Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64342
Gene name Gene Name - the full gene name approved by the HGNC.	HCLS1 binding protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HS1BP3
Synonyms (NCBI Gene) Gene synonyms aliases	ETM2, HS1-BP3
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p24.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1/Hs1-interacting protein that may be involved in lymphocyte activation. [provided by RefSeq, Jul 2008]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023188	hsa-miR-124-3p	Microarray	18668037
MIRT1054780	hsa-miR-1185	CLIP-seq
MIRT1054781	hsa-miR-1324	CLIP-seq
MIRT1054782	hsa-miR-147	CLIP-seq
MIRT1054783	hsa-miR-1827	CLIP-seq
MIRT1054784	hsa-miR-2467-3p	CLIP-seq
MIRT1054785	hsa-miR-3135	CLIP-seq
MIRT1054786	hsa-miR-3177-5p	CLIP-seq
MIRT1054787	hsa-miR-3179	CLIP-seq
MIRT1054788	hsa-miR-3202	CLIP-seq
MIRT1054789	hsa-miR-330-3p	CLIP-seq
MIRT1054790	hsa-miR-3679-5p	CLIP-seq
MIRT1054791	hsa-miR-3684	CLIP-seq
MIRT1054792	hsa-miR-370	CLIP-seq
MIRT1054793	hsa-miR-3911	CLIP-seq
MIRT1054794	hsa-miR-4271	CLIP-seq
MIRT1054795	hsa-miR-4640-5p	CLIP-seq
MIRT1054796	hsa-miR-4650-5p	CLIP-seq
MIRT1054797	hsa-miR-4725-3p	CLIP-seq
MIRT1054798	hsa-miR-4726-5p	CLIP-seq
MIRT1054799	hsa-miR-4731-5p	CLIP-seq
MIRT1054800	hsa-miR-4747-5p	CLIP-seq
MIRT1054801	hsa-miR-4779	CLIP-seq
MIRT1054802	hsa-miR-489	CLIP-seq
MIRT1054803	hsa-miR-580	CLIP-seq
MIRT1054804	hsa-miR-644	CLIP-seq
MIRT1054805	hsa-miR-892a	CLIP-seq
MIRT2012461	hsa-miR-1237	CLIP-seq
MIRT2012462	hsa-miR-124	CLIP-seq
MIRT2012463	hsa-miR-1248	CLIP-seq
MIRT2012464	hsa-miR-1291	CLIP-seq
MIRT2012465	hsa-miR-1913	CLIP-seq
MIRT2012466	hsa-miR-3173-5p	CLIP-seq
MIRT2012467	hsa-miR-3189-5p	CLIP-seq
MIRT2012468	hsa-miR-324-3p	CLIP-seq
MIRT2012469	hsa-miR-3607-5p	CLIP-seq
MIRT2012470	hsa-miR-3622a-5p	CLIP-seq
MIRT2012471	hsa-miR-3714	CLIP-seq
MIRT2012472	hsa-miR-3910	CLIP-seq
MIRT1054794	hsa-miR-4271	CLIP-seq
MIRT2012473	hsa-miR-4501	CLIP-seq
MIRT2012474	hsa-miR-4504	CLIP-seq
MIRT2012475	hsa-miR-4521	CLIP-seq
MIRT2012476	hsa-miR-4713-5p	CLIP-seq
MIRT1054797	hsa-miR-4725-3p	CLIP-seq
MIRT1054800	hsa-miR-4747-5p	CLIP-seq
MIRT2012477	hsa-miR-4758-3p	CLIP-seq
MIRT2012478	hsa-miR-506	CLIP-seq
MIRT2012479	hsa-miR-542-3p	CLIP-seq
MIRT2012480	hsa-miR-564	CLIP-seq
MIRT2012481	hsa-miR-670	CLIP-seq
MIRT2244753	hsa-miR-1343	CLIP-seq
MIRT2244754	hsa-miR-193a-5p	CLIP-seq
MIRT2244755	hsa-miR-204	CLIP-seq
MIRT2244756	hsa-miR-211	CLIP-seq
MIRT2244757	hsa-miR-3153	CLIP-seq
MIRT1054787	hsa-miR-3179	CLIP-seq
MIRT1054788	hsa-miR-3202	CLIP-seq
MIRT2244758	hsa-miR-4251	CLIP-seq
MIRT1054794	hsa-miR-4271	CLIP-seq
MIRT2244759	hsa-miR-4283	CLIP-seq
MIRT2244760	hsa-miR-4287	CLIP-seq
MIRT2244761	hsa-miR-4420	CLIP-seq
MIRT2244762	hsa-miR-4469	CLIP-seq
MIRT2244763	hsa-miR-4477a	CLIP-seq
MIRT2244764	hsa-miR-4489	CLIP-seq
MIRT2244765	hsa-miR-4492	CLIP-seq
MIRT2244766	hsa-miR-4498	CLIP-seq
MIRT2244767	hsa-miR-4646-5p	CLIP-seq
MIRT2244768	hsa-miR-4685-3p	CLIP-seq
MIRT2244769	hsa-miR-4711-5p	CLIP-seq
MIRT1054797	hsa-miR-4725-3p	CLIP-seq
MIRT1054799	hsa-miR-4731-5p	CLIP-seq
MIRT1054800	hsa-miR-4747-5p	CLIP-seq
MIRT2244770	hsa-miR-508-5p	CLIP-seq
MIRT1054803	hsa-miR-580	CLIP-seq
MIRT2244771	hsa-miR-762	CLIP-seq
MIRT2389184	hsa-miR-4663	CLIP-seq
MIRT2389185	hsa-miR-558	CLIP-seq
MIRT1054782	hsa-miR-147	CLIP-seq
MIRT1054789	hsa-miR-330-3p	CLIP-seq
MIRT1054793	hsa-miR-3911	CLIP-seq
MIRT1054804	hsa-miR-644	CLIP-seq
MIRT1054805	hsa-miR-892a	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005739	Component	Mitochondrion	IDA	21699750
GO:0005783	Component	Endoplasmic reticulum	IDA	21699750
GO:0035091	Function	Phosphatidylinositol binding	IEA
GO:0042981	Process	Regulation of apoptotic process	IMP	21699750

MIM	HGNC	e!Ensembl
609359	24979	ENSG00000118960

Protein

UniProt ID

Q53T59

Protein name

HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3)

Protein function

May be a modulator of IL-2 signaling.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00787	PX	57 → 138	PX domain	Domain

Sequence

MQSPAVLVTSRRLQNAHTGLDLTVPQHQEVRGKMMSGHVEYQILVVTRLAAFKSAKHRPE
DVVQFLVSKKYSEIEEFYQKLSSRYAAASLPPLPRKVLFVGESDIRERRAVFNEILRCVS
KDAELAGSPELLEFLGTRSPGAAGLTSRDSSVLDGTDSQTGNDEEAFDFFEEQDQVAEEG
PPVQSLKGEDAEESLEEEEALDPLGIMRSKKPKKHPKVAVKAKPSPRLTIFDEEVDPDEG
LFGPGRKLSPQDPSEDVSSVDPLKLFDDPDLGGAIPLGDSLLLPAACESGGPTPSLSHRD
ASKELFRVEEDLDQILNLGAEPKPKPQLKPKPPVAAKPVIPRKPAVPPKAGPAEAVAGQQ
KPQEQIQAMDEMDILQYIQDHDTPAQAAPSLF

Sequence length

392

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Essential Tremor	Associate	15699368, 19524641
Pain	Associate	29156910

HS1BP3 (HCLS1 binding protein 3)