DPEP3 (dipeptidase 3)

Gene

• Entrez ID: 64180
• Gene name: Dipeptidase 3
• Gene symbol: DPEP3
• Synonyms (NCBI Gene): MBD3
• Chromosome: 16
• Chromosome location: 16q22.1
• Summary: This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with anothe

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0001669	Component	Acrosomal vesicle	ISS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016805	Function	Dipeptidase activity	IBA
GO:0016805	Function	Dipeptidase activity	IDA	32325220
GO:0016805	Function	Dipeptidase activity	ISS
GO:0098552	Component	Side of membrane	IEA
GO:1901749	Process	Leukotriene D4 catabolic process	IEA

Other IDs

• MIM: 609926
• HGNC: 23029
• e!Ensembl: ENSG00000141096

Protein

• UniProt ID: Q9H4B8
• Protein name: Dipeptidase 3
• Protein function: Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (PubMed:32325220). The absence of activity may be due to the inability of asparagine (instead of aspartate found i
• PDB: 6VGO, 6VGR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01244	Peptidase_M19	86 → 407	Membrane dipeptidase (Peptidase family M19)	Domain

• Sequence:

  MQPTGREGSRALSRRYLRRLLLLLLLLLLRQPVTRAETTPGAPRALSTLGSPSLFTTPGV
  PSALTTPGLTTPGTPKTLDLRGRAQALMRSFPLVDGHNDLPQVLRQRYKNVLQDVNLRNF
  SHGQTSLDRLRDGLVGAQFWSASVSCQSQDQTAVRLALEQIDLIHRMCASYSELELVTSA
  EGLNSSQKLACLIGVEGGHSLDSSLSVLRSFYVLGVRYLTLTFTCSTPWAESSTKFRHHM
  YTNVSGLTSFGEKVVEELNRLGMMIDLSYASDTLIRRVLEVSQAPVIFSHSAARAVCDNL
  LNVPDDILQLLKKNGGIVMVTLSMGVLQCNLLANVSTVADHFDHIRAVIGSEFIGIGGNY
  DGTGRFPQGLEDVSTYPVLIEELLSRSWSEEELQGVLRGNLLRVFRQVEKVREESRAQSP
  VEAEFPYGQLSTSCHSHLVPQNGHQATHLEVTKQPTNRVPWRSSNASPYLVPGLVAAATI
  PTFTQWLC

• Sequence length: 488

Pathways

Reactome:

Synthesis of Leukotrienes (LT) and Eoxins (EX)
Aflatoxin activation and detoxification
LTC4-CYSLTR mediated IL4 production