NPAS3 (neuronal PAS domain protein 3)

Gene

• Entrez ID: 64067
• Gene name: Neuronal PAS domain protein 3
• Gene symbol: NPAS3
• Synonyms (NCBI Gene): MOP6, PASD6, bHLHe12
• Chromosome: 14
• Chromosome location: 14q13.1
• Summary: This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT623065	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT623066	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT623066	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616233	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616233	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT623066	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT623065	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616233	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT623065	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT623066	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT623066	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616233	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616233	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT623066	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT623065	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616236	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616235	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT616233	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT616234	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1190337	hsa-miR-1	CLIP-seq
MIRT1190338	hsa-miR-103a	CLIP-seq
MIRT1190339	hsa-miR-107	CLIP-seq
MIRT1190340	hsa-miR-1179	CLIP-seq
MIRT1190341	hsa-miR-1273d	CLIP-seq
MIRT1190342	hsa-miR-127-5p	CLIP-seq
MIRT1190343	hsa-miR-128	CLIP-seq
MIRT1190344	hsa-miR-1324	CLIP-seq
MIRT1190345	hsa-miR-15a	CLIP-seq
MIRT1190346	hsa-miR-15b	CLIP-seq
MIRT1190347	hsa-miR-16	CLIP-seq
MIRT1190348	hsa-miR-183	CLIP-seq
MIRT1190349	hsa-miR-195	CLIP-seq
MIRT1190350	hsa-miR-1972	CLIP-seq
MIRT1190351	hsa-miR-206	CLIP-seq
MIRT1190352	hsa-miR-21	CLIP-seq
MIRT1190353	hsa-miR-2467-3p	CLIP-seq
MIRT1190354	hsa-miR-25	CLIP-seq
MIRT1190355	hsa-miR-3065-5p	CLIP-seq
MIRT1190356	hsa-miR-3120-5p	CLIP-seq
MIRT1190357	hsa-miR-3128	CLIP-seq
MIRT1190358	hsa-miR-3145-3p	CLIP-seq
MIRT1190359	hsa-miR-3192	CLIP-seq
MIRT1190360	hsa-miR-32	CLIP-seq
MIRT1190361	hsa-miR-3200-5p	CLIP-seq
MIRT1190362	hsa-miR-323-3p	CLIP-seq
MIRT1190363	hsa-miR-323b-5p	CLIP-seq
MIRT1190364	hsa-miR-326	CLIP-seq
MIRT1190365	hsa-miR-330-5p	CLIP-seq
MIRT1190366	hsa-miR-3614-5p	CLIP-seq
MIRT1190367	hsa-miR-3617	CLIP-seq
MIRT1190368	hsa-miR-363	CLIP-seq
MIRT1190369	hsa-miR-3664-3p	CLIP-seq
MIRT1190370	hsa-miR-367	CLIP-seq
MIRT1190371	hsa-miR-3689a-5p	CLIP-seq
MIRT1190372	hsa-miR-3689b	CLIP-seq
MIRT1190373	hsa-miR-3689e	CLIP-seq
MIRT1190374	hsa-miR-3689f	CLIP-seq
MIRT1190375	hsa-miR-377	CLIP-seq
MIRT1190376	hsa-miR-3914	CLIP-seq
MIRT1190377	hsa-miR-424	CLIP-seq
MIRT1190378	hsa-miR-4269	CLIP-seq
MIRT1190379	hsa-miR-4272	CLIP-seq
MIRT1190380	hsa-miR-4303	CLIP-seq
MIRT1190381	hsa-miR-4314	CLIP-seq
MIRT1190382	hsa-miR-4457	CLIP-seq
MIRT1190383	hsa-miR-4475	CLIP-seq
MIRT1190384	hsa-miR-4477a	CLIP-seq
MIRT1190385	hsa-miR-4522	CLIP-seq
MIRT1190386	hsa-miR-4643	CLIP-seq
MIRT1190387	hsa-miR-4645-3p	CLIP-seq
MIRT1190388	hsa-miR-4645-5p	CLIP-seq
MIRT1190389	hsa-miR-4646-5p	CLIP-seq
MIRT1190390	hsa-miR-466	CLIP-seq
MIRT1190391	hsa-miR-4670-3p	CLIP-seq
MIRT1190392	hsa-miR-4673	CLIP-seq
MIRT1190393	hsa-miR-4698	CLIP-seq
MIRT1190394	hsa-miR-4720-5p	CLIP-seq
MIRT1190395	hsa-miR-4755-3p	CLIP-seq
MIRT1190396	hsa-miR-4789-3p	CLIP-seq
MIRT1190397	hsa-miR-4789-5p	CLIP-seq
MIRT1190398	hsa-miR-4799-3p	CLIP-seq
MIRT1190399	hsa-miR-496	CLIP-seq
MIRT1190400	hsa-miR-497	CLIP-seq
MIRT1190401	hsa-miR-510	CLIP-seq
MIRT1190402	hsa-miR-513a-5p	CLIP-seq
MIRT1190403	hsa-miR-554	CLIP-seq
MIRT1190404	hsa-miR-590-5p	CLIP-seq
MIRT1190405	hsa-miR-607	CLIP-seq
MIRT1190406	hsa-miR-613	CLIP-seq
MIRT1190407	hsa-miR-630	CLIP-seq
MIRT1190408	hsa-miR-641	CLIP-seq
MIRT1190409	hsa-miR-642b	CLIP-seq
MIRT1190410	hsa-miR-656	CLIP-seq
MIRT1190411	hsa-miR-660	CLIP-seq
MIRT1190412	hsa-miR-668	CLIP-seq
MIRT1190413	hsa-miR-671-3p	CLIP-seq
MIRT1190414	hsa-miR-873	CLIP-seq
MIRT1190415	hsa-miR-889	CLIP-seq
MIRT1190416	hsa-miR-92a	CLIP-seq
MIRT1190417	hsa-miR-92b	CLIP-seq
MIRT1190418	hsa-miR-936	CLIP-seq
MIRT1190338	hsa-miR-103a	CLIP-seq
MIRT1190339	hsa-miR-107	CLIP-seq
MIRT2055115	hsa-miR-27a	CLIP-seq
MIRT2055116	hsa-miR-27b	CLIP-seq
MIRT2055117	hsa-miR-3125	CLIP-seq
MIRT2055118	hsa-miR-3616-5p	CLIP-seq
MIRT2055119	hsa-miR-3647-5p	CLIP-seq
MIRT2055120	hsa-miR-3916	CLIP-seq
MIRT2055121	hsa-miR-4311	CLIP-seq
MIRT2055122	hsa-miR-4328	CLIP-seq
MIRT2055123	hsa-miR-4476	CLIP-seq
MIRT2055124	hsa-miR-4795-3p	CLIP-seq
MIRT2055125	hsa-miR-4795-5p	CLIP-seq
MIRT1190402	hsa-miR-513a-5p	CLIP-seq
MIRT2055126	hsa-miR-543	CLIP-seq
MIRT2055127	hsa-miR-548ag	CLIP-seq
MIRT2055128	hsa-miR-548ai	CLIP-seq
MIRT2055129	hsa-miR-548m	CLIP-seq
MIRT2055130	hsa-miR-573	CLIP-seq
MIRT2284073	hsa-miR-1226	CLIP-seq
MIRT2055115	hsa-miR-27a	CLIP-seq
MIRT2055116	hsa-miR-27b	CLIP-seq
MIRT1190367	hsa-miR-3617	CLIP-seq
MIRT1190402	hsa-miR-513a-5p	CLIP-seq
MIRT2055126	hsa-miR-543	CLIP-seq
MIRT1190408	hsa-miR-641	CLIP-seq
MIRT2284074	hsa-miR-1197	CLIP-seq
MIRT2284075	hsa-miR-1229	CLIP-seq
MIRT2284076	hsa-miR-2277-3p	CLIP-seq
MIRT1190362	hsa-miR-323-3p	CLIP-seq
MIRT2284077	hsa-miR-342-3p	CLIP-seq
MIRT1190369	hsa-miR-3664-3p	CLIP-seq
MIRT1190375	hsa-miR-377	CLIP-seq
MIRT2284078	hsa-miR-412	CLIP-seq
MIRT1190378	hsa-miR-4269	CLIP-seq
MIRT2284079	hsa-miR-4277	CLIP-seq
MIRT1190386	hsa-miR-4643	CLIP-seq
MIRT1190388	hsa-miR-4645-5p	CLIP-seq
MIRT1190390	hsa-miR-466	CLIP-seq
MIRT1190391	hsa-miR-4670-3p	CLIP-seq
MIRT1190392	hsa-miR-4673	CLIP-seq
MIRT1190395	hsa-miR-4755-3p	CLIP-seq
MIRT1190396	hsa-miR-4789-3p	CLIP-seq
MIRT1190401	hsa-miR-510	CLIP-seq
MIRT2284080	hsa-miR-582-5p	CLIP-seq
MIRT1190409	hsa-miR-642b	CLIP-seq
MIRT1190413	hsa-miR-671-3p	CLIP-seq
MIRT1190414	hsa-miR-873	CLIP-seq
MIRT1190355	hsa-miR-3065-5p	CLIP-seq
MIRT1190357	hsa-miR-3128	CLIP-seq
MIRT2455341	hsa-miR-3175	CLIP-seq
MIRT2455342	hsa-miR-4419a	CLIP-seq
MIRT2455343	hsa-miR-4510	CLIP-seq
MIRT2455344	hsa-miR-4709-3p	CLIP-seq
MIRT2455345	hsa-miR-4716-3p	CLIP-seq
MIRT1190394	hsa-miR-4720-5p	CLIP-seq
MIRT2455346	hsa-miR-4723-5p	CLIP-seq
MIRT2455347	hsa-miR-4779	CLIP-seq
MIRT1190398	hsa-miR-4799-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	24722188, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0045893	Process	Positive regulation of DNA-templated transcription	ISS
GO:0046982	Function	Protein heterodimerization activity	ISS
GO:0046983	Function	Protein dimerization activity	IEA

Other IDs

• MIM: 609430
• HGNC: 19311
• e!Ensembl: ENSG00000151322

Protein

• UniProt ID: Q8IXF0
• Protein name: Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6)
• Protein function: May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00989	PAS	150 → 229	PAS fold	Domain
  PF08447	PAS_3	343 → 430	PAS fold	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed in the adult brain.
• Sequence:

  MAPTKPSFQQDPSRRERITAQHPLPNQSECRKIYRYDGIYCESTYQNLQALRKEKSRDAA
  RSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEG
  PPPNTSVKVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSI
  YLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSE
  TPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSH
  GRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVD
  IVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKN
  ANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNEN
  SKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENP
  KAGEDGFGALGAMQIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKR
  KKRRKRQKGGSASRRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDN
  DSSIWNYPPNREISRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPG
  ADGAAARKTQFGASATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSA
  SNSLLYTGDLEALQRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAM
  QSNLLPNAHAVNFVDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAG
  NVFTTAEGLFSTLPFPVYSNGIHAAQTLERKED

• Sequence length: 933