Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6430
Gene name Gene Name - the full gene name approved by the HGNC.	Serine and arginine rich splicing factor 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SRSF5
Synonyms (NCBI Gene) Gene synonyms aliases	HRS, SFRS5, SRP40
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q24.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023067	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT024020	hsa-miR-1-3p	Proteomics	18668040
MIRT049180	hsa-miR-92a-3p	CLASH	23622248
MIRT036252	hsa-miR-1236-3p	CLASH	23622248
MIRT1390809	hsa-miR-1197	CLIP-seq
MIRT1390810	hsa-miR-1276	CLIP-seq
MIRT1390811	hsa-miR-1283	CLIP-seq
MIRT1390812	hsa-miR-198	CLIP-seq
MIRT1390813	hsa-miR-3065-5p	CLIP-seq
MIRT1390814	hsa-miR-3127-3p	CLIP-seq
MIRT1390815	hsa-miR-323-5p	CLIP-seq
MIRT1390816	hsa-miR-338-3p	CLIP-seq
MIRT1390817	hsa-miR-4311	CLIP-seq
MIRT1390818	hsa-miR-4530	CLIP-seq
MIRT1390819	hsa-miR-4690-3p	CLIP-seq
MIRT1390820	hsa-miR-4725-5p	CLIP-seq
MIRT1390821	hsa-miR-4780	CLIP-seq
MIRT1390822	hsa-miR-504	CLIP-seq
MIRT1390823	hsa-miR-520d-5p	CLIP-seq
MIRT1390824	hsa-miR-524-5p	CLIP-seq
MIRT1390825	hsa-miR-570	CLIP-seq
MIRT1390826	hsa-miR-583	CLIP-seq
MIRT1390827	hsa-miR-646	CLIP-seq
MIRT1390828	hsa-miR-765	CLIP-seq
MIRT1390829	hsa-miR-876-3p	CLIP-seq
MIRT1390830	hsa-miR-1303	CLIP-seq
MIRT1390831	hsa-miR-1305	CLIP-seq
MIRT1390813	hsa-miR-3065-5p	CLIP-seq
MIRT1390832	hsa-miR-3122	CLIP-seq
MIRT1390814	hsa-miR-3127-3p	CLIP-seq
MIRT1390833	hsa-miR-374c	CLIP-seq
MIRT1390834	hsa-miR-3913-5p	CLIP-seq
MIRT1390835	hsa-miR-3924	CLIP-seq
MIRT1390836	hsa-miR-421	CLIP-seq
MIRT1390837	hsa-miR-451b	CLIP-seq
MIRT1390838	hsa-miR-4666-3p	CLIP-seq
MIRT1390819	hsa-miR-4690-3p	CLIP-seq
MIRT1390820	hsa-miR-4725-5p	CLIP-seq
MIRT1390839	hsa-miR-4766-3p	CLIP-seq
MIRT1390821	hsa-miR-4780	CLIP-seq
MIRT1390822	hsa-miR-504	CLIP-seq
MIRT1390840	hsa-miR-584	CLIP-seq
MIRT1390841	hsa-miR-655	CLIP-seq
MIRT1390809	hsa-miR-1197	CLIP-seq
MIRT1390810	hsa-miR-1276	CLIP-seq
MIRT1390812	hsa-miR-198	CLIP-seq
MIRT2116980	hsa-miR-3143	CLIP-seq
MIRT1390816	hsa-miR-338-3p	CLIP-seq
MIRT1390817	hsa-miR-4311	CLIP-seq
MIRT2116981	hsa-miR-4511	CLIP-seq
MIRT1390818	hsa-miR-4530	CLIP-seq
MIRT1390819	hsa-miR-4690-3p	CLIP-seq
MIRT2116982	hsa-miR-4711-3p	CLIP-seq
MIRT1390820	hsa-miR-4725-5p	CLIP-seq
MIRT1390821	hsa-miR-4780	CLIP-seq
MIRT1390822	hsa-miR-504	CLIP-seq
MIRT2116983	hsa-miR-543	CLIP-seq
MIRT1390826	hsa-miR-583	CLIP-seq
MIRT1390827	hsa-miR-646	CLIP-seq
MIRT1390828	hsa-miR-765	CLIP-seq
MIRT2633171	hsa-miR-124	CLIP-seq
MIRT1390830	hsa-miR-1303	CLIP-seq
MIRT2633172	hsa-miR-3129-3p	CLIP-seq
MIRT2633173	hsa-miR-3714	CLIP-seq
MIRT2633174	hsa-miR-3910	CLIP-seq
MIRT1390835	hsa-miR-3924	CLIP-seq
MIRT2633175	hsa-miR-4427	CLIP-seq
MIRT2633176	hsa-miR-4680-3p	CLIP-seq
MIRT1390820	hsa-miR-4725-5p	CLIP-seq
MIRT1390821	hsa-miR-4780	CLIP-seq
MIRT1390822	hsa-miR-504	CLIP-seq
MIRT2633177	hsa-miR-506	CLIP-seq
MIRT1390825	hsa-miR-570	CLIP-seq
MIRT2633178	hsa-miR-595	CLIP-seq
MIRT1390835	hsa-miR-3924	CLIP-seq
MIRT1390820	hsa-miR-4725-5p	CLIP-seq
MIRT1390821	hsa-miR-4780	CLIP-seq
MIRT1390822	hsa-miR-504	CLIP-seq
MIRT1390825	hsa-miR-570	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA	21873635
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003729	Function	MRNA binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	12762840, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006376	Process	MRNA splice site selection	TAS	7556075
GO:0006397	Process	MRNA processing	TAS	7556075
GO:0006405	Process	RNA export from nucleus	TAS
GO:0006406	Process	MRNA export from nucleus	TAS
GO:0016607	Component	Nuclear speck	IBA	21873635
GO:0016607	Component	Nuclear speck	ISS
GO:0031124	Process	MRNA 3'-end processing	TAS
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0033120	Process	Positive regulation of RNA splicing	IEA
GO:0043422	Function	Protein kinase B binding	IEA
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0097421	Process	Liver regeneration	IEA

MIM	HGNC	e!Ensembl
600914	10787	ENSG00000100650

Protein

UniProt ID

Q13243

Protein name

Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)

Protein function

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	6 → 68	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	110 → 175	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Sequence

MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGK
ELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLIVENLSSRVS
WQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGRKIKLIEGS
KRHSRSRSRSRSRTRSSSRSRSRSRSRSRKSYSRSRSRSRSRSRSKSRSVSRSPVPEKSQ
KRGSSSRSKSPASVDRQRSRSRSRSRSVDSGN

Sequence length

272

Interactions

View interactions

	KEGG		Reactome
	Spliceosome Herpes simplex virus 1 infection		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination

SRSF5 (serine and arginine rich splicing factor 5)