Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6423
Gene name Gene Name - the full gene name approved by the HGNC.
Secreted frizzled related protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SFRP2
Synonyms (NCBI Gene) Gene synonyms aliases
FRP-2, SARP1, SDF-5
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q31.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the p
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003607 hsa-miR-29a-3p Luciferase reporter assay, qRT-PCR, Western blot 20551325
MIRT006749 hsa-miR-218-5p Luciferase reporter assay 21501592
MIRT006749 hsa-miR-218-5p Luciferase reporter assay 21501592
MIRT006749 hsa-miR-218-5p Luciferase reporter assay 21501592
MIRT006749 hsa-miR-218-5p Luciferase reporter assay 23060446
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001569 Process Branching involved in blood vessel morphogenesis ISS
GO:0001968 Function Fibronectin binding ISS
GO:0002063 Process Chondrocyte development IEA
GO:0003151 Process Outflow tract morphogenesis IMP 19593212
GO:0003214 Process Cardiac left ventricle morphogenesis IMP 19593212
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604157 10777 ENSG00000145423
Protein
UniProt ID Q96HF1
Protein name Secreted frizzled-related protein 2 (FRP-2) (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1)
Protein function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01392 Fz 40 150 Fz domain Domain
PF01759 NTR 187 285 UNC-6/NTR/C345C module Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. {ECO:0000269|PubMed:9391078, ECO:0000269|Pub
Sequence
Sequence length 295
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Wnt signaling pathway  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
18283316
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
18283316
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
18716850, 17923031
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
18716850, 17923031
Unknown
Disease term Disease name Evidence References Source
Chromophobe carcinoma Chromophobe Renal Cell Carcinoma 18404682 ClinVar
Diabetes Diabetes GWAS
Dermatitis Dermatitis GWAS
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
ACTH Secreting Pituitary Adenoma Inhibit 29620167
Adenocarcinoma Associate 19513747, 26482433
Adenocarcinoma Inhibit 37999144
Adenocarcinoma Mucinous Associate 20686305
Adenoma Inhibit 17131472
Adenoma Associate 17352030, 19700653, 21154739, 25432628, 25759530, 27896617, 28753106, 29620167, 30578081, 34477243
Alopecia Associate 35862273
Alzheimer Disease Associate 26482433
Astrocytoma Associate 32647207
Breast Neoplasms Associate 18283316, 18403594, 18990230, 19513569, 22026417