CXCR5 (C-X-C motif chemokine receptor 5)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
643
Gene name Gene Name - the full gene name approved by the HGNC.
C-X-C motif chemokine receptor 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CXCR5
Synonyms (NCBI Gene) Gene synonyms aliases
BLR1, CD185, MDR15
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt`s lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migr
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(48)
miRTarBase ID miRNA Experiments Reference
MIRT659242 hsa-miR-548ae-3p HITS-CLIP 23824327
MIRT659241 hsa-miR-548ah-3p HITS-CLIP 23824327
MIRT659240 hsa-miR-548aj-3p HITS-CLIP 23824327
MIRT659239 hsa-miR-548am-3p HITS-CLIP 23824327
MIRT659238 hsa-miR-548aq-3p HITS-CLIP 23824327
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
RARA Activation 14993281
RXRA Activation 14993281
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(26)
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity TAS 1425907
GO:0005515 Function Protein binding IPI 23773523, 25241761
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS 1425907
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601613 1060 ENSG00000160683
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P32302
Protein name C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185)
Protein function Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burk
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 68 → 322 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expression in mature B-cells and Burkitt lymphoma cells.
Sequence
Sequence length 372
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (14)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Asthma onset (childhood vs adult), Asthma (age of onset), Asthma, Asthma (childhood onset), Atopic asthma, Asthma in any disease N/A N/A GWAS
Biliary Cholangitis Primary biliary cholangitis N/A N/A GWAS
Biliary Cirrhosis Primary biliary cirrhosis N/A N/A GWAS
Celiac disease Celiac disease N/A N/A GWAS
Show/Hide Text Mining Associations (128)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Inhibit 33579314
Achondroplasia and Swiss type agammaglobulinemia Associate 21488866
Acquired Immunodeficiency Syndrome Associate 9226150
Adenocarcinoma of Lung Associate 32549766
Adenocarcinoma of Lung Inhibit 35768814
Alopecia Areata Associate 20546884
Arthritis Rheumatoid Associate 15780119, 19804625, 28569167, 31882654, 36270740, 36341562, 37382265, 39586747
Arthritis Rheumatoid Inhibit 16207316, 34382069
Arthritis Rheumatoid Stimulate 22649468, 28004828, 28150777, 35095831
Autoimmune Diseases Associate 30632146, 34446066, 39739032