DPEP2 (dipeptidase 2)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
64174
Gene name Gene Name - the full gene name approved by the HGNC.
Dipeptidase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DPEP2
Synonyms (NCBI Gene) Gene synonyms aliases
MBD2
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione de
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
GO ID Ontology Definition Evidence Reference
GO:0006508 Process Proteolysis IEA
GO:0006629 Process Lipid metabolic process IEA
GO:0006691 Process Leukotriene metabolic process ISS
GO:0016805 Function Dipeptidase activity ISS
GO:0031225 Component Anchored component of membrane ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
609925 23028 ENSG00000167261
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9H4A9
Protein name Dipeptidase 2 (EC 3.4.13.19)
Protein function Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:32325220). Hydrolyzes cystinyl-bis-glycine (PubMed:32325220). ; Independently of its dipeptidase activity can also modul
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01244 Peptidase_M19 78 → 399 Membrane dipeptidase (Peptidase family M19) Domain
Sequence
Sequence length 486
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Synthesis of Leukotrienes (LT) and Eoxins (EX)
Aflatoxin activation and detoxification
LTC4-CYSLTR mediated IL4 production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Coronary heart disease Coronary heart disease 21347282 ClinVar
Show/Hide Text Mining Associations (4)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 36564744, 38204755
Coronary Artery Disease Associate 22664640
HIV Infections Associate 36123690
Neoplasms Associate 38204755