SFTPD (surfactant protein D)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6441
Gene name Gene Name - the full gene name approved by the HGNC.
Surfactant protein D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SFTPD
Synonyms (NCBI Gene) Gene synonyms aliases
COLEC7, PSP-D, SFTP4, SP-D
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT019062 hsa-miR-335-5p Microarray 18185580
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
Transcription factor Regulation Reference
CEBPA Activation 11912209
CEBPB Activation 11912209
CEBPG Activation 11912209
FOSL1 Unknown 10915785
JUNB Unknown 10915785
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(31)
GO ID Ontology Definition Evidence Reference
GO:0001817 Process Regulation of cytokine production NAS 9751757
GO:0002376 Process Immune system process IEA
GO:0002682 Process Regulation of immune system process IEA
GO:0005515 Function Protein binding IPI 12884308, 28228557, 33784482, 34054808, 34439781
GO:0005576 Component Extracellular region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
178635 10803 ENSG00000133661
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P35247
Protein name Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D)
Protein function Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. Ma
PDB 1B08 , 1M7L , 1PW9 , 1PWB , 2GGU , 2GGX , 2ORJ , 2ORK , 2OS9 , 2RIA , 2RIB , 2RIC , 2RID , 2RIE , 3DBZ , 3G81 , 3G83 , 3G84 , 3IKN , 3IKP , 3IKQ , 3IKR , 4E52 , 4M17 , 4M18 , 5OXR , 5OXS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01391 Collagen 42 → 105 Collagen triple helix repeat (20 copies) Repeat
PF01391 Collagen 163 → 224 Collagen triple helix repeat (20 copies) Repeat
PF09006 Surfac_D-trimer 224 → 269 Lung surfactant protein D coiled-coil trimerisation Coiled-coil
PF00059 Lectin_C 271 → 375 Lectin C-type domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes). {ECO:0000269|PubMed:23478426}.
Sequence
Sequence length 375
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Phagosome   Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Signal regulatory protein family interactions
Surfactant metabolism
Regulation of TLR by endogenous ligand
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Rheumatoid arthritis Rheumatoid arthritis N/A N/A GWAS
Show/Hide Text Mining Associations (95)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 28212617
Adenocarcinoma Associate 24168624
Adenocarcinoma of Lung Associate 11912209
Allergic Fungal Sinusitis Inhibit 26521790
Amyopathic dermatomyositis Associate 29065861
Arthritis Psoriatic Associate 16489709
Arthritis Rheumatoid Stimulate 16489709
Arthritis Rheumatoid Inhibit 18052966
Arthritis Rheumatoid Associate 18052966, 20211020, 31875586
Asthma Associate 25848896, 34780682