CLSTN2 (calsyntenin 2)

Gene

• Entrez ID: 64084
• Gene name: Calsyntenin 2
• Gene symbol: CLSTN2
• Synonyms (NCBI Gene): ALC-GAMMA, CDHR13, CS2, CSTN2, alcagamma
• Chromosome: 3
• Chromosome location: 3q23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029777	hsa-miR-26b-5p	Microarray	19088304
MIRT668977	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT668976	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT668975	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT668974	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT668977	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT668976	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT668975	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT668974	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT897964	hsa-miR-1207-5p	CLIP-seq
MIRT897965	hsa-miR-1245b-5p	CLIP-seq
MIRT897966	hsa-miR-1301	CLIP-seq
MIRT897967	hsa-miR-22	CLIP-seq
MIRT897968	hsa-miR-299-3p	CLIP-seq
MIRT897969	hsa-miR-3123	CLIP-seq
MIRT897970	hsa-miR-3142	CLIP-seq
MIRT897971	hsa-miR-3611	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT897973	hsa-miR-4265	CLIP-seq
MIRT897974	hsa-miR-4296	CLIP-seq
MIRT897975	hsa-miR-4297	CLIP-seq
MIRT897976	hsa-miR-4322	CLIP-seq
MIRT897977	hsa-miR-4417	CLIP-seq
MIRT897978	hsa-miR-4493	CLIP-seq
MIRT897979	hsa-miR-4514	CLIP-seq
MIRT897980	hsa-miR-4531	CLIP-seq
MIRT897981	hsa-miR-4640-5p	CLIP-seq
MIRT897982	hsa-miR-4645-5p	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT897984	hsa-miR-4670-3p	CLIP-seq
MIRT897985	hsa-miR-4673	CLIP-seq
MIRT897986	hsa-miR-4692	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT897988	hsa-miR-4726-5p	CLIP-seq
MIRT897989	hsa-miR-4736	CLIP-seq
MIRT897990	hsa-miR-4755-3p	CLIP-seq
MIRT897991	hsa-miR-4763-3p	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897993	hsa-miR-5047	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT897996	hsa-miR-922	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT1546523	hsa-miR-935	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq
MIRT1966287	hsa-miR-103a	CLIP-seq
MIRT1966288	hsa-miR-107	CLIP-seq
MIRT1966289	hsa-miR-10a	CLIP-seq
MIRT1966290	hsa-miR-10b	CLIP-seq
MIRT897964	hsa-miR-1207-5p	CLIP-seq
MIRT897966	hsa-miR-1301	CLIP-seq
MIRT897967	hsa-miR-22	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT1966291	hsa-miR-4436a	CLIP-seq
MIRT1966292	hsa-miR-4471	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT1966293	hsa-miR-4700-3p	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT897989	hsa-miR-4736	CLIP-seq
MIRT897991	hsa-miR-4763-3p	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897993	hsa-miR-5047	CLIP-seq
MIRT1966294	hsa-miR-548v	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT1546523	hsa-miR-935	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq
MIRT2202135	hsa-miR-1294	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT2202136	hsa-miR-3929	CLIP-seq
MIRT2202137	hsa-miR-4419b	CLIP-seq
MIRT2202138	hsa-miR-4478	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT2202139	hsa-miR-4710	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq
MIRT2386227	hsa-miR-3187-3p	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT2386228	hsa-miR-378g	CLIP-seq
MIRT2386229	hsa-miR-4420	CLIP-seq
MIRT2386230	hsa-miR-4529-5p	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT2386231	hsa-miR-4731-5p	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0009986	Component	Cell surface	IBA	21873635
GO:0030425	Component	Dendrite	IEA
GO:0045211	Component	Postsynaptic membrane	IBA	21873635
GO:0050806	Process	Positive regulation of synaptic transmission	IBA	21873635
GO:0051965	Process	Positive regulation of synapse assembly	IBA	21873635
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099061	Component	Integral component of postsynaptic density membrane	IEA

Other IDs

• MIM: 611323
• HGNC: 17448
• e!Ensembl: ENSG00000158258

Protein

• UniProt ID: Q9H4D0
• Protein name: Calsyntenin-2 (Alcadein-gamma) (Alc-gamma)
• Protein function: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00028	Cadherin	165 → 254	Cadherin domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Restricted to the brain. {ECO:0000269|PubMed:12498782}.
• Sequence:

  MLPGRLCWVPLLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENNDTVI
  LDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEY
  TFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQ
  VEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQ
  KPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQIVTE
  LQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEMIFKFDG
  RQGAKVPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHN
  CRLVFLLRKDFDQADTFRPAEFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLV
  TNDWPIHPSHIAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKVISCLQA
  CKEGLDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRR
  LKVSSKVQCFGEDVCISIPEVDAYVMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFP
  DIKIVSTFAKTEAPGDVKTTDPKSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSEL
  HQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTS
  NEFNLEVSILHEDQVSDKEHVNHLIVQPPFLQSVHHPESRSSIQHSSVVPSIATVVIIIS
  VCMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEKHEGPGHGEDE
  TEGEEEEEAEEEMSSSSGSDDSEEEEEEEGMGRGRHGQNGARQAQLEWDDSTLPY

• Sequence length: 955

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	23472185
Myopia	Myopia, Degenerative	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805, rs782555528, rs1554862601, rs1586620121, rs1387950081, rs2051026773, rs1422332023	23049088
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	19503088

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Asthma			GWAS
Insomnia	Insomnia			GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA
Oligodendroglioma	Oligodendroglioma			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	33797837
Carcinogenesis	Associate	29991755
Down Syndrome	Associate	40667715
Neoplasm Metastasis	Associate	29991755