Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64359
Gene name Gene Name - the full gene name approved by the HGNC.	Nucleoredoxin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NXN
Synonyms (NCBI Gene) Gene synonyms aliases	NRX, RRS2, TRG-4
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation an

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1555607285	TCC>-	Likely-pathogenic, pathogenic	Inframe deletion, genic downstream transcript variant, coding sequence variant
rs1555610590	G>A	Likely-pathogenic, pathogenic	Stop gained, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001611	hsa-let-7b-5p	pSILAC	18668040
MIRT022572	hsa-miR-124-3p	Microarray	18668037
MIRT023721	hsa-miR-1-3p	Proteomics	18668040
MIRT001611	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT049102	hsa-miR-92a-3p	CLASH	23622248
MIRT045235	hsa-miR-186-5p	CLASH	23622248
MIRT039562	hsa-miR-652-3p	CLASH	23622248
MIRT689465	hsa-miR-5684	HITS-CLIP	23313552
MIRT689464	hsa-miR-3664-5p	HITS-CLIP	23313552
MIRT689463	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT689462	hsa-miR-6784-5p	HITS-CLIP	23313552
MIRT689461	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT689460	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT689459	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT689458	hsa-miR-1251-5p	HITS-CLIP	23313552
MIRT689457	hsa-miR-3120-5p	HITS-CLIP	23313552
MIRT689456	hsa-miR-4522	HITS-CLIP	23313552
MIRT689455	hsa-miR-1273a	HITS-CLIP	23313552
MIRT689454	hsa-miR-1287-3p	HITS-CLIP	23313552
MIRT689453	hsa-miR-6888-3p	HITS-CLIP	23313552
MIRT689452	hsa-miR-6510-3p	HITS-CLIP	23313552
MIRT482692	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT482691	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT482690	hsa-miR-4476	PAR-CLIP	20371350
MIRT482689	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT482687	hsa-miR-4779	PAR-CLIP	20371350
MIRT482688	hsa-miR-3929	PAR-CLIP	20371350
MIRT482686	hsa-miR-4419b	PAR-CLIP	20371350
MIRT482685	hsa-miR-4478	PAR-CLIP	20371350
MIRT482684	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT482683	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT482682	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT482681	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT482680	hsa-miR-4784	PAR-CLIP	20371350
MIRT482679	hsa-miR-4533	PAR-CLIP	20371350
MIRT482678	hsa-miR-4434	PAR-CLIP	20371350
MIRT482677	hsa-miR-4516	PAR-CLIP	20371350
MIRT482676	hsa-miR-5703	PAR-CLIP	20371350
MIRT482675	hsa-miR-765	PAR-CLIP	20371350
MIRT482673	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT482674	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT482672	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT482671	hsa-miR-5698	PAR-CLIP	20371350
MIRT482670	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT482669	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT482668	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT492827	hsa-miR-6840-5p	PAR-CLIP	20371350
MIRT492826	hsa-miR-4707-5p	PAR-CLIP	20371350
MIRT492825	hsa-miR-4529-5p	PAR-CLIP	20371350
MIRT572331	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT492824	hsa-miR-296-5p	PAR-CLIP	20371350
MIRT482692	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT482691	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT482690	hsa-miR-4476	PAR-CLIP	20371350
MIRT482689	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT482687	hsa-miR-4779	PAR-CLIP	20371350
MIRT482688	hsa-miR-3929	PAR-CLIP	20371350
MIRT482686	hsa-miR-4419b	PAR-CLIP	20371350
MIRT482685	hsa-miR-4478	PAR-CLIP	20371350
MIRT482684	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT482683	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT482682	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT482681	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT482680	hsa-miR-4784	PAR-CLIP	20371350
MIRT482679	hsa-miR-4533	PAR-CLIP	20371350
MIRT482678	hsa-miR-4434	PAR-CLIP	20371350
MIRT482677	hsa-miR-4516	PAR-CLIP	20371350
MIRT482676	hsa-miR-5703	PAR-CLIP	20371350
MIRT482675	hsa-miR-765	PAR-CLIP	20371350
MIRT482673	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT482674	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT482672	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT482671	hsa-miR-5698	PAR-CLIP	20371350
MIRT482670	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT482669	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT482668	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT492827	hsa-miR-6840-5p	PAR-CLIP	23592263
MIRT492826	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT492825	hsa-miR-4529-5p	PAR-CLIP	23592263
MIRT492824	hsa-miR-296-5p	PAR-CLIP	23592263
MIRT482692	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT482691	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT482690	hsa-miR-4476	PAR-CLIP	23592263
MIRT482689	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT482687	hsa-miR-4779	PAR-CLIP	23592263
MIRT482688	hsa-miR-3929	PAR-CLIP	23592263
MIRT482686	hsa-miR-4419b	PAR-CLIP	23592263
MIRT482685	hsa-miR-4478	PAR-CLIP	23592263
MIRT482684	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT482683	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT482682	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT482681	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT482680	hsa-miR-4784	PAR-CLIP	23592263
MIRT482679	hsa-miR-4533	PAR-CLIP	23592263
MIRT482678	hsa-miR-4434	PAR-CLIP	23592263
MIRT482677	hsa-miR-4516	PAR-CLIP	23592263
MIRT482676	hsa-miR-5703	PAR-CLIP	23592263
MIRT482675	hsa-miR-765	PAR-CLIP	23592263
MIRT482673	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT482674	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT482672	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT482671	hsa-miR-5698	PAR-CLIP	23592263
MIRT482670	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT482669	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT482668	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT689465	hsa-miR-5684	HITS-CLIP	23313552
MIRT689464	hsa-miR-3664-5p	HITS-CLIP	23313552
MIRT689463	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT689462	hsa-miR-6784-5p	HITS-CLIP	23313552
MIRT689461	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT689460	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT689459	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT689458	hsa-miR-1251-5p	HITS-CLIP	23313552
MIRT689457	hsa-miR-3120-5p	HITS-CLIP	23313552
MIRT689456	hsa-miR-4522	HITS-CLIP	23313552
MIRT689455	hsa-miR-1273a	HITS-CLIP	23313552
MIRT689454	hsa-miR-1287-3p	HITS-CLIP	23313552
MIRT689453	hsa-miR-6888-3p	HITS-CLIP	23313552
MIRT689452	hsa-miR-6510-3p	HITS-CLIP	23313552
MIRT482692	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT482691	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT482690	hsa-miR-4476	PAR-CLIP	20371350
MIRT482689	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT482687	hsa-miR-4779	PAR-CLIP	20371350
MIRT482688	hsa-miR-3929	PAR-CLIP	20371350
MIRT482686	hsa-miR-4419b	PAR-CLIP	20371350
MIRT482685	hsa-miR-4478	PAR-CLIP	20371350
MIRT482684	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT482683	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT482682	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT482681	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT482680	hsa-miR-4784	PAR-CLIP	20371350
MIRT482679	hsa-miR-4533	PAR-CLIP	20371350
MIRT482678	hsa-miR-4434	PAR-CLIP	20371350
MIRT482677	hsa-miR-4516	PAR-CLIP	20371350
MIRT482676	hsa-miR-5703	PAR-CLIP	20371350
MIRT482675	hsa-miR-765	PAR-CLIP	20371350
MIRT482673	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT482674	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT482672	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT482671	hsa-miR-5698	PAR-CLIP	20371350
MIRT482670	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT482669	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT482668	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT492827	hsa-miR-6840-5p	PAR-CLIP	20371350
MIRT492826	hsa-miR-4707-5p	PAR-CLIP	20371350
MIRT492825	hsa-miR-4529-5p	PAR-CLIP	20371350
MIRT572331	hsa-miR-4743-5p	PAR-CLIP	20371350
MIRT492824	hsa-miR-296-5p	PAR-CLIP	20371350
MIRT482692	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT482691	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT482690	hsa-miR-4476	PAR-CLIP	20371350
MIRT482689	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT482687	hsa-miR-4779	PAR-CLIP	20371350
MIRT482688	hsa-miR-3929	PAR-CLIP	20371350
MIRT482686	hsa-miR-4419b	PAR-CLIP	20371350
MIRT482685	hsa-miR-4478	PAR-CLIP	20371350
MIRT482684	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT482683	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT482682	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT482681	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT482680	hsa-miR-4784	PAR-CLIP	20371350
MIRT482679	hsa-miR-4533	PAR-CLIP	20371350
MIRT482678	hsa-miR-4434	PAR-CLIP	20371350
MIRT482677	hsa-miR-4516	PAR-CLIP	20371350
MIRT482676	hsa-miR-5703	PAR-CLIP	20371350
MIRT482675	hsa-miR-765	PAR-CLIP	20371350
MIRT482673	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT482674	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT482672	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT482671	hsa-miR-5698	PAR-CLIP	20371350
MIRT482670	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT482669	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT482668	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT492827	hsa-miR-6840-5p	PAR-CLIP	23592263
MIRT492826	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT492825	hsa-miR-4529-5p	PAR-CLIP	23592263
MIRT492824	hsa-miR-296-5p	PAR-CLIP	23592263
MIRT482692	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT482691	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT482690	hsa-miR-4476	PAR-CLIP	23592263
MIRT482689	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT482687	hsa-miR-4779	PAR-CLIP	23592263
MIRT482688	hsa-miR-3929	PAR-CLIP	23592263
MIRT482686	hsa-miR-4419b	PAR-CLIP	23592263
MIRT482685	hsa-miR-4478	PAR-CLIP	23592263
MIRT482684	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT482683	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT482682	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT482681	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT482680	hsa-miR-4784	PAR-CLIP	23592263
MIRT482679	hsa-miR-4533	PAR-CLIP	23592263
MIRT482678	hsa-miR-4434	PAR-CLIP	23592263
MIRT482677	hsa-miR-4516	PAR-CLIP	23592263
MIRT482676	hsa-miR-5703	PAR-CLIP	23592263
MIRT482675	hsa-miR-765	PAR-CLIP	23592263
MIRT482673	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT482674	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT482672	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT482671	hsa-miR-5698	PAR-CLIP	23592263
MIRT482670	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT482669	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT482668	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT1200446	hsa-miR-3122	CLIP-seq
MIRT1200447	hsa-miR-3165	CLIP-seq
MIRT1200448	hsa-miR-3622a-3p	CLIP-seq
MIRT1200449	hsa-miR-3622b-3p	CLIP-seq
MIRT1200450	hsa-miR-3656	CLIP-seq
MIRT1200451	hsa-miR-3689a-3p	CLIP-seq
MIRT1200452	hsa-miR-3689c	CLIP-seq
MIRT1200453	hsa-miR-3913-5p	CLIP-seq
MIRT1200454	hsa-miR-3926	CLIP-seq
MIRT1200455	hsa-miR-4433	CLIP-seq
MIRT1200456	hsa-miR-4459	CLIP-seq
MIRT1200457	hsa-miR-4728-5p	CLIP-seq
MIRT1200458	hsa-miR-4768-3p	CLIP-seq
MIRT1200459	hsa-miR-4786-5p	CLIP-seq
MIRT1200460	hsa-miR-544b	CLIP-seq
MIRT1200461	hsa-miR-548s	CLIP-seq
MIRT1200462	hsa-miR-1257	CLIP-seq
MIRT1200463	hsa-miR-1266	CLIP-seq
MIRT1200464	hsa-miR-1273	CLIP-seq
MIRT1200465	hsa-miR-138	CLIP-seq
MIRT1200466	hsa-miR-1827	CLIP-seq
MIRT1200467	hsa-miR-1908	CLIP-seq
MIRT1200468	hsa-miR-1915	CLIP-seq
MIRT1200469	hsa-miR-2467-3p	CLIP-seq
MIRT1200470	hsa-miR-2467-5p	CLIP-seq
MIRT1200471	hsa-miR-2861	CLIP-seq
MIRT1200472	hsa-miR-2964a-5p	CLIP-seq
MIRT1200473	hsa-miR-3117-3p	CLIP-seq
MIRT1200446	hsa-miR-3122	CLIP-seq
MIRT1200474	hsa-miR-3127-5p	CLIP-seq
MIRT1200447	hsa-miR-3165	CLIP-seq
MIRT1200475	hsa-miR-3169	CLIP-seq
MIRT1200476	hsa-miR-3188	CLIP-seq
MIRT1200448	hsa-miR-3622a-3p	CLIP-seq
MIRT1200449	hsa-miR-3622b-3p	CLIP-seq
MIRT1200450	hsa-miR-3656	CLIP-seq
MIRT1200477	hsa-miR-3667-3p	CLIP-seq
MIRT1200478	hsa-miR-3678-3p	CLIP-seq
MIRT1200451	hsa-miR-3689a-3p	CLIP-seq
MIRT1200452	hsa-miR-3689c	CLIP-seq
MIRT1200479	hsa-miR-3692	CLIP-seq
MIRT1200480	hsa-miR-371-5p	CLIP-seq
MIRT1200481	hsa-miR-3907	CLIP-seq
MIRT1200453	hsa-miR-3913-5p	CLIP-seq
MIRT1200482	hsa-miR-3918	CLIP-seq
MIRT1200454	hsa-miR-3926	CLIP-seq
MIRT1200483	hsa-miR-3975	CLIP-seq
MIRT1200484	hsa-miR-4257	CLIP-seq
MIRT1200485	hsa-miR-4268	CLIP-seq
MIRT1200486	hsa-miR-4432	CLIP-seq
MIRT1200455	hsa-miR-4433	CLIP-seq
MIRT1200487	hsa-miR-4448	CLIP-seq
MIRT1200456	hsa-miR-4459	CLIP-seq
MIRT1200488	hsa-miR-4486	CLIP-seq
MIRT1200489	hsa-miR-4518	CLIP-seq
MIRT1200490	hsa-miR-451b	CLIP-seq
MIRT1200491	hsa-miR-4649-3p	CLIP-seq
MIRT1200492	hsa-miR-4649-5p	CLIP-seq
MIRT1200493	hsa-miR-4696	CLIP-seq
MIRT1200494	hsa-miR-4722-5p	CLIP-seq
MIRT1200457	hsa-miR-4728-5p	CLIP-seq
MIRT1200495	hsa-miR-4747-5p	CLIP-seq
MIRT1200496	hsa-miR-4759	CLIP-seq
MIRT1200497	hsa-miR-4765	CLIP-seq
MIRT1200458	hsa-miR-4768-3p	CLIP-seq
MIRT1200459	hsa-miR-4786-5p	CLIP-seq
MIRT1200498	hsa-miR-485-5p	CLIP-seq
MIRT1200499	hsa-miR-508-5p	CLIP-seq
MIRT1200500	hsa-miR-510	CLIP-seq
MIRT1200460	hsa-miR-544b	CLIP-seq
MIRT1200501	hsa-miR-548ad	CLIP-seq
MIRT1200502	hsa-miR-548q	CLIP-seq
MIRT1200461	hsa-miR-548s	CLIP-seq
MIRT1200503	hsa-miR-550a	CLIP-seq
MIRT1200504	hsa-miR-572	CLIP-seq
MIRT1200505	hsa-miR-578	CLIP-seq
MIRT1200506	hsa-miR-635	CLIP-seq
MIRT1200507	hsa-miR-661	CLIP-seq
MIRT1200508	hsa-miR-663	CLIP-seq
MIRT1200509	hsa-miR-766	CLIP-seq
MIRT1200510	hsa-miR-940	CLIP-seq
MIRT1200447	hsa-miR-3165	CLIP-seq
MIRT1200448	hsa-miR-3622a-3p	CLIP-seq
MIRT1200449	hsa-miR-3622b-3p	CLIP-seq
MIRT2058016	hsa-miR-3652	CLIP-seq
MIRT1200450	hsa-miR-3656	CLIP-seq
MIRT1200454	hsa-miR-3926	CLIP-seq
MIRT2058017	hsa-miR-4430	CLIP-seq
MIRT1200455	hsa-miR-4433	CLIP-seq
MIRT1200456	hsa-miR-4459	CLIP-seq
MIRT1200458	hsa-miR-4768-3p	CLIP-seq
MIRT1200459	hsa-miR-4786-5p	CLIP-seq
MIRT1200498	hsa-miR-485-5p	CLIP-seq
MIRT1200460	hsa-miR-544b	CLIP-seq
MIRT1200461	hsa-miR-548s	CLIP-seq
MIRT2286396	hsa-miR-1227	CLIP-seq
MIRT2286397	hsa-miR-1229	CLIP-seq
MIRT1200464	hsa-miR-1273	CLIP-seq
MIRT2286398	hsa-miR-150	CLIP-seq
MIRT1200472	hsa-miR-2964a-5p	CLIP-seq
MIRT1200446	hsa-miR-3122	CLIP-seq
MIRT1200447	hsa-miR-3165	CLIP-seq
MIRT1200448	hsa-miR-3622a-3p	CLIP-seq
MIRT1200449	hsa-miR-3622b-3p	CLIP-seq
MIRT1200450	hsa-miR-3656	CLIP-seq
MIRT1200451	hsa-miR-3689a-3p	CLIP-seq
MIRT1200452	hsa-miR-3689c	CLIP-seq
MIRT1200453	hsa-miR-3913-5p	CLIP-seq
MIRT1200454	hsa-miR-3926	CLIP-seq
MIRT2286399	hsa-miR-4252	CLIP-seq
MIRT2286400	hsa-miR-4426	CLIP-seq
MIRT1200455	hsa-miR-4433	CLIP-seq
MIRT1200456	hsa-miR-4459	CLIP-seq
MIRT1200488	hsa-miR-4486	CLIP-seq
MIRT2286401	hsa-miR-4647	CLIP-seq
MIRT1200492	hsa-miR-4649-5p	CLIP-seq
MIRT2286402	hsa-miR-4659a-3p	CLIP-seq
MIRT2286403	hsa-miR-4659b-3p	CLIP-seq
MIRT2286404	hsa-miR-4662b	CLIP-seq
MIRT1200457	hsa-miR-4728-5p	CLIP-seq
MIRT1200495	hsa-miR-4747-5p	CLIP-seq
MIRT1200458	hsa-miR-4768-3p	CLIP-seq
MIRT1200459	hsa-miR-4786-5p	CLIP-seq
MIRT2286405	hsa-miR-4793-3p	CLIP-seq
MIRT2286406	hsa-miR-4797-5p	CLIP-seq
MIRT1200499	hsa-miR-508-5p	CLIP-seq
MIRT1200460	hsa-miR-544b	CLIP-seq
MIRT1200461	hsa-miR-548s	CLIP-seq
MIRT1200505	hsa-miR-578	CLIP-seq
MIRT1200506	hsa-miR-635	CLIP-seq
MIRT1200507	hsa-miR-661	CLIP-seq
MIRT1200509	hsa-miR-766	CLIP-seq
MIRT2286407	hsa-miR-942	CLIP-seq
MIRT1200450	hsa-miR-3656	CLIP-seq
MIRT2465760	hsa-miR-190	CLIP-seq
MIRT2465761	hsa-miR-190b	CLIP-seq
MIRT2465762	hsa-miR-297	CLIP-seq
MIRT1200446	hsa-miR-3122	CLIP-seq
MIRT2465763	hsa-miR-3149	CLIP-seq
MIRT1200447	hsa-miR-3165	CLIP-seq
MIRT1200448	hsa-miR-3622a-3p	CLIP-seq
MIRT1200449	hsa-miR-3622b-3p	CLIP-seq
MIRT1200450	hsa-miR-3656	CLIP-seq
MIRT1200451	hsa-miR-3689a-3p	CLIP-seq
MIRT1200452	hsa-miR-3689c	CLIP-seq
MIRT1200453	hsa-miR-3913-5p	CLIP-seq
MIRT1200455	hsa-miR-4433	CLIP-seq
MIRT1200456	hsa-miR-4459	CLIP-seq
MIRT1200457	hsa-miR-4728-5p	CLIP-seq
MIRT1200458	hsa-miR-4768-3p	CLIP-seq
MIRT1200459	hsa-miR-4786-5p	CLIP-seq
MIRT1200460	hsa-miR-544b	CLIP-seq
MIRT2465764	hsa-miR-885-5p	CLIP-seq
MIRT2584379	hsa-miR-1200	CLIP-seq
MIRT2286396	hsa-miR-1227	CLIP-seq
MIRT1200464	hsa-miR-1273	CLIP-seq
MIRT1200465	hsa-miR-138	CLIP-seq
MIRT2584380	hsa-miR-146a	CLIP-seq
MIRT2584381	hsa-miR-146b-5p	CLIP-seq
MIRT1200466	hsa-miR-1827	CLIP-seq
MIRT1200467	hsa-miR-1908	CLIP-seq
MIRT1200470	hsa-miR-2467-5p	CLIP-seq
MIRT1200446	hsa-miR-3122	CLIP-seq
MIRT1200447	hsa-miR-3165	CLIP-seq
MIRT1200476	hsa-miR-3188	CLIP-seq
MIRT2584382	hsa-miR-34b	CLIP-seq
MIRT2584383	hsa-miR-3614-5p	CLIP-seq
MIRT1200448	hsa-miR-3622a-3p	CLIP-seq
MIRT1200449	hsa-miR-3622b-3p	CLIP-seq
MIRT1200450	hsa-miR-3656	CLIP-seq
MIRT1200477	hsa-miR-3667-3p	CLIP-seq
MIRT2584384	hsa-miR-3675-3p	CLIP-seq
MIRT1200451	hsa-miR-3689a-3p	CLIP-seq
MIRT1200452	hsa-miR-3689c	CLIP-seq
MIRT1200480	hsa-miR-371-5p	CLIP-seq
MIRT1200481	hsa-miR-3907	CLIP-seq
MIRT1200453	hsa-miR-3913-5p	CLIP-seq
MIRT1200454	hsa-miR-3926	CLIP-seq
MIRT1200483	hsa-miR-3975	CLIP-seq
MIRT2584385	hsa-miR-4251	CLIP-seq
MIRT2286399	hsa-miR-4252	CLIP-seq
MIRT2584386	hsa-miR-4290	CLIP-seq
MIRT2584387	hsa-miR-4324	CLIP-seq
MIRT1200486	hsa-miR-4432	CLIP-seq
MIRT1200455	hsa-miR-4433	CLIP-seq
MIRT1200487	hsa-miR-4448	CLIP-seq
MIRT1200456	hsa-miR-4459	CLIP-seq
MIRT2584388	hsa-miR-4484	CLIP-seq
MIRT1200488	hsa-miR-4486	CLIP-seq
MIRT2584389	hsa-miR-4490	CLIP-seq
MIRT2584390	hsa-miR-4496	CLIP-seq
MIRT1200490	hsa-miR-451b	CLIP-seq
MIRT2584391	hsa-miR-4532	CLIP-seq
MIRT1200491	hsa-miR-4649-3p	CLIP-seq
MIRT1200492	hsa-miR-4649-5p	CLIP-seq
MIRT2584392	hsa-miR-4662a-5p	CLIP-seq
MIRT2584393	hsa-miR-4676-5p	CLIP-seq
MIRT2584394	hsa-miR-4684-5p	CLIP-seq
MIRT1200493	hsa-miR-4696	CLIP-seq
MIRT1200494	hsa-miR-4722-5p	CLIP-seq
MIRT1200457	hsa-miR-4728-5p	CLIP-seq
MIRT1200458	hsa-miR-4768-3p	CLIP-seq
MIRT2584395	hsa-miR-4773	CLIP-seq
MIRT2584396	hsa-miR-4774-5p	CLIP-seq
MIRT1200459	hsa-miR-4786-5p	CLIP-seq
MIRT2286405	hsa-miR-4793-3p	CLIP-seq
MIRT2286406	hsa-miR-4797-5p	CLIP-seq
MIRT2584397	hsa-miR-483-3p	CLIP-seq
MIRT1200498	hsa-miR-485-5p	CLIP-seq
MIRT1200499	hsa-miR-508-5p	CLIP-seq
MIRT1200460	hsa-miR-544b	CLIP-seq
MIRT1200501	hsa-miR-548ad	CLIP-seq
MIRT2584398	hsa-miR-548c-3p	CLIP-seq
MIRT1200502	hsa-miR-548q	CLIP-seq
MIRT1200461	hsa-miR-548s	CLIP-seq
MIRT1200503	hsa-miR-550a	CLIP-seq
MIRT1200504	hsa-miR-572	CLIP-seq
MIRT2584399	hsa-miR-575	CLIP-seq
MIRT2584400	hsa-miR-589	CLIP-seq
MIRT1200507	hsa-miR-661	CLIP-seq
MIRT1200508	hsa-miR-663	CLIP-seq
MIRT1200509	hsa-miR-766	CLIP-seq
MIRT1200510	hsa-miR-940	CLIP-seq
MIRT2584379	hsa-miR-1200	CLIP-seq
MIRT2286396	hsa-miR-1227	CLIP-seq
MIRT1200464	hsa-miR-1273	CLIP-seq
MIRT1200465	hsa-miR-138	CLIP-seq
MIRT2584380	hsa-miR-146a	CLIP-seq
MIRT2584381	hsa-miR-146b-5p	CLIP-seq
MIRT1200466	hsa-miR-1827	CLIP-seq
MIRT1200467	hsa-miR-1908	CLIP-seq
MIRT1200470	hsa-miR-2467-5p	CLIP-seq
MIRT1200446	hsa-miR-3122	CLIP-seq
MIRT1200447	hsa-miR-3165	CLIP-seq
MIRT1200476	hsa-miR-3188	CLIP-seq
MIRT2584382	hsa-miR-34b	CLIP-seq
MIRT2584383	hsa-miR-3614-5p	CLIP-seq
MIRT1200448	hsa-miR-3622a-3p	CLIP-seq
MIRT1200449	hsa-miR-3622b-3p	CLIP-seq
MIRT1200450	hsa-miR-3656	CLIP-seq
MIRT1200477	hsa-miR-3667-3p	CLIP-seq
MIRT2584384	hsa-miR-3675-3p	CLIP-seq
MIRT1200451	hsa-miR-3689a-3p	CLIP-seq
MIRT1200452	hsa-miR-3689c	CLIP-seq
MIRT1200480	hsa-miR-371-5p	CLIP-seq
MIRT1200481	hsa-miR-3907	CLIP-seq
MIRT1200453	hsa-miR-3913-5p	CLIP-seq
MIRT1200454	hsa-miR-3926	CLIP-seq
MIRT1200483	hsa-miR-3975	CLIP-seq
MIRT2584385	hsa-miR-4251	CLIP-seq
MIRT2286399	hsa-miR-4252	CLIP-seq
MIRT2584386	hsa-miR-4290	CLIP-seq
MIRT2584387	hsa-miR-4324	CLIP-seq
MIRT1200486	hsa-miR-4432	CLIP-seq
MIRT1200455	hsa-miR-4433	CLIP-seq
MIRT1200487	hsa-miR-4448	CLIP-seq
MIRT1200456	hsa-miR-4459	CLIP-seq
MIRT1200488	hsa-miR-4486	CLIP-seq
MIRT1200490	hsa-miR-451b	CLIP-seq
MIRT2584391	hsa-miR-4532	CLIP-seq
MIRT1200491	hsa-miR-4649-3p	CLIP-seq
MIRT1200492	hsa-miR-4649-5p	CLIP-seq
MIRT2584392	hsa-miR-4662a-5p	CLIP-seq
MIRT2584393	hsa-miR-4676-5p	CLIP-seq
MIRT2584394	hsa-miR-4684-5p	CLIP-seq
MIRT1200493	hsa-miR-4696	CLIP-seq
MIRT1200494	hsa-miR-4722-5p	CLIP-seq
MIRT1200457	hsa-miR-4728-5p	CLIP-seq
MIRT1200458	hsa-miR-4768-3p	CLIP-seq
MIRT2584395	hsa-miR-4773	CLIP-seq
MIRT1200459	hsa-miR-4786-5p	CLIP-seq
MIRT2286405	hsa-miR-4793-3p	CLIP-seq
MIRT2286406	hsa-miR-4797-5p	CLIP-seq
MIRT2584397	hsa-miR-483-3p	CLIP-seq
MIRT1200498	hsa-miR-485-5p	CLIP-seq
MIRT1200499	hsa-miR-508-5p	CLIP-seq
MIRT1200460	hsa-miR-544b	CLIP-seq
MIRT1200501	hsa-miR-548ad	CLIP-seq
MIRT2584398	hsa-miR-548c-3p	CLIP-seq
MIRT1200502	hsa-miR-548q	CLIP-seq
MIRT1200461	hsa-miR-548s	CLIP-seq
MIRT1200503	hsa-miR-550a	CLIP-seq
MIRT1200504	hsa-miR-572	CLIP-seq
MIRT2584399	hsa-miR-575	CLIP-seq
MIRT2584400	hsa-miR-589	CLIP-seq
MIRT1200507	hsa-miR-661	CLIP-seq
MIRT1200508	hsa-miR-663	CLIP-seq
MIRT1200509	hsa-miR-766	CLIP-seq
MIRT1200510	hsa-miR-940	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0004791	Function	Thioredoxin-disulfide reductase (NADPH) activity	IBA
GO:0004791	Function	Thioredoxin-disulfide reductase (NADPH) activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016055	Process	Wnt signaling pathway	IMP	29276006
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IBA
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IEA
GO:0030178	Process	Negative regulation of Wnt signaling pathway	ISS
GO:0031397	Process	Negative regulation of protein ubiquitination	IBA
GO:0031397	Process	Negative regulation of protein ubiquitination	IEA
GO:0031397	Process	Negative regulation of protein ubiquitination	ISS
GO:0047134	Function	Protein-disulfide reductase [NAD(P)H] activity	IEA
GO:0072359	Process	Circulatory system development	IEA
GO:0072359	Process	Circulatory system development	ISS
GO:0098869	Process	Cellular oxidant detoxification	IEA

MIM	HGNC	e!Ensembl
612895	18008	ENSG00000167693

Protein

UniProt ID

Q6DKJ4

Protein name

Nucleoredoxin (EC 1.8.1.8)

Protein function

Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13905	Thioredoxin_8	30 → 145	Thioredoxin-like	Domain
PF13905	Thioredoxin_8	193 → 287	Thioredoxin-like	Domain
PF13848	Thioredoxin_6	307 → 424		Domain

Sequence

MSGFLEELLGEKLVTGGGEEVDVHSLGARGISLLGLYFGCSLSAPCAQLSASLAAFYGRL
RGDAAAGPGPGAGAGAAAEPEPRRRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRK
LKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLR
NNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSE
ESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDE
DCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYK
AKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEA
FVNDFLAEKLKPEPI

Sequence length

435

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Robinow Syndrome	Robinow syndrome, autosomal recessive 2	rs1555607285, rs1555610590	N/A

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast Cancer	Breast cancer specific mortality in estrogen receptor positive breast cancer	N/A	N/A	GWAS
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	35406633
Carcinoma Hepatocellular	Inhibit	35927236
Neoplasm Metastasis	Inhibit	35927236
Neoplastic Syndromes Hereditary	Associate	32700628
Robinow Syndrome	Associate	33048444
Wilms Tumor	Associate	35578692

NXN (nucleoredoxin)