SH3BP2 (SH3 domain binding protein 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 6452 |
| Gene name | SH3 domain binding protein 2 |
| Gene symbol | SH3BP2 |
| Synonyms (NCBI Gene) |
3BP-23BP2CRBMCRPMRES4-23
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| Chromosome | 4 |
| Chromosome location | 4p16.3 |
| Summary | The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinas |
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SNPs
SNP information provided by dbSNP.
9
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miRNA
miRNA information provided by mirtarbase database.
995
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Transcription factors
Transcription factors information provided by TRRUST V2 database.
1
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P78314 | |||||||||||||||
| Protein name | SH3 domain-binding protein 2 (3BP-2) | |||||||||||||||
| Protein function | Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. | |||||||||||||||
| PDB | 2CR4 , 3TWR | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9734812}. | |||||||||||||||
| Sequence |
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| Sequence length | 561 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
788
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