Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64084
Gene name Gene Name - the full gene name approved by the HGNC.	Calsyntenin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CLSTN2
Synonyms (NCBI Gene) Gene synonyms aliases	ALC-GAMMA, CDHR13, CS2, CSTN2, alcagamma
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q23

Show/Hide all(104)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029777	hsa-miR-26b-5p	Microarray	19088304
MIRT668977	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT668976	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT668975	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT668974	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT668977	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT668976	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT668975	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT668974	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT897964	hsa-miR-1207-5p	CLIP-seq
MIRT897965	hsa-miR-1245b-5p	CLIP-seq
MIRT897966	hsa-miR-1301	CLIP-seq
MIRT897967	hsa-miR-22	CLIP-seq
MIRT897968	hsa-miR-299-3p	CLIP-seq
MIRT897969	hsa-miR-3123	CLIP-seq
MIRT897970	hsa-miR-3142	CLIP-seq
MIRT897971	hsa-miR-3611	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT897973	hsa-miR-4265	CLIP-seq
MIRT897974	hsa-miR-4296	CLIP-seq
MIRT897975	hsa-miR-4297	CLIP-seq
MIRT897976	hsa-miR-4322	CLIP-seq
MIRT897977	hsa-miR-4417	CLIP-seq
MIRT897978	hsa-miR-4493	CLIP-seq
MIRT897979	hsa-miR-4514	CLIP-seq
MIRT897980	hsa-miR-4531	CLIP-seq
MIRT897981	hsa-miR-4640-5p	CLIP-seq
MIRT897982	hsa-miR-4645-5p	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT897984	hsa-miR-4670-3p	CLIP-seq
MIRT897985	hsa-miR-4673	CLIP-seq
MIRT897986	hsa-miR-4692	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT897988	hsa-miR-4726-5p	CLIP-seq
MIRT897989	hsa-miR-4736	CLIP-seq
MIRT897990	hsa-miR-4755-3p	CLIP-seq
MIRT897991	hsa-miR-4763-3p	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897993	hsa-miR-5047	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT897996	hsa-miR-922	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT1546523	hsa-miR-935	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq
MIRT1966287	hsa-miR-103a	CLIP-seq
MIRT1966288	hsa-miR-107	CLIP-seq
MIRT1966289	hsa-miR-10a	CLIP-seq
MIRT1966290	hsa-miR-10b	CLIP-seq
MIRT897964	hsa-miR-1207-5p	CLIP-seq
MIRT897966	hsa-miR-1301	CLIP-seq
MIRT897967	hsa-miR-22	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT1966291	hsa-miR-4436a	CLIP-seq
MIRT1966292	hsa-miR-4471	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT1966293	hsa-miR-4700-3p	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT897989	hsa-miR-4736	CLIP-seq
MIRT897991	hsa-miR-4763-3p	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897993	hsa-miR-5047	CLIP-seq
MIRT1966294	hsa-miR-548v	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT1546523	hsa-miR-935	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq
MIRT2202135	hsa-miR-1294	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT2202136	hsa-miR-3929	CLIP-seq
MIRT2202137	hsa-miR-4419b	CLIP-seq
MIRT2202138	hsa-miR-4478	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT2202139	hsa-miR-4710	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq
MIRT2386227	hsa-miR-3187-3p	CLIP-seq
MIRT897972	hsa-miR-3689d	CLIP-seq
MIRT2386228	hsa-miR-378g	CLIP-seq
MIRT2386229	hsa-miR-4420	CLIP-seq
MIRT2386230	hsa-miR-4529-5p	CLIP-seq
MIRT897983	hsa-miR-4667-5p	CLIP-seq
MIRT897987	hsa-miR-4700-5p	CLIP-seq
MIRT2386231	hsa-miR-4731-5p	CLIP-seq
MIRT897992	hsa-miR-4765	CLIP-seq
MIRT897994	hsa-miR-642b	CLIP-seq
MIRT897995	hsa-miR-661	CLIP-seq
MIRT897997	hsa-miR-939	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence
GO:0000139	Component	Golgi membrane	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0008306	Process	Associative learning	IEA
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IBA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050806	Process	Positive regulation of synaptic transmission	IBA
GO:0050806	Process	Positive regulation of synaptic transmission	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IBA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1904862	Process	Inhibitory synapse assembly	IEA

MIM	HGNC	e!Ensembl
611323	17448	ENSG00000158258

Protein

UniProt ID

Q9H4D0

Protein name

Calsyntenin-2 (Alcadein-gamma) (Alc-gamma)

Protein function

Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00028	Cadherin	165 → 254	Cadherin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Restricted to the brain. {ECO:0000269|PubMed:12498782}.

Sequence

MLPGRLCWVPLLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENNDTVI
LDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEY
TFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQ
VEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQ
KPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQIVTE
LQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEMIFKFDG
RQGAKVPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHN
CRLVFLLRKDFDQADTFRPAEFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLV
TNDWPIHPSHIAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKVISCLQA
CKEGLDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRR
LKVSSKVQCFGEDVCISIPEVDAYVMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFP
DIKIVSTFAKTEAPGDVKTTDPKSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSEL
HQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTS
NEFNLEVSILHEDQVSDKEHVNHLIVQPPFLQSVHHPESRSSIQHSSVVPSIATVVIIIS
VCMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEKHEGPGHGEDE
TEGEEEEEAEEEMSSSSGSDDSEEEEEEEGMGRGRHGQNGARQAQLEWDDSTLPY

Sequence length

955

Interactions

View interactions

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma	N/A	N/A	GWAS
Glioblastoma	Glioblastoma	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Oligodendroglioma	Oligodendroglioma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	33797837
Carcinogenesis	Associate	29991755
Down Syndrome	Associate	40667715
Neoplasm Metastasis	Associate	29991755

CLSTN2 (calsyntenin 2)