Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	64211
Gene name	LIM homeobox 5
Gene symbol	LHX5
Synonyms (NCBI Gene)	-
Chromosome	12
Chromosome location	12q24.13
Summary	This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of different

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miRTarBase ID	miRNA	Experiments	Reference
MIRT711617	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT711615	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT711614	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT711613	hsa-miR-3183	HITS-CLIP	19536157
MIRT711612	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT711611	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT711610	hsa-miR-4469	HITS-CLIP	19536157
MIRT711609	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT711607	hsa-miR-4287	HITS-CLIP	19536157
MIRT711608	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT711606	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT711605	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT711604	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT711603	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT711602	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT711601	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT711600	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT711599	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT711598	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT711596	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT711597	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT711617	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT711615	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT711614	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT711613	hsa-miR-3183	HITS-CLIP	19536157
MIRT711612	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT711611	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT711610	hsa-miR-4469	HITS-CLIP	19536157
MIRT711609	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT711607	hsa-miR-4287	HITS-CLIP	19536157
MIRT711608	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT711606	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT711605	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT711604	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT711603	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT711602	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT711601	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT711600	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT711599	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT711598	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT711596	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT711597	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT2390128	hsa-miR-1270	CLIP-seq
MIRT2390129	hsa-miR-1273f	CLIP-seq
MIRT2390130	hsa-miR-185	CLIP-seq
MIRT2390131	hsa-miR-4254	CLIP-seq
MIRT2390132	hsa-miR-4306	CLIP-seq
MIRT2390133	hsa-miR-4644	CLIP-seq
MIRT2390134	hsa-miR-4651	CLIP-seq
MIRT2390135	hsa-miR-4683	CLIP-seq
MIRT2390136	hsa-miR-608	CLIP-seq
MIRT2390137	hsa-miR-620	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007267	Process	Cell-cell signaling	IEA
GO:0007405	Process	Neuroblast proliferation	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0021527	Process	Spinal cord association neuron differentiation	IEA
GO:0021549	Process	Cerebellum development	IEA
GO:0021702	Process	Cerebellar Purkinje cell differentiation	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0021846	Process	Cell proliferation in forebrain	IEA
GO:0021879	Process	Forebrain neuron differentiation	IEA
GO:0021937	Process	Cerebellar Purkinje cell-granule cell precursor cell signaling	IEA
GO:0030182	Process	Neuron differentiation	IBA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1902692	Process	Regulation of neuroblast proliferation	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
605992	14216	ENSG00000089116

Q9H2C1

Protein name

LIM/homeobox protein Lhx5 (LIM homeobox protein 5)

Protein function

Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00412	LIM	5 → 60	LIM domain	Domain
PF00412	LIM	64 → 123	LIM domain	Domain
PF00046	Homeodomain	181 → 237	Homeodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in fetal brain and in various regions of the adult central nervous system including the spinal cord, the thalamus, and the cerebellum.

Sequence

MMVHCAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCFSREGKLYCKNDFFRRF
GTKCAGCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDYL
SSSSLKEGSLNSVSSCTDRSLSPDLQDALQDDPKETDNSTSSDKETANNENEEQNSGTKR
RGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQ
LSALGARRHAFFRSPRRMRPLGGRLDESEMLGSTPYTYYGDYQGDYYAPGSNYDFFAHGP
PSQAQSPADSSFLAASGPGSTPLGALEPPLAGPHAADNPRFTDMISHPDTPSPEPGLPGT
LHPMPGEVFSGGPSPPFPMSGTSGYSGPLSHPNPELNEAAVW

Sequence length

402

Interactions

View interactions

	KEGG
	Signaling pathways regulating pluripotency of stem cells

LHX5 (LIM homeobox 5)