Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6422
Gene name Gene Name - the full gene name approved by the HGNC.
Secreted frizzled related protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SFRP1
Synonyms (NCBI Gene) Gene synonyms aliases
FRP, FRP-1, FRP1, FrzA, SARP2
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p11.21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes lead
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017159 hsa-miR-335-5p Microarray 18185580
MIRT052899 hsa-miR-1260b Luciferase reporter assay, qRT-PCR, Western blot 23591200
MIRT052899 hsa-miR-1260b Luciferase reporter assay, qRT-PCR, Western blot 23591200
MIRT438354 hsa-miR-206 Flow, qRT-PCR 24855559
MIRT438280 hsa-miR-127-3p Luciferase reporter assay, qRT-PCR, Western blot 24517116
Transcription factors
Transcription factor Regulation Reference
DNMT1 Unknown 23770846;24374650
DNMT3A Unknown 24374650
EZH2 Unknown 21515604
GLI1 Activation 19930158
HDAC1 Unknown 23770846
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001649 Process Osteoblast differentiation IEP 16149051
GO:0001657 Process Ureteric bud development IEA
GO:0001756 Process Somitogenesis IEA
GO:0001843 Process Neural tube closure IEA
GO:0001954 Process Positive regulation of cell-matrix adhesion ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604156 10776 ENSG00000104332
Protein
UniProt ID Q8N474
Protein name Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2)
Protein function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-cat
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01392 Fz 58 165 Fz domain Domain
PF01759 NTR 200 296 UNC-6/NTR/C345C module Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle c
Sequence
Sequence length 314
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Wnt signaling pathway  
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acro Osteolysis Associate 23334979
Adenocarcinoma Associate 18831746, 19513747, 26482433, 32764696
Adenocarcinoma in Situ Associate 21731750
Adenocarcinoma of Lung Associate 21731750
Adenoma Inhibit 16523202, 17131472
Adenoma Associate 21154739, 22248913, 25432628, 25915531, 27896617, 28058013, 28753106, 30578081
Adenomatous Polyposis Coli Associate 20628379, 28708837
Aphasia Associate 27251476
Arthritis Rheumatoid Associate 12428226, 21515604
Asthma Associate 25147914