Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64582
Gene name Gene Name - the full gene name approved by the HGNC.	G protein-coupled receptor 135
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GPR135
Synonyms (NCBI Gene) Gene synonyms aliases	HUMNPIIY20
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q23.1

Show/Hide all(52)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029231	hsa-miR-26b-5p	Microarray	19088304
MIRT657692	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT657691	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT537095	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT537094	hsa-miR-624-5p	PAR-CLIP	22012620
MIRT537093	hsa-miR-4645-3p	PAR-CLIP	22012620
MIRT537092	hsa-miR-433-3p	PAR-CLIP	22012620
MIRT657692	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT657691	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT537095	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT537094	hsa-miR-624-5p	PAR-CLIP	22012620
MIRT537093	hsa-miR-4645-3p	PAR-CLIP	22012620
MIRT537092	hsa-miR-433-3p	PAR-CLIP	22012620
MIRT1030410	hsa-miR-1271	CLIP-seq
MIRT1030411	hsa-miR-129-5p	CLIP-seq
MIRT1030412	hsa-miR-181a	CLIP-seq
MIRT1030413	hsa-miR-181b	CLIP-seq
MIRT1030414	hsa-miR-181c	CLIP-seq
MIRT1030415	hsa-miR-181d	CLIP-seq
MIRT1030416	hsa-miR-182	CLIP-seq
MIRT1030417	hsa-miR-299-5p	CLIP-seq
MIRT1030418	hsa-miR-3154	CLIP-seq
MIRT1030419	hsa-miR-3185	CLIP-seq
MIRT1030420	hsa-miR-33a	CLIP-seq
MIRT1030421	hsa-miR-33b	CLIP-seq
MIRT1030422	hsa-miR-361-3p	CLIP-seq
MIRT1030423	hsa-miR-3658	CLIP-seq
MIRT1030424	hsa-miR-4262	CLIP-seq
MIRT1030425	hsa-miR-4445	CLIP-seq
MIRT1030426	hsa-miR-4475	CLIP-seq
MIRT1030427	hsa-miR-450b-5p	CLIP-seq
MIRT1030428	hsa-miR-4709-3p	CLIP-seq
MIRT1030429	hsa-miR-4775	CLIP-seq
MIRT1030430	hsa-miR-507	CLIP-seq
MIRT1030431	hsa-miR-557	CLIP-seq
MIRT1030432	hsa-miR-590-3p	CLIP-seq
MIRT1030433	hsa-miR-96	CLIP-seq
MIRT1030418	hsa-miR-3154	CLIP-seq
MIRT1030419	hsa-miR-3185	CLIP-seq
MIRT1030422	hsa-miR-361-3p	CLIP-seq
MIRT1030426	hsa-miR-4475	CLIP-seq
MIRT1030428	hsa-miR-4709-3p	CLIP-seq
MIRT2005739	hsa-miR-4781-3p	CLIP-seq
MIRT2005740	hsa-miR-511	CLIP-seq
MIRT2005740	hsa-miR-511	CLIP-seq
MIRT2437472	hsa-miR-2110	CLIP-seq
MIRT2437473	hsa-miR-3150a-3p	CLIP-seq
MIRT2437474	hsa-miR-3153	CLIP-seq
MIRT2437475	hsa-miR-4260	CLIP-seq
MIRT2437476	hsa-miR-4271	CLIP-seq
MIRT2437477	hsa-miR-4725-3p	CLIP-seq
MIRT2437478	hsa-miR-4796-3p	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	28827538
GO:0005768	Component	Endosome	IDA	28827538
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IDA	28827538
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:1990763	Function	Arrestin family protein binding	IDA	28827538

MIM	HGNC	e!Ensembl
607970	19991	ENSG00000181619

Protein

UniProt ID

Q8IZ08

Protein name

G-protein coupled receptor 135

Protein function

Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). {ECO:0000269

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	120 → 387	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MEEPQPPRPPASMALLGSQHSGAPSAAGPPGGTSSAATAAVLSFSTVATAALGNLSDASG
GGTAAAPGGGGLGGSGAAREAGAAVRRPLGPEAAPLLSHGAAVAAQALVLLLIFLLSSLG
NCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAAAGPW
RGFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGF
SLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHI
CKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQAQ
TMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNISMLLGRNREEGYRTRNVDAFLPSQGP
GLQARSRSRLRNRYANRLGACNRMSSSNPASGVAGDVAMWARKNPVVLFCREGPPEPVTA
VTKQPKSEAGDTSL

Sequence length

494

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Obsessive-Compulsive Disorder	Obsessive-compulsive disorder	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Azoospermia	Associate	37283758
COVID 19	Associate	37283758

GPR135 (G protein-coupled receptor 135)