DPEP3 (dipeptidase 3)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
64180
Gene name Gene Name - the full gene name approved by the HGNC.
Dipeptidase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DPEP3
Synonyms (NCBI Gene) Gene synonyms aliases
MBD3
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with anothe
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
GO ID Ontology Definition Evidence Reference
GO:0001669 Component Acrosomal vesicle ISS
GO:0005515 Function Protein binding IPI 30097533
GO:0005886 Component Plasma membrane ISS
GO:0006508 Process Proteolysis IEA
GO:0016805 Function Dipeptidase activity ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
609926 23029 ENSG00000141096
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9H4B8
Protein name Dipeptidase 3
Protein function Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (PubMed:32325220). The absence of activity may be due to the inability of asparagine (instead of aspartate found i
PDB 6VGO , 6VGR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01244 Peptidase_M19 86 → 407 Membrane dipeptidase (Peptidase family M19) Domain
Sequence
Sequence length 488
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Synthesis of Leukotrienes (LT) and Eoxins (EX)
Aflatoxin activation and detoxification
LTC4-CYSLTR mediated IL4 production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Coronary heart disease Coronary heart disease 21347282 ClinVar
Show/Hide Text Mining Associations (5)
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Non Small Cell Lung Associate 37341056
Carcinoma Ovarian Epithelial Associate 32513564
Neoplasms Associate 32513564, 37341056
Ovarian Neoplasms Stimulate 32325220
Triple Negative Breast Neoplasms Associate 22140552