Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	64101
Gene name	Leucine rich repeat containing 4
Gene symbol	LRRC4
Synonyms (NCBI Gene)	NAG14NGL-2
Chromosome	7
Chromosome location	7q32.1
Summary	This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016733	hsa-miR-335-5p	Microarray	18185580
MIRT022116	hsa-miR-124-3p	Microarray	18668037
MIRT437991	hsa-miR-182-5p	qRT-PCRImmunohistochemistryLuciferase reporter assay	24404152
MIRT437991	hsa-miR-182-5p	qRT-PCRImmunohistochemistryLuciferase reporter assay	24404152
MIRT437991	hsa-miR-182-5p	qRT-PCRImmunohistochemistryLuciferase reporter assay	24404152
MIRT437991	hsa-miR-182-5p	qRT-PCRImmunohistochemistryLuciferase reporter assay	24404152
MIRT719827	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT719825	hsa-miR-4469	HITS-CLIP	19536157
MIRT719826	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT719824	hsa-miR-4287	HITS-CLIP	19536157
MIRT719823	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT719822	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT719821	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT719820	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT719819	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT719818	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT719817	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT656617	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT656616	hsa-miR-5688	HITS-CLIP	23824327
MIRT656615	hsa-miR-8063	HITS-CLIP	23824327
MIRT719827	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT719825	hsa-miR-4469	HITS-CLIP	19536157
MIRT719826	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT719824	hsa-miR-4287	HITS-CLIP	19536157
MIRT719823	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT719822	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT719821	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT719820	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT719819	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT719818	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT719817	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT656617	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT656616	hsa-miR-5688	HITS-CLIP	23824327
MIRT656615	hsa-miR-8063	HITS-CLIP	23824327
MIRT1119619	hsa-miR-1237	CLIP-seq
MIRT1119620	hsa-miR-1247	CLIP-seq
MIRT1119621	hsa-miR-1248	CLIP-seq
MIRT1119622	hsa-miR-1283	CLIP-seq
MIRT1119623	hsa-miR-1343	CLIP-seq
MIRT1119624	hsa-miR-183	CLIP-seq
MIRT1119625	hsa-miR-2861	CLIP-seq
MIRT1119626	hsa-miR-3138	CLIP-seq
MIRT1119627	hsa-miR-3140-5p	CLIP-seq
MIRT1119628	hsa-miR-3153	CLIP-seq
MIRT1119629	hsa-miR-3184	CLIP-seq
MIRT1119630	hsa-miR-3192	CLIP-seq
MIRT1119631	hsa-miR-3607-5p	CLIP-seq
MIRT1119632	hsa-miR-3618	CLIP-seq
MIRT1119633	hsa-miR-423-5p	CLIP-seq
MIRT1119634	hsa-miR-4267	CLIP-seq
MIRT1119635	hsa-miR-4289	CLIP-seq
MIRT1119636	hsa-miR-4427	CLIP-seq
MIRT1119637	hsa-miR-4643	CLIP-seq
MIRT1119638	hsa-miR-4646-5p	CLIP-seq
MIRT1119639	hsa-miR-4668-5p	CLIP-seq
MIRT1119640	hsa-miR-4735-5p	CLIP-seq
MIRT1119641	hsa-miR-4757-5p	CLIP-seq
MIRT1119642	hsa-miR-552	CLIP-seq
MIRT1119643	hsa-miR-592	CLIP-seq
MIRT1119644	hsa-miR-597	CLIP-seq
MIRT1119645	hsa-miR-642b	CLIP-seq
MIRT1119646	hsa-miR-661	CLIP-seq
MIRT1119647	hsa-miR-759	CLIP-seq
MIRT1119648	hsa-miR-767-3p	CLIP-seq
MIRT1119649	hsa-miR-934	CLIP-seq
MIRT1119650	hsa-miR-942	CLIP-seq
MIRT1119629	hsa-miR-3184	CLIP-seq
MIRT1119633	hsa-miR-423-5p	CLIP-seq
MIRT2033809	hsa-miR-544b	CLIP-seq
MIRT2033810	hsa-miR-605	CLIP-seq
MIRT1119644	hsa-miR-597	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21946559
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0044309	Component	Neuron spine	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IBA
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0050808	Process	Synapse organization	IEA
GO:0060076	Component	Excitatory synapse	IEA
GO:0097119	Process	Postsynaptic density protein 95 clustering	IBA
GO:0097119	Process	Postsynaptic density protein 95 clustering	IEA
GO:0098632	Function	Cell-cell adhesion mediator activity	IBA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IBA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099560	Process	Synaptic membrane adhesion	IBA
GO:0099560	Process	Synaptic membrane adhesion	IEA
GO:1904861	Process	Excitatory synapse assembly	IBA
GO:1904861	Process	Excitatory synapse assembly	IEA

MIM	HGNC	e!Ensembl
610486	15586	ENSG00000128594

Q9HBW1

Protein name

Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein BAG) (Nasopharyngeal carcinoma-associated gene 14 protein) (Netrin-G2 ligand) (NGL-2)

Protein function

Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic r

PDB

2DL9 , 3ZYI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	75 → 135	Leucine rich repeat	Repeat
PF13855	LRR_8	109 → 159	Leucine rich repeat	Repeat
PF13855	LRR_8	242 → 301	Leucine rich repeat	Repeat
PF07679	I-set	353 → 441	Immunoglobulin I-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Specifically expressed in brain. {ECO:0000269|PubMed:15967442}.

Sequence

MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVV
CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFN
GLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGE
LKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHG
LSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN
PWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPR
DLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTG
VYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTS
TGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLA
AAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPT
IHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI

Sequence length

653

Interactions

View interactions

	KEGG
	Axon guidance Cell adhesion molecules

LRRC4 (leucine rich repeat containing 4)