DPEP2 (dipeptidase 2)

Gene

• Entrez ID: 64174
• Gene name: Dipeptidase 2
• Gene symbol: DPEP2
• Synonyms (NCBI Gene): MBD2
• Chromosome: 16
• Chromosome location: 16q22.1
• Summary: DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione de

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006691	Process	Leukotriene metabolic process	ISS
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0016805	Function	Dipeptidase activity	IBA
GO:0016805	Function	Dipeptidase activity	IDA	32325220
GO:0016805	Function	Dipeptidase activity	IEA
GO:0016805	Function	Dipeptidase activity	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0070573	Function	Metallodipeptidase activity	IEA
GO:0098552	Component	Side of membrane	IEA
GO:1901749	Process	Leukotriene D4 catabolic process	IDA	32325220
GO:1901749	Process	Leukotriene D4 catabolic process	IEA

Other IDs

• MIM: 609925
• HGNC: 23028
• e!Ensembl: ENSG00000167261

Protein

• UniProt ID: Q9H4A9
• Protein name: Dipeptidase 2 (EC 3.4.13.19)
• Protein function: Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:32325220). Hydrolyzes cystinyl-bis-glycine (PubMed:32325220). ; Independently of its dipeptidase activity can also modul
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01244	Peptidase_M19	78 → 399	Membrane dipeptidase (Peptidase family M19)	Domain

• Sequence:

  MQPSGLEGPGTFGRWPLLSLLLLLLLLQPVTCAYTTPGPPRALTTLGAPRAHTMPGTYAP
  STTLSSPSTQGLQEQARALMRDFPLVDGHNDLPLVLRQVYQKGLQDVNLRNFSYGQTSLD
  RLRDGLVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRRMCASYSELELVTSAKALNDTQK
  LACLIGVEGGHSLDNSLSILRTFYMLGVRYLTLTHTCNTPWAESSAKGVHSFYNNISGLT
  DFGEKVVAEMNRLGMMVDLSHVSDAVARRALEVSQAPVIFSHSAARGVCNSARNVPDDIL
  QLLKKNGGVVMVSLSMGVIQCNPSANVSTVADHFDHIKAVIGSKFIGIGGDYDGAGKFPQ
  GLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDE
  QLSSSCHSDLSRLRQRQSLTSGQELTEIPIHWTAKLPAKWSVSESSPHMAPVLAVVATFP
  VLILWL

• Sequence length: 486

Pathways

Reactome:

Synthesis of Leukotrienes (LT) and Eoxins (EX)
Aflatoxin activation and detoxification
LTC4-CYSLTR mediated IL4 production