Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
64077
Gene name Gene Name - the full gene name approved by the HGNC.
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LHPP
Synonyms (NCBI Gene) Gene synonyms aliases
HDHD2B
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q26.13
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018083 hsa-miR-335-5p Microarray 18185580
MIRT456243 hsa-miR-224-3p PAR-CLIP 21572407
MIRT456242 hsa-miR-522-3p PAR-CLIP 21572407
MIRT456241 hsa-miR-6808-5p PAR-CLIP 21572407
MIRT456240 hsa-miR-6893-5p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding ISS
GO:0004427 Function Inorganic diphosphatase activity IBA 21873635
GO:0004427 Function Inorganic diphosphatase activity IDA 12801912
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IDA 16430861
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
617231 30042 ENSG00000107902
Protein
UniProt ID Q9H008
Protein name Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (hLHPP) (EC 3.1.3.-) (EC 3.6.1.1)
Protein function Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).
PDB 2X4D
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13344 Hydrolase_6 14 116 Haloacid dehalogenase-like hydrolase Domain
PF13242 Hydrolase_like 186 260 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in brain, and at lower levels in liver and kidney. Detected in thyroid (at protein level). Expressed in liver, kidney and moderately in brain. {ECO:0000269|PubMed:12801912, ECO:0000269|PubMed:16430861}.
Sequence
Sequence length 270
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Oxidative phosphorylation   Purine ribonucleoside monophosphate biosynthesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lymphoblastic leukemia Precursor B-Cell Lymphoblastic Leukemia-Lymphoma rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699
View all (13 more)
29632299, 27694927
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 18268499, 26176920 ClinVar
Asthma Asthma GWAS
Mental Depression Mental Depression GWAS
Testicular Germ Cell Tumor Testicular Germ Cell Tumor GWAS
Associations from Text Mining
Disease Name Relationship Type References
Asthma Associate 35858526
Carcinoma Hepatocellular Inhibit 31262971, 32186702, 32404854, 32578511, 34485511
Carcinoma Hepatocellular Associate 31693242
Carcinoma Pancreatic Ductal Associate 37321804
Carcinoma Renal Cell Associate 34699621, 36376886
Colorectal Neoplasms Associate 36376892
Depressive Disorder Major Associate 26176920, 26655122
Glaucoma Open Angle Associate 29452408
Glioma of Brain Familial Associate 36376886
Lymphatic Metastasis Associate 32186702