Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6446
Gene name	Serum/glucocorticoid regulated kinase 1
Gene symbol	SGK1
Synonyms (NCBI Gene)	SGK
Chromosome	6
Chromosome location	6q23.2
Summary	This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell sur

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1171390403	T>C	Likely-pathogenic	Missense variant, coding sequence variant

539

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022117	hsa-miR-124-3p	Microarray	18668037
MIRT468242	hsa-miR-19a-3p	PAR-CLIP	23592263
MIRT468241	hsa-miR-19b-3p	PAR-CLIP	23592263
MIRT468242	hsa-miR-19a-3p	PAR-CLIP	23592263
MIRT468241	hsa-miR-19b-3p	PAR-CLIP	23592263
MIRT167753	hsa-miR-100-3p	PAR-CLIP	23592263
MIRT468240	hsa-miR-5571-5p	PAR-CLIP	23592263
MIRT468239	hsa-miR-576-3p	PAR-CLIP	23592263
MIRT468238	hsa-miR-648	PAR-CLIP	23592263
MIRT468237	hsa-miR-4302	PAR-CLIP	23592263
MIRT468236	hsa-miR-4738-5p	PAR-CLIP	23592263
MIRT468235	hsa-miR-2115-5p	PAR-CLIP	23592263
MIRT468234	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT468233	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT468232	hsa-miR-6512-3p	PAR-CLIP	23592263
MIRT468231	hsa-miR-6720-5p	PAR-CLIP	23592263
MIRT468230	hsa-miR-4753-3p	PAR-CLIP	23592263
MIRT468229	hsa-miR-4639-5p	PAR-CLIP	23592263
MIRT468228	hsa-miR-3180-5p	PAR-CLIP	23592263
MIRT468227	hsa-miR-6809-3p	PAR-CLIP	23592263
MIRT468226	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT468225	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT468224	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT468223	hsa-miR-548c-3p	PAR-CLIP	23592263
MIRT468222	hsa-miR-3662	PAR-CLIP	23592263
MIRT468221	hsa-miR-3646	PAR-CLIP	23592263
MIRT468220	hsa-miR-6507-5p	PAR-CLIP	23592263
MIRT468219	hsa-miR-6871-3p	PAR-CLIP	23592263
MIRT468218	hsa-miR-3919	PAR-CLIP	23592263
MIRT468217	hsa-miR-4756-3p	PAR-CLIP	23592263
MIRT468216	hsa-miR-570-3p	PAR-CLIP	23592263
MIRT468215	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT468214	hsa-miR-4533	PAR-CLIP	23592263
MIRT468213	hsa-miR-3202	PAR-CLIP	23592263
MIRT468212	hsa-miR-5682	PAR-CLIP	23592263
MIRT167795	hsa-miR-6079	PAR-CLIP	23592263
MIRT468211	hsa-miR-3942-3p	PAR-CLIP	23592263
MIRT468210	hsa-miR-365a-3p	PAR-CLIP	23592263
MIRT468209	hsa-miR-365b-3p	PAR-CLIP	23592263
MIRT468208	hsa-miR-5692a	PAR-CLIP	23592263
MIRT468207	hsa-miR-21-3p	PAR-CLIP	23592263
MIRT468206	hsa-miR-3591-3p	PAR-CLIP	23592263
MIRT468205	hsa-miR-4803	PAR-CLIP	23592263
MIRT468204	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT468203	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT468202	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT468201	hsa-miR-548aj-5p	PAR-CLIP	23592263
MIRT468200	hsa-miR-548f-5p	PAR-CLIP	23592263
MIRT468199	hsa-miR-548g-5p	PAR-CLIP	23592263
MIRT468198	hsa-miR-548x-5p	PAR-CLIP	23592263
MIRT468197	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT468196	hsa-miR-4641	PAR-CLIP	23592263
MIRT468195	hsa-miR-5095	PAR-CLIP	23592263
MIRT468194	hsa-miR-7151-3p	PAR-CLIP	23592263
MIRT468193	hsa-miR-361-5p	PAR-CLIP	23592263
MIRT468192	hsa-miR-548aw	PAR-CLIP	23592263
MIRT468191	hsa-miR-374a-3p	PAR-CLIP	23592263
MIRT468242	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT468241	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT735220	hsa-miR-133b	Luciferase reporter assayqRT-PCRWestern blot	26840046
MIRT735220	hsa-miR-133b	Luciferase reporter assayqRT-PCRWestern blot	26840046
MIRT732886	hsa-miR-424-3p	Luciferase reporter assayMicroarrayqRT-PCR	32432919
MIRT732887	hsa-miR-503-3p	Luciferase reporter assayMicroarrayqRT-PCR	32432919
MIRT735220	hsa-miR-133b	Luciferase reporter assayWestern blottingqRT-PCRFlow cytometry	32597300
MIRT735246	hsa-miR-195-5p	Luciferase reporter assayWestern blottingMicroarrayImmunofluorescenceChIP-seqqRT-PCR	31729781
MIRT468242	hsa-miR-19a-3p	PAR-CLIP	23592263
MIRT468241	hsa-miR-19b-3p	PAR-CLIP	23592263
MIRT468242	hsa-miR-19a-3p	PAR-CLIP	23592263
MIRT468241	hsa-miR-19b-3p	PAR-CLIP	23592263
MIRT167753	hsa-miR-100-3p	PAR-CLIP	23592263
MIRT468240	hsa-miR-5571-5p	PAR-CLIP	23592263
MIRT468239	hsa-miR-576-3p	PAR-CLIP	23592263
MIRT468238	hsa-miR-648	PAR-CLIP	23592263
MIRT468237	hsa-miR-4302	PAR-CLIP	23592263
MIRT468236	hsa-miR-4738-5p	PAR-CLIP	23592263
MIRT468235	hsa-miR-2115-5p	PAR-CLIP	23592263
MIRT468234	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT468233	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT468232	hsa-miR-6512-3p	PAR-CLIP	23592263
MIRT468231	hsa-miR-6720-5p	PAR-CLIP	23592263
MIRT468230	hsa-miR-4753-3p	PAR-CLIP	23592263
MIRT468229	hsa-miR-4639-5p	PAR-CLIP	23592263
MIRT468228	hsa-miR-3180-5p	PAR-CLIP	23592263
MIRT468227	hsa-miR-6809-3p	PAR-CLIP	23592263
MIRT468226	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT468225	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT468224	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT468223	hsa-miR-548c-3p	PAR-CLIP	23592263
MIRT468222	hsa-miR-3662	PAR-CLIP	23592263
MIRT468221	hsa-miR-3646	PAR-CLIP	23592263
MIRT468220	hsa-miR-6507-5p	PAR-CLIP	23592263
MIRT468219	hsa-miR-6871-3p	PAR-CLIP	23592263
MIRT468218	hsa-miR-3919	PAR-CLIP	23592263
MIRT468217	hsa-miR-4756-3p	PAR-CLIP	23592263
MIRT468216	hsa-miR-570-3p	PAR-CLIP	23592263
MIRT468215	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT468214	hsa-miR-4533	PAR-CLIP	23592263
MIRT468213	hsa-miR-3202	PAR-CLIP	23592263
MIRT468212	hsa-miR-5682	PAR-CLIP	23592263
MIRT167795	hsa-miR-6079	PAR-CLIP	23592263
MIRT468211	hsa-miR-3942-3p	PAR-CLIP	23592263
MIRT468210	hsa-miR-365a-3p	PAR-CLIP	23592263
MIRT468209	hsa-miR-365b-3p	PAR-CLIP	23592263
MIRT468208	hsa-miR-5692a	PAR-CLIP	23592263
MIRT468207	hsa-miR-21-3p	PAR-CLIP	23592263
MIRT468206	hsa-miR-3591-3p	PAR-CLIP	23592263
MIRT468205	hsa-miR-4803	PAR-CLIP	23592263
MIRT468204	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT468203	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT468202	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT468201	hsa-miR-548aj-5p	PAR-CLIP	23592263
MIRT468200	hsa-miR-548f-5p	PAR-CLIP	23592263
MIRT468199	hsa-miR-548g-5p	PAR-CLIP	23592263
MIRT468198	hsa-miR-548x-5p	PAR-CLIP	23592263
MIRT468197	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT468196	hsa-miR-4641	PAR-CLIP	23592263
MIRT468195	hsa-miR-5095	PAR-CLIP	23592263
MIRT468194	hsa-miR-7151-3p	PAR-CLIP	23592263
MIRT468193	hsa-miR-361-5p	PAR-CLIP	23592263
MIRT468192	hsa-miR-548aw	PAR-CLIP	23592263
MIRT468191	hsa-miR-374a-3p	PAR-CLIP	23592263
MIRT1343074	hsa-miR-140-3p	CLIP-seq
MIRT1343075	hsa-miR-342-3p	CLIP-seq
MIRT1343076	hsa-miR-377	CLIP-seq
MIRT1343077	hsa-miR-4317	CLIP-seq
MIRT1343078	hsa-miR-4696	CLIP-seq
MIRT1343079	hsa-miR-513a-3p	CLIP-seq
MIRT1343080	hsa-miR-590-3p	CLIP-seq
MIRT1343081	hsa-miR-616	CLIP-seq
MIRT1343082	hsa-miR-1207-3p	CLIP-seq
MIRT1343083	hsa-miR-1255a	CLIP-seq
MIRT1343084	hsa-miR-1255b	CLIP-seq
MIRT1343085	hsa-miR-1256	CLIP-seq
MIRT1343086	hsa-miR-133a	CLIP-seq
MIRT1343087	hsa-miR-147	CLIP-seq
MIRT1343088	hsa-miR-15a	CLIP-seq
MIRT1343089	hsa-miR-15b	CLIP-seq
MIRT1343090	hsa-miR-16	CLIP-seq
MIRT1343091	hsa-miR-195	CLIP-seq
MIRT1343092	hsa-miR-2964a-5p	CLIP-seq
MIRT1343093	hsa-miR-3121-3p	CLIP-seq
MIRT1343094	hsa-miR-3126-5p	CLIP-seq
MIRT1343095	hsa-miR-3160-5p	CLIP-seq
MIRT1343096	hsa-miR-3613-3p	CLIP-seq
MIRT1343097	hsa-miR-3674	CLIP-seq
MIRT1343076	hsa-miR-377	CLIP-seq
MIRT1343098	hsa-miR-382	CLIP-seq
MIRT1343099	hsa-miR-3908	CLIP-seq
MIRT1343100	hsa-miR-424	CLIP-seq
MIRT1343101	hsa-miR-4263	CLIP-seq
MIRT1343102	hsa-miR-4419a	CLIP-seq
MIRT1343103	hsa-miR-4421	CLIP-seq
MIRT1343104	hsa-miR-4426	CLIP-seq
MIRT1343105	hsa-miR-4427	CLIP-seq
MIRT1343106	hsa-miR-4503	CLIP-seq
MIRT1343107	hsa-miR-4510	CLIP-seq
MIRT1343108	hsa-miR-4524	CLIP-seq
MIRT1343109	hsa-miR-4647	CLIP-seq
MIRT1343110	hsa-miR-4662b	CLIP-seq
MIRT1343111	hsa-miR-4680-3p	CLIP-seq
MIRT1343112	hsa-miR-4747-5p	CLIP-seq
MIRT1343113	hsa-miR-4799-5p	CLIP-seq
MIRT1343114	hsa-miR-486-3p	CLIP-seq
MIRT1343115	hsa-miR-497	CLIP-seq
MIRT1343116	hsa-miR-503	CLIP-seq
MIRT1343117	hsa-miR-508-3p	CLIP-seq
MIRT1343118	hsa-miR-548ac	CLIP-seq
MIRT1343119	hsa-miR-548ae	CLIP-seq
MIRT1343120	hsa-miR-548aj	CLIP-seq
MIRT1343121	hsa-miR-548am	CLIP-seq
MIRT1343122	hsa-miR-548d-3p	CLIP-seq
MIRT1343123	hsa-miR-548x	CLIP-seq
MIRT1343124	hsa-miR-548z	CLIP-seq
MIRT1343125	hsa-miR-549	CLIP-seq
MIRT1343126	hsa-miR-576-5p	CLIP-seq
MIRT1343127	hsa-miR-643	CLIP-seq
MIRT1343128	hsa-miR-646	CLIP-seq
MIRT1343082	hsa-miR-1207-3p	CLIP-seq
MIRT1343085	hsa-miR-1256	CLIP-seq
MIRT1343086	hsa-miR-133a	CLIP-seq
MIRT1343088	hsa-miR-15a	CLIP-seq
MIRT1343089	hsa-miR-15b	CLIP-seq
MIRT1343090	hsa-miR-16	CLIP-seq
MIRT1343091	hsa-miR-195	CLIP-seq
MIRT2101404	hsa-miR-19a	CLIP-seq
MIRT2101405	hsa-miR-19b	CLIP-seq
MIRT1343092	hsa-miR-2964a-5p	CLIP-seq
MIRT1343095	hsa-miR-3160-5p	CLIP-seq
MIRT1343097	hsa-miR-3674	CLIP-seq
MIRT1343099	hsa-miR-3908	CLIP-seq
MIRT1343100	hsa-miR-424	CLIP-seq
MIRT1343103	hsa-miR-4421	CLIP-seq
MIRT1343104	hsa-miR-4426	CLIP-seq
MIRT1343105	hsa-miR-4427	CLIP-seq
MIRT2101406	hsa-miR-4467	CLIP-seq
MIRT1343106	hsa-miR-4503	CLIP-seq
MIRT1343108	hsa-miR-4524	CLIP-seq
MIRT1343109	hsa-miR-4647	CLIP-seq
MIRT1343110	hsa-miR-4662b	CLIP-seq
MIRT1343111	hsa-miR-4680-3p	CLIP-seq
MIRT1343114	hsa-miR-486-3p	CLIP-seq
MIRT1343115	hsa-miR-497	CLIP-seq
MIRT1343116	hsa-miR-503	CLIP-seq
MIRT1343118	hsa-miR-548ac	CLIP-seq
MIRT1343119	hsa-miR-548ae	CLIP-seq
MIRT1343120	hsa-miR-548aj	CLIP-seq
MIRT1343121	hsa-miR-548am	CLIP-seq
MIRT1343122	hsa-miR-548d-3p	CLIP-seq
MIRT1343123	hsa-miR-548x	CLIP-seq
MIRT1343124	hsa-miR-548z	CLIP-seq
MIRT1343125	hsa-miR-549	CLIP-seq
MIRT2101407	hsa-miR-552	CLIP-seq
MIRT2101408	hsa-miR-556-5p	CLIP-seq
MIRT1343127	hsa-miR-643	CLIP-seq
MIRT1343128	hsa-miR-646	CLIP-seq
MIRT2325776	hsa-miR-186	CLIP-seq
MIRT2325777	hsa-miR-3133	CLIP-seq
MIRT2325778	hsa-miR-4511	CLIP-seq
MIRT1343074	hsa-miR-140-3p	CLIP-seq
MIRT2101404	hsa-miR-19a	CLIP-seq
MIRT2101405	hsa-miR-19b	CLIP-seq
MIRT1343075	hsa-miR-342-3p	CLIP-seq
MIRT1343096	hsa-miR-3613-3p	CLIP-seq
MIRT1343076	hsa-miR-377	CLIP-seq
MIRT2433078	hsa-miR-101	CLIP-seq
MIRT2433079	hsa-miR-1236	CLIP-seq
MIRT2433080	hsa-miR-124	CLIP-seq
MIRT1343085	hsa-miR-1256	CLIP-seq
MIRT2433081	hsa-miR-1273d	CLIP-seq
MIRT1343086	hsa-miR-133a	CLIP-seq
MIRT1343074	hsa-miR-140-3p	CLIP-seq
MIRT2433082	hsa-miR-144	CLIP-seq
MIRT2325776	hsa-miR-186	CLIP-seq
MIRT2433083	hsa-miR-2053	CLIP-seq
MIRT2433084	hsa-miR-216b	CLIP-seq
MIRT2433085	hsa-miR-23a	CLIP-seq
MIRT2433086	hsa-miR-23b	CLIP-seq
MIRT2433087	hsa-miR-23c	CLIP-seq
MIRT2433088	hsa-miR-299-5p	CLIP-seq
MIRT2433089	hsa-miR-300	CLIP-seq
MIRT2325777	hsa-miR-3133	CLIP-seq
MIRT2433090	hsa-miR-323-3p	CLIP-seq
MIRT2433091	hsa-miR-323-5p	CLIP-seq
MIRT2433092	hsa-miR-338-5p	CLIP-seq
MIRT1343096	hsa-miR-3613-3p	CLIP-seq
MIRT2433093	hsa-miR-3618	CLIP-seq
MIRT2433094	hsa-miR-3688-3p	CLIP-seq
MIRT1343076	hsa-miR-377	CLIP-seq
MIRT2433095	hsa-miR-381	CLIP-seq
MIRT2433096	hsa-miR-383	CLIP-seq
MIRT2433097	hsa-miR-3923	CLIP-seq
MIRT2433098	hsa-miR-4255	CLIP-seq
MIRT2433099	hsa-miR-4269	CLIP-seq
MIRT2433100	hsa-miR-4457	CLIP-seq
MIRT2433101	hsa-miR-4477a	CLIP-seq
MIRT2433102	hsa-miR-451	CLIP-seq
MIRT2433103	hsa-miR-4514	CLIP-seq
MIRT2433104	hsa-miR-4643	CLIP-seq
MIRT2433105	hsa-miR-466	CLIP-seq
MIRT2433106	hsa-miR-4666-3p	CLIP-seq
MIRT2433107	hsa-miR-4668-3p	CLIP-seq
MIRT2433108	hsa-miR-4668-5p	CLIP-seq
MIRT2433109	hsa-miR-4677-3p	CLIP-seq
MIRT2433110	hsa-miR-4679	CLIP-seq
MIRT2433111	hsa-miR-4692	CLIP-seq
MIRT2433112	hsa-miR-4716-5p	CLIP-seq
MIRT2433113	hsa-miR-4742-5p	CLIP-seq
MIRT2433114	hsa-miR-4772-5p	CLIP-seq
MIRT2433115	hsa-miR-4789-3p	CLIP-seq
MIRT2433116	hsa-miR-4789-5p	CLIP-seq
MIRT1343114	hsa-miR-486-3p	CLIP-seq
MIRT2433117	hsa-miR-494	CLIP-seq
MIRT2433118	hsa-miR-495	CLIP-seq
MIRT2433119	hsa-miR-506	CLIP-seq
MIRT1343117	hsa-miR-508-3p	CLIP-seq
MIRT2433120	hsa-miR-520d-5p	CLIP-seq
MIRT2433121	hsa-miR-522	CLIP-seq
MIRT2433122	hsa-miR-524-5p	CLIP-seq
MIRT1343118	hsa-miR-548ac	CLIP-seq
MIRT1343119	hsa-miR-548ae	CLIP-seq
MIRT1343120	hsa-miR-548aj	CLIP-seq
MIRT1343121	hsa-miR-548am	CLIP-seq
MIRT2433123	hsa-miR-548an	CLIP-seq
MIRT1343122	hsa-miR-548d-3p	CLIP-seq
MIRT1343123	hsa-miR-548x	CLIP-seq
MIRT1343124	hsa-miR-548z	CLIP-seq
MIRT1343125	hsa-miR-549	CLIP-seq
MIRT2433124	hsa-miR-569	CLIP-seq
MIRT2433125	hsa-miR-582-5p	CLIP-seq
MIRT2433126	hsa-miR-600	CLIP-seq
MIRT2433127	hsa-miR-873	CLIP-seq
MIRT2433128	hsa-miR-876-3p	CLIP-seq
MIRT2433106	hsa-miR-4666-3p	CLIP-seq
MIRT2440262	hsa-miR-1184	CLIP-seq
MIRT2440263	hsa-miR-1205	CLIP-seq
MIRT2433079	hsa-miR-1236	CLIP-seq
MIRT2433080	hsa-miR-124	CLIP-seq
MIRT2440264	hsa-miR-1252	CLIP-seq
MIRT1343085	hsa-miR-1256	CLIP-seq
MIRT2440265	hsa-miR-1286	CLIP-seq
MIRT2440266	hsa-miR-1324	CLIP-seq
MIRT1343086	hsa-miR-133a	CLIP-seq
MIRT2440267	hsa-miR-141	CLIP-seq
MIRT1343088	hsa-miR-15a	CLIP-seq
MIRT1343089	hsa-miR-15b	CLIP-seq
MIRT1343090	hsa-miR-16	CLIP-seq
MIRT2325776	hsa-miR-186	CLIP-seq
MIRT1343091	hsa-miR-195	CLIP-seq
MIRT2440268	hsa-miR-1976	CLIP-seq
MIRT2440269	hsa-miR-200a	CLIP-seq
MIRT2433084	hsa-miR-216b	CLIP-seq
MIRT2440270	hsa-miR-29a	CLIP-seq
MIRT2440271	hsa-miR-29b	CLIP-seq
MIRT2440272	hsa-miR-29c	CLIP-seq
MIRT1343093	hsa-miR-3121-3p	CLIP-seq
MIRT2325777	hsa-miR-3133	CLIP-seq
MIRT2440273	hsa-miR-3158-5p	CLIP-seq
MIRT1343095	hsa-miR-3160-5p	CLIP-seq
MIRT1343097	hsa-miR-3674	CLIP-seq
MIRT1343076	hsa-miR-377	CLIP-seq
MIRT1343099	hsa-miR-3908	CLIP-seq
MIRT1343100	hsa-miR-424	CLIP-seq
MIRT1343101	hsa-miR-4263	CLIP-seq
MIRT2440274	hsa-miR-4315	CLIP-seq
MIRT1343105	hsa-miR-4427	CLIP-seq
MIRT2433100	hsa-miR-4457	CLIP-seq
MIRT2440275	hsa-miR-4496	CLIP-seq
MIRT1343106	hsa-miR-4503	CLIP-seq
MIRT2325778	hsa-miR-4511	CLIP-seq
MIRT2440276	hsa-miR-4521	CLIP-seq
MIRT1343108	hsa-miR-4524	CLIP-seq
MIRT2440277	hsa-miR-4633-3p	CLIP-seq
MIRT2433108	hsa-miR-4668-5p	CLIP-seq
MIRT1343111	hsa-miR-4680-3p	CLIP-seq
MIRT2440278	hsa-miR-4690-3p	CLIP-seq
MIRT2440279	hsa-miR-4722-3p	CLIP-seq
MIRT2440280	hsa-miR-4722-5p	CLIP-seq
MIRT2440281	hsa-miR-4768-3p	CLIP-seq
MIRT2440282	hsa-miR-4773	CLIP-seq
MIRT1343113	hsa-miR-4799-5p	CLIP-seq
MIRT1343114	hsa-miR-486-3p	CLIP-seq
MIRT2433117	hsa-miR-494	CLIP-seq
MIRT1343115	hsa-miR-497	CLIP-seq
MIRT1343116	hsa-miR-503	CLIP-seq
MIRT2433119	hsa-miR-506	CLIP-seq
MIRT2440283	hsa-miR-524-3p	CLIP-seq
MIRT2440284	hsa-miR-525-3p	CLIP-seq
MIRT1343118	hsa-miR-548ac	CLIP-seq
MIRT1343119	hsa-miR-548ae	CLIP-seq
MIRT1343120	hsa-miR-548aj	CLIP-seq
MIRT1343121	hsa-miR-548am	CLIP-seq
MIRT2433123	hsa-miR-548an	CLIP-seq
MIRT1343122	hsa-miR-548d-3p	CLIP-seq
MIRT1343123	hsa-miR-548x	CLIP-seq
MIRT1343124	hsa-miR-548z	CLIP-seq
MIRT1343125	hsa-miR-549	CLIP-seq
MIRT1343126	hsa-miR-576-5p	CLIP-seq
MIRT2440285	hsa-miR-610	CLIP-seq
MIRT1343128	hsa-miR-646	CLIP-seq
MIRT2440286	hsa-miR-769-5p	CLIP-seq
MIRT2440262	hsa-miR-1184	CLIP-seq
MIRT2440263	hsa-miR-1205	CLIP-seq
MIRT2433079	hsa-miR-1236	CLIP-seq
MIRT2433080	hsa-miR-124	CLIP-seq
MIRT2440265	hsa-miR-1286	CLIP-seq
MIRT2440266	hsa-miR-1324	CLIP-seq
MIRT2440268	hsa-miR-1976	CLIP-seq
MIRT2433084	hsa-miR-216b	CLIP-seq
MIRT2440273	hsa-miR-3158-5p	CLIP-seq
MIRT1343095	hsa-miR-3160-5p	CLIP-seq
MIRT1343076	hsa-miR-377	CLIP-seq
MIRT1343101	hsa-miR-4263	CLIP-seq
MIRT2440274	hsa-miR-4315	CLIP-seq
MIRT2440276	hsa-miR-4521	CLIP-seq
MIRT2440279	hsa-miR-4722-3p	CLIP-seq
MIRT2440280	hsa-miR-4722-5p	CLIP-seq
MIRT2440281	hsa-miR-4768-3p	CLIP-seq
MIRT2440282	hsa-miR-4773	CLIP-seq
MIRT2433119	hsa-miR-506	CLIP-seq
MIRT2440283	hsa-miR-524-3p	CLIP-seq
MIRT2440284	hsa-miR-525-3p	CLIP-seq
MIRT2433123	hsa-miR-548an	CLIP-seq
MIRT1343126	hsa-miR-576-5p	CLIP-seq
MIRT2440286	hsa-miR-769-5p	CLIP-seq
MIRT2440262	hsa-miR-1184	CLIP-seq
MIRT2440263	hsa-miR-1205	CLIP-seq
MIRT2433079	hsa-miR-1236	CLIP-seq
MIRT2433080	hsa-miR-124	CLIP-seq
MIRT1343085	hsa-miR-1256	CLIP-seq
MIRT2440265	hsa-miR-1286	CLIP-seq
MIRT2440266	hsa-miR-1324	CLIP-seq
MIRT1343086	hsa-miR-133a	CLIP-seq
MIRT2440267	hsa-miR-141	CLIP-seq
MIRT1343088	hsa-miR-15a	CLIP-seq
MIRT1343089	hsa-miR-15b	CLIP-seq
MIRT1343090	hsa-miR-16	CLIP-seq
MIRT2325776	hsa-miR-186	CLIP-seq
MIRT1343091	hsa-miR-195	CLIP-seq
MIRT2440268	hsa-miR-1976	CLIP-seq
MIRT2440269	hsa-miR-200a	CLIP-seq
MIRT2433084	hsa-miR-216b	CLIP-seq
MIRT1343093	hsa-miR-3121-3p	CLIP-seq
MIRT2325777	hsa-miR-3133	CLIP-seq
MIRT2440273	hsa-miR-3158-5p	CLIP-seq
MIRT1343095	hsa-miR-3160-5p	CLIP-seq
MIRT1343097	hsa-miR-3674	CLIP-seq
MIRT1343076	hsa-miR-377	CLIP-seq
MIRT1343099	hsa-miR-3908	CLIP-seq
MIRT1343100	hsa-miR-424	CLIP-seq
MIRT1343101	hsa-miR-4263	CLIP-seq
MIRT2440274	hsa-miR-4315	CLIP-seq
MIRT1343077	hsa-miR-4317	CLIP-seq
MIRT1343105	hsa-miR-4427	CLIP-seq
MIRT2433100	hsa-miR-4457	CLIP-seq
MIRT2433101	hsa-miR-4477a	CLIP-seq
MIRT2440275	hsa-miR-4496	CLIP-seq
MIRT1343106	hsa-miR-4503	CLIP-seq
MIRT2433102	hsa-miR-451	CLIP-seq
MIRT2325778	hsa-miR-4511	CLIP-seq
MIRT2440276	hsa-miR-4521	CLIP-seq
MIRT1343108	hsa-miR-4524	CLIP-seq
MIRT2440277	hsa-miR-4633-3p	CLIP-seq
MIRT2433108	hsa-miR-4668-5p	CLIP-seq
MIRT1343111	hsa-miR-4680-3p	CLIP-seq
MIRT2440278	hsa-miR-4690-3p	CLIP-seq
MIRT1343078	hsa-miR-4696	CLIP-seq
MIRT2440279	hsa-miR-4722-3p	CLIP-seq
MIRT2440280	hsa-miR-4722-5p	CLIP-seq
MIRT2440281	hsa-miR-4768-3p	CLIP-seq
MIRT2440282	hsa-miR-4773	CLIP-seq
MIRT1343113	hsa-miR-4799-5p	CLIP-seq
MIRT1343114	hsa-miR-486-3p	CLIP-seq
MIRT2433117	hsa-miR-494	CLIP-seq
MIRT1343115	hsa-miR-497	CLIP-seq
MIRT1343116	hsa-miR-503	CLIP-seq
MIRT2433119	hsa-miR-506	CLIP-seq
MIRT1343079	hsa-miR-513a-3p	CLIP-seq
MIRT2440283	hsa-miR-524-3p	CLIP-seq
MIRT2440284	hsa-miR-525-3p	CLIP-seq
MIRT1343118	hsa-miR-548ac	CLIP-seq
MIRT1343119	hsa-miR-548ae	CLIP-seq
MIRT1343120	hsa-miR-548aj	CLIP-seq
MIRT1343121	hsa-miR-548am	CLIP-seq
MIRT2433123	hsa-miR-548an	CLIP-seq
MIRT1343122	hsa-miR-548d-3p	CLIP-seq
MIRT1343123	hsa-miR-548x	CLIP-seq
MIRT1343124	hsa-miR-548z	CLIP-seq
MIRT1343125	hsa-miR-549	CLIP-seq
MIRT1343126	hsa-miR-576-5p	CLIP-seq
MIRT1343080	hsa-miR-590-3p	CLIP-seq
MIRT2440285	hsa-miR-610	CLIP-seq
MIRT1343081	hsa-miR-616	CLIP-seq
MIRT1343128	hsa-miR-646	CLIP-seq
MIRT2440286	hsa-miR-769-5p	CLIP-seq
MIRT1343095	hsa-miR-3160-5p	CLIP-seq
MIRT1343101	hsa-miR-4263	CLIP-seq
MIRT2433117	hsa-miR-494	CLIP-seq
MIRT1343126	hsa-miR-576-5p	CLIP-seq
MIRT1343095	hsa-miR-3160-5p	CLIP-seq
MIRT1343101	hsa-miR-4263	CLIP-seq
MIRT2433117	hsa-miR-494	CLIP-seq
MIRT1343126	hsa-miR-576-5p	CLIP-seq
MIRT2440262	hsa-miR-1184	CLIP-seq
MIRT2440263	hsa-miR-1205	CLIP-seq
MIRT2433079	hsa-miR-1236	CLIP-seq
MIRT2433080	hsa-miR-124	CLIP-seq
MIRT2440264	hsa-miR-1252	CLIP-seq
MIRT1343085	hsa-miR-1256	CLIP-seq
MIRT2440265	hsa-miR-1286	CLIP-seq
MIRT2440266	hsa-miR-1324	CLIP-seq
MIRT1343086	hsa-miR-133a	CLIP-seq
MIRT2440267	hsa-miR-141	CLIP-seq
MIRT1343088	hsa-miR-15a	CLIP-seq
MIRT1343089	hsa-miR-15b	CLIP-seq
MIRT1343090	hsa-miR-16	CLIP-seq
MIRT2325776	hsa-miR-186	CLIP-seq
MIRT1343091	hsa-miR-195	CLIP-seq
MIRT2440268	hsa-miR-1976	CLIP-seq
MIRT2440269	hsa-miR-200a	CLIP-seq
MIRT2690583	hsa-miR-2115	CLIP-seq
MIRT2433084	hsa-miR-216b	CLIP-seq
MIRT2440270	hsa-miR-29a	CLIP-seq
MIRT2440271	hsa-miR-29b	CLIP-seq
MIRT2440272	hsa-miR-29c	CLIP-seq
MIRT1343093	hsa-miR-3121-3p	CLIP-seq
MIRT2325777	hsa-miR-3133	CLIP-seq
MIRT2440273	hsa-miR-3158-5p	CLIP-seq
MIRT1343095	hsa-miR-3160-5p	CLIP-seq
MIRT1343096	hsa-miR-3613-3p	CLIP-seq
MIRT1343097	hsa-miR-3674	CLIP-seq
MIRT1343076	hsa-miR-377	CLIP-seq
MIRT1343099	hsa-miR-3908	CLIP-seq
MIRT1343100	hsa-miR-424	CLIP-seq
MIRT1343101	hsa-miR-4263	CLIP-seq
MIRT2440274	hsa-miR-4315	CLIP-seq
MIRT1343077	hsa-miR-4317	CLIP-seq
MIRT1343105	hsa-miR-4427	CLIP-seq
MIRT2433100	hsa-miR-4457	CLIP-seq
MIRT2433101	hsa-miR-4477a	CLIP-seq
MIRT2440275	hsa-miR-4496	CLIP-seq
MIRT1343106	hsa-miR-4503	CLIP-seq
MIRT2433102	hsa-miR-451	CLIP-seq
MIRT2325778	hsa-miR-4511	CLIP-seq
MIRT2440276	hsa-miR-4521	CLIP-seq
MIRT1343108	hsa-miR-4524	CLIP-seq
MIRT2440277	hsa-miR-4633-3p	CLIP-seq
MIRT2433108	hsa-miR-4668-5p	CLIP-seq
MIRT1343111	hsa-miR-4680-3p	CLIP-seq
MIRT2440278	hsa-miR-4690-3p	CLIP-seq
MIRT1343078	hsa-miR-4696	CLIP-seq
MIRT2440279	hsa-miR-4722-3p	CLIP-seq
MIRT2440280	hsa-miR-4722-5p	CLIP-seq
MIRT2440281	hsa-miR-4768-3p	CLIP-seq
MIRT2440282	hsa-miR-4773	CLIP-seq
MIRT1343113	hsa-miR-4799-5p	CLIP-seq
MIRT1343114	hsa-miR-486-3p	CLIP-seq
MIRT2433117	hsa-miR-494	CLIP-seq
MIRT1343115	hsa-miR-497	CLIP-seq
MIRT1343116	hsa-miR-503	CLIP-seq
MIRT2433119	hsa-miR-506	CLIP-seq
MIRT1343079	hsa-miR-513a-3p	CLIP-seq
MIRT2440283	hsa-miR-524-3p	CLIP-seq
MIRT2440284	hsa-miR-525-3p	CLIP-seq
MIRT1343118	hsa-miR-548ac	CLIP-seq
MIRT1343119	hsa-miR-548ae	CLIP-seq
MIRT1343120	hsa-miR-548aj	CLIP-seq
MIRT1343121	hsa-miR-548am	CLIP-seq
MIRT2433123	hsa-miR-548an	CLIP-seq
MIRT1343122	hsa-miR-548d-3p	CLIP-seq
MIRT1343123	hsa-miR-548x	CLIP-seq
MIRT1343124	hsa-miR-548z	CLIP-seq
MIRT1343125	hsa-miR-549	CLIP-seq
MIRT2690584	hsa-miR-570	CLIP-seq
MIRT1343126	hsa-miR-576-5p	CLIP-seq
MIRT1343080	hsa-miR-590-3p	CLIP-seq
MIRT2440285	hsa-miR-610	CLIP-seq
MIRT1343081	hsa-miR-616	CLIP-seq
MIRT1343128	hsa-miR-646	CLIP-seq
MIRT2440286	hsa-miR-769-5p	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
APC	Repression	18487207

Show/Hide all (51)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001558	Process	Regulation of cell growth	IEA
GO:0001558	Process	Regulation of cell growth	TAS	20919962
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	9114008
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IDA	22797923
GO:0005246	Function	Calcium channel regulator activity	TAS	20530112
GO:0005515	Function	Protein binding	IPI	17360471, 20237237, 27451907, 28514442, 32296183, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0006468	Process	Protein phosphorylation	TAS	9114008
GO:0006814	Process	Sodium ion transport	TAS	10884438
GO:0006915	Process	Apoptotic process	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0007616	Process	Long-term memory	TAS	20530112
GO:0008217	Process	Regulation of blood pressure	TAS	16460280
GO:0015459	Function	Potassium channel regulator activity	IBA
GO:0015459	Function	Potassium channel regulator activity	TAS	20530112
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0017080	Function	Sodium channel regulator activity	IEA
GO:0017080	Function	Sodium channel regulator activity	TAS	20530112
GO:0017081	Function	Chloride channel regulator activity	TAS	20530112
GO:0030334	Process	Regulation of cell migration	TAS	20919962
GO:0032411	Process	Positive regulation of transporter activity	TAS	20530112
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042127	Process	Regulation of cell population proliferation	TAS	20530112
GO:0042981	Process	Regulation of apoptotic process	TAS	20530112
GO:0048812	Process	Neuron projection morphogenesis	IBA
GO:0050790	Process	Regulation of catalytic activity	TAS	20530112
GO:0051090	Process	Regulation of DNA-binding transcription factor activity	TAS	20530112
GO:0060453	Process	Regulation of gastric acid secretion	TAS	20530112
GO:0070294	Process	Renal sodium ion absorption	TAS	16460280
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS
GO:1904045	Process	Cellular response to aldosterone	IEA

MIM	HGNC	e!Ensembl
602958	10810	ENSG00000118515

O00141

Protein name

Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1)

Protein function

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apo

PDB

2R5T , 3HDM , 3HDN , 7PUE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	98 → 355	Protein kinase domain	Domain
PF00433	Pkinase_C	376 → 423	Protein kinase C terminal domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle. {ECO:0000269|PubMe

Sequence

MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL

Sequence length

431

Interactions

View interactions

	KEGG		Reactome
	FoxO signaling pathway Efferocytosis mTOR signaling pathway PI3K-Akt signaling pathway Parathyroid hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption		Stimuli-sensing channels Regulation of TP53 Degradation NGF-stimulated transcription

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Multiple myeloma	Likely pathogenic	rs1171390403	RCV000984130

Show/Hide Text Mining Associations (66)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abortion Habitual	Associate	28393453
Abortion Spontaneous	Inhibit	31203134
Adenocarcinoma of Lung	Associate	30257988
Adrenocortical Adenoma	Associate	22496620
Adrenocortical Carcinoma	Associate	22496620, 23055545
Anxiety	Associate	29249830
Asthma	Stimulate	36611927
Breast Neoplasms	Associate	22842983, 30337371, 33783250, 37854018
Calcinosis	Associate	33003561, 35339998
Carcinogenesis	Associate	22496620
Carcinoma Hepatocellular	Associate	12521301, 39273406
Carcinoma Non Small Cell Lung	Associate	22240294
Carcinoma Squamous Cell	Associate	22240294
Cholangiocarcinoma	Associate	15917303
Colonic Neoplasms	Associate	21079778
Colorectal Neoplasms	Associate	21079778, 28902367, 33783250
Colorectal Neoplasms	Inhibit	21079778
Dermatitis Atopic	Associate	39245941
Diabetes Mellitus Type 2	Associate	18985156
Diabetic Nephropathies	Associate	37079269
Diarrhea 5 With Tufting Enteropathy Congenital	Associate	31641423
Drug Related Side Effects and Adverse Reactions	Associate	15917303
Endometriosis	Associate	26827666
Esophageal Squamous Cell Carcinoma	Associate	32106831
Glioblastoma	Associate	28848088, 28993509, 29976632, 33783250
Glioma	Associate	26908461, 27560795, 31734653
Graves Ophthalmopathy	Associate	22554965
Helicobacter Infections	Stimulate	26942879
Hodgkin Disease	Associate	30213827
Hyperglycemia	Associate	33003561
Hyperglycemic Hyperosmolar Nonketotic Coma	Associate	33003561
Hyperinsulinism	Associate	16221215
Hypertension	Associate	16221215, 22648267, 27664953
Hypoxia	Associate	27251632
Hypoxia	Stimulate	27560795
Hypoxia Brain	Associate	29976632
Infections	Stimulate	26942879
Kidney Diseases	Stimulate	32015442
Lung Neoplasms	Associate	28662101
Lymphoma B Cell	Associate	30213827, 32187361
Lymphoma Large B Cell Diffuse	Associate	32187361, 33988691, 35106936, 36215154, 37032379
Melanoma	Associate	30728070
Meningioma	Associate	26219339
Mitochondrial Diseases	Associate	31641423
Mouth Diseases	Associate	26827666
Neoplasm Metastasis	Associate	24485798, 29516642, 37854018
Neoplasms	Associate	16221215, 19383827, 21563193, 23055545, 26229090, 26942879, 27251632, 28471257, 28848088, 28992614, 29976632, 30728070, 33783250
Neoplasms	Inhibit	33988691
Nerve Degeneration	Associate	36624125
Osteoarthritis	Stimulate	31330080
Osteoporosis	Inhibit	39884015
Ovarian Neoplasms	Associate	32878513
Panic Disorder	Associate	29249830
Plasmablastic Lymphoma	Associate	32273478
Primary cortisol resistance	Associate	22496620, 23055545
Prostatic Neoplasms	Associate	18794135, 21563193, 35075115
Prostatic Neoplasms	Stimulate	33783250
Psychological Distress	Associate	31641423
Respiratory Distress Syndrome	Associate	37336980
Rhabdomyosarcoma	Associate	27960157, 28992614
Rhabdomyosarcoma Embryonal	Associate	28992614
Sepsis	Associate	37336980
Squamous Cell Carcinoma of Head and Neck	Associate	39272022
Stomach Neoplasms	Associate	26942879
Tongue Neoplasms	Associate	25749387
Vascular Calcification	Associate	33003561

SGK1 (serum/glucocorticoid regulated kinase 1)