRT2290066	hsa-miR-199b-5p	CLIP-seq
MIRT2290067	hsa-miR-218	CLIP-seq
MIRT2290068	hsa-miR-299-3p	CLIP-seq
MIRT2290069	hsa-miR-3065-5p	CLIP-seq
MIRT2290070	hsa-miR-3664-5p	CLIP-seq
MIRT2290071	hsa-miR-3925-5p	CLIP-seq
MIRT2290072	hsa-miR-424	CLIP-seq
MIRT2290073	hsa-miR-4292	CLIP-seq
MIRT2290074	hsa-miR-4302	CLIP-seq
MIRT2290075	hsa-miR-4308	CLIP-seq
MIRT2290076	hsa-miR-4496	CLIP-seq
MIRT2061698	hsa-miR-4504	CLIP-seq
MIRT2290077	hsa-miR-4705	CLIP-seq
MIRT2290078	hsa-miR-4773	CLIP-seq
MIRT2290079	hsa-miR-497	CLIP-seq
MIRT2290080	hsa-miR-505	CLIP-seq
MIRT2290081	hsa-miR-513a-5p	CLIP-seq
MIRT2061702	hsa-miR-542-3p	CLIP-seq
MIRT2290082	hsa-miR-542-5p	CLIP-seq
MIRT2290083	hsa-miR-545	CLIP-seq
MIRT2290084	hsa-miR-548q	CLIP-seq
MIRT2290085	hsa-miR-615-5p	CLIP-seq
MIRT2290086	hsa-miR-629	CLIP-seq
MIRT2290087	hsa-miR-634	CLIP-seq
MIRT2290088	hsa-miR-636	CLIP-seq
MIRT2290089	hsa-miR-637	CLIP-seq
MIRT2290090	hsa-miR-648	CLIP-seq
MIRT2290091	hsa-miR-661	CLIP-seq
MIRT2061698	hsa-miR-4504	CLIP-seq
MIRT2061702	hsa-miR-542-3p	CLIP-seq
MIRT2588072	hsa-miR-1254	CLIP-seq
MIRT2588073	hsa-miR-1272	CLIP-seq
MIRT2588074	hsa-miR-1299	CLIP-seq
MIRT2588075	hsa-miR-1322	CLIP-seq
MIRT2588076	hsa-miR-1587	CLIP-seq
MIRT2588077	hsa-miR-22	CLIP-seq
MIRT2588078	hsa-miR-2467-3p	CLIP-seq
MIRT2588079	hsa-miR-3116	CLIP-seq
MIRT2588080	hsa-miR-3129-3p	CLIP-seq
MIRT2588081	hsa-miR-3148	CLIP-seq
MIRT2588082	hsa-miR-3158-5p	CLIP-seq
MIRT2061695	hsa-miR-34b	CLIP-seq
MIRT2588083	hsa-miR-365	CLIP-seq
MIRT2588084	hsa-miR-3653	CLIP-seq
MIRT2588085	hsa-miR-3658	CLIP-seq
MIRT2588086	hsa-miR-3672	CLIP-seq
MIRT2588087	hsa-miR-3678-3p	CLIP-seq
MIRT2588088	hsa-miR-3921	CLIP-seq
MIRT2290071	hsa-miR-3925-5p	CLIP-seq
MIRT2588089	hsa-miR-3940-5p	CLIP-seq
MIRT2588090	hsa-miR-4251	CLIP-seq
MIRT2588091	hsa-miR-4318	CLIP-seq
MIRT2588092	hsa-miR-4329	CLIP-seq
MIRT2588093	hsa-miR-4417	CLIP-seq
MIRT2588094	hsa-miR-4418	CLIP-seq
MIRT2588095	hsa-miR-4434	CLIP-seq
MIRT2588096	hsa-miR-4461	CLIP-seq
MIRT2588097	hsa-miR-4492	CLIP-seq
MIRT2588098	hsa-miR-4498	CLIP-seq
MIRT2588099	hsa-miR-4507	CLIP-seq
MIRT2588100	hsa-miR-4511	CLIP-seq
MIRT2588101	hsa-miR-4516	CLIP-seq
MIRT2588102	hsa-miR-451b	CLIP-seq
MIRT2588103	hsa-miR-4522	CLIP-seq
MIRT2588104	hsa-miR-4528	CLIP-seq
MIRT2061700	hsa-miR-4632	CLIP-seq
MIRT2588105	hsa-miR-4652-3p	CLIP-seq
MIRT2588106	hsa-miR-4653-5p	CLIP-seq
MIRT2588107	hsa-miR-4656	CLIP-seq
MIRT2588108	hsa-miR-4659a-5p	CLIP-seq
MIRT2588109	hsa-miR-4659b-5p	CLIP-seq
MIRT2588110	hsa-miR-4675	CLIP-seq
MIRT2588111	hsa-miR-4693-5p	CLIP-seq
MIRT2588112	hsa-miR-4714-5p	CLIP-seq
MIRT2588113	hsa-miR-4741	CLIP-seq
MIRT2588114	hsa-miR-4766-3p	CLIP-seq
MIRT2588115	hsa-miR-4768-3p	CLIP-seq
MIRT2290078	hsa-miR-4773	CLIP-seq
MIRT2588116	hsa-miR-4782-5p	CLIP-seq
MIRT2588117	hsa-miR-4786-3p	CLIP-seq
MIRT2588118	hsa-miR-4803	CLIP-seq
MIRT2588119	hsa-miR-509-3-5p	CLIP-seq
MIRT2588120	hsa-miR-509-5p	CLIP-seq
MIRT2588121	hsa-miR-516b	CLIP-seq
MIRT2588122	hsa-miR-539	CLIP-seq
MIRT2588123	hsa-miR-548a-5p	CLIP-seq
MIRT2588124	hsa-miR-548ab	CLIP-seq
MIRT2588125	hsa-miR-548ae	CLIP-seq
MIRT2588126	hsa-miR-548aj	CLIP-seq
MIRT2588127	hsa-miR-548ak	CLIP-seq
MIRT2588128	hsa-miR-548am	CLIP-seq
MIRT2588129	hsa-miR-548b-3p	CLIP-seq
MIRT2588130	hsa-miR-548b-5p	CLIP-seq
MIRT2588131	hsa-miR-548c-3p	CLIP-seq
MIRT2588132	hsa-miR-548c-5p	CLIP-seq
MIRT2588133	hsa-miR-548d-5p	CLIP-seq
MIRT2588134	hsa-miR-548h	CLIP-seq
MIRT2588135	hsa-miR-548i	CLIP-seq
MIRT2588136	hsa-miR-548j	CLIP-seq
MIRT2588137	hsa-miR-548n	CLIP-seq
MIRT2588138	hsa-miR-548t	CLIP-seq
MIRT2588139	hsa-miR-548w	CLIP-seq
MIRT2588140	hsa-miR-548x	CLIP-seq
MIRT2588141	hsa-miR-548y	CLIP-seq
MIRT2588142	hsa-miR-558	CLIP-seq
MIRT2588143	hsa-miR-559	CLIP-seq
MIRT2588144	hsa-miR-561	CLIP-seq
MIRT2588145	hsa-miR-592	CLIP-seq
MIRT2588146	hsa-miR-597	CLIP-seq
MIRT2588147	hsa-miR-616	CLIP-seq
MIRT2588148	hsa-miR-642b	CLIP-seq
MIRT2290091	hsa-miR-661	CLIP-seq
MIRT2588149	hsa-miR-665	CLIP-seq
MIRT2588150	hsa-miR-762	CLIP-seq
MIRT2588151	hsa-miR-875-3p	CLIP-seq
MIRT2588152	hsa-miR-892a	CLIP-seq
MIRT2588153	hsa-miR-922	CLIP-seq
MIRT2588072	hsa-miR-1254	CLIP-seq
MIRT2588073	hsa-miR-1272	CLIP-seq
MIRT2588074	hsa-miR-1299	CLIP-seq
MIRT2588075	hsa-miR-1322	CLIP-seq
MIRT2588076	hsa-miR-1587	CLIP-seq
MIRT2588077	hsa-miR-22	CLIP-seq
MIRT2588078	hsa-miR-2467-3p	CLIP-seq
MIRT2588079	hsa-miR-3116	CLIP-seq
MIRT2588080	hsa-miR-3129-3p	CLIP-seq
MIRT2588081	hsa-miR-3148	CLIP-seq
MIRT2588082	hsa-miR-3158-5p	CLIP-seq
MIRT2061695	hsa-miR-34b	CLIP-seq
MIRT2588083	hsa-miR-365	CLIP-seq
MIRT2588084	hsa-miR-3653	CLIP-seq
MIRT2588085	hsa-miR-3658	CLIP-seq
MIRT2588086	hsa-miR-3672	CLIP-seq
MIRT2588087	hsa-miR-3678-3p	CLIP-seq
MIRT2588088	hsa-miR-3921	CLIP-seq
MIRT2290071	hsa-miR-3925-5p	CLIP-seq
MIRT2588089	hsa-miR-3940-5p	CLIP-seq
MIRT2588090	hsa-miR-4251	CLIP-seq
MIRT2588091	hsa-miR-4318	CLIP-seq
MIRT2588092	hsa-miR-4329	CLIP-seq
MIRT2588093	hsa-miR-4417	CLIP-seq
MIRT2588094	hsa-miR-4418	CLIP-seq
MIRT2588095	hsa-miR-4434	CLIP-seq
MIRT2588096	hsa-miR-4461	CLIP-seq
MIRT2588097	hsa-miR-4492	CLIP-seq
MIRT2588098	hsa-miR-4498	CLIP-seq
MIRT2588099	hsa-miR-4507	CLIP-seq
MIRT2588100	hsa-miR-4511	CLIP-seq
MIRT2588101	hsa-miR-4516	CLIP-seq
MIRT2588102	hsa-miR-451b	CLIP-seq
MIRT2588103	hsa-miR-4522	CLIP-seq
MIRT2588104	hsa-miR-4528	CLIP-seq
MIRT2061700	hsa-miR-4632	CLIP-seq
MIRT2588106	hsa-miR-4653-5p	CLIP-seq
MIRT2588107	hsa-miR-4656	CLIP-seq
MIRT2588108	hsa-miR-4659a-5p	CLIP-seq
MIRT2588109	hsa-miR-4659b-5p	CLIP-seq
MIRT2588110	hsa-miR-4675	CLIP-seq
MIRT2588111	hsa-miR-4693-5p	CLIP-seq
MIRT2588112	hsa-miR-4714-5p	CLIP-seq
MIRT2588113	hsa-miR-4741	CLIP-seq
MIRT2588114	hsa-miR-4766-3p	CLIP-seq
MIRT2588115	hsa-miR-4768-3p	CLIP-seq
MIRT2290078	hsa-miR-4773	CLIP-seq
MIRT2588116	hsa-miR-4782-5p	CLIP-seq
MIRT2588117	hsa-miR-4786-3p	CLIP-seq
MIRT2588118	hsa-miR-4803	CLIP-seq
MIRT2588119	hsa-miR-509-3-5p	CLIP-seq
MIRT2588120	hsa-miR-509-5p	CLIP-seq
MIRT2588121	hsa-miR-516b	CLIP-seq
MIRT2588122	hsa-miR-539	CLIP-seq
MIRT2588123	hsa-miR-548a-5p	CLIP-seq
MIRT2588124	hsa-miR-548ab	CLIP-seq
MIRT2588125	hsa-miR-548ae	CLIP-seq
MIRT2588126	hsa-miR-548aj	CLIP-seq
MIRT2588127	hsa-miR-548ak	CLIP-seq
MIRT2588128	hsa-miR-548am	CLIP-seq
MIRT2588129	hsa-miR-548b-3p	CLIP-seq
MIRT2588130	hsa-miR-548b-5p	CLIP-seq
MIRT2588131	hsa-miR-548c-3p	CLIP-seq
MIRT2588132	hsa-miR-548c-5p	CLIP-seq
MIRT2588133	hsa-miR-548d-5p	CLIP-seq
MIRT2588134	hsa-miR-548h	CLIP-seq
MIRT2588135	hsa-miR-548i	CLIP-seq
MIRT2588136	hsa-miR-548j	CLIP-seq
MIRT2588137	hsa-miR-548n	CLIP-seq
MIRT2588138	hsa-miR-548t	CLIP-seq
MIRT2588139	hsa-miR-548w	CLIP-seq
MIRT2588140	hsa-miR-548x	CLIP-seq
MIRT2588141	hsa-miR-548y	CLIP-seq
MIRT2588142	hsa-miR-558	CLIP-seq
MIRT2588143	hsa-miR-559	CLIP-seq
MIRT2588145	hsa-miR-592	CLIP-seq
MIRT2588146	hsa-miR-597	CLIP-seq
MIRT2588147	hsa-miR-616	CLIP-seq
MIRT2588148	hsa-miR-642b	CLIP-seq
MIRT2290091	hsa-miR-661	CLIP-seq
MIRT2588149	hsa-miR-665	CLIP-seq
MIRT2588150	hsa-miR-762	CLIP-seq
MIRT2588151	hsa-miR-875-3p	CLIP-seq
MIRT2588152	hsa-miR-892a	CLIP-seq
MIRT2588153	hsa-miR-922	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IBA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IDA	29070863
GO:0008270	Function	Zinc ion binding	IEA
GO:0010494	Component	Cytoplasmic stress granule	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0044331	Process	Cell-cell adhesion mediated by cadherin	IDA	18593713
GO:0046872	Function	Metal ion binding	IEA
GO:0070213	Process	Protein auto-ADP-ribosylation	IDA	25043379
GO:0070633	Process	Transepithelial transport	IDA	34969853
GO:0070633	Process	Transepithelial transport	IDA	34969853
GO:0140803	Function	NAD+-protein-cysteine ADP-ribosyltransferase activity	IEA
GO:0140806	Function	NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IDA	25043379
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IEA

MIM	HGNC	e!Ensembl
612481	21919	ENSG00000059378

Q9H0J9

Protein name

Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1)

Protein function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alp

PDB

2PQF , 6V3W , 8XPX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00642	zf-CCCH	177 → 201	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family
PF02825	WWE	377 → 458	WWE domain	Family
PF00644	PARP	507 → 679	Poly(ADP-ribose) polymerase catalytic domain	Family

Sequence

MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAA
APERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTT
EHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHI
CQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAP
SRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYR
WQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLS
TASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGS
DGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPG
PKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEV
YQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARD
AAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSI
FVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ

Sequence length

701

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Clear cell carcinoma of kidney	Uncertain significance	rs77876256	RCV005929134
Hepatocellular carcinoma	Uncertain significance	rs770028402	RCV005930986

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	34514952
Carcinoma Hepatocellular	Associate	38302034
Colorectal Neoplasms	Associate	22194930, 28615517
Diffuse Intrinsic Pontine Glioma	Associate	32229503
Drug Related Side Effects and Adverse Reactions	Inhibit	26505995
Hypomagnesemia 5 Renal with Ocular Involvement	Associate	26005050
Lymphoma Large B Cell Diffuse	Associate	35322192
Neoplasms	Associate	31408463, 35945529, 36929572
Ovarian Neoplasms	Associate	36063278
Recombinant chromosome 8 syndrome	Associate	36929572
Sarcoma	Associate	36929572
Triple Negative Breast Neoplasms	Associate	34880209

PARP12 (poly(ADP-ribose) polymerase family member 12)