Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
64426
Gene name Gene Name - the full gene name approved by the HGNC.
SIN3A corepressor complex component SDS3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SUDS3
Synonyms (NCBI Gene) Gene synonyms aliases
SAP45, SDS3
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.23
Summary Summary of gene provided in NCBI Entrez Gene.
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT048697 hsa-miR-99a-5p CLASH 23622248
MIRT048097 hsa-miR-197-3p CLASH 23622248
MIRT048097 hsa-miR-197-3p CLASH 23622248
MIRT1402281 hsa-miR-106a CLIP-seq
MIRT1402282 hsa-miR-106b CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 22783022
GO:0004407 Function Histone deacetylase activity IDA 21239494
GO:0005515 Function Protein binding IPI 12670868, 16919237, 32296183
GO:0005634 Component Nucleus IDA 21239494
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608250 29545 ENSG00000111707
Protein
UniProt ID Q9H7L9
Protein name Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)
Protein function Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity o
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08598 Sds3 59 259 Sds3-like Family
Tissue specificity TISSUE SPECIFICITY: Expressed in various cancer cell ines. {ECO:0000269|PubMed:12724404}.
Sequence
Sequence length 328
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    HDACs deacetylate histones
Ub-specific processing proteases
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Mental depression Major Depressive Disorder 29662059 ClinVar
Neuroticism Neuroticism GWAS
Associations from Text Mining
Disease Name Relationship Type References
Neoplasms Associate 21239494
Neoplasms Inhibit 22662218
Uterine Cervical Neoplasms Associate 21239494