Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	64506
Gene name	Cytoplasmic polyadenylation element binding protein 1
Gene symbol	CPEB1
Synonyms (NCBI Gene)	CPE-BP1CPEBCPEB-1h-CPEBhCPEB-1
Chromosome	15
Chromosome location	15q25.2
Summary	This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3` untranslated region of some mRNAs

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miRTarBase ID	miRNA	Experiments	Reference
MIRT053584	hsa-miR-101-3p	SHG44	23788032
MIRT054121	hsa-let-7b-5p	Luciferase reporter assayMicroarrayqRT-PCR	22995917
MIRT731347	hsa-miR-25-3p	Luciferase reporter assay	25923408
MIRT731347	hsa-miR-25-3p	Luciferase reporter assay	25923408
MIRT567974	hsa-miR-107	qRT-PCRWestern blot	26497556
MIRT567974	hsa-miR-107	qRT-PCRWestern blot	26497556
MIRT905854	hsa-miR-1305	CLIP-seq
MIRT905855	hsa-miR-3671	CLIP-seq
MIRT905856	hsa-miR-607	CLIP-seq
MIRT905857	hsa-miR-22	CLIP-seq
MIRT905858	hsa-miR-320a	CLIP-seq
MIRT905859	hsa-miR-320b	CLIP-seq
MIRT905860	hsa-miR-320c	CLIP-seq
MIRT905861	hsa-miR-320d	CLIP-seq
MIRT905862	hsa-miR-361-3p	CLIP-seq
MIRT905863	hsa-miR-3679-3p	CLIP-seq
MIRT905864	hsa-miR-409-3p	CLIP-seq
MIRT905865	hsa-miR-4429	CLIP-seq
MIRT905866	hsa-miR-4446-5p	CLIP-seq
MIRT905867	hsa-miR-4719	CLIP-seq
MIRT905868	hsa-miR-4755-3p	CLIP-seq
MIRT905863	hsa-miR-3679-3p	CLIP-seq
MIRT905866	hsa-miR-4446-5p	CLIP-seq
MIRT905863	hsa-miR-3679-3p	CLIP-seq
MIRT905866	hsa-miR-4446-5p	CLIP-seq
MIRT905863	hsa-miR-3679-3p	CLIP-seq
MIRT905866	hsa-miR-4446-5p	CLIP-seq
MIRT905863	hsa-miR-3679-3p	CLIP-seq
MIRT905866	hsa-miR-4446-5p	CLIP-seq
MIRT905863	hsa-miR-3679-3p	CLIP-seq
MIRT905866	hsa-miR-4446-5p	CLIP-seq
MIRT905863	hsa-miR-3679-3p	CLIP-seq
MIRT905866	hsa-miR-4446-5p	CLIP-seq
MIRT905863	hsa-miR-3679-3p	CLIP-seq
MIRT905866	hsa-miR-4446-5p	CLIP-seq
MIRT2204575	hsa-miR-130a	CLIP-seq
MIRT2204576	hsa-miR-130b	CLIP-seq
MIRT2204577	hsa-miR-19a	CLIP-seq
MIRT2204578	hsa-miR-19b	CLIP-seq
MIRT2204579	hsa-miR-301a	CLIP-seq
MIRT2204580	hsa-miR-301b	CLIP-seq
MIRT2204581	hsa-miR-3137	CLIP-seq
MIRT2204582	hsa-miR-3666	CLIP-seq
MIRT905863	hsa-miR-3679-3p	CLIP-seq
MIRT2204583	hsa-miR-4291	CLIP-seq
MIRT2204584	hsa-miR-4295	CLIP-seq
MIRT905866	hsa-miR-4446-5p	CLIP-seq
MIRT2204585	hsa-miR-454	CLIP-seq
MIRT2204586	hsa-miR-4693-3p	CLIP-seq
MIRT905867	hsa-miR-4719	CLIP-seq
MIRT2204587	hsa-miR-4797-5p	CLIP-seq
MIRT2204588	hsa-miR-513b	CLIP-seq
MIRT2204589	hsa-miR-518a-5p	CLIP-seq
MIRT2204590	hsa-miR-519a	CLIP-seq
MIRT2204591	hsa-miR-519b-3p	CLIP-seq
MIRT2204592	hsa-miR-519c-3p	CLIP-seq
MIRT2204593	hsa-miR-527	CLIP-seq
MIRT2204594	hsa-miR-545	CLIP-seq
MIRT905863	hsa-miR-3679-3p	CLIP-seq
MIRT905866	hsa-miR-4446-5p	CLIP-seq
MIRT905863	hsa-miR-3679-3p	CLIP-seq
MIRT905866	hsa-miR-4446-5p	CLIP-seq
MIRT2204575	hsa-miR-130a	CLIP-seq
MIRT2204576	hsa-miR-130b	CLIP-seq
MIRT2204579	hsa-miR-301a	CLIP-seq
MIRT2204580	hsa-miR-301b	CLIP-seq
MIRT2204582	hsa-miR-3666	CLIP-seq
MIRT2204584	hsa-miR-4295	CLIP-seq
MIRT2204585	hsa-miR-454	CLIP-seq
MIRT2507993	hsa-miR-1271	CLIP-seq
MIRT2204575	hsa-miR-130a	CLIP-seq
MIRT2204576	hsa-miR-130b	CLIP-seq
MIRT2507994	hsa-miR-1323	CLIP-seq
MIRT2507995	hsa-miR-182	CLIP-seq
MIRT2204577	hsa-miR-19a	CLIP-seq
MIRT2204578	hsa-miR-19b	CLIP-seq
MIRT2507996	hsa-miR-298	CLIP-seq
MIRT2204579	hsa-miR-301a	CLIP-seq
MIRT2204580	hsa-miR-301b	CLIP-seq
MIRT2507997	hsa-miR-3117-5p	CLIP-seq
MIRT2507998	hsa-miR-3184	CLIP-seq
MIRT2204582	hsa-miR-3666	CLIP-seq
MIRT2507999	hsa-miR-423-5p	CLIP-seq
MIRT2508000	hsa-miR-4266	CLIP-seq
MIRT2204583	hsa-miR-4291	CLIP-seq
MIRT2204584	hsa-miR-4295	CLIP-seq
MIRT2508001	hsa-miR-4473	CLIP-seq
MIRT2204585	hsa-miR-454	CLIP-seq
MIRT2508002	hsa-miR-4671-3p	CLIP-seq
MIRT2508003	hsa-miR-4688	CLIP-seq
MIRT2508004	hsa-miR-4695-5p	CLIP-seq
MIRT2508005	hsa-miR-4779	CLIP-seq
MIRT2204589	hsa-miR-518a-5p	CLIP-seq
MIRT2204590	hsa-miR-519a	CLIP-seq
MIRT2204591	hsa-miR-519b-3p	CLIP-seq
MIRT2204592	hsa-miR-519c-3p	CLIP-seq
MIRT2204593	hsa-miR-527	CLIP-seq
MIRT2204594	hsa-miR-545	CLIP-seq
MIRT2508006	hsa-miR-548o	CLIP-seq
MIRT2508007	hsa-miR-9	CLIP-seq
MIRT2508008	hsa-miR-96	CLIP-seq
MIRT2507993	hsa-miR-1271	CLIP-seq
MIRT2204575	hsa-miR-130a	CLIP-seq
MIRT2204576	hsa-miR-130b	CLIP-seq
MIRT2507994	hsa-miR-1323	CLIP-seq
MIRT2507995	hsa-miR-182	CLIP-seq
MIRT2204577	hsa-miR-19a	CLIP-seq
MIRT2204578	hsa-miR-19b	CLIP-seq
MIRT2507996	hsa-miR-298	CLIP-seq
MIRT2204579	hsa-miR-301a	CLIP-seq
MIRT2204580	hsa-miR-301b	CLIP-seq
MIRT2507997	hsa-miR-3117-5p	CLIP-seq
MIRT2507998	hsa-miR-3184	CLIP-seq
MIRT2204582	hsa-miR-3666	CLIP-seq
MIRT2507999	hsa-miR-423-5p	CLIP-seq
MIRT2508000	hsa-miR-4266	CLIP-seq
MIRT2204583	hsa-miR-4291	CLIP-seq
MIRT2204584	hsa-miR-4295	CLIP-seq
MIRT2508001	hsa-miR-4473	CLIP-seq
MIRT2204585	hsa-miR-454	CLIP-seq
MIRT2508002	hsa-miR-4671-3p	CLIP-seq
MIRT2508003	hsa-miR-4688	CLIP-seq
MIRT2508004	hsa-miR-4695-5p	CLIP-seq
MIRT2508005	hsa-miR-4779	CLIP-seq
MIRT2204589	hsa-miR-518a-5p	CLIP-seq
MIRT2204590	hsa-miR-519a	CLIP-seq
MIRT2204591	hsa-miR-519b-3p	CLIP-seq
MIRT2204592	hsa-miR-519c-3p	CLIP-seq
MIRT2204593	hsa-miR-527	CLIP-seq
MIRT2204594	hsa-miR-545	CLIP-seq
MIRT2508006	hsa-miR-548o	CLIP-seq
MIRT2508007	hsa-miR-9	CLIP-seq
MIRT2508008	hsa-miR-96	CLIP-seq

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Transcription factor	Regulation	Reference
EED	Unknown	23788032
EZH2	Unknown	23788032

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000900	Function	MRNA regulatory element binding translation repressor activity	IBA
GO:0000900	Function	MRNA regulatory element binding translation repressor activity	ISS
GO:0000932	Component	P-body	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003730	Function	MRNA 3'-UTR binding	IBA
GO:0003730	Function	MRNA 3'-UTR binding	IEA
GO:0005515	Function	Protein binding	IPI	28383716
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	28383716
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0006397	Process	MRNA processing	IEA
GO:0006412	Process	Translation	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0008135	Function	Translation factor activity, RNA binding	IBA
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	IEA
GO:0017148	Process	Negative regulation of translation	IEA
GO:0030425	Component	Dendrite	IEA
GO:0031440	Process	Regulation of mRNA 3'-end processing	IDA	28383716
GO:0032869	Process	Cellular response to insulin stimulus	IDA	18752464
GO:0035925	Function	MRNA 3'-UTR AU-rich region binding	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0043022	Function	Ribosome binding	IBA
GO:0045182	Function	Translation regulator activity	IEA
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0071230	Process	Cellular response to amino acid stimulus	ISS
GO:0071456	Process	Cellular response to hypoxia	IDA	18752464
GO:1990904	Component	Ribonucleoprotein complex	IEA
GO:2000766	Process	Negative regulation of cytoplasmic translation	IBA
GO:2000766	Process	Negative regulation of cytoplasmic translation	IMP	18752464

MIM	HGNC	e!Ensembl
607342	21744	ENSG00000214575

Q9BZB8

Protein name

Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1)

Protein function

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (C

PDB

2M13 , 2MKE , 2MKH , 2MKK , 2N1O

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16368	CEBP1_N	1 → 307	Cytoplasmic polyadenylation element-binding protein 1 N-terminus	Family
PF16367	RRM_7	310 → 410	RNA recognition motif	Domain
PF16366	CEBP_ZZ	502 → 559	Cytoplasmic polyadenylation element-binding protein ZZ domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines. {ECO:0000269|PubMed

Sequence

MALSLEEEAGRIKDCWDNQEAPALSTCSNANIFRRINAILDNSLDFSRVCTTPINRGIHD
HLPDFQDSEETVTSRMLFPTSAQESSRGLPDANDLCLGLQSLSLTGWDRPWSTQDSDSSA
QSSTHSVLSMLHNPLGNVLGKPPLSFLPLDPLGSDLVDKFPAPSVRGSRLDTRPILDSRS
SSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSLSGGGPRDPLKMGVGSRMDQEQAAL
AAVTPSPTSASKRWPGASVWPSWDLLEAPKDPFSIEREARLHRQAAAVNEATCTWSGQLP
PRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGNMPKG
YVYLVFELEKSVRSLLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVR
SPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNN
QRSYLKAVSAAFVEIKTTKFTKKVQIDPYLEDSLCHICSSQPGPFFCRDQVCFKYFCRSC
WHWRHSMEGLRHHSPLMRNQKNRDSS

Sequence length

566

Interactions

View interactions

	KEGG
	Oocyte meiosis Progesterone-mediated oocyte maturation

CPEB1 (cytoplasmic polyadenylation element binding protein 1)