Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64174
Gene name Gene Name - the full gene name approved by the HGNC.	Dipeptidase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DPEP2
Synonyms (NCBI Gene) Gene synonyms aliases	MBD2
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione de

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006691	Process	Leukotriene metabolic process	ISS
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0016805	Function	Dipeptidase activity	IBA
GO:0016805	Function	Dipeptidase activity	IDA	32325220
GO:0016805	Function	Dipeptidase activity	IEA
GO:0016805	Function	Dipeptidase activity	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0070573	Function	Metallodipeptidase activity	IEA
GO:0098552	Component	Side of membrane	IEA
GO:1901749	Process	Leukotriene D4 catabolic process	IDA	32325220
GO:1901749	Process	Leukotriene D4 catabolic process	IEA

MIM	HGNC	e!Ensembl
609925	23028	ENSG00000167261

Protein

UniProt ID

Q9H4A9

Protein name

Dipeptidase 2 (EC 3.4.13.19)

Protein function

Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:32325220). Hydrolyzes cystinyl-bis-glycine (PubMed:32325220). ; Independently of its dipeptidase activity can also modul

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01244	Peptidase_M19	78 → 399	Membrane dipeptidase (Peptidase family M19)	Domain

Sequence

MQPSGLEGPGTFGRWPLLSLLLLLLLLQPVTCAYTTPGPPRALTTLGAPRAHTMPGTYAP
STTLSSPSTQGLQEQARALMRDFPLVDGHNDLPLVLRQVYQKGLQDVNLRNFSYGQTSLD
RLRDGLVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRRMCASYSELELVTSAKALNDTQK
LACLIGVEGGHSLDNSLSILRTFYMLGVRYLTLTHTCNTPWAESSAKGVHSFYNNISGLT
DFGEKVVAEMNRLGMMVDLSHVSDAVARRALEVSQAPVIFSHSAARGVCNSARNVPDDIL
QLLKKNGGVVMVSLSMGVIQCNPSANVSTVADHFDHIKAVIGSKFIGIGGDYDGAGKFPQ
GLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDE
QLSSSCHSDLSRLRQRQSLTSGQELTEIPIHWTAKLPAKWSVSESSPHMAPVLAVVATFP
VLILWL

Sequence length

486

Interactions

View interactions

	Reactome
			Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production

DPEP2 (dipeptidase 2)