Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64431
Gene name	Actin related protein 6
Gene symbol	ACTR6
Synonyms (NCBI Gene)	ARP6CDA12HSPC281MSTP136hARP6hARPX
Chromosome	12
Chromosome location	12q23.1

Show/Hide all (92)

miRTarBase ID	miRNA	Experiments	Reference
MIRT543225	hsa-miR-5692a	PAR-CLIP	21572407
MIRT543223	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT543224	hsa-miR-568	PAR-CLIP	21572407
MIRT543225	hsa-miR-5692a	PAR-CLIP	21572407
MIRT543223	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT543224	hsa-miR-568	PAR-CLIP	21572407
MIRT764745	hsa-miR-1183	CLIP-seq
MIRT764746	hsa-miR-1298	CLIP-seq
MIRT764747	hsa-miR-3647-3p	CLIP-seq
MIRT764748	hsa-miR-3653	CLIP-seq
MIRT764749	hsa-miR-3908	CLIP-seq
MIRT764750	hsa-miR-3942-5p	CLIP-seq
MIRT764751	hsa-miR-3973	CLIP-seq
MIRT764752	hsa-miR-4424	CLIP-seq
MIRT764753	hsa-miR-4659a-3p	CLIP-seq
MIRT764754	hsa-miR-4659b-3p	CLIP-seq
MIRT764755	hsa-miR-4693-5p	CLIP-seq
MIRT764756	hsa-miR-4699-3p	CLIP-seq
MIRT764757	hsa-miR-4703-5p	CLIP-seq
MIRT764758	hsa-miR-4766-3p	CLIP-seq
MIRT764759	hsa-miR-4778-3p	CLIP-seq
MIRT764760	hsa-miR-520g	CLIP-seq
MIRT764761	hsa-miR-520h	CLIP-seq
MIRT764762	hsa-miR-548l	CLIP-seq
MIRT764763	hsa-miR-582-5p	CLIP-seq
MIRT764764	hsa-miR-664	CLIP-seq
MIRT764765	hsa-miR-802	CLIP-seq
MIRT1925306	hsa-miR-128	CLIP-seq
MIRT1925307	hsa-miR-1323	CLIP-seq
MIRT1925308	hsa-miR-198	CLIP-seq
MIRT1925309	hsa-miR-27a	CLIP-seq
MIRT1925310	hsa-miR-27b	CLIP-seq
MIRT764747	hsa-miR-3647-3p	CLIP-seq
MIRT1925311	hsa-miR-377	CLIP-seq
MIRT1925312	hsa-miR-4263	CLIP-seq
MIRT1925313	hsa-miR-4521	CLIP-seq
MIRT1925314	hsa-miR-4704-3p	CLIP-seq
MIRT1925315	hsa-miR-4724-3p	CLIP-seq
MIRT1925316	hsa-miR-548a-3p	CLIP-seq
MIRT1925317	hsa-miR-548e	CLIP-seq
MIRT1925318	hsa-miR-548f	CLIP-seq
MIRT1925319	hsa-miR-548g	CLIP-seq
MIRT1925320	hsa-miR-548o	CLIP-seq
MIRT1925321	hsa-miR-584	CLIP-seq
MIRT764745	hsa-miR-1183	CLIP-seq
MIRT2166811	hsa-miR-1269	CLIP-seq
MIRT2166812	hsa-miR-1269b	CLIP-seq
MIRT2166813	hsa-miR-1288	CLIP-seq
MIRT2166814	hsa-miR-3138	CLIP-seq
MIRT2166815	hsa-miR-3646	CLIP-seq
MIRT764747	hsa-miR-3647-3p	CLIP-seq
MIRT764752	hsa-miR-4424	CLIP-seq
MIRT2166816	hsa-miR-4491	CLIP-seq
MIRT2166817	hsa-miR-4515	CLIP-seq
MIRT2166818	hsa-miR-4657	CLIP-seq
MIRT2166819	hsa-miR-4682	CLIP-seq
MIRT764755	hsa-miR-4693-5p	CLIP-seq
MIRT2166820	hsa-miR-4740-5p	CLIP-seq
MIRT2166821	hsa-miR-4800-5p	CLIP-seq
MIRT764763	hsa-miR-582-5p	CLIP-seq
MIRT1925321	hsa-miR-584	CLIP-seq
MIRT764765	hsa-miR-802	CLIP-seq
MIRT2435194	hsa-miR-4528	CLIP-seq
MIRT2435195	hsa-miR-4643	CLIP-seq
MIRT2435196	hsa-miR-466	CLIP-seq
MIRT2435197	hsa-miR-4789-3p	CLIP-seq
MIRT2435198	hsa-miR-4789-5p	CLIP-seq
MIRT2435194	hsa-miR-4528	CLIP-seq
MIRT2435195	hsa-miR-4643	CLIP-seq
MIRT2435196	hsa-miR-466	CLIP-seq
MIRT2435197	hsa-miR-4789-3p	CLIP-seq
MIRT2435198	hsa-miR-4789-5p	CLIP-seq
MIRT1925307	hsa-miR-1323	CLIP-seq
MIRT2469299	hsa-miR-1825	CLIP-seq
MIRT1925308	hsa-miR-198	CLIP-seq
MIRT2469300	hsa-miR-199a-5p	CLIP-seq
MIRT2469301	hsa-miR-199b-5p	CLIP-seq
MIRT2469302	hsa-miR-2113	CLIP-seq
MIRT2469303	hsa-miR-218	CLIP-seq
MIRT2469304	hsa-miR-3160-5p	CLIP-seq
MIRT1925311	hsa-miR-377	CLIP-seq
MIRT1925312	hsa-miR-4263	CLIP-seq
MIRT1925313	hsa-miR-4521	CLIP-seq
MIRT1925315	hsa-miR-4724-3p	CLIP-seq
MIRT2469305	hsa-miR-4786-3p	CLIP-seq
MIRT2469306	hsa-miR-513a-3p	CLIP-seq
MIRT1925316	hsa-miR-548a-3p	CLIP-seq
MIRT1925317	hsa-miR-548e	CLIP-seq
MIRT1925318	hsa-miR-548f	CLIP-seq
MIRT1925319	hsa-miR-548g	CLIP-seq
MIRT1925320	hsa-miR-548o	CLIP-seq
MIRT2469307	hsa-miR-636	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000786	Component	Nucleosome	NAS	16634648
GO:0000812	Component	Swr1 complex	IBA
GO:0005515	Function	Protein binding	IPI	15647280, 16230350, 20473270, 24463511, 28514442, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005730	Component	Nucleolus	IDA	26164235
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006338	Process	Chromatin remodeling	NAS	16634648
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	16634648
GO:0007000	Process	Nucleolus organization	IMP	26164235
GO:0016479	Process	Negative regulation of transcription by RNA polymerase I	ISS
GO:0031491	Function	Nucleosome binding	IBA
GO:0045943	Process	Positive regulation of transcription by RNA polymerase I	ISS

MIM	HGNC	e!Ensembl
619729	24025	ENSG00000075089

Q9GZN1

Protein name

Actin-related protein 6 (hArp6) (hARPX)

Protein function

Required for formation and/or maintenance of proper nucleolar structure and function (PubMed:26164235). Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription (By similarity). In the presence of high glucose, maintains active

PDB

6IGM , 8X15 , 8X19 , 8X1C

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00022	Actin	1 → 395	Actin	Family

Sequence

MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPF
QKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQ
AVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLL
TNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKLKGEENTVMIDYVLPD
FSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVY
SIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAW
EGGKLISENDDFEDMVVTREDYEENGHSVCEEKFDI

Sequence length

396

Interactions

View interactions

	KEGG
	ATP-dependent chromatin remodeling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UVEAL MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	36077333	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Associate	38225273	★★★★★ ★☆☆☆☆ Found in Text Mining only

ACTR6 (actin related protein 6)