MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2)

Gene

• Entrez ID: 643246
• Gene name: Microtubule associated protein 1 light chain 3 beta 2
• Gene symbol: MAP1LC3B2
• Synonyms (NCBI Gene): ATG8G
• Chromosome: 12
• Chromosome location: 12q24.22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028572	hsa-miR-30a-5p	Proteomics	18668040
MIRT1127716	hsa-miR-1178	CLIP-seq
MIRT1127717	hsa-miR-124	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT1127721	hsa-miR-3614-5p	CLIP-seq
MIRT1127722	hsa-miR-3670	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT1127724	hsa-miR-3714	CLIP-seq
MIRT1127725	hsa-miR-3910	CLIP-seq
MIRT1127726	hsa-miR-432	CLIP-seq
MIRT1127727	hsa-miR-4328	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127730	hsa-miR-4633-3p	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127732	hsa-miR-4677-3p	CLIP-seq
MIRT1127733	hsa-miR-4679	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq
MIRT1127735	hsa-miR-506	CLIP-seq
MIRT1127736	hsa-miR-890	CLIP-seq
MIRT1127716	hsa-miR-1178	CLIP-seq
MIRT1551100	hsa-miR-320a	CLIP-seq
MIRT1551101	hsa-miR-320b	CLIP-seq
MIRT1551102	hsa-miR-320c	CLIP-seq
MIRT1551103	hsa-miR-320d	CLIP-seq
MIRT1551104	hsa-miR-4429	CLIP-seq
MIRT2036234	hsa-miR-1273e	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT2036235	hsa-miR-3545-3p	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT1127727	hsa-miR-4328	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127732	hsa-miR-4677-3p	CLIP-seq
MIRT1127733	hsa-miR-4679	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq
MIRT2036236	hsa-miR-494	CLIP-seq
MIRT2036237	hsa-miR-544	CLIP-seq
MIRT2036234	hsa-miR-1273e	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT2036235	hsa-miR-3545-3p	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT2266535	hsa-miR-369-5p	CLIP-seq
MIRT2266536	hsa-miR-4264	CLIP-seq
MIRT1127727	hsa-miR-4328	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127732	hsa-miR-4677-3p	CLIP-seq
MIRT1127733	hsa-miR-4679	CLIP-seq
MIRT2266537	hsa-miR-4695-3p	CLIP-seq
MIRT2266538	hsa-miR-4797-3p	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq
MIRT2036236	hsa-miR-494	CLIP-seq
MIRT2036237	hsa-miR-544	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT2036235	hsa-miR-3545-3p	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT2266535	hsa-miR-369-5p	CLIP-seq
MIRT2266536	hsa-miR-4264	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127732	hsa-miR-4677-3p	CLIP-seq
MIRT1127733	hsa-miR-4679	CLIP-seq
MIRT2266537	hsa-miR-4695-3p	CLIP-seq
MIRT2266538	hsa-miR-4797-3p	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127732	hsa-miR-4677-3p	CLIP-seq
MIRT1127733	hsa-miR-4679	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq
MIRT1127718	hsa-miR-1292	CLIP-seq
MIRT1127719	hsa-miR-141	CLIP-seq
MIRT1127720	hsa-miR-200a	CLIP-seq
MIRT1127723	hsa-miR-3682-3p	CLIP-seq
MIRT1127728	hsa-miR-4471	CLIP-seq
MIRT1127729	hsa-miR-452	CLIP-seq
MIRT1127731	hsa-miR-4676-3p	CLIP-seq
MIRT1127734	hsa-miR-483-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000045	Process	Autophagosome assembly	IBA
GO:0000045	Process	Autophagosome assembly	IEA
GO:0000421	Component	Autophagosome membrane	IBA
GO:0000421	Component	Autophagosome membrane	IEA
GO:0000422	Process	Autophagy of mitochondrion	IEA
GO:0000423	Process	Mitophagy	IBA
GO:0005543	Function	Phospholipid binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005776	Component	Autophagosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0006914	Process	Autophagy	IEA
GO:0006995	Process	Cellular response to nitrogen starvation	IBA
GO:0008017	Function	Microtubule binding	IBA
GO:0008429	Function	Phosphatidylethanolamine binding	IBA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IBA
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0097352	Process	Autophagosome maturation	IBA
GO:0097352	Process	Autophagosome maturation	IEA

Other IDs

• MIM: 620673
• HGNC: 34390
• e!Ensembl: ENSG00000258102

Protein

• UniProt ID: A6NCE7
• Protein name: Microtubule-associated protein 1 light chain 3 beta 2 (Microtubule-associated proteins 1A/1B light chain 3 beta 2) (Microtubule-associated proteins 1A/1B light chain 3B-like) (MAP1A/MAP1B LC3 B-like) (MAP1A/MAP1B light chain 3 B-like)
• Protein function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cel
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02991	Atg8	15 → 120	Autophagy protein Atg8 ubiquitin like	Domain

• Sequence:

  MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
  SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVCASQETFG
  MKLSV

• Sequence length: 125

Pathways

KEGG:

Mitophagy - animal
Autophagy - animal
Ferroptosis
Apelin signaling pathway
NOD-like receptor signaling pathway
Amyotrophic lateral sclerosis
Pathways of neurodegeneration - multiple diseases
Shigellosis
Kaposi sarcoma-associated herpesvirus infection

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