Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64101
Gene name Gene Name - the full gene name approved by the HGNC.	Leucine rich repeat containing 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LRRC4
Synonyms (NCBI Gene) Gene synonyms aliases	NAG14, NGL-2
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q32.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008]

Show/Hide all(71)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016733	hsa-miR-335-5p	Microarray	18185580
MIRT022116	hsa-miR-124-3p	Microarray	18668037
MIRT437991	hsa-miR-182-5p	qRT-PCR, Immunohistochemistry, Luciferase reporter assay	24404152
MIRT437991	hsa-miR-182-5p	qRT-PCR, Immunohistochemistry, Luciferase reporter assay	24404152
MIRT437991	hsa-miR-182-5p	qRT-PCR, Immunohistochemistry, Luciferase reporter assay	24404152
MIRT437991	hsa-miR-182-5p	qRT-PCR, Immunohistochemistry, Luciferase reporter assay	24404152
MIRT719827	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT719825	hsa-miR-4469	HITS-CLIP	19536157
MIRT719826	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT719824	hsa-miR-4287	HITS-CLIP	19536157
MIRT719823	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT719822	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT719821	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT719820	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT719819	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT719818	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT719817	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT656617	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT656616	hsa-miR-5688	HITS-CLIP	23824327
MIRT656615	hsa-miR-8063	HITS-CLIP	23824327
MIRT719827	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT719825	hsa-miR-4469	HITS-CLIP	19536157
MIRT719826	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT719824	hsa-miR-4287	HITS-CLIP	19536157
MIRT719823	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT719822	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT719821	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT719820	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT719819	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT719818	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT719817	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT656617	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT656616	hsa-miR-5688	HITS-CLIP	23824327
MIRT656615	hsa-miR-8063	HITS-CLIP	23824327
MIRT1119619	hsa-miR-1237	CLIP-seq
MIRT1119620	hsa-miR-1247	CLIP-seq
MIRT1119621	hsa-miR-1248	CLIP-seq
MIRT1119622	hsa-miR-1283	CLIP-seq
MIRT1119623	hsa-miR-1343	CLIP-seq
MIRT1119624	hsa-miR-183	CLIP-seq
MIRT1119625	hsa-miR-2861	CLIP-seq
MIRT1119626	hsa-miR-3138	CLIP-seq
MIRT1119627	hsa-miR-3140-5p	CLIP-seq
MIRT1119628	hsa-miR-3153	CLIP-seq
MIRT1119629	hsa-miR-3184	CLIP-seq
MIRT1119630	hsa-miR-3192	CLIP-seq
MIRT1119631	hsa-miR-3607-5p	CLIP-seq
MIRT1119632	hsa-miR-3618	CLIP-seq
MIRT1119633	hsa-miR-423-5p	CLIP-seq
MIRT1119634	hsa-miR-4267	CLIP-seq
MIRT1119635	hsa-miR-4289	CLIP-seq
MIRT1119636	hsa-miR-4427	CLIP-seq
MIRT1119637	hsa-miR-4643	CLIP-seq
MIRT1119638	hsa-miR-4646-5p	CLIP-seq
MIRT1119639	hsa-miR-4668-5p	CLIP-seq
MIRT1119640	hsa-miR-4735-5p	CLIP-seq
MIRT1119641	hsa-miR-4757-5p	CLIP-seq
MIRT1119642	hsa-miR-552	CLIP-seq
MIRT1119643	hsa-miR-592	CLIP-seq
MIRT1119644	hsa-miR-597	CLIP-seq
MIRT1119645	hsa-miR-642b	CLIP-seq
MIRT1119646	hsa-miR-661	CLIP-seq
MIRT1119647	hsa-miR-759	CLIP-seq
MIRT1119648	hsa-miR-767-3p	CLIP-seq
MIRT1119649	hsa-miR-934	CLIP-seq
MIRT1119650	hsa-miR-942	CLIP-seq
MIRT1119629	hsa-miR-3184	CLIP-seq
MIRT1119633	hsa-miR-423-5p	CLIP-seq
MIRT2033809	hsa-miR-544b	CLIP-seq
MIRT2033810	hsa-miR-605	CLIP-seq
MIRT1119644	hsa-miR-597	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21946559
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0044309	Component	Neuron spine	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IBA
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0050808	Process	Synapse organization	IEA
GO:0060076	Component	Excitatory synapse	IEA
GO:0097119	Process	Postsynaptic density protein 95 clustering	IBA
GO:0097119	Process	Postsynaptic density protein 95 clustering	IEA
GO:0098632	Function	Cell-cell adhesion mediator activity	IBA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IBA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099560	Process	Synaptic membrane adhesion	IBA
GO:0099560	Process	Synaptic membrane adhesion	IEA
GO:1904861	Process	Excitatory synapse assembly	IBA
GO:1904861	Process	Excitatory synapse assembly	IEA

MIM	HGNC	e!Ensembl
610486	15586	ENSG00000128594

Protein

UniProt ID

Q9HBW1

Protein name

Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein BAG) (Nasopharyngeal carcinoma-associated gene 14 protein) (Netrin-G2 ligand) (NGL-2)

Protein function

Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic r

PDB

2DL9 , 3ZYI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	75 → 135	Leucine rich repeat	Repeat
PF13855	LRR_8	109 → 159	Leucine rich repeat	Repeat
PF13855	LRR_8	242 → 301	Leucine rich repeat	Repeat
PF07679	I-set	353 → 441	Immunoglobulin I-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Specifically expressed in brain. {ECO:0000269|PubMed:15967442}.

Sequence

MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVV
CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFN
GLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGE
LKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHG
LSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN
PWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPR
DLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTG
VYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTS
TGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLA
AAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPT
IHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI

Sequence length

653

Interactions

View interactions

	KEGG
	Axon guidance Cell adhesion molecules

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Oligodendroglioma	Oligodendroglioma	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Autism Spectrum Disorder	Associate	31332282
Brain Neoplasms	Inhibit	16215635
Carcinogenesis	Inhibit	16215635
Carcinoma Pancreatic Ductal	Associate	33593879
Colorectal Neoplasms	Associate	37728516
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	37728516
Endometrial Neoplasms	Associate	37728516
Glioblastoma	Associate	16215635, 27884160
Glioma	Associate	16215635, 27884160
Glioma	Inhibit	16723503, 18976507
Leukemia Myeloid Acute	Associate	32751923
Liposarcoma	Associate	30790560
Nasopharyngeal Carcinoma	Associate	26662436
Nasopharyngeal Diseases	Associate	26662436
Nasopharyngitis	Associate	26662436
Neoplasm Metastasis	Associate	16215635
Neoplasms	Associate	16215635, 18976507
Neoplasms	Inhibit	16723503, 27884160

LRRC4 (leucine rich repeat containing 4)