Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6464
Gene name Gene Name - the full gene name approved by the HGNC.	SHC adaptor protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SHC1
Synonyms (NCBI Gene) Gene synonyms aliases	SHC, SHCA
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q21.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016646	hsa-miR-429	Reporter assay	20005803
MIRT020350	hsa-miR-200a-3p	Reporter assay	20005803
MIRT021079	hsa-miR-200c-3p	Reporter assay	20005803
MIRT021650	hsa-miR-141-3p	Reporter assay	20005803
MIRT023035	hsa-miR-124-3p	Microarray	18668037
MIRT024134	hsa-miR-200b-3p	Reporter assay	20005803
MIRT046156	hsa-miR-30b-5p	CLASH	23622248
MIRT438197	hsa-miR-27b-3p	Luciferase reporter assay	24177325
MIRT438197	hsa-miR-27b-3p	Luciferase reporter assay	24177325
MIRT438183	hsa-miR-365a-3p	Microarray, Western blot	24216611
MIRT438197	hsa-miR-27b-3p	Luciferase reporter assay	24177325
MIRT438197	hsa-miR-27b-3p	Luciferase reporter assay	24177325
MIRT438183	hsa-miR-365a-3p	Microarray, Western blot	24216611
MIRT732288	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732288	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732288	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732288	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT735655	hsa-miR-203a-3p	Luciferase reporter assay, Western blotting, Immunofluorescence, qRT-PCR	32781430
MIRT736626	hsa-miR-219a-5p	Luciferase reporter assay, Western blotting, qRT-PCR	31428222
MIRT021650	hsa-miR-141-3p	Microarray, qRT-PCR	35816043
MIRT016646	hsa-miR-429	Microarray, qRT-PCR	35816043
MIRT1346400	hsa-miR-1207-5p	CLIP-seq
MIRT1346401	hsa-miR-1229	CLIP-seq
MIRT1346402	hsa-miR-1321	CLIP-seq
MIRT1346403	hsa-miR-134	CLIP-seq
MIRT1346404	hsa-miR-1827	CLIP-seq
MIRT1346405	hsa-miR-2467-3p	CLIP-seq
MIRT1346406	hsa-miR-2861	CLIP-seq
MIRT1346407	hsa-miR-3118	CLIP-seq
MIRT1346408	hsa-miR-3136-3p	CLIP-seq
MIRT1346409	hsa-miR-3154	CLIP-seq
MIRT1346410	hsa-miR-3188	CLIP-seq
MIRT1346411	hsa-miR-3192	CLIP-seq
MIRT1346412	hsa-miR-3202	CLIP-seq
MIRT1346413	hsa-miR-3612	CLIP-seq
MIRT1346414	hsa-miR-3679-3p	CLIP-seq
MIRT1346415	hsa-miR-375	CLIP-seq
MIRT1346416	hsa-miR-3978	CLIP-seq
MIRT1346417	hsa-miR-4257	CLIP-seq
MIRT1346418	hsa-miR-4325	CLIP-seq
MIRT1346419	hsa-miR-4424	CLIP-seq
MIRT1346420	hsa-miR-4433	CLIP-seq
MIRT1346421	hsa-miR-4436b-3p	CLIP-seq
MIRT1346422	hsa-miR-4436b-5p	CLIP-seq
MIRT1346423	hsa-miR-4443	CLIP-seq
MIRT1346424	hsa-miR-4446-3p	CLIP-seq
MIRT1346425	hsa-miR-4459	CLIP-seq
MIRT1346426	hsa-miR-4476	CLIP-seq
MIRT1346427	hsa-miR-4668-3p	CLIP-seq
MIRT1346428	hsa-miR-4739	CLIP-seq
MIRT1346429	hsa-miR-4756-5p	CLIP-seq
MIRT1346430	hsa-miR-4763-3p	CLIP-seq
MIRT1346431	hsa-miR-4768-3p	CLIP-seq
MIRT1346432	hsa-miR-4786-3p	CLIP-seq
MIRT1346433	hsa-miR-4793-3p	CLIP-seq
MIRT1346434	hsa-miR-650	CLIP-seq
MIRT1346435	hsa-miR-940	CLIP-seq
MIRT1346436	hsa-miR-943	CLIP-seq
MIRT1346400	hsa-miR-1207-5p	CLIP-seq
MIRT1346402	hsa-miR-1321	CLIP-seq
MIRT1346404	hsa-miR-1827	CLIP-seq
MIRT1346437	hsa-miR-200b	CLIP-seq
MIRT1346438	hsa-miR-200c	CLIP-seq
MIRT1346405	hsa-miR-2467-3p	CLIP-seq
MIRT1346410	hsa-miR-3188	CLIP-seq
MIRT1346412	hsa-miR-3202	CLIP-seq
MIRT1346439	hsa-miR-323-3p	CLIP-seq
MIRT1346413	hsa-miR-3612	CLIP-seq
MIRT1346440	hsa-miR-3664-5p	CLIP-seq
MIRT1346441	hsa-miR-374c	CLIP-seq
MIRT1346442	hsa-miR-376c	CLIP-seq
MIRT1346443	hsa-miR-409-3p	CLIP-seq
MIRT1346418	hsa-miR-4325	CLIP-seq
MIRT1346421	hsa-miR-4436b-3p	CLIP-seq
MIRT1346424	hsa-miR-4446-3p	CLIP-seq
MIRT1346425	hsa-miR-4459	CLIP-seq
MIRT1346426	hsa-miR-4476	CLIP-seq
MIRT1346428	hsa-miR-4739	CLIP-seq
MIRT1346429	hsa-miR-4756-5p	CLIP-seq
MIRT1346430	hsa-miR-4763-3p	CLIP-seq
MIRT1346433	hsa-miR-4793-3p	CLIP-seq
MIRT1346434	hsa-miR-650	CLIP-seq
MIRT1346444	hsa-miR-655	CLIP-seq
MIRT1346445	hsa-miR-9	CLIP-seq
MIRT1346435	hsa-miR-940	CLIP-seq
MIRT1346401	hsa-miR-1229	CLIP-seq
MIRT1346446	hsa-miR-124	CLIP-seq
MIRT1346447	hsa-miR-1273f	CLIP-seq
MIRT1346448	hsa-miR-139-5p	CLIP-seq
MIRT1346449	hsa-miR-150	CLIP-seq
MIRT1346450	hsa-miR-153	CLIP-seq
MIRT1346451	hsa-miR-186	CLIP-seq
MIRT1346452	hsa-miR-1912	CLIP-seq
MIRT1346453	hsa-miR-219-5p	CLIP-seq
MIRT1346454	hsa-miR-299-3p	CLIP-seq
MIRT1346455	hsa-miR-3148	CLIP-seq
MIRT1346456	hsa-miR-3151	CLIP-seq
MIRT1346457	hsa-miR-3163	CLIP-seq
MIRT1346458	hsa-miR-3171	CLIP-seq
MIRT1346459	hsa-miR-3180	CLIP-seq
MIRT1346460	hsa-miR-3180-3p	CLIP-seq
MIRT1346461	hsa-miR-3196	CLIP-seq
MIRT1346462	hsa-miR-3613-3p	CLIP-seq
MIRT1346463	hsa-miR-3618	CLIP-seq
MIRT1346464	hsa-miR-365	CLIP-seq
MIRT1346465	hsa-miR-3656	CLIP-seq
MIRT1346466	hsa-miR-3684	CLIP-seq
MIRT1346416	hsa-miR-3978	CLIP-seq
MIRT1346467	hsa-miR-4261	CLIP-seq
MIRT1346468	hsa-miR-4447	CLIP-seq
MIRT1346469	hsa-miR-4450	CLIP-seq
MIRT1346470	hsa-miR-4472	CLIP-seq
MIRT1346471	hsa-miR-4474-5p	CLIP-seq
MIRT1346472	hsa-miR-448	CLIP-seq
MIRT1346473	hsa-miR-4488	CLIP-seq
MIRT1346474	hsa-miR-4491	CLIP-seq
MIRT1346475	hsa-miR-4657	CLIP-seq
MIRT1346476	hsa-miR-4697-5p	CLIP-seq
MIRT1346477	hsa-miR-4749-3p	CLIP-seq
MIRT1346478	hsa-miR-4782-3p	CLIP-seq
MIRT1346479	hsa-miR-4786-5p	CLIP-seq
MIRT1346480	hsa-miR-491-5p	CLIP-seq
MIRT1346481	hsa-miR-494	CLIP-seq
MIRT1346482	hsa-miR-506	CLIP-seq
MIRT1346483	hsa-miR-548a-3p	CLIP-seq
MIRT1346484	hsa-miR-548an	CLIP-seq
MIRT1346485	hsa-miR-548e	CLIP-seq
MIRT1346486	hsa-miR-548f	CLIP-seq
MIRT1346487	hsa-miR-561	CLIP-seq
MIRT1346488	hsa-miR-568	CLIP-seq
MIRT1346489	hsa-miR-586	CLIP-seq
MIRT1346490	hsa-miR-609	CLIP-seq
MIRT1346491	hsa-miR-618	CLIP-seq
MIRT1346492	hsa-miR-769-5p	CLIP-seq
MIRT1346493	hsa-miR-934	CLIP-seq
MIRT1346494	hsa-miR-1976	CLIP-seq
MIRT1346495	hsa-miR-22	CLIP-seq
MIRT1346496	hsa-miR-4252	CLIP-seq
MIRT1346497	hsa-miR-4722-3p	CLIP-seq
MIRT1346498	hsa-miR-483-3p	CLIP-seq
MIRT1346464	hsa-miR-365	CLIP-seq
MIRT1346471	hsa-miR-4474-5p	CLIP-seq
MIRT1346477	hsa-miR-4749-3p	CLIP-seq
MIRT2102495	hsa-miR-10a	CLIP-seq
MIRT2102496	hsa-miR-10b	CLIP-seq
MIRT2102497	hsa-miR-1205	CLIP-seq
MIRT2102498	hsa-miR-1207-3p	CLIP-seq
MIRT1346401	hsa-miR-1229	CLIP-seq
MIRT1346446	hsa-miR-124	CLIP-seq
MIRT1346447	hsa-miR-1273f	CLIP-seq
MIRT2102499	hsa-miR-1287	CLIP-seq
MIRT1346448	hsa-miR-139-5p	CLIP-seq
MIRT2102500	hsa-miR-140-3p	CLIP-seq
MIRT1346449	hsa-miR-150	CLIP-seq
MIRT1346404	hsa-miR-1827	CLIP-seq
MIRT1346452	hsa-miR-1912	CLIP-seq
MIRT2102501	hsa-miR-197	CLIP-seq
MIRT1346437	hsa-miR-200b	CLIP-seq
MIRT1346438	hsa-miR-200c	CLIP-seq
MIRT2102502	hsa-miR-203	CLIP-seq
MIRT2102503	hsa-miR-2110	CLIP-seq
MIRT1346453	hsa-miR-219-5p	CLIP-seq
MIRT1346406	hsa-miR-2861	CLIP-seq
MIRT1346454	hsa-miR-299-3p	CLIP-seq
MIRT2102504	hsa-miR-3119	CLIP-seq
MIRT2102505	hsa-miR-3120-3p	CLIP-seq
MIRT2102506	hsa-miR-3127-5p	CLIP-seq
MIRT2102507	hsa-miR-3135	CLIP-seq
MIRT2102508	hsa-miR-3140-3p	CLIP-seq
MIRT2102509	hsa-miR-3150a-3p	CLIP-seq
MIRT1346456	hsa-miR-3151	CLIP-seq
MIRT1346409	hsa-miR-3154	CLIP-seq
MIRT2102510	hsa-miR-3162-5p	CLIP-seq
MIRT1346457	hsa-miR-3163	CLIP-seq
MIRT2102511	hsa-miR-3173-3p	CLIP-seq
MIRT1346459	hsa-miR-3180	CLIP-seq
MIRT1346460	hsa-miR-3180-3p	CLIP-seq
MIRT2102512	hsa-miR-3184	CLIP-seq
MIRT1346411	hsa-miR-3192	CLIP-seq
MIRT1346461	hsa-miR-3196	CLIP-seq
MIRT2102513	hsa-miR-3201	CLIP-seq
MIRT1346412	hsa-miR-3202	CLIP-seq
MIRT1346439	hsa-miR-323-3p	CLIP-seq
MIRT2102514	hsa-miR-335	CLIP-seq
MIRT2102515	hsa-miR-3607-3p	CLIP-seq
MIRT1346413	hsa-miR-3612	CLIP-seq
MIRT1346463	hsa-miR-3618	CLIP-seq
MIRT2102516	hsa-miR-3650	CLIP-seq
MIRT1346465	hsa-miR-3656	CLIP-seq
MIRT2102517	hsa-miR-3664-3p	CLIP-seq
MIRT1346440	hsa-miR-3664-5p	CLIP-seq
MIRT2102518	hsa-miR-3665	CLIP-seq
MIRT1346414	hsa-miR-3679-3p	CLIP-seq
MIRT2102519	hsa-miR-3689a-3p	CLIP-seq
MIRT2102520	hsa-miR-3689c	CLIP-seq
MIRT2102521	hsa-miR-371-5p	CLIP-seq
MIRT1346441	hsa-miR-374c	CLIP-seq
MIRT1346415	hsa-miR-375	CLIP-seq
MIRT1346442	hsa-miR-376c	CLIP-seq
MIRT2102522	hsa-miR-3922-5p	CLIP-seq
MIRT2102523	hsa-miR-3929	CLIP-seq
MIRT1346416	hsa-miR-3978	CLIP-seq
MIRT1346443	hsa-miR-409-3p	CLIP-seq
MIRT2102524	hsa-miR-423-5p	CLIP-seq
MIRT1346417	hsa-miR-4257	CLIP-seq
MIRT2102525	hsa-miR-4281	CLIP-seq
MIRT2102526	hsa-miR-4314	CLIP-seq
MIRT2102527	hsa-miR-4320	CLIP-seq
MIRT1346418	hsa-miR-4325	CLIP-seq
MIRT2102528	hsa-miR-4418	CLIP-seq
MIRT2102529	hsa-miR-4419b	CLIP-seq
MIRT1346420	hsa-miR-4433	CLIP-seq
MIRT2102530	hsa-miR-4436a	CLIP-seq
MIRT1346422	hsa-miR-4436b-5p	CLIP-seq
MIRT1346424	hsa-miR-4446-3p	CLIP-seq
MIRT1346468	hsa-miR-4447	CLIP-seq
MIRT1346469	hsa-miR-4450	CLIP-seq
MIRT2102531	hsa-miR-4452	CLIP-seq
MIRT2102532	hsa-miR-4457	CLIP-seq
MIRT1346425	hsa-miR-4459	CLIP-seq
MIRT1346470	hsa-miR-4472	CLIP-seq
MIRT1346426	hsa-miR-4476	CLIP-seq
MIRT2102533	hsa-miR-4478	CLIP-seq
MIRT1346472	hsa-miR-448	CLIP-seq
MIRT2102534	hsa-miR-4480	CLIP-seq
MIRT1346473	hsa-miR-4488	CLIP-seq
MIRT1346474	hsa-miR-4491	CLIP-seq
MIRT2102535	hsa-miR-4505	CLIP-seq
MIRT2102536	hsa-miR-450a	CLIP-seq
MIRT2102537	hsa-miR-4511	CLIP-seq
MIRT2102538	hsa-miR-4646-5p	CLIP-seq
MIRT1346475	hsa-miR-4657	CLIP-seq
MIRT2102539	hsa-miR-4695-5p	CLIP-seq
MIRT1346476	hsa-miR-4697-5p	CLIP-seq
MIRT2102540	hsa-miR-4700-3p	CLIP-seq
MIRT2102541	hsa-miR-4710	CLIP-seq
MIRT2102542	hsa-miR-4728-5p	CLIP-seq
MIRT2102543	hsa-miR-4731-3p	CLIP-seq
MIRT2102544	hsa-miR-4740-3p	CLIP-seq
MIRT2102545	hsa-miR-4753-5p	CLIP-seq
MIRT1346431	hsa-miR-4768-3p	CLIP-seq
MIRT1346478	hsa-miR-4782-3p	CLIP-seq
MIRT1346432	hsa-miR-4786-3p	CLIP-seq
MIRT2102546	hsa-miR-4791	CLIP-seq
MIRT1346433	hsa-miR-4793-3p	CLIP-seq
MIRT2102547	hsa-miR-4801	CLIP-seq
MIRT1346480	hsa-miR-491-5p	CLIP-seq
MIRT1346481	hsa-miR-494	CLIP-seq
MIRT1346482	hsa-miR-506	CLIP-seq
MIRT2102548	hsa-miR-509-3-5p	CLIP-seq
MIRT2102549	hsa-miR-509-5p	CLIP-seq
MIRT2102550	hsa-miR-510	CLIP-seq
MIRT2102551	hsa-miR-512-5p	CLIP-seq
MIRT2102552	hsa-miR-545	CLIP-seq
MIRT1346484	hsa-miR-548an	CLIP-seq
MIRT2102553	hsa-miR-548p	CLIP-seq
MIRT1346487	hsa-miR-561	CLIP-seq
MIRT2102554	hsa-miR-587	CLIP-seq
MIRT1346490	hsa-miR-609	CLIP-seq
MIRT2102555	hsa-miR-615-5p	CLIP-seq
MIRT1346491	hsa-miR-618	CLIP-seq
MIRT2102556	hsa-miR-642b	CLIP-seq
MIRT2102557	hsa-miR-645	CLIP-seq
MIRT1346434	hsa-miR-650	CLIP-seq
MIRT1346444	hsa-miR-655	CLIP-seq
MIRT2102558	hsa-miR-657	CLIP-seq
MIRT2102559	hsa-miR-873	CLIP-seq
MIRT2102560	hsa-miR-888	CLIP-seq
MIRT1346445	hsa-miR-9	CLIP-seq
MIRT1346493	hsa-miR-934	CLIP-seq
MIRT1346435	hsa-miR-940	CLIP-seq
MIRT1346401	hsa-miR-1229	CLIP-seq
MIRT1346446	hsa-miR-124	CLIP-seq
MIRT2327011	hsa-miR-1245b-5p	CLIP-seq
MIRT2102502	hsa-miR-203	CLIP-seq
MIRT2327012	hsa-miR-3142	CLIP-seq
MIRT2327013	hsa-miR-3616-3p	CLIP-seq
MIRT1346463	hsa-miR-3618	CLIP-seq
MIRT1346464	hsa-miR-365	CLIP-seq
MIRT2102519	hsa-miR-3689a-3p	CLIP-seq
MIRT2102520	hsa-miR-3689c	CLIP-seq
MIRT2327014	hsa-miR-3907	CLIP-seq
MIRT2102522	hsa-miR-3922-5p	CLIP-seq
MIRT2327015	hsa-miR-4267	CLIP-seq
MIRT1346421	hsa-miR-4436b-3p	CLIP-seq
MIRT2102532	hsa-miR-4457	CLIP-seq
MIRT2327016	hsa-miR-451b	CLIP-seq
MIRT2327017	hsa-miR-4650-5p	CLIP-seq
MIRT1346427	hsa-miR-4668-3p	CLIP-seq
MIRT2102542	hsa-miR-4728-5p	CLIP-seq
MIRT2102543	hsa-miR-4731-3p	CLIP-seq
MIRT1346477	hsa-miR-4749-3p	CLIP-seq
MIRT2102545	hsa-miR-4753-5p	CLIP-seq
MIRT2102547	hsa-miR-4801	CLIP-seq
MIRT1346482	hsa-miR-506	CLIP-seq
MIRT2102552	hsa-miR-545	CLIP-seq
MIRT1346484	hsa-miR-548an	CLIP-seq
MIRT1346487	hsa-miR-561	CLIP-seq
MIRT1346490	hsa-miR-609	CLIP-seq
MIRT2102556	hsa-miR-642b	CLIP-seq
MIRT1346448	hsa-miR-139-5p	CLIP-seq
MIRT1346454	hsa-miR-299-3p	CLIP-seq
MIRT1346456	hsa-miR-3151	CLIP-seq
MIRT2102522	hsa-miR-3922-5p	CLIP-seq
MIRT1346468	hsa-miR-4447	CLIP-seq
MIRT1346469	hsa-miR-4450	CLIP-seq
MIRT2102532	hsa-miR-4457	CLIP-seq
MIRT1346470	hsa-miR-4472	CLIP-seq
MIRT1346474	hsa-miR-4491	CLIP-seq
MIRT1346475	hsa-miR-4657	CLIP-seq
MIRT2102543	hsa-miR-4731-3p	CLIP-seq
MIRT2102545	hsa-miR-4753-5p	CLIP-seq
MIRT2102547	hsa-miR-4801	CLIP-seq
MIRT1346480	hsa-miR-491-5p	CLIP-seq
MIRT1346491	hsa-miR-618	CLIP-seq
MIRT2102498	hsa-miR-1207-3p	CLIP-seq
MIRT2440393	hsa-miR-1248	CLIP-seq
MIRT2102499	hsa-miR-1287	CLIP-seq
MIRT2102500	hsa-miR-140-3p	CLIP-seq
MIRT1346449	hsa-miR-150	CLIP-seq
MIRT2102501	hsa-miR-197	CLIP-seq
MIRT2102503	hsa-miR-2110	CLIP-seq
MIRT2102509	hsa-miR-3150a-3p	CLIP-seq
MIRT2440394	hsa-miR-3179	CLIP-seq
MIRT2102513	hsa-miR-3201	CLIP-seq
MIRT1346412	hsa-miR-3202	CLIP-seq
MIRT2102522	hsa-miR-3922-5p	CLIP-seq
MIRT2440395	hsa-miR-4271	CLIP-seq
MIRT2102525	hsa-miR-4281	CLIP-seq
MIRT2102530	hsa-miR-4436a	CLIP-seq
MIRT2102532	hsa-miR-4457	CLIP-seq
MIRT2440396	hsa-miR-4688	CLIP-seq
MIRT2102540	hsa-miR-4700-3p	CLIP-seq
MIRT2440397	hsa-miR-4711-5p	CLIP-seq
MIRT2440398	hsa-miR-4725-3p	CLIP-seq
MIRT2102543	hsa-miR-4731-3p	CLIP-seq
MIRT2102544	hsa-miR-4740-3p	CLIP-seq
MIRT2440399	hsa-miR-4747-5p	CLIP-seq
MIRT2102545	hsa-miR-4753-5p	CLIP-seq
MIRT2102546	hsa-miR-4791	CLIP-seq
MIRT2102547	hsa-miR-4801	CLIP-seq
MIRT2102551	hsa-miR-512-5p	CLIP-seq
MIRT2102554	hsa-miR-587	CLIP-seq
MIRT2440400	hsa-miR-635	CLIP-seq
MIRT2102556	hsa-miR-642b	CLIP-seq
MIRT2102522	hsa-miR-3922-5p	CLIP-seq
MIRT2102545	hsa-miR-4753-5p	CLIP-seq
MIRT2102498	hsa-miR-1207-3p	CLIP-seq
MIRT2440393	hsa-miR-1248	CLIP-seq
MIRT2622336	hsa-miR-125a-3p	CLIP-seq
MIRT2622337	hsa-miR-1271	CLIP-seq
MIRT2102499	hsa-miR-1287	CLIP-seq
MIRT2102500	hsa-miR-140-3p	CLIP-seq
MIRT1346449	hsa-miR-150	CLIP-seq
MIRT1346404	hsa-miR-1827	CLIP-seq
MIRT2102501	hsa-miR-197	CLIP-seq
MIRT1346494	hsa-miR-1976	CLIP-seq
MIRT1346437	hsa-miR-200b	CLIP-seq
MIRT1346438	hsa-miR-200c	CLIP-seq
MIRT2102503	hsa-miR-2110	CLIP-seq
MIRT2102505	hsa-miR-3120-3p	CLIP-seq
MIRT2102506	hsa-miR-3127-5p	CLIP-seq
MIRT2102507	hsa-miR-3135	CLIP-seq
MIRT2102509	hsa-miR-3150a-3p	CLIP-seq
MIRT2102510	hsa-miR-3162-5p	CLIP-seq
MIRT2102511	hsa-miR-3173-3p	CLIP-seq
MIRT2622338	hsa-miR-3175	CLIP-seq
MIRT2440394	hsa-miR-3179	CLIP-seq
MIRT2622339	hsa-miR-3181	CLIP-seq
MIRT2102512	hsa-miR-3184	CLIP-seq
MIRT2102513	hsa-miR-3201	CLIP-seq
MIRT1346412	hsa-miR-3202	CLIP-seq
MIRT1346439	hsa-miR-323-3p	CLIP-seq
MIRT2622340	hsa-miR-324-5p	CLIP-seq
MIRT2622341	hsa-miR-339-5p	CLIP-seq
MIRT1346440	hsa-miR-3664-5p	CLIP-seq
MIRT2622342	hsa-miR-3688-3p	CLIP-seq
MIRT1346441	hsa-miR-374c	CLIP-seq
MIRT2327014	hsa-miR-3907	CLIP-seq
MIRT2102522	hsa-miR-3922-5p	CLIP-seq
MIRT2622343	hsa-miR-3944-3p	CLIP-seq
MIRT1346416	hsa-miR-3978	CLIP-seq
MIRT1346443	hsa-miR-409-3p	CLIP-seq
MIRT2102524	hsa-miR-423-5p	CLIP-seq
MIRT1346496	hsa-miR-4252	CLIP-seq
MIRT2622344	hsa-miR-4260	CLIP-seq
MIRT1346467	hsa-miR-4261	CLIP-seq
MIRT2622345	hsa-miR-4264	CLIP-seq
MIRT2440395	hsa-miR-4271	CLIP-seq
MIRT2102525	hsa-miR-4281	CLIP-seq
MIRT2622346	hsa-miR-4287	CLIP-seq
MIRT2102530	hsa-miR-4436a	CLIP-seq
MIRT1346423	hsa-miR-4443	CLIP-seq
MIRT2102531	hsa-miR-4452	CLIP-seq
MIRT2102532	hsa-miR-4457	CLIP-seq
MIRT2622347	hsa-miR-4469	CLIP-seq
MIRT2327016	hsa-miR-451b	CLIP-seq
MIRT2622348	hsa-miR-4540	CLIP-seq
MIRT2622349	hsa-miR-4642	CLIP-seq
MIRT2622350	hsa-miR-4656	CLIP-seq
MIRT2622351	hsa-miR-4685-3p	CLIP-seq
MIRT2440396	hsa-miR-4688	CLIP-seq
MIRT2102539	hsa-miR-4695-5p	CLIP-seq
MIRT2102540	hsa-miR-4700-3p	CLIP-seq
MIRT2102541	hsa-miR-4710	CLIP-seq
MIRT2440397	hsa-miR-4711-5p	CLIP-seq
MIRT1346497	hsa-miR-4722-3p	CLIP-seq
MIRT2440398	hsa-miR-4725-3p	CLIP-seq
MIRT2622352	hsa-miR-4726-3p	CLIP-seq
MIRT2622353	hsa-miR-4727-5p	CLIP-seq
MIRT2102543	hsa-miR-4731-3p	CLIP-seq
MIRT2622354	hsa-miR-4733-5p	CLIP-seq
MIRT2102544	hsa-miR-4740-3p	CLIP-seq
MIRT2440399	hsa-miR-4747-5p	CLIP-seq
MIRT2622355	hsa-miR-4750	CLIP-seq
MIRT2102545	hsa-miR-4753-5p	CLIP-seq
MIRT1346432	hsa-miR-4786-3p	CLIP-seq
MIRT1346479	hsa-miR-4786-5p	CLIP-seq
MIRT2102546	hsa-miR-4791	CLIP-seq
MIRT2622356	hsa-miR-4797-3p	CLIP-seq
MIRT2102547	hsa-miR-4801	CLIP-seq
MIRT1346498	hsa-miR-483-3p	CLIP-seq
MIRT1346481	hsa-miR-494	CLIP-seq
MIRT2102551	hsa-miR-512-5p	CLIP-seq
MIRT2622357	hsa-miR-513a-3p	CLIP-seq
MIRT2102552	hsa-miR-545	CLIP-seq
MIRT2102553	hsa-miR-548p	CLIP-seq
MIRT2622358	hsa-miR-553	CLIP-seq
MIRT2622359	hsa-miR-554	CLIP-seq
MIRT2622360	hsa-miR-570	CLIP-seq
MIRT2102554	hsa-miR-587	CLIP-seq
MIRT2622361	hsa-miR-616	CLIP-seq
MIRT2622362	hsa-miR-617	CLIP-seq
MIRT2622363	hsa-miR-622	CLIP-seq
MIRT2440400	hsa-miR-635	CLIP-seq
MIRT2102556	hsa-miR-642b	CLIP-seq
MIRT1346444	hsa-miR-655	CLIP-seq
MIRT1346492	hsa-miR-769-5p	CLIP-seq
MIRT1346445	hsa-miR-9	CLIP-seq
MIRT2622364	hsa-miR-939	CLIP-seq
MIRT1346435	hsa-miR-940	CLIP-seq
MIRT2622365	hsa-miR-96	CLIP-seq
MIRT2102498	hsa-miR-1207-3p	CLIP-seq
MIRT2440393	hsa-miR-1248	CLIP-seq
MIRT2622336	hsa-miR-125a-3p	CLIP-seq
MIRT2622337	hsa-miR-1271	CLIP-seq
MIRT2102499	hsa-miR-1287	CLIP-seq
MIRT2102500	hsa-miR-140-3p	CLIP-seq
MIRT1346449	hsa-miR-150	CLIP-seq
MIRT2102501	hsa-miR-197	CLIP-seq
MIRT1346494	hsa-miR-1976	CLIP-seq
MIRT1346437	hsa-miR-200b	CLIP-seq
MIRT1346438	hsa-miR-200c	CLIP-seq
MIRT2102503	hsa-miR-2110	CLIP-seq
MIRT2102505	hsa-miR-3120-3p	CLIP-seq
MIRT2102509	hsa-miR-3150a-3p	CLIP-seq
MIRT2102510	hsa-miR-3162-5p	CLIP-seq
MIRT1346457	hsa-miR-3163	CLIP-seq
MIRT2102511	hsa-miR-3173-3p	CLIP-seq
MIRT2440394	hsa-miR-3179	CLIP-seq
MIRT2622339	hsa-miR-3181	CLIP-seq
MIRT2102512	hsa-miR-3184	CLIP-seq
MIRT2102513	hsa-miR-3201	CLIP-seq
MIRT1346412	hsa-miR-3202	CLIP-seq
MIRT1346439	hsa-miR-323-3p	CLIP-seq
MIRT2622340	hsa-miR-324-5p	CLIP-seq
MIRT2690697	hsa-miR-326	CLIP-seq
MIRT2690698	hsa-miR-330-5p	CLIP-seq
MIRT2622341	hsa-miR-339-5p	CLIP-seq
MIRT1346440	hsa-miR-3664-5p	CLIP-seq
MIRT2622342	hsa-miR-3688-3p	CLIP-seq
MIRT1346441	hsa-miR-374c	CLIP-seq
MIRT2327014	hsa-miR-3907	CLIP-seq
MIRT2102522	hsa-miR-3922-5p	CLIP-seq
MIRT2690699	hsa-miR-3926	CLIP-seq
MIRT2622343	hsa-miR-3944-3p	CLIP-seq
MIRT1346416	hsa-miR-3978	CLIP-seq
MIRT1346443	hsa-miR-409-3p	CLIP-seq
MIRT2102524	hsa-miR-423-5p	CLIP-seq
MIRT1346496	hsa-miR-4252	CLIP-seq
MIRT1346467	hsa-miR-4261	CLIP-seq
MIRT2622345	hsa-miR-4264	CLIP-seq
MIRT2440395	hsa-miR-4271	CLIP-seq
MIRT2102525	hsa-miR-4281	CLIP-seq
MIRT2622346	hsa-miR-4287	CLIP-seq
MIRT2102530	hsa-miR-4436a	CLIP-seq
MIRT2102532	hsa-miR-4457	CLIP-seq
MIRT2622347	hsa-miR-4469	CLIP-seq
MIRT2690700	hsa-miR-4490	CLIP-seq
MIRT2327016	hsa-miR-451b	CLIP-seq
MIRT2622348	hsa-miR-4540	CLIP-seq
MIRT2622349	hsa-miR-4642	CLIP-seq
MIRT2622350	hsa-miR-4656	CLIP-seq
MIRT2622351	hsa-miR-4685-3p	CLIP-seq
MIRT2440396	hsa-miR-4688	CLIP-seq
MIRT2102539	hsa-miR-4695-5p	CLIP-seq
MIRT2102540	hsa-miR-4700-3p	CLIP-seq
MIRT2102541	hsa-miR-4710	CLIP-seq
MIRT2440397	hsa-miR-4711-5p	CLIP-seq
MIRT1346497	hsa-miR-4722-3p	CLIP-seq
MIRT2440398	hsa-miR-4725-3p	CLIP-seq
MIRT2622352	hsa-miR-4726-3p	CLIP-seq
MIRT2622353	hsa-miR-4727-5p	CLIP-seq
MIRT2102543	hsa-miR-4731-3p	CLIP-seq
MIRT2622354	hsa-miR-4733-5p	CLIP-seq
MIRT2102544	hsa-miR-4740-3p	CLIP-seq
MIRT2440399	hsa-miR-4747-5p	CLIP-seq
MIRT2622355	hsa-miR-4750	CLIP-seq
MIRT2102545	hsa-miR-4753-5p	CLIP-seq
MIRT2690701	hsa-miR-4774-5p	CLIP-seq
MIRT1346432	hsa-miR-4786-3p	CLIP-seq
MIRT1346479	hsa-miR-4786-5p	CLIP-seq
MIRT2102546	hsa-miR-4791	CLIP-seq
MIRT2622356	hsa-miR-4797-3p	CLIP-seq
MIRT2102547	hsa-miR-4801	CLIP-seq
MIRT1346498	hsa-miR-483-3p	CLIP-seq
MIRT1346481	hsa-miR-494	CLIP-seq
MIRT2102551	hsa-miR-512-5p	CLIP-seq
MIRT2622357	hsa-miR-513a-3p	CLIP-seq
MIRT2102552	hsa-miR-545	CLIP-seq
MIRT2102553	hsa-miR-548p	CLIP-seq
MIRT2622358	hsa-miR-553	CLIP-seq
MIRT2622359	hsa-miR-554	CLIP-seq
MIRT2622360	hsa-miR-570	CLIP-seq
MIRT2690702	hsa-miR-583	CLIP-seq
MIRT2102554	hsa-miR-587	CLIP-seq
MIRT2690703	hsa-miR-593	CLIP-seq
MIRT2622361	hsa-miR-616	CLIP-seq
MIRT2622362	hsa-miR-617	CLIP-seq
MIRT2622363	hsa-miR-622	CLIP-seq
MIRT2440400	hsa-miR-635	CLIP-seq
MIRT2102556	hsa-miR-642b	CLIP-seq
MIRT1346444	hsa-miR-655	CLIP-seq
MIRT1346492	hsa-miR-769-5p	CLIP-seq
MIRT1346445	hsa-miR-9	CLIP-seq
MIRT2622365	hsa-miR-96	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
SIRT1	Unknown	21778425

Show/Hide all(51)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001525	Process	Angiogenesis	IEA
GO:0001784	Function	Phosphotyrosine residue binding	IPI	20624904
GO:0005068	Function	Transmembrane receptor protein tyrosine kinase adaptor activity	IEA
GO:0005068	Function	Transmembrane receptor protein tyrosine kinase adaptor activity	TAS	1623525, 14676841
GO:0005154	Function	Epidermal growth factor receptor binding	ISS
GO:0005158	Function	Insulin receptor binding	IPI	7537849
GO:0005159	Function	Insulin-like growth factor receptor binding	IPI	7541045
GO:0005168	Function	Neurotrophin TRKA receptor binding	IPI	15488758
GO:0005515	Function	Protein binding	IPI	7518560, 7535773, 7541045, 7542744, 7559478, 8034616, 8491186, 8663178, 8939605, 8940013, 8995379, 9175774, 9254595, 9544989, 9593725, 10356320, 11694516, 11827484, 11877420, 12213123, 12577067, 15629149, 15657067, 16189514, 16273093, 16520382, 16843263, 19172738, 19380743, 20010870
GO:0005543	Function	Phospholipid binding	TAS	14676841
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	14676841
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	IEA
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IBA
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IEA
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	TAS	1623525
GO:0007507	Process	Heart development	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	ISS
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	1623525
GO:0008286	Process	Insulin receptor signaling pathway	IBA
GO:0008286	Process	Insulin receptor signaling pathway	ISS
GO:0016525	Process	Negative regulation of angiogenesis	IGI	24177325
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030971	Function	Receptor tyrosine kinase binding	IBA
GO:0030971	Function	Receptor tyrosine kinase binding	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042742	Process	Defense response to bacterium	IMP	20624904
GO:0043066	Process	Negative regulation of apoptotic process	IMP	20624904
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	14676841
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0043410	Process	Positive regulation of MAPK cascade	IMP	20624904
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	20624904
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	20624904
GO:0046875	Function	Ephrin receptor binding	IEA
GO:0046875	Function	Ephrin receptor binding	IPI	12925710
GO:0048009	Process	Insulin-like growth factor receptor signaling pathway	IEA
GO:0048408	Function	Epidermal growth factor binding	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	20624904
GO:0070435	Component	Shc-EGFR complex	ISS
GO:0071363	Process	Cellular response to growth factor stimulus	IDA	20010870
GO:0071864	Process	Positive regulation of cell proliferation in bone marrow	IGI	24177325
GO:0090322	Process	Regulation of superoxide metabolic process	IGI	24177325
GO:0098609	Process	Cell-cell adhesion	IEA

MIM	HGNC	e!Ensembl
600560	10840	ENSG00000160691

Protein

UniProt ID

P29353

Protein name

SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)

Protein function

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated recept

PDB

1MIL , 1N3H , 1OY2 , 1QG1 , 1SHC , 1TCE , 2L1C , 4JMH , 4XWX , 5CZI , 6DM4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00640	PID	162 → 318	Phosphotyrosine interaction domain (PTB/PID)	Domain
PF00017	SH2	488 → 559	SH2 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expressed in neural stem cells but absent in mature neurons.

Sequence

MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRE
LFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMA
EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEG
VVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL

Sequence length

583

Interactions

View interactions

	KEGG		Reactome
	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway Ras signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway Focal adhesion Natural killer cell mediated cytotoxicity Neurotrophin signaling pathway Insulin signaling pathway Estrogen signaling pathway Prolactin signaling pathway Relaxin signaling pathway Growth hormone synthesis, secretion and action Alcoholism Bacterial invasion of epithelial cells MicroRNAs in cancer Glioma Chronic myeloid leukemia Breast cancer Hepatocellular carcinoma Gastric cancer		Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling DAP12 signaling SHC-related events triggered by IGF1R Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 SHC-mediated cascade:FGFR2 SHC-mediated cascade:FGFR3 SHC-mediated cascade:FGFR4 RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade MET activates RAS signaling RET signaling Interleukin-15 signaling Extra-nuclear estrogen signaling Interleukin-2 signaling Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (46)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma Clear Cell	Associate	24815386
Adenocarcinoma Mucinous	Associate	24815386
Adenocarcinoma of Lung	Associate	23815759, 34117717, 35421944, 36254009, 36311724, 37965333
Alzheimer Disease	Associate	22788679, 37406134
Atherosclerosis	Stimulate	16519809
Atherosclerosis	Associate	20842738
Azoospermia	Associate	39391879
Bone Diseases	Associate	22740707
Breast Neoplasms	Associate	16288304, 18611262, 21704603, 26976638, 29453318, 31759986
Breast Neoplasms	Inhibit	39527598
Carcinogenesis	Associate	29453318
Carcinoma Hepatocellular	Associate	32191631
Carcinoma Non Small Cell Lung	Associate	34117717
Carcinoma Pancreatic Ductal	Associate	25791160
Carcinoma Renal Cell	Associate	26198048, 35935986, 39209911
Carcinoma Squamous Cell	Associate	34117717
Cardiovascular Diseases	Associate	16519809
Cerebrovascular Disorders	Associate	16519809, 24349153
Colorectal Neoplasms	Associate	26464652, 29693170
Coronary Artery Disease	Associate	16519809, 20842738
Diabetes Mellitus Type 1	Associate	33029194
Diabetes Mellitus Type 2	Associate	22740707
Endometriosis	Associate	19055724
Glaucoma	Associate	34646884
Glioblastoma	Associate	36980184
Glomerulonephritis IGA	Associate	28831120
Hemangioblastoma	Associate	33446752
Hereditary Breast and Ovarian Cancer Syndrome	Associate	29453318
Infections	Associate	20624904
Leukemia	Associate	20697350
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	10194451
Lung Neoplasms	Associate	24189400, 34117717, 37965333
Macular Degeneration	Associate	34646884
Neoplasm Metastasis	Inhibit	23815759
Neoplasm Metastasis	Associate	26976638
Neoplasms	Associate	20347606, 24289556, 26660229, 27475256, 28392480, 39209911
Obesity	Associate	18611262
Osteoporosis	Associate	25815782
Ovarian Neoplasms	Associate	24395385
Pancreatic Neoplasms	Associate	25791160, 27605668
Periodic fever familial autosomal dominant	Associate	20624904
Plasmablastic Lymphoma	Associate	37105495
Retinoblastoma	Associate	34646884
Tachycardia	Associate	26774166
Uterine Cervical Neoplasms	Associate	38537385
Vascular Diseases	Associate	24349153

SHC1 (SHC adaptor protein 1)