RBKS (ribokinase)

Gene

• Entrez ID: 64080
• Gene name: Ribokinase
• Gene symbol: RBKS
• Synonyms (NCBI Gene): RBSK, RK
• Chromosome: 2
• Chromosome location: 2p23.2
• Summary: This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative splicing results in multiple tra

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1294326	hsa-miR-105	CLIP-seq
MIRT1294327	hsa-miR-1302	CLIP-seq
MIRT1294328	hsa-miR-19a	CLIP-seq
MIRT1294329	hsa-miR-19b	CLIP-seq
MIRT1294330	hsa-miR-2052	CLIP-seq
MIRT1294331	hsa-miR-2113	CLIP-seq
MIRT1294332	hsa-miR-3122	CLIP-seq
MIRT1294333	hsa-miR-3199	CLIP-seq
MIRT1294334	hsa-miR-323b-5p	CLIP-seq
MIRT1294335	hsa-miR-3913-5p	CLIP-seq
MIRT1294336	hsa-miR-4298	CLIP-seq
MIRT1294337	hsa-miR-4662a-5p	CLIP-seq
MIRT1294338	hsa-miR-4676-5p	CLIP-seq
MIRT1294339	hsa-miR-4691-3p	CLIP-seq
MIRT1294340	hsa-miR-575	CLIP-seq
MIRT1294341	hsa-miR-665	CLIP-seq
MIRT1294326	hsa-miR-105	CLIP-seq
MIRT1294328	hsa-miR-19a	CLIP-seq
MIRT1294329	hsa-miR-19b	CLIP-seq
MIRT1294330	hsa-miR-2052	CLIP-seq
MIRT1294331	hsa-miR-2113	CLIP-seq
MIRT1294334	hsa-miR-323b-5p	CLIP-seq
MIRT1294326	hsa-miR-105	CLIP-seq
MIRT1294328	hsa-miR-19a	CLIP-seq
MIRT1294329	hsa-miR-19b	CLIP-seq
MIRT1294330	hsa-miR-2052	CLIP-seq
MIRT1294331	hsa-miR-2113	CLIP-seq
MIRT1294334	hsa-miR-323b-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004747	Function	Ribokinase activity	TAS
GO:0005515	Function	Protein binding	IPI	21044950
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006098	Process	Pentose-phosphate shunt	TAS
GO:0019303	Process	D-ribose catabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	31515488, 32296183
GO:0046835	Process	Carbohydrate phosphorylation	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 611132
• HGNC: 30325
• e!Ensembl: ENSG00000171174

Protein

• UniProt ID: Q9H477
• Protein name: Ribokinase (RK) (EC 2.7.1.15)
• Protein function: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phospha
• PDB: 2FV7, 5BYC, 5BYD, 5BYE, 5BYF, 5C3Y, 5C3Z, 5C40, 5C41, 6WJZ, 6WK0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00294	PfkB	15 → 314	pfkB family carbohydrate kinase	Family

• Sequence:

  MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV
  QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI
  IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP
  AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG
  CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV
  SVQAAGTQSSYPYKKDLPLTLF

• Sequence length: 322

Pathways

KEGG:

Pentose phosphate pathway
Metabolic pathways

Reactome:

Pentose phosphate pathway

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	26198764, 28991256, 30285260

Unknown
Disease term	Disease name	Evidence	References	Source
Bipolar Disorder	Bipolar Disorder			GWAS
Psoriasis	Psoriasis			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	36464806
Atrophy	Associate	36464806
Trigeminal Neuralgia	Associate	38158702