Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64409
Gene name	Polypeptide N-acetylgalactosaminyltransferase 17
Gene symbol	GALNT17
Synonyms (NCBI Gene)	GALNACT17GALNT16GALNT20GALNTL3GalNAc-T17GalNAc-T19GalNAc-T5LWBSCR17
Chromosome	7
Chromosome location	7q11.22
Summary	This gene encodes an N-acetylgalactosaminyltransferase. This gene is located centromeric to the common deleted region in Williams-Beuren syndrome (WBS), a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. This prote

152

Show/Hide all (152)

miRTarBase ID	miRNA	Experiments	Reference
MIRT614216	hsa-miR-8485	HITS-CLIP	19536157
MIRT611192	hsa-miR-329-3p	HITS-CLIP	19536157
MIRT611191	hsa-miR-362-3p	HITS-CLIP	19536157
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT614216	hsa-miR-8485	HITS-CLIP	19536157
MIRT611192	hsa-miR-329-3p	HITS-CLIP	19536157
MIRT611191	hsa-miR-362-3p	HITS-CLIP	19536157
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT641066	hsa-miR-603	HITS-CLIP	23824327
MIRT641065	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT641064	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT641063	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT641062	hsa-miR-4269	HITS-CLIP	23824327
MIRT641061	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT641066	hsa-miR-603	HITS-CLIP	23824327
MIRT641065	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT641064	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT641063	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT641062	hsa-miR-4269	HITS-CLIP	23824327
MIRT641061	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT614216	hsa-miR-8485	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT611192	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611191	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611190	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT611189	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT611188	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT611187	hsa-miR-6727-3p	HITS-CLIP	23824327

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence
GO:0000139	Component	Golgi membrane	IEA
GO:0004653	Function	Polypeptide N-acetylgalactosaminyltransferase activity	IBA
GO:0004653	Function	Polypeptide N-acetylgalactosaminyltransferase activity	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006493	Process	Protein O-linked glycosylation	IBA
GO:0006493	Process	Protein O-linked glycosylation	IEA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
615137	16347	ENSG00000185274

Q6IS24

Protein name

Polypeptide N-acetylgalactosaminyltransferase 17 (EC 2.4.1.41) (Polypeptide GalNAc transferase-like protein 3) (GalNAc-T-like protein 3) (pp-GaNTase-like protein 3) (Protein-UDP acetylgalactosaminyltransferase-like protein 3) (UDP-GalNAc:polypeptide N-ace

Protein function

May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00535	Glycos_transf_2	155 → 341	Glycosyl transferase family 2	Family
PF00652	Ricin_B_lectin	465 → 591	Ricin-type beta-trefoil lectin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in brain and heart. Weakly expressed in kidney, liver, lung and spleen. {ECO:0000269|PubMed:12073013}.

Sequence

MASLRRVKVLLVLNLIAVAGFVLFLAKCRPIAVRSGDAFHEIRPRAEVANLSAHSASPIQ
DAVLKRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPAEEEKAKGPHEKYGY
NSYLSEKISLDRSIPDYRPTKCKELKYSKDLPQISIIFIFVNEALSVILRSVHSAVNHTP
THLLKEIILVDDNSDEEELKVPLEEYVHKRYPGLVKVVRNQKREGLIRARIEGWKVATGQ
VTGFFDAHVEFTAGWAEPVLSRIQENRKRVILPSIDNIKQDNFEVQRYENSAHGYSWELW
CMYISPPKDWWDAGDPSLPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIK
VWLCGGSMEVLPCSRVAHIERKKKPYNSNIGFYTKRNALRVAEVWMDDYKSHVYIAWNLP
LENPGIDIGDVSERRALRKSLKCKNFQWYLDHVYPEMRRYNNTVAYGELRNNKAKDVCLD
QGPLENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRCLVDNSKSRLPQLLD
CDKVKSSLYKRWNFIQNGAIMNKGTGRCLEVENRGLAGIDLILRSCTGQRWTIKNSIK

Sequence length

598

Interactions

View interactions

	KEGG		Reactome
	Mucin type O-glycan biosynthesis Other types of O-glycan biosynthesis Metabolic pathways		O-linked glycosylation of mucins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BRONCHOPNEUMONIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Autism Spectrum Disorder	Associate	27876814	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	25774687	★★★★★ ★☆☆☆☆ Found in Text Mining only
Plaque Atherosclerotic	Associate	29221444	★★★★★ ★☆☆☆☆ Found in Text Mining only
Williams Syndrome	Associate	27876814	★★★★★ ★☆☆☆☆ Found in Text Mining only

GALNT17 (polypeptide N-acetylgalactosaminyltransferase 17)