Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64087
Gene name	Methylcrotonyl-CoA carboxylase subunit 2
Gene symbol	MCCC2
Synonyms (NCBI Gene)	MCCBMCCCbeta
Chromosome	5
Chromosome location	5q13.2
Summary	This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrot

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SNP ID	Visualize variation	Clinical significance	Consequence
rs35068278	C>G	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Non coding transcript variant, coding sequence variant, genic downstream transcript variant, missense variant
rs119103219	G>A,C	Pathogenic, uncertain-significance	Missense variant, coding sequence variant, non coding transcript variant
rs119103220	G>A	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs119103221	C>G	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs119103223	G>C	Pathogenic, uncertain-significance	Missense variant, coding sequence variant, non coding transcript variant
rs119103225	A>G	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs119103226	G>T	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs140806722	T>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant, non coding transcript variant
rs141030969	C>T	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs147903984	C>G,T	Pathogenic	Coding sequence variant, stop gained, missense variant, non coding transcript variant
rs148773718	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, missense variant, genic downstream transcript variant
rs150591260	G>A,C	Conflicting-interpretations-of-pathogenicity, pathogenic-likely-pathogenic	Non coding transcript variant, genic downstream transcript variant, coding sequence variant, missense variant, intron variant
rs398124372	C>G	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs587776533	->T	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs727504010	C>T	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs730880265	G>A	Pathogenic	Splice donor variant, genic downstream transcript variant
rs748028684	C>A,T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs757052602	A>T	Pathogenic-likely-pathogenic, pathogenic	Missense variant, non coding transcript variant, coding sequence variant, intron variant, genic downstream transcript variant
rs763293192	C>T	Pathogenic	Coding sequence variant, stop gained, 3 prime UTR variant, non coding transcript variant, genic downstream transcript variant
rs766753795	A>G	Pathogenic	Intron variant, coding sequence variant, missense variant, non coding transcript variant
rs770769655	->C	Pathogenic	Intron variant, coding sequence variant, frameshift variant, non coding transcript variant
rs770917710	A>G	Likely-pathogenic	Intron variant
rs773774134	C>T	Pathogenic, conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, missense variant
rs776559643	A>G	Conflicting-interpretations-of-pathogenicity	Intron variant
rs780011606	C>T	Pathogenic	Coding sequence variant, stop gained, non coding transcript variant
rs780304038	CA>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant, genic downstream transcript variant
rs797044772	CAGA>TTGTCGAGGTAAGTGT	Likely-pathogenic	Coding sequence variant, inframe indel, non coding transcript variant
rs886043524	G>A	Likely-pathogenic	Coding sequence variant, intron variant, non coding transcript variant, missense variant
rs886060738	A>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, genic downstream transcript variant, non coding transcript variant, synonymous variant
rs1184301452	C>T	Pathogenic	Stop gained, coding sequence variant, non coding transcript variant
rs1190325113	C>-	Pathogenic	Frameshift variant, coding sequence variant, non coding transcript variant
rs1554134061	TG>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs1554137532	->T	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs1554138265	T>C	Likely-pathogenic	Splice donor variant, genic downstream transcript variant
rs1580273474	G>T	Likely-pathogenic	Splice donor variant
rs1580280976	->A	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs1580319814	GA>-	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant

640

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016273	hsa-miR-193b-3p	Proteomics	21512034
MIRT039205	hsa-miR-769-5p	CLASH	23622248
MIRT646936	hsa-miR-4714-3p	HITS-CLIP	23824327
MIRT646935	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT646934	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT646933	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT646932	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT646931	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT646930	hsa-miR-612	HITS-CLIP	23824327
MIRT646929	hsa-miR-6860	HITS-CLIP	23824327
MIRT646928	hsa-miR-4786-5p	HITS-CLIP	23824327
MIRT039205	hsa-miR-769-5p	HITS-CLIP	23824327
MIRT646927	hsa-miR-661	HITS-CLIP	23824327
MIRT646925	hsa-miR-3606-5p	HITS-CLIP	23824327
MIRT646926	hsa-miR-3672	HITS-CLIP	23824327
MIRT646924	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT646933	hsa-miR-1285-3p	PAR-CLIP	27292025
MIRT646932	hsa-miR-3187-5p	PAR-CLIP	27292025
MIRT646926	hsa-miR-3672	PAR-CLIP	27292025
MIRT646936	hsa-miR-4714-3p	PAR-CLIP	27292025
MIRT646928	hsa-miR-4786-5p	PAR-CLIP	27292025
MIRT646931	hsa-miR-5189-5p	PAR-CLIP	27292025
MIRT646930	hsa-miR-612	PAR-CLIP	27292025
MIRT646927	hsa-miR-661	PAR-CLIP	27292025
MIRT646935	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT646929	hsa-miR-6860	PAR-CLIP	27292025
MIRT646924	hsa-miR-6864-3p	PAR-CLIP	27292025
MIRT039205	hsa-miR-769-5p	PAR-CLIP	27292025
MIRT646934	hsa-miR-939-3p	PAR-CLIP	27292025
MIRT646936	hsa-miR-4714-3p	HITS-CLIP	23824327
MIRT646935	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT646934	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT646933	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT646932	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT646931	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT646930	hsa-miR-612	HITS-CLIP	23824327
MIRT646929	hsa-miR-6860	HITS-CLIP	23824327
MIRT646928	hsa-miR-4786-5p	HITS-CLIP	23824327
MIRT039205	hsa-miR-769-5p	HITS-CLIP	23824327
MIRT646927	hsa-miR-661	HITS-CLIP	23824327
MIRT646925	hsa-miR-3606-5p	HITS-CLIP	23824327
MIRT646926	hsa-miR-3672	HITS-CLIP	23824327
MIRT646924	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT1136561	hsa-miR-1183	CLIP-seq
MIRT1136562	hsa-miR-1207-3p	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136564	hsa-miR-1246	CLIP-seq
MIRT1136565	hsa-miR-1247	CLIP-seq
MIRT1136566	hsa-miR-1252	CLIP-seq
MIRT1136567	hsa-miR-1265	CLIP-seq
MIRT1136568	hsa-miR-1270	CLIP-seq
MIRT1136569	hsa-miR-1272	CLIP-seq
MIRT1136570	hsa-miR-1276	CLIP-seq
MIRT1136571	hsa-miR-128	CLIP-seq
MIRT1136572	hsa-miR-1285	CLIP-seq
MIRT1136573	hsa-miR-1290	CLIP-seq
MIRT1136574	hsa-miR-1294	CLIP-seq
MIRT1136575	hsa-miR-1298	CLIP-seq
MIRT1136576	hsa-miR-1299	CLIP-seq
MIRT1136577	hsa-miR-1321	CLIP-seq
MIRT1136578	hsa-miR-143	CLIP-seq
MIRT1136579	hsa-miR-146a	CLIP-seq
MIRT1136580	hsa-miR-146b-5p	CLIP-seq
MIRT1136581	hsa-miR-151-3p	CLIP-seq
MIRT1136582	hsa-miR-181a	CLIP-seq
MIRT1136583	hsa-miR-181b	CLIP-seq
MIRT1136584	hsa-miR-181c	CLIP-seq
MIRT1136585	hsa-miR-181d	CLIP-seq
MIRT1136586	hsa-miR-1827	CLIP-seq
MIRT1136587	hsa-miR-194	CLIP-seq
MIRT1136588	hsa-miR-2053	CLIP-seq
MIRT1136589	hsa-miR-2114	CLIP-seq
MIRT1136590	hsa-miR-24	CLIP-seq
MIRT1136591	hsa-miR-2682	CLIP-seq
MIRT1136592	hsa-miR-2964a-5p	CLIP-seq
MIRT1136593	hsa-miR-299-3p	CLIP-seq
MIRT1136594	hsa-miR-302a	CLIP-seq
MIRT1136595	hsa-miR-302b	CLIP-seq
MIRT1136596	hsa-miR-302c	CLIP-seq
MIRT1136597	hsa-miR-302d	CLIP-seq
MIRT1136598	hsa-miR-302e	CLIP-seq
MIRT1136599	hsa-miR-30a	CLIP-seq
MIRT1136600	hsa-miR-30b	CLIP-seq
MIRT1136601	hsa-miR-30c	CLIP-seq
MIRT1136602	hsa-miR-30d	CLIP-seq
MIRT1136603	hsa-miR-30e	CLIP-seq
MIRT1136604	hsa-miR-3122	CLIP-seq
MIRT1136605	hsa-miR-3135b	CLIP-seq
MIRT1136606	hsa-miR-3150a-3p	CLIP-seq
MIRT1136607	hsa-miR-3152-3p	CLIP-seq
MIRT1136608	hsa-miR-3154	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT1136610	hsa-miR-3167	CLIP-seq
MIRT1136611	hsa-miR-3173-3p	CLIP-seq
MIRT1136612	hsa-miR-3175	CLIP-seq
MIRT1136613	hsa-miR-3185	CLIP-seq
MIRT1136614	hsa-miR-323-5p	CLIP-seq
MIRT1136615	hsa-miR-335	CLIP-seq
MIRT1136616	hsa-miR-338-3p	CLIP-seq
MIRT1136617	hsa-miR-338-5p	CLIP-seq
MIRT1136618	hsa-miR-342-3p	CLIP-seq
MIRT1136619	hsa-miR-3529	CLIP-seq
MIRT1136620	hsa-miR-3606	CLIP-seq
MIRT1136621	hsa-miR-3612	CLIP-seq
MIRT1136622	hsa-miR-3613-3p	CLIP-seq
MIRT1136623	hsa-miR-362-5p	CLIP-seq
MIRT1136624	hsa-miR-3647-3p	CLIP-seq
MIRT1136625	hsa-miR-3653	CLIP-seq
MIRT1136626	hsa-miR-3654	CLIP-seq
MIRT1136627	hsa-miR-3656	CLIP-seq
MIRT1136628	hsa-miR-3658	CLIP-seq
MIRT1136629	hsa-miR-3662	CLIP-seq
MIRT1136630	hsa-miR-3663-3p	CLIP-seq
MIRT1136631	hsa-miR-3684	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136634	hsa-miR-3689d	CLIP-seq
MIRT1136635	hsa-miR-3714	CLIP-seq
MIRT1136636	hsa-miR-372	CLIP-seq
MIRT1136637	hsa-miR-373	CLIP-seq
MIRT1136638	hsa-miR-378	CLIP-seq
MIRT1136639	hsa-miR-378b	CLIP-seq
MIRT1136640	hsa-miR-378c	CLIP-seq
MIRT1136641	hsa-miR-378d	CLIP-seq
MIRT1136642	hsa-miR-378e	CLIP-seq
MIRT1136643	hsa-miR-378f	CLIP-seq
MIRT1136644	hsa-miR-378h	CLIP-seq
MIRT1136645	hsa-miR-378i	CLIP-seq
MIRT1136646	hsa-miR-379	CLIP-seq
MIRT1136647	hsa-miR-3913-3p	CLIP-seq
MIRT1136648	hsa-miR-3913-5p	CLIP-seq
MIRT1136649	hsa-miR-3919	CLIP-seq
MIRT1136650	hsa-miR-3922-5p	CLIP-seq
MIRT1136651	hsa-miR-3927	CLIP-seq
MIRT1136652	hsa-miR-3929	CLIP-seq
MIRT1136653	hsa-miR-3935	CLIP-seq
MIRT1136654	hsa-miR-3937	CLIP-seq
MIRT1136655	hsa-miR-409-3p	CLIP-seq
MIRT1136656	hsa-miR-422a	CLIP-seq
MIRT1136657	hsa-miR-425	CLIP-seq
MIRT1136658	hsa-miR-4251	CLIP-seq
MIRT1136659	hsa-miR-4255	CLIP-seq
MIRT1136660	hsa-miR-4257	CLIP-seq
MIRT1136661	hsa-miR-4262	CLIP-seq
MIRT1136662	hsa-miR-4263	CLIP-seq
MIRT1136663	hsa-miR-4265	CLIP-seq
MIRT1136664	hsa-miR-4270	CLIP-seq
MIRT1136665	hsa-miR-4272	CLIP-seq
MIRT1136666	hsa-miR-4275	CLIP-seq
MIRT1136667	hsa-miR-4282	CLIP-seq
MIRT1136668	hsa-miR-4284	CLIP-seq
MIRT1136669	hsa-miR-4296	CLIP-seq
MIRT1136670	hsa-miR-4302	CLIP-seq
MIRT1136671	hsa-miR-4311	CLIP-seq
MIRT1136672	hsa-miR-4316	CLIP-seq
MIRT1136673	hsa-miR-4322	CLIP-seq
MIRT1136674	hsa-miR-4326	CLIP-seq
MIRT1136675	hsa-miR-4419b	CLIP-seq
MIRT1136676	hsa-miR-4420	CLIP-seq
MIRT1136677	hsa-miR-4428	CLIP-seq
MIRT1136678	hsa-miR-4432	CLIP-seq
MIRT1136679	hsa-miR-4435	CLIP-seq
MIRT1136680	hsa-miR-4437	CLIP-seq
MIRT1136681	hsa-miR-4441	CLIP-seq
MIRT1136682	hsa-miR-4443	CLIP-seq
MIRT1136683	hsa-miR-4459	CLIP-seq
MIRT1136684	hsa-miR-4463	CLIP-seq
MIRT1136685	hsa-miR-4477b	CLIP-seq
MIRT1136686	hsa-miR-4478	CLIP-seq
MIRT1136687	hsa-miR-4491	CLIP-seq
MIRT1136688	hsa-miR-4496	CLIP-seq
MIRT1136689	hsa-miR-4499	CLIP-seq
MIRT1136690	hsa-miR-449c	CLIP-seq
MIRT1136691	hsa-miR-4511	CLIP-seq
MIRT1136692	hsa-miR-4519	CLIP-seq
MIRT1136693	hsa-miR-4521	CLIP-seq
MIRT1136694	hsa-miR-4530	CLIP-seq
MIRT1136695	hsa-miR-4649-3p	CLIP-seq
MIRT1136696	hsa-miR-4650-3p	CLIP-seq
MIRT1136697	hsa-miR-4653-3p	CLIP-seq
MIRT1136698	hsa-miR-4657	CLIP-seq
MIRT1136699	hsa-miR-4661-3p	CLIP-seq
MIRT1136700	hsa-miR-4666-5p	CLIP-seq
MIRT1136701	hsa-miR-4674	CLIP-seq
MIRT1136702	hsa-miR-4683	CLIP-seq
MIRT1136703	hsa-miR-4684-5p	CLIP-seq
MIRT1136704	hsa-miR-4690-5p	CLIP-seq
MIRT1136705	hsa-miR-4691-5p	CLIP-seq
MIRT1136706	hsa-miR-4693-5p	CLIP-seq
MIRT1136707	hsa-miR-4705	CLIP-seq
MIRT1136708	hsa-miR-4709-3p	CLIP-seq
MIRT1136709	hsa-miR-4712-5p	CLIP-seq
MIRT1136710	hsa-miR-4716-3p	CLIP-seq
MIRT1136711	hsa-miR-4720-3p	CLIP-seq
MIRT1136712	hsa-miR-4722-5p	CLIP-seq
MIRT1136713	hsa-miR-4723-5p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136715	hsa-miR-4735-5p	CLIP-seq
MIRT1136716	hsa-miR-4736	CLIP-seq
MIRT1136717	hsa-miR-4739	CLIP-seq
MIRT1136718	hsa-miR-4740-5p	CLIP-seq
MIRT1136719	hsa-miR-4753-5p	CLIP-seq
MIRT1136720	hsa-miR-4756-5p	CLIP-seq
MIRT1136721	hsa-miR-4764-5p	CLIP-seq
MIRT1136722	hsa-miR-4768-5p	CLIP-seq
MIRT1136723	hsa-miR-4770	CLIP-seq
MIRT1136724	hsa-miR-4773	CLIP-seq
MIRT1136725	hsa-miR-4775	CLIP-seq
MIRT1136726	hsa-miR-4782-5p	CLIP-seq
MIRT1136727	hsa-miR-4787-5p	CLIP-seq
MIRT1136728	hsa-miR-4790-3p	CLIP-seq
MIRT1136729	hsa-miR-4795-5p	CLIP-seq
MIRT1136730	hsa-miR-4804-3p	CLIP-seq
MIRT1136731	hsa-miR-485-3p	CLIP-seq
MIRT1136732	hsa-miR-485-5p	CLIP-seq
MIRT1136733	hsa-miR-499-5p	CLIP-seq
MIRT1136734	hsa-miR-500b	CLIP-seq
MIRT1136735	hsa-miR-502-5p	CLIP-seq
MIRT1136736	hsa-miR-513a-3p	CLIP-seq
MIRT1136737	hsa-miR-516b	CLIP-seq
MIRT1136738	hsa-miR-520a-3p	CLIP-seq
MIRT1136739	hsa-miR-520b	CLIP-seq
MIRT1136740	hsa-miR-520c-3p	CLIP-seq
MIRT1136741	hsa-miR-520d-3p	CLIP-seq
MIRT1136742	hsa-miR-520e	CLIP-seq
MIRT1136743	hsa-miR-520f	CLIP-seq
MIRT1136744	hsa-miR-539	CLIP-seq
MIRT1136745	hsa-miR-545	CLIP-seq
MIRT1136746	hsa-miR-548a-3p	CLIP-seq
MIRT1136747	hsa-miR-548ag	CLIP-seq
MIRT1136748	hsa-miR-548ai	CLIP-seq
MIRT1136749	hsa-miR-548b-3p	CLIP-seq
MIRT1136750	hsa-miR-548c-3p	CLIP-seq
MIRT1136751	hsa-miR-548e	CLIP-seq
MIRT1136752	hsa-miR-548f	CLIP-seq
MIRT1136753	hsa-miR-548g	CLIP-seq
MIRT1136754	hsa-miR-548k	CLIP-seq
MIRT1136755	hsa-miR-548n	CLIP-seq
MIRT1136756	hsa-miR-548p	CLIP-seq
MIRT1136757	hsa-miR-569	CLIP-seq
MIRT1136758	hsa-miR-576-3p	CLIP-seq
MIRT1136759	hsa-miR-583	CLIP-seq
MIRT1136760	hsa-miR-589	CLIP-seq
MIRT1136761	hsa-miR-590-3p	CLIP-seq
MIRT1136762	hsa-miR-593	CLIP-seq
MIRT1136763	hsa-miR-604	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq
MIRT1136765	hsa-miR-607	CLIP-seq
MIRT1136766	hsa-miR-620	CLIP-seq
MIRT1136767	hsa-miR-625	CLIP-seq
MIRT1136768	hsa-miR-634	CLIP-seq
MIRT1136769	hsa-miR-647	CLIP-seq
MIRT1136770	hsa-miR-650	CLIP-seq
MIRT1136771	hsa-miR-653	CLIP-seq
MIRT1136772	hsa-miR-663b	CLIP-seq
MIRT1136773	hsa-miR-664	CLIP-seq
MIRT1136774	hsa-miR-770-5p	CLIP-seq
MIRT1136775	hsa-miR-876-3p	CLIP-seq
MIRT1136776	hsa-miR-876-5p	CLIP-seq
MIRT1136777	hsa-miR-939	CLIP-seq
MIRT1136778	hsa-miR-940	CLIP-seq
MIRT1136779	hsa-miR-95	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136564	hsa-miR-1246	CLIP-seq
MIRT1136565	hsa-miR-1247	CLIP-seq
MIRT2038883	hsa-miR-1256	CLIP-seq
MIRT1136567	hsa-miR-1265	CLIP-seq
MIRT2038884	hsa-miR-1271	CLIP-seq
MIRT1136569	hsa-miR-1272	CLIP-seq
MIRT2038885	hsa-miR-1283	CLIP-seq
MIRT1136572	hsa-miR-1285	CLIP-seq
MIRT1136573	hsa-miR-1290	CLIP-seq
MIRT1136574	hsa-miR-1294	CLIP-seq
MIRT1136582	hsa-miR-181a	CLIP-seq
MIRT1136583	hsa-miR-181b	CLIP-seq
MIRT1136584	hsa-miR-181c	CLIP-seq
MIRT1136585	hsa-miR-181d	CLIP-seq
MIRT1136586	hsa-miR-1827	CLIP-seq
MIRT1136589	hsa-miR-2114	CLIP-seq
MIRT1136593	hsa-miR-299-3p	CLIP-seq
MIRT2038886	hsa-miR-3117-3p	CLIP-seq
MIRT1136604	hsa-miR-3122	CLIP-seq
MIRT2038887	hsa-miR-3127-5p	CLIP-seq
MIRT1136608	hsa-miR-3154	CLIP-seq
MIRT2038888	hsa-miR-3156-5p	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT1136610	hsa-miR-3167	CLIP-seq
MIRT2038889	hsa-miR-3169	CLIP-seq
MIRT1136613	hsa-miR-3185	CLIP-seq
MIRT2038890	hsa-miR-3190	CLIP-seq
MIRT1136614	hsa-miR-323-5p	CLIP-seq
MIRT1136617	hsa-miR-338-5p	CLIP-seq
MIRT1136620	hsa-miR-3606	CLIP-seq
MIRT2038891	hsa-miR-3616-3p	CLIP-seq
MIRT1136623	hsa-miR-362-5p	CLIP-seq
MIRT1136624	hsa-miR-3647-3p	CLIP-seq
MIRT1136628	hsa-miR-3658	CLIP-seq
MIRT1136629	hsa-miR-3662	CLIP-seq
MIRT1136630	hsa-miR-3663-3p	CLIP-seq
MIRT1136634	hsa-miR-3689d	CLIP-seq
MIRT1136647	hsa-miR-3913-3p	CLIP-seq
MIRT1136648	hsa-miR-3913-5p	CLIP-seq
MIRT1136651	hsa-miR-3927	CLIP-seq
MIRT1136655	hsa-miR-409-3p	CLIP-seq
MIRT2038892	hsa-miR-411	CLIP-seq
MIRT2038893	hsa-miR-4252	CLIP-seq
MIRT1136660	hsa-miR-4257	CLIP-seq
MIRT1136661	hsa-miR-4262	CLIP-seq
MIRT1136664	hsa-miR-4270	CLIP-seq
MIRT1136666	hsa-miR-4275	CLIP-seq
MIRT1136670	hsa-miR-4302	CLIP-seq
MIRT1136672	hsa-miR-4316	CLIP-seq
MIRT1136674	hsa-miR-4326	CLIP-seq
MIRT1136679	hsa-miR-4435	CLIP-seq
MIRT1136681	hsa-miR-4441	CLIP-seq
MIRT1136683	hsa-miR-4459	CLIP-seq
MIRT1136687	hsa-miR-4491	CLIP-seq
MIRT1136688	hsa-miR-4496	CLIP-seq
MIRT1136692	hsa-miR-4519	CLIP-seq
MIRT2038894	hsa-miR-4633-5p	CLIP-seq
MIRT1136696	hsa-miR-4650-3p	CLIP-seq
MIRT1136698	hsa-miR-4657	CLIP-seq
MIRT1136704	hsa-miR-4690-5p	CLIP-seq
MIRT1136705	hsa-miR-4691-5p	CLIP-seq
MIRT1136707	hsa-miR-4705	CLIP-seq
MIRT1136708	hsa-miR-4709-3p	CLIP-seq
MIRT2038895	hsa-miR-4721	CLIP-seq
MIRT1136712	hsa-miR-4722-5p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136715	hsa-miR-4735-5p	CLIP-seq
MIRT2038896	hsa-miR-4759	CLIP-seq
MIRT1136721	hsa-miR-4764-5p	CLIP-seq
MIRT1136724	hsa-miR-4773	CLIP-seq
MIRT1136725	hsa-miR-4775	CLIP-seq
MIRT1136728	hsa-miR-4790-3p	CLIP-seq
MIRT1136731	hsa-miR-485-3p	CLIP-seq
MIRT2038897	hsa-miR-491-3p	CLIP-seq
MIRT1136734	hsa-miR-500b	CLIP-seq
MIRT1136735	hsa-miR-502-5p	CLIP-seq
MIRT2038898	hsa-miR-532-5p	CLIP-seq
MIRT1136745	hsa-miR-545	CLIP-seq
MIRT1136746	hsa-miR-548a-3p	CLIP-seq
MIRT1136751	hsa-miR-548e	CLIP-seq
MIRT1136752	hsa-miR-548f	CLIP-seq
MIRT1136753	hsa-miR-548g	CLIP-seq
MIRT1136754	hsa-miR-548k	CLIP-seq
MIRT1136755	hsa-miR-548n	CLIP-seq
MIRT1136756	hsa-miR-548p	CLIP-seq
MIRT1136761	hsa-miR-590-3p	CLIP-seq
MIRT1136762	hsa-miR-593	CLIP-seq
MIRT1136763	hsa-miR-604	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq
MIRT1136768	hsa-miR-634	CLIP-seq
MIRT1136769	hsa-miR-647	CLIP-seq
MIRT1136771	hsa-miR-653	CLIP-seq
MIRT1136772	hsa-miR-663b	CLIP-seq
MIRT2038899	hsa-miR-671-5p	CLIP-seq
MIRT2038900	hsa-miR-802	CLIP-seq
MIRT1136775	hsa-miR-876-3p	CLIP-seq
MIRT1136776	hsa-miR-876-5p	CLIP-seq
MIRT2038901	hsa-miR-96	CLIP-seq
MIRT1136561	hsa-miR-1183	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136564	hsa-miR-1246	CLIP-seq
MIRT1136568	hsa-miR-1270	CLIP-seq
MIRT1136569	hsa-miR-1272	CLIP-seq
MIRT1136571	hsa-miR-128	CLIP-seq
MIRT1136572	hsa-miR-1285	CLIP-seq
MIRT1136573	hsa-miR-1290	CLIP-seq
MIRT1136575	hsa-miR-1298	CLIP-seq
MIRT1136577	hsa-miR-1321	CLIP-seq
MIRT1136578	hsa-miR-143	CLIP-seq
MIRT1136582	hsa-miR-181a	CLIP-seq
MIRT1136583	hsa-miR-181b	CLIP-seq
MIRT1136584	hsa-miR-181c	CLIP-seq
MIRT1136585	hsa-miR-181d	CLIP-seq
MIRT1136586	hsa-miR-1827	CLIP-seq
MIRT1136587	hsa-miR-194	CLIP-seq
MIRT2268861	hsa-miR-203	CLIP-seq
MIRT1136588	hsa-miR-2053	CLIP-seq
MIRT1136589	hsa-miR-2114	CLIP-seq
MIRT1136590	hsa-miR-24	CLIP-seq
MIRT1136593	hsa-miR-299-3p	CLIP-seq
MIRT1136599	hsa-miR-30a	CLIP-seq
MIRT1136600	hsa-miR-30b	CLIP-seq
MIRT1136601	hsa-miR-30c	CLIP-seq
MIRT1136602	hsa-miR-30d	CLIP-seq
MIRT1136603	hsa-miR-30e	CLIP-seq
MIRT2038886	hsa-miR-3117-3p	CLIP-seq
MIRT2038887	hsa-miR-3127-5p	CLIP-seq
MIRT2268862	hsa-miR-3136-3p	CLIP-seq
MIRT1136607	hsa-miR-3152-3p	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT1136610	hsa-miR-3167	CLIP-seq
MIRT2038889	hsa-miR-3169	CLIP-seq
MIRT1136612	hsa-miR-3175	CLIP-seq
MIRT1136613	hsa-miR-3185	CLIP-seq
MIRT2038890	hsa-miR-3190	CLIP-seq
MIRT1136614	hsa-miR-323-5p	CLIP-seq
MIRT1136616	hsa-miR-338-3p	CLIP-seq
MIRT1136617	hsa-miR-338-5p	CLIP-seq
MIRT1136618	hsa-miR-342-3p	CLIP-seq
MIRT1136620	hsa-miR-3606	CLIP-seq
MIRT1136623	hsa-miR-362-5p	CLIP-seq
MIRT1136624	hsa-miR-3647-3p	CLIP-seq
MIRT1136625	hsa-miR-3653	CLIP-seq
MIRT1136626	hsa-miR-3654	CLIP-seq
MIRT1136627	hsa-miR-3656	CLIP-seq
MIRT1136628	hsa-miR-3658	CLIP-seq
MIRT1136629	hsa-miR-3662	CLIP-seq
MIRT1136630	hsa-miR-3663-3p	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136634	hsa-miR-3689d	CLIP-seq
MIRT2268863	hsa-miR-369-3p	CLIP-seq
MIRT2268864	hsa-miR-374c	CLIP-seq
MIRT1136647	hsa-miR-3913-3p	CLIP-seq
MIRT1136649	hsa-miR-3919	CLIP-seq
MIRT1136650	hsa-miR-3922-5p	CLIP-seq
MIRT1136651	hsa-miR-3927	CLIP-seq
MIRT1136652	hsa-miR-3929	CLIP-seq
MIRT1136654	hsa-miR-3937	CLIP-seq
MIRT1136655	hsa-miR-409-3p	CLIP-seq
MIRT1136660	hsa-miR-4257	CLIP-seq
MIRT1136661	hsa-miR-4262	CLIP-seq
MIRT1136663	hsa-miR-4265	CLIP-seq
MIRT1136664	hsa-miR-4270	CLIP-seq
MIRT1136665	hsa-miR-4272	CLIP-seq
MIRT1136666	hsa-miR-4275	CLIP-seq
MIRT2268865	hsa-miR-4276	CLIP-seq
MIRT1136668	hsa-miR-4284	CLIP-seq
MIRT1136669	hsa-miR-4296	CLIP-seq
MIRT1136673	hsa-miR-4322	CLIP-seq
MIRT1136674	hsa-miR-4326	CLIP-seq
MIRT1136675	hsa-miR-4419b	CLIP-seq
MIRT1136679	hsa-miR-4435	CLIP-seq
MIRT1136681	hsa-miR-4441	CLIP-seq
MIRT1136682	hsa-miR-4443	CLIP-seq
MIRT1136683	hsa-miR-4459	CLIP-seq
MIRT1136685	hsa-miR-4477b	CLIP-seq
MIRT1136686	hsa-miR-4478	CLIP-seq
MIRT2268866	hsa-miR-4487	CLIP-seq
MIRT1136687	hsa-miR-4491	CLIP-seq
MIRT1136688	hsa-miR-4496	CLIP-seq
MIRT2268867	hsa-miR-451	CLIP-seq
MIRT1136691	hsa-miR-4511	CLIP-seq
MIRT2268868	hsa-miR-451b	CLIP-seq
MIRT1136693	hsa-miR-4521	CLIP-seq
MIRT1136694	hsa-miR-4530	CLIP-seq
MIRT2268869	hsa-miR-4537	CLIP-seq
MIRT1136695	hsa-miR-4649-3p	CLIP-seq
MIRT1136696	hsa-miR-4650-3p	CLIP-seq
MIRT2268870	hsa-miR-4656	CLIP-seq
MIRT1136698	hsa-miR-4657	CLIP-seq
MIRT1136699	hsa-miR-4661-3p	CLIP-seq
MIRT1136700	hsa-miR-4666-5p	CLIP-seq
MIRT2268871	hsa-miR-4682	CLIP-seq
MIRT1136702	hsa-miR-4683	CLIP-seq
MIRT1136704	hsa-miR-4690-5p	CLIP-seq
MIRT1136705	hsa-miR-4691-5p	CLIP-seq
MIRT1136706	hsa-miR-4693-5p	CLIP-seq
MIRT1136707	hsa-miR-4705	CLIP-seq
MIRT1136712	hsa-miR-4722-5p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136715	hsa-miR-4735-5p	CLIP-seq
MIRT1136717	hsa-miR-4739	CLIP-seq
MIRT1136720	hsa-miR-4756-5p	CLIP-seq
MIRT2038896	hsa-miR-4759	CLIP-seq
MIRT2268872	hsa-miR-4760-5p	CLIP-seq
MIRT1136723	hsa-miR-4770	CLIP-seq
MIRT1136725	hsa-miR-4775	CLIP-seq
MIRT2268873	hsa-miR-4786-3p	CLIP-seq
MIRT1136728	hsa-miR-4790-3p	CLIP-seq
MIRT1136729	hsa-miR-4795-5p	CLIP-seq
MIRT1136731	hsa-miR-485-3p	CLIP-seq
MIRT1136732	hsa-miR-485-5p	CLIP-seq
MIRT1136734	hsa-miR-500b	CLIP-seq
MIRT2268874	hsa-miR-501-5p	CLIP-seq
MIRT1136735	hsa-miR-502-5p	CLIP-seq
MIRT2268875	hsa-miR-508-5p	CLIP-seq
MIRT1136737	hsa-miR-516b	CLIP-seq
MIRT1136745	hsa-miR-545	CLIP-seq
MIRT1136746	hsa-miR-548a-3p	CLIP-seq
MIRT1136747	hsa-miR-548ag	CLIP-seq
MIRT1136748	hsa-miR-548ai	CLIP-seq
MIRT1136749	hsa-miR-548b-3p	CLIP-seq
MIRT1136751	hsa-miR-548e	CLIP-seq
MIRT1136752	hsa-miR-548f	CLIP-seq
MIRT1136753	hsa-miR-548g	CLIP-seq
MIRT1136754	hsa-miR-548k	CLIP-seq
MIRT1136755	hsa-miR-548n	CLIP-seq
MIRT1136756	hsa-miR-548p	CLIP-seq
MIRT1136757	hsa-miR-569	CLIP-seq
MIRT2268876	hsa-miR-570	CLIP-seq
MIRT1136761	hsa-miR-590-3p	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq
MIRT1136766	hsa-miR-620	CLIP-seq
MIRT1136768	hsa-miR-634	CLIP-seq
MIRT2268877	hsa-miR-655	CLIP-seq
MIRT2268878	hsa-miR-656	CLIP-seq
MIRT1136772	hsa-miR-663b	CLIP-seq
MIRT1136773	hsa-miR-664	CLIP-seq
MIRT2038899	hsa-miR-671-5p	CLIP-seq
MIRT2268879	hsa-miR-766	CLIP-seq
MIRT1136775	hsa-miR-876-3p	CLIP-seq
MIRT1136776	hsa-miR-876-5p	CLIP-seq
MIRT1136779	hsa-miR-95	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136565	hsa-miR-1247	CLIP-seq
MIRT1136604	hsa-miR-3122	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT1136627	hsa-miR-3656	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136648	hsa-miR-3913-5p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136762	hsa-miR-593	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq
MIRT2568311	hsa-miR-10a	CLIP-seq
MIRT2568312	hsa-miR-10b	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136565	hsa-miR-1247	CLIP-seq
MIRT1136569	hsa-miR-1272	CLIP-seq
MIRT2038885	hsa-miR-1283	CLIP-seq
MIRT1136572	hsa-miR-1285	CLIP-seq
MIRT1136582	hsa-miR-181a	CLIP-seq
MIRT1136583	hsa-miR-181b	CLIP-seq
MIRT1136584	hsa-miR-181c	CLIP-seq
MIRT1136585	hsa-miR-181d	CLIP-seq
MIRT1136589	hsa-miR-2114	CLIP-seq
MIRT2568313	hsa-miR-2392	CLIP-seq
MIRT1136599	hsa-miR-30a	CLIP-seq
MIRT1136600	hsa-miR-30b	CLIP-seq
MIRT1136601	hsa-miR-30c	CLIP-seq
MIRT1136602	hsa-miR-30d	CLIP-seq
MIRT1136603	hsa-miR-30e	CLIP-seq
MIRT1136604	hsa-miR-3122	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT2568314	hsa-miR-3179	CLIP-seq
MIRT2568315	hsa-miR-3187-3p	CLIP-seq
MIRT2568316	hsa-miR-323-3p	CLIP-seq
MIRT1136617	hsa-miR-338-5p	CLIP-seq
MIRT2568317	hsa-miR-339-5p	CLIP-seq
MIRT2568318	hsa-miR-34b	CLIP-seq
MIRT1136620	hsa-miR-3606	CLIP-seq
MIRT1136622	hsa-miR-3613-3p	CLIP-seq
MIRT2568319	hsa-miR-3620	CLIP-seq
MIRT1136623	hsa-miR-362-5p	CLIP-seq
MIRT1136627	hsa-miR-3656	CLIP-seq
MIRT2568320	hsa-miR-3660	CLIP-seq
MIRT1136629	hsa-miR-3662	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136634	hsa-miR-3689d	CLIP-seq
MIRT2568321	hsa-miR-371-5p	CLIP-seq
MIRT2568322	hsa-miR-371b-5p	CLIP-seq
MIRT1136648	hsa-miR-3913-5p	CLIP-seq
MIRT1136655	hsa-miR-409-3p	CLIP-seq
MIRT1136657	hsa-miR-425	CLIP-seq
MIRT1136661	hsa-miR-4262	CLIP-seq
MIRT1136676	hsa-miR-4420	CLIP-seq
MIRT2568323	hsa-miR-4421	CLIP-seq
MIRT1136682	hsa-miR-4443	CLIP-seq
MIRT1136683	hsa-miR-4459	CLIP-seq
MIRT2568324	hsa-miR-4466	CLIP-seq
MIRT1136688	hsa-miR-4496	CLIP-seq
MIRT2568325	hsa-miR-4526	CLIP-seq
MIRT2568326	hsa-miR-4529-5p	CLIP-seq
MIRT1136699	hsa-miR-4661-3p	CLIP-seq
MIRT1136704	hsa-miR-4690-5p	CLIP-seq
MIRT1136712	hsa-miR-4722-5p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT1136734	hsa-miR-500b	CLIP-seq
MIRT1136735	hsa-miR-502-5p	CLIP-seq
MIRT2268875	hsa-miR-508-5p	CLIP-seq
MIRT2568327	hsa-miR-5096	CLIP-seq
MIRT1136750	hsa-miR-548c-3p	CLIP-seq
MIRT1136762	hsa-miR-593	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq
MIRT2568328	hsa-miR-675	CLIP-seq
MIRT2568311	hsa-miR-10a	CLIP-seq
MIRT2568312	hsa-miR-10b	CLIP-seq
MIRT1136563	hsa-miR-1228	CLIP-seq
MIRT1136565	hsa-miR-1247	CLIP-seq
MIRT2038885	hsa-miR-1283	CLIP-seq
MIRT1136572	hsa-miR-1285	CLIP-seq
MIRT1136582	hsa-miR-181a	CLIP-seq
MIRT1136583	hsa-miR-181b	CLIP-seq
MIRT1136584	hsa-miR-181c	CLIP-seq
MIRT1136585	hsa-miR-181d	CLIP-seq
MIRT2684731	hsa-miR-2110	CLIP-seq
MIRT1136599	hsa-miR-30a	CLIP-seq
MIRT1136600	hsa-miR-30b	CLIP-seq
MIRT1136601	hsa-miR-30c	CLIP-seq
MIRT1136602	hsa-miR-30d	CLIP-seq
MIRT1136603	hsa-miR-30e	CLIP-seq
MIRT1136604	hsa-miR-3122	CLIP-seq
MIRT2038887	hsa-miR-3127-5p	CLIP-seq
MIRT1136609	hsa-miR-3165	CLIP-seq
MIRT2568314	hsa-miR-3179	CLIP-seq
MIRT2568316	hsa-miR-323-3p	CLIP-seq
MIRT1136617	hsa-miR-338-5p	CLIP-seq
MIRT2568317	hsa-miR-339-5p	CLIP-seq
MIRT2568318	hsa-miR-34b	CLIP-seq
MIRT1136620	hsa-miR-3606	CLIP-seq
MIRT1136622	hsa-miR-3613-3p	CLIP-seq
MIRT2568319	hsa-miR-3620	CLIP-seq
MIRT1136623	hsa-miR-362-5p	CLIP-seq
MIRT1136627	hsa-miR-3656	CLIP-seq
MIRT2568320	hsa-miR-3660	CLIP-seq
MIRT1136629	hsa-miR-3662	CLIP-seq
MIRT1136632	hsa-miR-3689a-3p	CLIP-seq
MIRT1136633	hsa-miR-3689c	CLIP-seq
MIRT1136634	hsa-miR-3689d	CLIP-seq
MIRT2568321	hsa-miR-371-5p	CLIP-seq
MIRT2568322	hsa-miR-371b-5p	CLIP-seq
MIRT1136648	hsa-miR-3913-5p	CLIP-seq
MIRT1136655	hsa-miR-409-3p	CLIP-seq
MIRT1136661	hsa-miR-4262	CLIP-seq
MIRT2684732	hsa-miR-4271	CLIP-seq
MIRT1136676	hsa-miR-4420	CLIP-seq
MIRT2568323	hsa-miR-4421	CLIP-seq
MIRT1136682	hsa-miR-4443	CLIP-seq
MIRT1136683	hsa-miR-4459	CLIP-seq
MIRT1136688	hsa-miR-4496	CLIP-seq
MIRT2568325	hsa-miR-4526	CLIP-seq
MIRT1136699	hsa-miR-4661-3p	CLIP-seq
MIRT1136704	hsa-miR-4690-5p	CLIP-seq
MIRT1136712	hsa-miR-4722-5p	CLIP-seq
MIRT2684733	hsa-miR-4725-3p	CLIP-seq
MIRT1136714	hsa-miR-4728-5p	CLIP-seq
MIRT2684734	hsa-miR-491-5p	CLIP-seq
MIRT1136734	hsa-miR-500b	CLIP-seq
MIRT1136735	hsa-miR-502-5p	CLIP-seq
MIRT1136750	hsa-miR-548c-3p	CLIP-seq
MIRT1136762	hsa-miR-593	CLIP-seq
MIRT1136764	hsa-miR-605	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004485	Function	Methylcrotonoyl-CoA carboxylase activity	IBA
GO:0004485	Function	Methylcrotonoyl-CoA carboxylase activity	IDA	17360195
GO:0004485	Function	Methylcrotonoyl-CoA carboxylase activity	IEA
GO:0004485	Function	Methylcrotonoyl-CoA carboxylase activity	IEA
GO:0004485	Function	Methylcrotonoyl-CoA carboxylase activity	NAS	11170888, 11181649
GO:0005515	Function	Protein binding	IPI	17360195, 27499296, 33961781, 35156780, 36012204
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	11170888
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	NAS	11181649
GO:0005759	Component	Mitochondrial matrix	IDA	16023992, 17360195
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006552	Process	L-leucine catabolic process	IBA
GO:0006552	Process	L-leucine catabolic process	IEA
GO:0006552	Process	L-leucine catabolic process	TAS	11170888
GO:0009083	Process	Branched-chain amino acid catabolic process	NAS	17360195
GO:0015936	Process	Coenzyme A metabolic process	IEA
GO:0016874	Function	Ligase activity	IEA
GO:1905202	Component	Methylcrotonoyl-CoA carboxylase complex	IBA
GO:1905202	Component	Methylcrotonoyl-CoA carboxylase complex	IDA	17360195
GO:1905202	Component	Methylcrotonoyl-CoA carboxylase complex	IPI	17360195
GO:1905202	Component	Methylcrotonoyl-CoA carboxylase complex	NAS	11170888, 11181649
GO:1905202	Component	Methylcrotonoyl-CoA carboxylase complex	TAS	22869039

MIM	HGNC	e!Ensembl
609014	6937	ENSG00000131844

Q9HCC0

Protein name

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)

Protein function

Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360

PDB

8J4Z , 8J73 , 8J78 , 8J7D , 8J99 , 8JAK , 8JAW , 8JXL , 8JXM , 8JXN , 8K2V , 8XL6 , 8XL7 , 8XL8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01039	Carboxyl_trans	74 → 558	Carboxyl transferase domain	Family

Sequence

MWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERV
EHIKLGGGEKARALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGII
TGIGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPR
QADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIF
LAGPPLVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKKL
DVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGFA
RIFGYPVGIVGNNGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAK
DGAKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISVMGGEQAAN
VLATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYSSARVWDDGIIDPADTRLV
LGLSFSAALNAPIEKTDFGIFRM

Sequence length

563

Interactions

View interactions

	KEGG		Reactome
	Valine, leucine and isoleucine degradation Metabolic pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Branched-chain amino acid catabolism

829

Show/Hide Causal Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
3-methylcrotonyl-CoA carboxylase 2 deficiency	Likely pathogenic; Pathogenic	rs1352606118, rs398124372, rs2112308599, rs2112460011, rs730880265, rs2112251301, rs2112308910, rs2112437401, rs2112438432, rs764286389, rs2112251855, rs758794885, rs2112427637, rs2112468012, rs2112437820 View all (128 more)	RCV001312292 RCV003764769 RCV001378821 RCV001379035 RCV001379033 RCV001390486 RCV001386774 RCV001385246 RCV001388010 RCV001420154 RCV001783635 RCV001782422 RCV002028002 RCV001990333 RCV001986574 RCV001946682 RCV002003115 RCV002003162 RCV001954556 RCV001898703 RCV002011249 RCV002007634 RCV002006612 RCV001971695 RCV002031040 RCV002031053 RCV002027785 RCV002031069 RCV002031082 RCV001941553 RCV002044282 RCV002050980 RCV002006480 RCV001882224 RCV000001996 RCV000001997 RCV000001998 RCV000001999 RCV000002000 RCV000002001 RCV000002002 RCV000002003 RCV000002004 RCV000002005 RCV003096363 RCV001384042 RCV003060779 RCV003093746 RCV003079060 RCV003078049 RCV001852125 RCV002624342 RCV002640731 RCV002640732 RCV003121443 RCV002662587 RCV002649877 RCV002685993 RCV001378263 RCV001248667 RCV000415228 RCV000525215 RCV001235788 RCV002715609 RCV002765693 RCV002880554 RCV002962073 RCV003018458 RCV003059079 RCV003600449 RCV001833370 RCV001228980 RCV003470070 RCV003470071 RCV003461841 RCV003470073 RCV003470074 RCV003461842 RCV003461843 RCV003470076 RCV003470077 RCV003470078 RCV003470079 RCV003470080 RCV003470081 RCV003476463 RCV003470082 RCV003470083 RCV003470084 RCV003470085 RCV003470086 RCV003461844 RCV003470087 RCV003470088 RCV003470089 RCV003470090 RCV003476464 RCV003498849 RCV003498236 RCV003499030 RCV003499938 RCV003499360 RCV003498676 RCV003601418 RCV003601628 RCV003602094 RCV003602453 RCV003599892 RCV003599901 RCV003600102 RCV003600128 RCV003860084 RCV003988729 RCV003990282 RCV004574828 RCV004574829 RCV004574830 RCV004574831 RCV004574832 RCV004574833 RCV004574834 RCV004574835 RCV004574836 RCV004574837 RCV004574838 RCV005091204 RCV000533421 RCV000556717 RCV000550314 RCV000532761 RCV001066211 RCV000644023 RCV000686151 RCV000697287 RCV000707096 RCV001220292 RCV000700140 RCV000691743 RCV002535156 RCV000804187 RCV000805067 RCV000794342 RCV000794997 RCV001044034 RCV001221718 RCV001211692 RCV001210072 RCV001207251 RCV001203492 RCV001237425 RCV001231606 RCV001253022 RCV001262588
Autism spectrum disorder	Likely pathogenic; Pathogenic	rs119103221	RCV003313912
MCCC2-related disorder	Likely pathogenic; Pathogenic	rs150591260, rs757052602, rs2530858195, rs148773718, rs760881963, rs751970792, rs277995	RCV003407683 RCV004751353 RCV003412441 RCV003915571 RCV004751926 RCV004751665 RCV003928278
Methylcrotonyl-CoA carboxylase deficiency	Likely pathogenic; Pathogenic	rs142887940, rs2112463755, rs765438239, rs769558016, rs119103219, rs119103221, rs119103222, rs119103224, rs2530723770, rs774241918, rs2530733439, rs547662164, rs150591260, rs757052602, rs781013376 View all (10 more)	RCV005419298 RCV004017888 RCV003403657 RCV004782864 RCV005406719 RCV005430912 RCV004689401 RCV005417410 RCV002283366 RCV005433194 RCV004700980 RCV002282018 RCV001271403 RCV001271404 RCV003155781 RCV003388500 RCV003226322 RCV001271399 RCV002222578 RCV006268946 RCV005418309 RCV001824869 RCV001271415 RCV003987709 RCV004782680
Nonpapillary renal cell carcinoma	Likely pathogenic; Pathogenic	rs142887940	RCV005925485
See cases	Likely pathogenic; Pathogenic	rs150591260	RCV002252031

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Colon adenocarcinoma	-	rs1746865964	RCV005930191
Familial cancer of breast	Benign; Likely benign; Uncertain significance	rs77085070, rs2242372, rs56007073, rs781483923	RCV005911389 RCV005911390 RCV005902153 RCV005913957
Gastric cancer	Conflicting classifications of pathogenicity	rs115328026	RCV005898824
Ovarian serous cystadenocarcinoma	Conflicting classifications of pathogenicity	rs115328026	RCV005898825
Thymoma	Likely benign	rs114421004	RCV005919206
Thyroid cancer, nonmedullary, 1	Likely benign	rs114421004	RCV005919207
Uterine carcinosarcoma	Conflicting classifications of pathogenicity	rs148369119	RCV005898835

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
3 methylcrotonyl CoA carboxylase 1 deficiency	Associate	11181649, 14960587, 15359379, 19706617, 22642865
Autism Spectrum Disorder	Associate	38287090
Autistic Disorder	Associate	38287090
Colorectal Neoplasms	Associate	37828426
Developmental Disabilities	Associate	38287090
Malaria	Associate	16277654, 29690995
Malaria Cerebral	Associate	29690995
Metabolic Syndrome	Associate	14960587
Muscular Atrophy Spinal	Associate	33148303
Propionic Acidemia	Associate	14960587, 20725044
Prostatic Neoplasms	Associate	21829708

MCCC2 (methylcrotonyl-CoA carboxylase subunit 2)