KLHL25 (kelch like family member 25)

Gene

• Entrez ID: 64410
• Gene name: Kelch like family member 25
• Gene symbol: KLHL25
• Synonyms (NCBI Gene): ENC-2, ENC2
• Chromosome: 15
• Chromosome location: 15q25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT647045	hsa-miR-224-3p	HITS-CLIP	23824327
MIRT647044	hsa-miR-522-3p	HITS-CLIP	23824327
MIRT647043	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT647042	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT647041	hsa-miR-3918	HITS-CLIP	23824327
MIRT647040	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647039	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT647038	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT647037	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT647036	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT647035	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT647034	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT647033	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT647032	hsa-miR-4469	HITS-CLIP	23824327
MIRT647031	hsa-miR-593-5p	HITS-CLIP	23824327
MIRT647030	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT647029	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT457818	hsa-miR-4779	PAR-CLIP	23592263
MIRT457817	hsa-miR-1265	PAR-CLIP	23592263
MIRT457815	hsa-miR-5584-5p	PAR-CLIP	23592263
MIRT457816	hsa-miR-4459	PAR-CLIP	23592263
MIRT457814	hsa-miR-1972	PAR-CLIP	23592263
MIRT457813	hsa-miR-665	PAR-CLIP	23592263
MIRT457812	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT457811	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT457810	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT457809	hsa-miR-3153	PAR-CLIP	23592263
MIRT457808	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT457807	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT457806	hsa-miR-3688-5p	PAR-CLIP	23592263
MIRT457805	hsa-miR-891a-3p	PAR-CLIP	23592263
MIRT457804	hsa-miR-3911	PAR-CLIP	23592263
MIRT457803	hsa-miR-644a	PAR-CLIP	23592263
MIRT457802	hsa-miR-147a	PAR-CLIP	23592263
MIRT647045	hsa-miR-224-3p	HITS-CLIP	23824327
MIRT647044	hsa-miR-522-3p	HITS-CLIP	23824327
MIRT647043	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT647042	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT647041	hsa-miR-3918	HITS-CLIP	23824327
MIRT647040	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647039	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT647038	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT647037	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT647036	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT647035	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT647034	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT647033	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT647032	hsa-miR-4469	HITS-CLIP	23824327
MIRT647031	hsa-miR-593-5p	HITS-CLIP	23824327
MIRT647030	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT647029	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT457818	hsa-miR-4779	PAR-CLIP	23592263
MIRT457817	hsa-miR-1265	PAR-CLIP	23592263
MIRT457815	hsa-miR-5584-5p	PAR-CLIP	23592263
MIRT457816	hsa-miR-4459	PAR-CLIP	23592263
MIRT457814	hsa-miR-1972	PAR-CLIP	23592263
MIRT457813	hsa-miR-665	PAR-CLIP	23592263
MIRT457812	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT457811	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT457810	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT457809	hsa-miR-3153	PAR-CLIP	23592263
MIRT457808	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT457807	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT457806	hsa-miR-3688-5p	PAR-CLIP	23592263
MIRT457805	hsa-miR-891a-3p	PAR-CLIP	23592263
MIRT457804	hsa-miR-3911	PAR-CLIP	23592263
MIRT457803	hsa-miR-644a	PAR-CLIP	23592263
MIRT457802	hsa-miR-147a	PAR-CLIP	23592263
MIRT1098098	hsa-miR-1184	CLIP-seq
MIRT1098099	hsa-miR-1205	CLIP-seq
MIRT1098100	hsa-miR-1254	CLIP-seq
MIRT1098101	hsa-miR-1909	CLIP-seq
MIRT1098102	hsa-miR-2114	CLIP-seq
MIRT1098103	hsa-miR-3116	CLIP-seq
MIRT1098104	hsa-miR-3150b-3p	CLIP-seq
MIRT1098105	hsa-miR-3158-5p	CLIP-seq
MIRT1098106	hsa-miR-3179	CLIP-seq
MIRT1098107	hsa-miR-3190	CLIP-seq
MIRT1098108	hsa-miR-3194-5p	CLIP-seq
MIRT1098109	hsa-miR-3202	CLIP-seq
MIRT1098110	hsa-miR-339-5p	CLIP-seq
MIRT1098111	hsa-miR-3620	CLIP-seq
MIRT1098112	hsa-miR-3665	CLIP-seq
MIRT1098113	hsa-miR-377	CLIP-seq
MIRT1098114	hsa-miR-4255	CLIP-seq
MIRT1098115	hsa-miR-4292	CLIP-seq
MIRT1098116	hsa-miR-4418	CLIP-seq
MIRT1098117	hsa-miR-4519	CLIP-seq
MIRT1098118	hsa-miR-4533	CLIP-seq
MIRT1098119	hsa-miR-4646-5p	CLIP-seq
MIRT1098120	hsa-miR-4659a-5p	CLIP-seq
MIRT1098121	hsa-miR-4659b-5p	CLIP-seq
MIRT1098122	hsa-miR-4689	CLIP-seq
MIRT1098123	hsa-miR-4728-5p	CLIP-seq
MIRT1098124	hsa-miR-4747-5p	CLIP-seq
MIRT1098125	hsa-miR-4752	CLIP-seq
MIRT1098126	hsa-miR-4784	CLIP-seq
MIRT1098127	hsa-miR-509-3-5p	CLIP-seq
MIRT1098128	hsa-miR-509-5p	CLIP-seq
MIRT1098129	hsa-miR-550a	CLIP-seq
MIRT1098130	hsa-miR-600	CLIP-seq
MIRT1098131	hsa-miR-615-5p	CLIP-seq
MIRT1098132	hsa-miR-657	CLIP-seq
MIRT1098133	hsa-miR-661	CLIP-seq
MIRT1098134	hsa-miR-671-5p	CLIP-seq
MIRT1098135	hsa-miR-764	CLIP-seq
MIRT2026677	hsa-miR-1260	CLIP-seq
MIRT2026678	hsa-miR-1260b	CLIP-seq
MIRT2026679	hsa-miR-1275	CLIP-seq
MIRT2026680	hsa-miR-3622b-5p	CLIP-seq
MIRT2026681	hsa-miR-3910	CLIP-seq
MIRT2026682	hsa-miR-4525	CLIP-seq
MIRT2026683	hsa-miR-4636	CLIP-seq
MIRT2026684	hsa-miR-4665-5p	CLIP-seq
MIRT2026685	hsa-miR-4690-3p	CLIP-seq
MIRT2026686	hsa-miR-4723-5p	CLIP-seq
MIRT2026687	hsa-miR-625	CLIP-seq
MIRT2026688	hsa-miR-648	CLIP-seq
MIRT2257898	hsa-miR-1208	CLIP-seq
MIRT2257899	hsa-miR-1273f	CLIP-seq
MIRT2257900	hsa-miR-1321	CLIP-seq
MIRT2257901	hsa-miR-138	CLIP-seq
MIRT2257902	hsa-miR-139-5p	CLIP-seq
MIRT2257903	hsa-miR-143	CLIP-seq
MIRT2257904	hsa-miR-1908	CLIP-seq
MIRT2257905	hsa-miR-193a-5p	CLIP-seq
MIRT2257906	hsa-miR-2110	CLIP-seq
MIRT2257907	hsa-miR-29a	CLIP-seq
MIRT2257908	hsa-miR-29b	CLIP-seq
MIRT2257909	hsa-miR-29c	CLIP-seq
MIRT2257910	hsa-miR-3126-5p	CLIP-seq
MIRT2257911	hsa-miR-3130-3p	CLIP-seq
MIRT2257912	hsa-miR-3150a-3p	CLIP-seq
MIRT2257913	hsa-miR-3618	CLIP-seq
MIRT2257914	hsa-miR-3689d	CLIP-seq
MIRT2257915	hsa-miR-3909	CLIP-seq
MIRT2257916	hsa-miR-3937	CLIP-seq
MIRT2257917	hsa-miR-4260	CLIP-seq
MIRT2257918	hsa-miR-4270	CLIP-seq
MIRT2257919	hsa-miR-4271	CLIP-seq
MIRT2257920	hsa-miR-4299	CLIP-seq
MIRT2257921	hsa-miR-4419a	CLIP-seq
MIRT2257922	hsa-miR-4441	CLIP-seq
MIRT2257923	hsa-miR-4510	CLIP-seq
MIRT2257924	hsa-miR-4527	CLIP-seq
MIRT2257925	hsa-miR-4691-5p	CLIP-seq
MIRT2257926	hsa-miR-4708-5p	CLIP-seq
MIRT2257927	hsa-miR-4710	CLIP-seq
MIRT2257928	hsa-miR-4725-3p	CLIP-seq
MIRT2257929	hsa-miR-4731-5p	CLIP-seq
MIRT2257930	hsa-miR-4739	CLIP-seq
MIRT2257931	hsa-miR-4756-5p	CLIP-seq
MIRT2257932	hsa-miR-4770	CLIP-seq
MIRT2257933	hsa-miR-4792	CLIP-seq
MIRT2257934	hsa-miR-4793-3p	CLIP-seq
MIRT2257935	hsa-miR-544	CLIP-seq
MIRT2257936	hsa-miR-548c-3p	CLIP-seq
MIRT2257937	hsa-miR-642b	CLIP-seq
MIRT2257938	hsa-miR-663	CLIP-seq
MIRT2389960	hsa-miR-432	CLIP-seq
MIRT2452667	hsa-miR-3663-5p	CLIP-seq
MIRT2452668	hsa-miR-4267	CLIP-seq
MIRT2452669	hsa-miR-4268	CLIP-seq
MIRT2452670	hsa-miR-4448	CLIP-seq
MIRT2465538	hsa-miR-103b	CLIP-seq
MIRT2465539	hsa-miR-136	CLIP-seq
MIRT2465540	hsa-miR-3651	CLIP-seq
MIRT2465541	hsa-miR-3934	CLIP-seq
MIRT2465542	hsa-miR-4726-3p	CLIP-seq
MIRT2452667	hsa-miR-3663-5p	CLIP-seq
MIRT2452668	hsa-miR-4267	CLIP-seq
MIRT2452669	hsa-miR-4268	CLIP-seq
MIRT2389960	hsa-miR-432	CLIP-seq
MIRT2452670	hsa-miR-4448	CLIP-seq
MIRT2452667	hsa-miR-3663-5p	CLIP-seq
MIRT2452668	hsa-miR-4267	CLIP-seq
MIRT2452669	hsa-miR-4268	CLIP-seq
MIRT2389960	hsa-miR-432	CLIP-seq
MIRT2452670	hsa-miR-4448	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005737	Component	Cytoplasm	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006417	Process	Regulation of translation	IEA
GO:0006446	Process	Regulation of translational initiation	IDA	22578813
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	22578813, 27664236, 34491895
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IDA	19286649
GO:0016567	Process	Protein ubiquitination	IDA	22578813
GO:0016567	Process	Protein ubiquitination	IEA
GO:0031463	Component	Cul3-RING ubiquitin ligase complex	IDA	22578813, 27664236
GO:0031463	Component	Cul3-RING ubiquitin ligase complex	IEA
GO:0032831	Process	Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IDA	34491895
GO:0032831	Process	Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IEA
GO:0045717	Process	Negative regulation of fatty acid biosynthetic process	IDA	27664236
GO:0046321	Process	Positive regulation of fatty acid oxidation	IDA	34491895
GO:0046321	Process	Positive regulation of fatty acid oxidation	IEA
GO:0046321	Process	Positive regulation of fatty acid oxidation	ISS
GO:0051603	Process	Proteolysis involved in protein catabolic process	IEA
GO:0080090	Process	Regulation of primary metabolic process	IEA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	22578813, 27664236, 34491895
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IEA

Other IDs

• MIM: 619893
• HGNC: 25732
• e!Ensembl: ENSG00000183655

Protein

• UniProt ID: Q9H0H3
• Protein name: Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2)
• Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:27664236, PubMed:34491895). The BCR(KLHL25) ubiquitin lig
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00651	BTB	36 → 144	BTB/POZ domain	Domain
  PF07707	BACK	149 → 251	BTB And C-terminal Kelch	Domain
  PF01344	Kelch_1	329 → 375	Kelch motif	Repeat
  PF01344	Kelch_1	377 → 431	Kelch motif	Repeat
  PF01344	Kelch_1	481 → 525	Kelch motif	Repeat
  PF01344	Kelch_1	527 → 572	Kelch motif	Repeat

• Sequence:

  MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCH
  RAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESL
  LEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVR
  QSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLAL
  LPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLIL
  GGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWV
  YDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPG
  ANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQ
  PWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKL
  YVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA

• Sequence length: 589

Pathways

Reactome:

Neddylation
Antigen processing: Ubiquitination & Proteasome degradation