Gene Gene information from NCBI Gene database.
Entrez ID 64393
Gene name Zinc finger matrin-type 3
Gene symbol ZMAT3
Synonyms (NCBI Gene)
PAG608WIG-1WIG1
Chromosome 3
Chromosome location 3q26.32
Summary This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene
miRNA miRNA information provided by mirtarbase database.
2214
miRTarBase ID miRNA Experiments Reference
MIRT024666 hsa-miR-215-5p Microarray 19074876
MIRT024666 hsa-miR-215-5p Microarray 19074876
MIRT026966 hsa-miR-192-5p Microarray 19074876
MIRT612293 hsa-miR-6865-3p HITS-CLIP 19536157
MIRT612292 hsa-miR-3620-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0003723 Function RNA binding IEA
GO:0005515 Function Protein binding IPI 18519039, 23085987, 25416956, 32296183
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606452 29983 ENSG00000172667
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HA38
Protein name Zinc finger matrin-type protein 3 (Zinc finger protein WIG-1) (p53-activated gene 608 protein)
Protein function Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus. {ECO:0000269
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12874 zf-met 70 94 Domain
PF12874 zf-met 148 171 Domain
PF12171 zf-C2H2_jaz 245 271 Zinc-finger double-stranded RNA-binding Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine. {ECO:0000269|PubMed:11689294}.
Sequence
MILLQHAVLPPPKQPSPSPPMSVATRSTGTLQLPPQKPFGQEASLPLAGEEELSKGGEQD
CALEELCKPLYCKLCNVTLNSAQQAQAHYQGKNHGKKLRNYYAANSCPPPARMSNVVEPA
ATPVVPVPPQMGSFKPGGRVILATENDYCKLCDASFSSPAVAQAHYQGKNHAKRLRLAEA
QSNSFSESSELGQRRARKEGNEFKMMPNRRNMYTVQNNSAGPYFNPRSRQRIPRDLAMCV
TPSGQFYCSMCNVGAGEEMEFRQHLESKQHKSKVSEQRYRNEMENLGYV
Sequence length 289
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  p53 signaling pathway  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 25379706
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 25501155
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 33334821
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 33334821
★☆☆☆☆
Found in Text Mining only
COVID 19 Associate 35927536
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Stimulate 35146866
★☆☆☆☆
Found in Text Mining only
Esophageal Squamous Cell Carcinoma Inhibit 21559779
★☆☆☆☆
Found in Text Mining only
Leukemia Lymphocytic Chronic B Cell Associate 18945750
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 22171072, 24374933
★☆☆☆☆
Found in Text Mining only
Neoplasms Inhibit 26672765
★☆☆☆☆
Found in Text Mining only