RBKS (ribokinase)

Gene

• Entrez ID: 64080
• Gene name: Ribokinase
• Gene symbol: RBKS
• Synonyms (NCBI Gene): RBSK, RK
• Chromosome: 2
• Chromosome location: 2p23.2
• Summary: This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative splicing results in multiple tra

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1294326	hsa-miR-105	CLIP-seq
MIRT1294327	hsa-miR-1302	CLIP-seq
MIRT1294328	hsa-miR-19a	CLIP-seq
MIRT1294329	hsa-miR-19b	CLIP-seq
MIRT1294330	hsa-miR-2052	CLIP-seq
MIRT1294331	hsa-miR-2113	CLIP-seq
MIRT1294332	hsa-miR-3122	CLIP-seq
MIRT1294333	hsa-miR-3199	CLIP-seq
MIRT1294334	hsa-miR-323b-5p	CLIP-seq
MIRT1294335	hsa-miR-3913-5p	CLIP-seq
MIRT1294336	hsa-miR-4298	CLIP-seq
MIRT1294337	hsa-miR-4662a-5p	CLIP-seq
MIRT1294338	hsa-miR-4676-5p	CLIP-seq
MIRT1294339	hsa-miR-4691-3p	CLIP-seq
MIRT1294340	hsa-miR-575	CLIP-seq
MIRT1294341	hsa-miR-665	CLIP-seq
MIRT1294326	hsa-miR-105	CLIP-seq
MIRT1294328	hsa-miR-19a	CLIP-seq
MIRT1294329	hsa-miR-19b	CLIP-seq
MIRT1294330	hsa-miR-2052	CLIP-seq
MIRT1294331	hsa-miR-2113	CLIP-seq
MIRT1294334	hsa-miR-323b-5p	CLIP-seq
MIRT1294326	hsa-miR-105	CLIP-seq
MIRT1294328	hsa-miR-19a	CLIP-seq
MIRT1294329	hsa-miR-19b	CLIP-seq
MIRT1294330	hsa-miR-2052	CLIP-seq
MIRT1294331	hsa-miR-2113	CLIP-seq
MIRT1294334	hsa-miR-323b-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004747	Function	Ribokinase activity	IBA
GO:0004747	Function	Ribokinase activity	IEA
GO:0004747	Function	Ribokinase activity	TAS
GO:0005515	Function	Protein binding	IPI	21044950, 28514442, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006014	Process	D-ribose metabolic process	IEA
GO:0006098	Process	Pentose-phosphate shunt	IEA
GO:0006098	Process	Pentose-phosphate shunt	TAS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019303	Process	D-ribose catabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	31515488, 32296183
GO:0046835	Process	Carbohydrate phosphorylation	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 611132
• HGNC: 30325
• e!Ensembl: ENSG00000171174

Protein

• UniProt ID: Q9H477
• Protein name: Ribokinase (RK) (EC 2.7.1.15)
• Protein function: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phospha
• PDB: 2FV7, 5BYC, 5BYD, 5BYE, 5BYF, 5C3Y, 5C3Z, 5C40, 5C41, 6WJZ, 6WK0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00294	PfkB	15 → 314	pfkB family carbohydrate kinase	Family

• Sequence:

  MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV
  QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI
  IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP
  AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG
  CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV
  SVQAAGTQSSYPYKKDLPLTLF

• Sequence length: 322

Pathways

KEGG:

Pentose phosphate pathway
Metabolic pathways

Reactome:

Pentose phosphate pathway