Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	64577
Gene name	Aldehyde dehydrogenase 8 family member A1
Gene symbol	ALDH8A1
Synonyms (NCBI Gene)	ALDH12DJ352A20.2
Chromosome	6
Chromosome location	6q23.3
Summary	This gene encodes a member of the aldehyde dehydrogenase family of proteins. The encoded protein has been implicated in the synthesis of 9-cis-retinoic acid and in the breakdown of the amino acid tryptophan. This enzyme converts 9-cis-retinal into the ret

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018613	hsa-miR-335-5p	Microarray	18185580
MIRT777747	hsa-miR-1224-3p	CLIP-seq
MIRT777748	hsa-miR-1245	CLIP-seq
MIRT777749	hsa-miR-1260	CLIP-seq
MIRT777750	hsa-miR-1260b	CLIP-seq
MIRT777751	hsa-miR-1272	CLIP-seq
MIRT777752	hsa-miR-1280	CLIP-seq
MIRT777753	hsa-miR-197	CLIP-seq
MIRT777754	hsa-miR-302f	CLIP-seq
MIRT777755	hsa-miR-3140-5p	CLIP-seq
MIRT777756	hsa-miR-3143	CLIP-seq
MIRT777757	hsa-miR-3167	CLIP-seq
MIRT777758	hsa-miR-3677-5p	CLIP-seq
MIRT777759	hsa-miR-378g	CLIP-seq
MIRT777760	hsa-miR-409-5p	CLIP-seq
MIRT777761	hsa-miR-4282	CLIP-seq
MIRT777762	hsa-miR-4437	CLIP-seq
MIRT777763	hsa-miR-4539	CLIP-seq
MIRT777764	hsa-miR-4674	CLIP-seq
MIRT777765	hsa-miR-4680-5p	CLIP-seq
MIRT777766	hsa-miR-4699-5p	CLIP-seq
MIRT777767	hsa-miR-4720-3p	CLIP-seq
MIRT777768	hsa-miR-4766-3p	CLIP-seq
MIRT777769	hsa-miR-4804-3p	CLIP-seq
MIRT777770	hsa-miR-5096	CLIP-seq
MIRT777771	hsa-miR-532-3p	CLIP-seq
MIRT777772	hsa-miR-548p	CLIP-seq
MIRT777773	hsa-miR-548u	CLIP-seq
MIRT777774	hsa-miR-640	CLIP-seq
MIRT777775	hsa-miR-661	CLIP-seq
MIRT777776	hsa-miR-876-5p	CLIP-seq
MIRT777777	hsa-miR-1184	CLIP-seq
MIRT777778	hsa-miR-1256	CLIP-seq
MIRT777779	hsa-miR-150	CLIP-seq
MIRT777780	hsa-miR-4283	CLIP-seq
MIRT777781	hsa-miR-4489	CLIP-seq
MIRT777782	hsa-miR-4645-5p	CLIP-seq
MIRT777783	hsa-miR-4673	CLIP-seq
MIRT777784	hsa-miR-4731-5p	CLIP-seq
MIRT777785	hsa-miR-4755-3p	CLIP-seq
MIRT777786	hsa-miR-4763-5p	CLIP-seq
MIRT777787	hsa-miR-562	CLIP-seq
MIRT777777	hsa-miR-1184	CLIP-seq
MIRT1929611	hsa-miR-24	CLIP-seq
MIRT1929612	hsa-miR-2681	CLIP-seq
MIRT777758	hsa-miR-3677-5p	CLIP-seq
MIRT777759	hsa-miR-378g	CLIP-seq
MIRT1929613	hsa-miR-4284	CLIP-seq
MIRT1929614	hsa-miR-4418	CLIP-seq
MIRT777762	hsa-miR-4437	CLIP-seq
MIRT777764	hsa-miR-4674	CLIP-seq
MIRT777768	hsa-miR-4766-3p	CLIP-seq
MIRT1929615	hsa-miR-509-3-5p	CLIP-seq
MIRT1929616	hsa-miR-509-5p	CLIP-seq
MIRT777772	hsa-miR-548p	CLIP-seq
MIRT777775	hsa-miR-661	CLIP-seq
MIRT1929617	hsa-miR-1	CLIP-seq
MIRT1929618	hsa-miR-206	CLIP-seq
MIRT1929619	hsa-miR-3673	CLIP-seq
MIRT1929620	hsa-miR-613	CLIP-seq
MIRT777777	hsa-miR-1184	CLIP-seq
MIRT777747	hsa-miR-1224-3p	CLIP-seq
MIRT777749	hsa-miR-1260	CLIP-seq
MIRT777750	hsa-miR-1260b	CLIP-seq
MIRT777752	hsa-miR-1280	CLIP-seq
MIRT1929611	hsa-miR-24	CLIP-seq
MIRT1929612	hsa-miR-2681	CLIP-seq
MIRT777758	hsa-miR-3677-5p	CLIP-seq
MIRT777759	hsa-miR-378g	CLIP-seq
MIRT1929613	hsa-miR-4284	CLIP-seq
MIRT1929614	hsa-miR-4418	CLIP-seq
MIRT777762	hsa-miR-4437	CLIP-seq
MIRT777764	hsa-miR-4674	CLIP-seq
MIRT777768	hsa-miR-4766-3p	CLIP-seq
MIRT1929615	hsa-miR-509-3-5p	CLIP-seq
MIRT1929616	hsa-miR-509-5p	CLIP-seq
MIRT777771	hsa-miR-532-3p	CLIP-seq
MIRT777772	hsa-miR-548p	CLIP-seq
MIRT777775	hsa-miR-661	CLIP-seq
MIRT777747	hsa-miR-1224-3p	CLIP-seq
MIRT777749	hsa-miR-1260	CLIP-seq
MIRT777750	hsa-miR-1260b	CLIP-seq
MIRT777752	hsa-miR-1280	CLIP-seq
MIRT2384075	hsa-miR-361-3p	CLIP-seq
MIRT777759	hsa-miR-378g	CLIP-seq
MIRT2384076	hsa-miR-3929	CLIP-seq
MIRT2384077	hsa-miR-4419b	CLIP-seq
MIRT777762	hsa-miR-4437	CLIP-seq
MIRT2384078	hsa-miR-4478	CLIP-seq
MIRT777764	hsa-miR-4674	CLIP-seq
MIRT777771	hsa-miR-532-3p	CLIP-seq
MIRT777775	hsa-miR-661	CLIP-seq
MIRT2384075	hsa-miR-361-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001758	Function	Retinal dehydrogenase (NAD+) activity	IBA
GO:0001758	Function	Retinal dehydrogenase (NAD+) activity	IDA	11007799
GO:0001758	Function	Retinal dehydrogenase (NAD+) activity	IEA
GO:0001758	Function	Retinal dehydrogenase (NAD+) activity	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016620	Function	Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA
GO:0042573	Process	Retinoic acid metabolic process	IBA
GO:0042573	Process	Retinoic acid metabolic process	IDA	11007799
GO:0042573	Process	Retinoic acid metabolic process	IEA
GO:0042574	Process	Retinal metabolic process	IDA	11007799
GO:0042904	Process	9-cis-retinoic acid biosynthetic process	IEA
GO:0047102	Function	Aminomuconate-semialdehyde dehydrogenase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0097053	Process	L-kynurenine catabolic process	IEA

MIM	HGNC	e!Ensembl
606467	15471	ENSG00000118514

Q9H2A2

Protein name

2-aminomuconic semialdehyde dehydrogenase (EC 1.2.1.32) (Aldehyde dehydrogenase 12) (Aldehyde dehydrogenase family 8 member A1)

Protein function

Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00171	Aldedh	19 → 483	Aldehyde dehydrogenase family	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in adult kidney and liver. Detected at lower levels in fetal liver and kidney. {ECO:0000269|PubMed:11007799}.

Sequence

MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS
WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS
SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS
ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT
QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIY
SEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDK
LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA
ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI
KTITVKH

Sequence length

487

Interactions

View interactions

	KEGG		Reactome
	Tryptophan metabolism Metabolic pathways		RA biosynthesis pathway

ALDH8A1 (aldehyde dehydrogenase 8 family member A1)