Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6470
Gene name Gene Name - the full gene name approved by the HGNC.	Serine hydroxymethyltransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SHMT1
Synonyms (NCBI Gene) Gene synonyms aliases	CSHMT, SHMT
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p11.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016266	hsa-miR-193b-3p	Microarray	20304954
MIRT045899	hsa-miR-125b-5p	CLASH	23622248
MIRT666395	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT666394	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT666393	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT666392	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT666391	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT505656	hsa-miR-4282	HITS-CLIP	23824327
MIRT666390	hsa-miR-548g-3p	HITS-CLIP	23824327
MIRT666389	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT666388	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT666387	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT666386	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT666385	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT666384	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT666382	hsa-miR-5696	HITS-CLIP	23824327
MIRT666383	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT666381	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT666380	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT666379	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT573047	hsa-miR-122-3p	PAR-CLIP	20371350
MIRT573045	hsa-miR-1234-3p	PAR-CLIP	20371350
MIRT573046	hsa-miR-7107-5p	PAR-CLIP	20371350
MIRT573044	hsa-miR-20b-3p	PAR-CLIP	20371350
MIRT573043	hsa-miR-4641	PAR-CLIP	20371350
MIRT573041	hsa-miR-4763-5p	PAR-CLIP	20371350
MIRT573042	hsa-miR-6735-3p	PAR-CLIP	20371350
MIRT505658	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT505657	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT505656	hsa-miR-4282	PAR-CLIP	21572407
MIRT505655	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT505654	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT554317	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT554316	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT505653	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT505652	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT505651	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT505650	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT505649	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT505648	hsa-miR-636	PAR-CLIP	21572407
MIRT554315	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT554314	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT505647	hsa-miR-4477a	PAR-CLIP	21572407
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	22012620
MIRT489667	hsa-miR-4302	PAR-CLIP	22012620
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	22012620
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	22012620
MIRT489664	hsa-miR-423-5p	PAR-CLIP	22012620
MIRT530206	hsa-miR-1914-3p	PAR-CLIP	22012620
MIRT530205	hsa-miR-5194	PAR-CLIP	22012620
MIRT530204	hsa-miR-6738-5p	PAR-CLIP	22012620
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	22012620
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	22012620
MIRT489660	hsa-miR-449a	PAR-CLIP	22012620
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	22012620
MIRT489658	hsa-miR-486-3p	PAR-CLIP	22012620
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	22012620
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	22012620
MIRT489654	hsa-let-7c-3p	PAR-CLIP	22012620
MIRT505658	hsa-miR-218-5p	PAR-CLIP	23446348
MIRT505657	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT505656	hsa-miR-4282	PAR-CLIP	23446348
MIRT505655	hsa-miR-224-3p	PAR-CLIP	23446348
MIRT505654	hsa-miR-522-3p	PAR-CLIP	23446348
MIRT505653	hsa-miR-508-3p	PAR-CLIP	23446348
MIRT505652	hsa-miR-219a-5p	PAR-CLIP	23446348
MIRT505651	hsa-miR-4782-3p	PAR-CLIP	23446348
MIRT505650	hsa-miR-6766-3p	PAR-CLIP	23446348
MIRT505649	hsa-miR-4445-5p	PAR-CLIP	23446348
MIRT505648	hsa-miR-636	PAR-CLIP	23446348
MIRT505647	hsa-miR-4477a	PAR-CLIP	23446348
MIRT489670	hsa-miR-4662a-3p	PAR-CLIP	23592263
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT489668	hsa-miR-3174	PAR-CLIP	23592263
MIRT489667	hsa-miR-4302	PAR-CLIP	23592263
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	23592263
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT489664	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT489660	hsa-miR-449a	PAR-CLIP	23592263
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT489658	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	23592263
MIRT489656	hsa-miR-921	PAR-CLIP	23592263
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT489654	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT489654	hsa-let-7c-3p	PAR-CLIP	27292025
MIRT489654	hsa-let-7c-3p	PAR-CLIP	27292025
MIRT530206	hsa-miR-1914-3p	PAR-CLIP	27292025
MIRT530206	hsa-miR-1914-3p	PAR-CLIP	27292025
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	27292025
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	27292025
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	27292025
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	27292025
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	27292025
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	27292025
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	27292025
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	27292025
MIRT489664	hsa-miR-423-5p	PAR-CLIP	27292025
MIRT489664	hsa-miR-423-5p	PAR-CLIP	27292025
MIRT489667	hsa-miR-4302	PAR-CLIP	27292025
MIRT489667	hsa-miR-4302	PAR-CLIP	27292025
MIRT489660	hsa-miR-449a	PAR-CLIP	27292025
MIRT489660	hsa-miR-449a	PAR-CLIP	27292025
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	27292025
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	27292025
MIRT489658	hsa-miR-486-3p	PAR-CLIP	27292025
MIRT489658	hsa-miR-486-3p	PAR-CLIP	27292025
MIRT530205	hsa-miR-5194	PAR-CLIP	27292025
MIRT530205	hsa-miR-5194	PAR-CLIP	27292025
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	27292025
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	27292025
MIRT530204	hsa-miR-6738-5p	PAR-CLIP	27292025
MIRT530204	hsa-miR-6738-5p	PAR-CLIP	27292025
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	27292025
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	27292025
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	27292025
MIRT735602	hsa-miR-6778-5p	Western blotting, Microarray, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR	32142918
MIRT666395	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT666394	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT666393	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT666392	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT666391	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT505656	hsa-miR-4282	HITS-CLIP	23824327
MIRT666390	hsa-miR-548g-3p	HITS-CLIP	23824327
MIRT666389	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT666388	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT666387	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT666386	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT666385	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT666384	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT666382	hsa-miR-5696	HITS-CLIP	23824327
MIRT666383	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT666381	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT666380	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT666379	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT573047	hsa-miR-122-3p	PAR-CLIP	20371350
MIRT573045	hsa-miR-1234-3p	PAR-CLIP	20371350
MIRT573046	hsa-miR-7107-5p	PAR-CLIP	20371350
MIRT573044	hsa-miR-20b-3p	PAR-CLIP	20371350
MIRT573043	hsa-miR-4641	PAR-CLIP	20371350
MIRT573041	hsa-miR-4763-5p	PAR-CLIP	20371350
MIRT573042	hsa-miR-6735-3p	PAR-CLIP	20371350
MIRT505658	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT505657	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT505656	hsa-miR-4282	PAR-CLIP	21572407
MIRT505655	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT505654	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT554317	hsa-miR-4778-5p	PAR-CLIP	21572407
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT554316	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT505653	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT505652	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT505651	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT505650	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT505649	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT505648	hsa-miR-636	PAR-CLIP	21572407
MIRT554315	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT554314	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT505647	hsa-miR-4477a	PAR-CLIP	21572407
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	22012620
MIRT489667	hsa-miR-4302	PAR-CLIP	22012620
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	22012620
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	22012620
MIRT489664	hsa-miR-423-5p	PAR-CLIP	22012620
MIRT530206	hsa-miR-1914-3p	PAR-CLIP	22012620
MIRT530205	hsa-miR-5194	PAR-CLIP	22012620
MIRT530204	hsa-miR-6738-5p	PAR-CLIP	22012620
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	22012620
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	22012620
MIRT489660	hsa-miR-449a	PAR-CLIP	22012620
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	22012620
MIRT489658	hsa-miR-486-3p	PAR-CLIP	22012620
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	22012620
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	22012620
MIRT489654	hsa-let-7c-3p	PAR-CLIP	22012620
MIRT505658	hsa-miR-218-5p	PAR-CLIP	23446348
MIRT505657	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT505656	hsa-miR-4282	PAR-CLIP	23446348
MIRT505655	hsa-miR-224-3p	PAR-CLIP	23446348
MIRT505654	hsa-miR-522-3p	PAR-CLIP	23446348
MIRT505653	hsa-miR-508-3p	PAR-CLIP	23446348
MIRT505652	hsa-miR-219a-5p	PAR-CLIP	23446348
MIRT505651	hsa-miR-4782-3p	PAR-CLIP	23446348
MIRT505650	hsa-miR-6766-3p	PAR-CLIP	23446348
MIRT505649	hsa-miR-4445-5p	PAR-CLIP	23446348
MIRT505648	hsa-miR-636	PAR-CLIP	23446348
MIRT505647	hsa-miR-4477a	PAR-CLIP	23446348
MIRT489670	hsa-miR-4662a-3p	PAR-CLIP	23592263
MIRT489669	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT489668	hsa-miR-3174	PAR-CLIP	23592263
MIRT489667	hsa-miR-4302	PAR-CLIP	23592263
MIRT489666	hsa-miR-7114-5p	PAR-CLIP	23592263
MIRT489665	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT489664	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT489663	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT489662	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT489661	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT489660	hsa-miR-449a	PAR-CLIP	23592263
MIRT489659	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT489658	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT489657	hsa-miR-3177-5p	PAR-CLIP	23592263
MIRT489656	hsa-miR-921	PAR-CLIP	23592263
MIRT489655	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT489654	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT505658	hsa-miR-218-5p	Luciferase reporter assay, Western blotting	37799388
MIRT755614	hsa-miR-9-5p	Luciferase reporter assay, Western blotting	37799388
MIRT1347430	hsa-miR-3184	CLIP-seq
MIRT1347431	hsa-miR-34a	CLIP-seq
MIRT1347432	hsa-miR-449b	CLIP-seq
MIRT1347433	hsa-miR-298	CLIP-seq
MIRT1347434	hsa-miR-3120-3p	CLIP-seq
MIRT1347435	hsa-miR-3920	CLIP-seq
MIRT1347436	hsa-miR-4762-3p	CLIP-seq
MIRT1347437	hsa-miR-922	CLIP-seq
MIRT1347435	hsa-miR-3920	CLIP-seq
MIRT1347436	hsa-miR-4762-3p	CLIP-seq
MIRT2327215	hsa-miR-1266	CLIP-seq
MIRT2327216	hsa-miR-3127-3p	CLIP-seq
MIRT2327217	hsa-miR-3664-3p	CLIP-seq
MIRT2327218	hsa-miR-421	CLIP-seq
MIRT2327219	hsa-miR-4518	CLIP-seq
MIRT2327220	hsa-miR-4660	CLIP-seq
MIRT2327221	hsa-miR-4709-5p	CLIP-seq
MIRT2327222	hsa-miR-505	CLIP-seq
MIRT2327223	hsa-miR-646	CLIP-seq
MIRT2622462	hsa-miR-1243	CLIP-seq
MIRT2622463	hsa-miR-1261	CLIP-seq
MIRT2622464	hsa-miR-1271	CLIP-seq
MIRT2622465	hsa-miR-182	CLIP-seq
MIRT1347433	hsa-miR-298	CLIP-seq
MIRT1347434	hsa-miR-3120-3p	CLIP-seq
MIRT2622466	hsa-miR-3121-5p	CLIP-seq
MIRT2622467	hsa-miR-3138	CLIP-seq
MIRT2622468	hsa-miR-3185	CLIP-seq
MIRT2622469	hsa-miR-3611	CLIP-seq
MIRT2622470	hsa-miR-3622b-5p	CLIP-seq
MIRT1347435	hsa-miR-3920	CLIP-seq
MIRT2622471	hsa-miR-3945	CLIP-seq
MIRT2622472	hsa-miR-4252	CLIP-seq
MIRT2622473	hsa-miR-4253	CLIP-seq
MIRT2622474	hsa-miR-4277	CLIP-seq
MIRT2622475	hsa-miR-4279	CLIP-seq
MIRT2622476	hsa-miR-4642	CLIP-seq
MIRT2622477	hsa-miR-4760-3p	CLIP-seq
MIRT1347436	hsa-miR-4762-3p	CLIP-seq
MIRT2622478	hsa-miR-4800-5p	CLIP-seq
MIRT2622479	hsa-miR-4803	CLIP-seq
MIRT2622480	hsa-miR-570	CLIP-seq
MIRT2622481	hsa-miR-758	CLIP-seq
MIRT1347437	hsa-miR-922	CLIP-seq
MIRT2622482	hsa-miR-96	CLIP-seq
MIRT2622467	hsa-miR-3138	CLIP-seq
MIRT2622471	hsa-miR-3945	CLIP-seq
MIRT2622473	hsa-miR-4253	CLIP-seq
MIRT2622478	hsa-miR-4800-5p	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
MYC	Unknown	12138190

Show/Hide all(50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000900	Function	MRNA regulatory element binding translation repressor activity	IDA	10995219
GO:0004372	Function	Glycine hydroxymethyltransferase activity	IBA
GO:0004372	Function	Glycine hydroxymethyltransferase activity	IDA	8505317, 10995219, 17482557, 24698160
GO:0004372	Function	Glycine hydroxymethyltransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 30613765, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IBA
GO:0005829	Component	Cytosol	IDA	17482557
GO:0005829	Component	Cytosol	TAS
GO:0006231	Process	DTMP biosynthetic process	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0006544	Process	Glycine metabolic process	IDA	24698160
GO:0006544	Process	Glycine metabolic process	IEA
GO:0006563	Process	L-serine metabolic process	IDA	24698160
GO:0006563	Process	L-serine metabolic process	IEA
GO:0006565	Process	L-serine catabolic process	IDA	17482557
GO:0006730	Process	One-carbon metabolic process	IEA
GO:0009113	Process	Purine nucleobase biosynthetic process	IDA	11516159
GO:0016740	Function	Transferase activity	IEA
GO:0016832	Function	Aldehyde-lyase activity	EXP	3110140, 6795186, 11802770
GO:0017148	Process	Negative regulation of translation	IDA	10995219
GO:0019264	Process	Glycine biosynthetic process from serine	IBA
GO:0019264	Process	Glycine biosynthetic process from serine	IEA
GO:0030170	Function	Pyridoxal phosphate binding	IBA
GO:0030170	Function	Pyridoxal phosphate binding	IDA	17482557, 24698160
GO:0030170	Function	Pyridoxal phosphate binding	IEA
GO:0035999	Process	Tetrahydrofolate interconversion	IDA	24698160
GO:0035999	Process	Tetrahydrofolate interconversion	IEA
GO:0036094	Function	Small molecule binding	IPI	24698160
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0042803	Function	Protein homodimerization activity	IDA	9753690
GO:0045329	Process	Carnitine biosynthetic process	TAS
GO:0046653	Process	Tetrahydrofolate metabolic process	IBA
GO:0046653	Process	Tetrahydrofolate metabolic process	IDA	24698160
GO:0046653	Process	Tetrahydrofolate metabolic process	IEA
GO:0046655	Process	Folic acid metabolic process	IDA	11278996
GO:0046655	Process	Folic acid metabolic process	TAS
GO:0048027	Function	MRNA 5'-UTR binding	IDA	10995219
GO:0051289	Process	Protein homotetramerization	IDA	24698160
GO:0051289	Process	Protein homotetramerization	IEA
GO:0070013	Component	Intracellular organelle lumen	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070905	Function	Serine binding	IDA	24698160
GO:1904482	Process	Cellular response to tetrahydrofolate	IDA	24698160
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

MIM	HGNC	e!Ensembl
182144	10850	ENSG00000176974

Protein

UniProt ID

P34896

Protein name

Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)

Protein function

Interconversion of serine and glycine (PubMed:24698160, PubMed:8505317).

PDB

1BJ4 , 6FL5 , 6M5W , 7RJL , 7RJP , 8A11 , 8R7H

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00464	SHMT	26 → 425	Serine hydroxymethyltransferase	Domain

Sequence

MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
PDF

Sequence length

483

Interactions

View interactions

	KEGG		Reactome
	Glycine, serine and threonine metabolism Glyoxylate and dicarboxylate metabolism One carbon pool by folate Metabolic pathways Carbon metabolism Biosynthesis of amino acids Biosynthesis of cofactors Antifolate resistance Folate transport and metabolism		Metabolism of folate and pterines Carnitine synthesis

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Gastrointestinal stromal tumor	gastrointestinal stromal tumor	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (64)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	26553359
Alopecia	Associate	16447238
Breast Neoplasms	Associate	17595805, 24979213, 25496516, 25598430, 27347936
Breast Neoplasms	Inhibit	27347936
Calcinosis	Associate	30071536
Carcinoma	Stimulate	27277113
Carcinoma Ductal	Associate	25053597
Carcinoma Hepatocellular	Associate	25318605, 27936032
Carcinoma Lobular	Associate	25053597
Carcinoma Medullary	Inhibit	27277113
Carcinoma Non Small Cell Lung	Associate	36615660
Carcinoma Ovarian Epithelial	Associate	18381459
Carcinoma Renal Cell	Associate	35096270, 37796681
Carcinoma Squamous Cell	Associate	31967407
Cardiovascular Diseases	Associate	25948668
Cerebral Infarction	Associate	21935458, 33259775
Colorectal Neoplasms	Associate	18996879, 19776626, 20920350, 25948668
Death	Associate	25227144
Down Syndrome	Associate	23421317
Drug Related Side Effects and Adverse Reactions	Associate	34525956
Essential Hypertension	Associate	30411815
Fatty Liver Alcoholic	Associate	24419221
Folate Malabsorption Hereditary	Associate	34502300
Gastrointestinal Stromal Tumors	Associate	25227144
Glioblastoma	Associate	37823569
Head and Neck Neoplasms	Associate	33369477
Heart Defects Congenital	Associate	28264803
Hereditary Breast and Ovarian Cancer Syndrome	Associate	17595805
Hyperhomocysteinemia	Associate	30411815
Hypertension	Associate	30411815
Hypoxia	Inhibit	37823569
Kidney Diseases	Associate	37796681
Leukemia Myeloid Acute	Associate	24641398
Leukoencephalopathies	Stimulate	36475386
Lung Neoplasms	Associate	17420066, 30035852
Lung Neoplasms	Stimulate	25412303
Lymphoma Large B Cell Diffuse	Associate	15198953
Lymphoma Mantle Cell	Stimulate	27277113
Lymphoma Non Hodgkin	Stimulate	17119116, 25384508
Lymphoma Non Hodgkin	Associate	17119116, 23913011, 25384508
Malaria	Associate	27198213
Metabolic Diseases	Associate	25318605
Mucocutaneous Lymph Node Syndrome	Associate	30761252
Multiple Sclerosis	Associate	11986237, 27386562, 36475386, 36759259
Neoplasm Metastasis	Associate	24485798
Neoplasms	Associate	24979213, 34502300, 36615660, 37796681, 9753690
Neural Tube Defects	Associate	22903727
Neurodegenerative Diseases	Associate	37796681
Osteosarcoma	Associate	22292074
Ovarian Neoplasms	Associate	18381459, 25066213
Pancreatic Neoplasms	Associate	29474406
Potocki Lupski syndrome	Associate	28413209
Primary hyperoxaluria type 1	Associate	24419221
Rectal Neoplasms	Inhibit	20920350
Renal Insufficiency Chronic	Associate	30071536
Smith Magenis Syndrome	Associate	8533763
Smooth Muscle Tumor	Associate	30071536
Temporomandibular Joint Disorders	Associate	21615938
Thyroid Cancer Papillary	Associate	27277113
Thyroid Neoplasms	Associate	27277113
Triple Negative Breast Neoplasms	Associate	24390667
Vascular Calcification	Associate	30071536
Vision Disorders	Associate	26316272
Weight Loss	Associate	30587867

SHMT1 (serine hydroxymethyltransferase 1)