Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6405
Gene name	Semaphorin 3F
Gene symbol	SEMA3F
Synonyms (NCBI Gene)	SEMA-IVSEMA4SEMAK
Chromosome	3
Chromosome location	3p21.31
Summary	This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic do

188

Show/Hide all (188)

miRTarBase ID	miRNA	Experiments	Reference
MIRT519572	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT697191	hsa-miR-3145-3p	HITS-CLIP	23313552
MIRT519571	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT519569	hsa-miR-6083	HITS-CLIP	23313552
MIRT519570	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT519572	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT519571	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT519569	hsa-miR-6083	HITS-CLIP	23313552
MIRT519570	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT519572	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612269	hsa-miR-656-3p	HITS-CLIP	23824327
MIRT519571	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT519569	hsa-miR-6083	HITS-CLIP	23824327
MIRT519570	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT519572	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612269	hsa-miR-656-3p	HITS-CLIP	23824327
MIRT519571	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT519569	hsa-miR-6083	HITS-CLIP	23824327
MIRT519570	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT519572	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612269	hsa-miR-656-3p	HITS-CLIP	23824327
MIRT519571	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT519569	hsa-miR-6083	HITS-CLIP	23824327
MIRT519570	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT519572	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT519571	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT519569	hsa-miR-6083	PAR-CLIP	23446348
MIRT519570	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT491753	hsa-miR-3154	PAR-CLIP	23592263
MIRT491752	hsa-miR-6085	PAR-CLIP	23592263
MIRT491751	hsa-miR-6813-5p	PAR-CLIP	23592263
MIRT491750	hsa-miR-3937	PAR-CLIP	23592263
MIRT491749	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT491747	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT491748	hsa-miR-3179	PAR-CLIP	23592263
MIRT491746	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT491745	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT491744	hsa-miR-4706	PAR-CLIP	23592263
MIRT491743	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT491742	hsa-miR-4434	PAR-CLIP	23592263
MIRT491741	hsa-miR-4516	PAR-CLIP	23592263
MIRT491740	hsa-miR-5703	PAR-CLIP	23592263
MIRT491739	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT491738	hsa-miR-663a	PAR-CLIP	23592263
MIRT491737	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491736	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT491735	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT491733	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT491734	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT491732	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT491731	hsa-miR-4656	PAR-CLIP	23592263
MIRT491730	hsa-miR-185-3p	PAR-CLIP	23592263
MIRT519572	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT697191	hsa-miR-3145-3p	HITS-CLIP	23313552
MIRT519571	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT519569	hsa-miR-6083	HITS-CLIP	23313552
MIRT519570	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT519572	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT519571	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT519569	hsa-miR-6083	HITS-CLIP	23313552
MIRT519570	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT519572	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612269	hsa-miR-656-3p	HITS-CLIP	23824327
MIRT519571	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT519569	hsa-miR-6083	HITS-CLIP	23824327
MIRT519570	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT519572	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612269	hsa-miR-656-3p	HITS-CLIP	23824327
MIRT519571	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT519569	hsa-miR-6083	HITS-CLIP	23824327
MIRT519570	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT519572	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612269	hsa-miR-656-3p	HITS-CLIP	23824327
MIRT519571	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT519569	hsa-miR-6083	HITS-CLIP	23824327
MIRT519570	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT519572	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT519571	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT519569	hsa-miR-6083	PAR-CLIP	23446348
MIRT519570	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT491753	hsa-miR-3154	PAR-CLIP	23592263
MIRT491752	hsa-miR-6085	PAR-CLIP	23592263
MIRT491751	hsa-miR-6813-5p	PAR-CLIP	23592263
MIRT491750	hsa-miR-3937	PAR-CLIP	23592263
MIRT491749	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT491747	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT491748	hsa-miR-3179	PAR-CLIP	23592263
MIRT491746	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT491745	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT491744	hsa-miR-4706	PAR-CLIP	23592263
MIRT491743	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT491742	hsa-miR-4434	PAR-CLIP	23592263
MIRT491741	hsa-miR-4516	PAR-CLIP	23592263
MIRT491740	hsa-miR-5703	PAR-CLIP	23592263
MIRT491739	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT491738	hsa-miR-663a	PAR-CLIP	23592263
MIRT491737	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491736	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT491735	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT491733	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT491734	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT491732	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT491731	hsa-miR-4656	PAR-CLIP	23592263
MIRT491730	hsa-miR-185-3p	PAR-CLIP	23592263
MIRT1334970	hsa-let-7a	CLIP-seq
MIRT1334971	hsa-let-7b	CLIP-seq
MIRT1334972	hsa-let-7c	CLIP-seq
MIRT1334973	hsa-let-7d	CLIP-seq
MIRT1334974	hsa-let-7e	CLIP-seq
MIRT1334975	hsa-let-7f	CLIP-seq
MIRT1334976	hsa-let-7g	CLIP-seq
MIRT1334977	hsa-let-7i	CLIP-seq
MIRT1334978	hsa-miR-2682	CLIP-seq
MIRT1334979	hsa-miR-2861	CLIP-seq
MIRT1334980	hsa-miR-3153	CLIP-seq
MIRT1334981	hsa-miR-3155	CLIP-seq
MIRT1334982	hsa-miR-3155b	CLIP-seq
MIRT1334983	hsa-miR-3173-3p	CLIP-seq
MIRT1334984	hsa-miR-342-5p	CLIP-seq
MIRT1334985	hsa-miR-3927	CLIP-seq
MIRT1334986	hsa-miR-4423-3p	CLIP-seq
MIRT1334987	hsa-miR-4428	CLIP-seq
MIRT1334988	hsa-miR-4451	CLIP-seq
MIRT1334989	hsa-miR-4458	CLIP-seq
MIRT1334990	hsa-miR-4481	CLIP-seq
MIRT1334991	hsa-miR-449c	CLIP-seq
MIRT1334992	hsa-miR-4500	CLIP-seq
MIRT1334993	hsa-miR-4521	CLIP-seq
MIRT1334994	hsa-miR-4651	CLIP-seq
MIRT1334995	hsa-miR-4664-5p	CLIP-seq
MIRT1334996	hsa-miR-4745-5p	CLIP-seq
MIRT1334997	hsa-miR-484	CLIP-seq
MIRT1334998	hsa-miR-608	CLIP-seq
MIRT1334999	hsa-miR-760	CLIP-seq
MIRT1335000	hsa-miR-940	CLIP-seq
MIRT1335001	hsa-miR-98	CLIP-seq
MIRT2099028	hsa-miR-1225-3p	CLIP-seq
MIRT2099029	hsa-miR-1827	CLIP-seq
MIRT2099030	hsa-miR-193a-5p	CLIP-seq
MIRT2099031	hsa-miR-3138	CLIP-seq
MIRT2099032	hsa-miR-3165	CLIP-seq
MIRT2099033	hsa-miR-331-3p	CLIP-seq
MIRT2099034	hsa-miR-338-3p	CLIP-seq
MIRT2099035	hsa-miR-3605-5p	CLIP-seq
MIRT2099036	hsa-miR-3616-5p	CLIP-seq
MIRT2099037	hsa-miR-3647-5p	CLIP-seq
MIRT2099038	hsa-miR-3921	CLIP-seq
MIRT2099039	hsa-miR-3943	CLIP-seq
MIRT2099040	hsa-miR-4252	CLIP-seq
MIRT2099041	hsa-miR-4256	CLIP-seq
MIRT2099042	hsa-miR-4272	CLIP-seq
MIRT2099043	hsa-miR-4443	CLIP-seq
MIRT2099044	hsa-miR-4649-3p	CLIP-seq
MIRT2099045	hsa-miR-4653-5p	CLIP-seq
MIRT2099046	hsa-miR-4727-5p	CLIP-seq
MIRT2099047	hsa-miR-4733-3p	CLIP-seq
MIRT2099048	hsa-miR-4795-5p	CLIP-seq
MIRT2099049	hsa-miR-544	CLIP-seq
MIRT2099050	hsa-miR-573	CLIP-seq
MIRT2099051	hsa-miR-593	CLIP-seq
MIRT2099052	hsa-miR-634	CLIP-seq
MIRT2099053	hsa-miR-665	CLIP-seq
MIRT1334999	hsa-miR-760	CLIP-seq
MIRT2099054	hsa-miR-765	CLIP-seq
MIRT1335000	hsa-miR-940	CLIP-seq
MIRT2323826	hsa-miR-214	CLIP-seq
MIRT2099034	hsa-miR-338-3p	CLIP-seq
MIRT2323827	hsa-miR-3529	CLIP-seq
MIRT2323828	hsa-miR-3619-5p	CLIP-seq
MIRT2323829	hsa-miR-379	CLIP-seq
MIRT1334985	hsa-miR-3927	CLIP-seq
MIRT2323830	hsa-miR-4530	CLIP-seq
MIRT2323831	hsa-miR-617	CLIP-seq
MIRT2323832	hsa-miR-761	CLIP-seq
MIRT2099038	hsa-miR-3921	CLIP-seq
MIRT2099041	hsa-miR-4256	CLIP-seq
MIRT2099045	hsa-miR-4653-5p	CLIP-seq
MIRT2099046	hsa-miR-4727-5p	CLIP-seq
MIRT2099049	hsa-miR-544	CLIP-seq
MIRT2099051	hsa-miR-593	CLIP-seq
MIRT2099052	hsa-miR-634	CLIP-seq
MIRT2099038	hsa-miR-3921	CLIP-seq
MIRT2099041	hsa-miR-4256	CLIP-seq
MIRT2099045	hsa-miR-4653-5p	CLIP-seq
MIRT2099046	hsa-miR-4727-5p	CLIP-seq
MIRT2099049	hsa-miR-544	CLIP-seq
MIRT2099051	hsa-miR-593	CLIP-seq
MIRT2099052	hsa-miR-634	CLIP-seq

Show/Hide all (44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001755	Process	Neural crest cell migration	IBA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	TAS	8786119
GO:0005886	Component	Plasma membrane	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IDA	15814794
GO:0007411	Process	Axon guidance	IEA
GO:0021612	Process	Facial nerve structural organization	IEA
GO:0021612	Process	Facial nerve structural organization	ISS
GO:0021637	Process	Trigeminal nerve structural organization	IEA
GO:0021637	Process	Trigeminal nerve structural organization	ISS
GO:0021675	Process	Nerve development	IEA
GO:0021675	Process	Nerve development	ISS
GO:0021785	Process	Branchiomotor neuron axon guidance	IEA
GO:0021785	Process	Branchiomotor neuron axon guidance	ISS
GO:0030215	Function	Semaphorin receptor binding	IBA
GO:0030215	Function	Semaphorin receptor binding	IEA
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0036484	Process	Trunk neural crest cell migration	IEA
GO:0036486	Process	Ventral trunk neural crest cell migration	IEA
GO:0038191	Function	Neuropilin binding	IBA
GO:0045499	Function	Chemorepellent activity	IBA
GO:0045499	Function	Chemorepellent activity	IDA	15814794
GO:0045499	Function	Chemorepellent activity	IEA
GO:0048731	Process	System development	IEA
GO:0048843	Process	Negative regulation of axon extension involved in axon guidance	IEA
GO:0048846	Process	Axon extension involved in axon guidance	IEA
GO:0048846	Process	Axon extension involved in axon guidance	ISS
GO:0050919	Process	Negative chemotaxis	IBA
GO:0050919	Process	Negative chemotaxis	IEA
GO:0061549	Process	Sympathetic ganglion development	IEA
GO:0061549	Process	Sympathetic ganglion development	ISS
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:0097490	Process	Sympathetic neuron projection extension	IEA
GO:0097490	Process	Sympathetic neuron projection extension	ISS
GO:0097491	Process	Sympathetic neuron projection guidance	IEA
GO:0097491	Process	Sympathetic neuron projection guidance	ISS
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099175	Process	Regulation of postsynapse organization	IEA
GO:1901166	Process	Neural crest cell migration involved in autonomic nervous system development	IEA

MIM	HGNC	e!Ensembl
601124	10728	ENSG00000001617

Q13275

Protein name

Semaphorin-3F (Sema III/F) (Semaphorin IV) (Sema IV)

Protein function

May play a role in cell motility and cell adhesion.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01403	Sema	59 → 527	Sema domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver.

Sequence

MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRIL
LKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVR
LIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTA
PRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQ
TAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAVYARIGRIC
LNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFT
SSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPS
MKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEV
LFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGV
THLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRG
FNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTE
QGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRDAVHAALFPPLSMSAPPPPGA
GPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQKKPRNRRH
HPPDT

Sequence length

785

Interactions

View interactions

	KEGG
	Axon guidance

118

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs374308618	RCV005933241
Cervical cancer	Likely benign	rs374355347	RCV005933435
Familial cancer of breast	Likely benign	rs200014361	RCV005933498
Hearing impairment	Uncertain significance	rs1399111219	RCV001375120
Hypogonadotropic hypogonadism	Uncertain significance; Affects	rs768661142, rs141286158, rs777811058, rs2109128819, rs768027884, rs749838132	RCV001374676 RCV001374677 RCV001374678 RCV001374679 RCV001374680 RCV001374684
Ovarian serous cystadenocarcinoma	Likely benign	rs374308618	RCV005933242
SEMA3F-related disorder	Uncertain significance; Conflicting classifications of pathogenicity; Likely benign; Benign	rs1399111219, rs112128203, rs753733068, rs772280883, rs745746219, rs149408865, rs372829300, rs145958913, rs757018373, rs149131307, rs985333083, rs753100848, rs759861492, rs754401762, rs375597719 View all (91 more)	RCV004746361 RCV003410169 RCV004747242 RCV003906587 RCV004747246 RCV003396832 RCV003396859 RCV003420514 RCV003984345 RCV003420598 RCV004747280 RCV003410320 RCV004747281 RCV004747282 RCV003420638 RCV003399729 RCV003399826 RCV003414107 RCV003408637 RCV003408705 RCV003410703 RCV003393075 RCV003397658 RCV003419084 RCV003403074 RCV003399571 RCV003420714 RCV003422517 RCV003421049 RCV003410836 RCV003402965 RCV003410775 RCV003919183 RCV003954184 RCV003896664 RCV003894289 RCV003897053 RCV003894595 RCV003894644 RCV003921657 RCV003921763 RCV003921775 RCV003921788 RCV003981628 RCV003893619 RCV003896348 RCV003893992 RCV003894196 RCV003902267 RCV003902279 RCV003894391 RCV003894427 RCV003912322 RCV003897410 RCV003904453 RCV003904624 RCV003964496 RCV003974135 RCV003967363 RCV003901509 RCV003901761 RCV003982251 RCV003984541 RCV003899198 RCV003899261 RCV003899488 RCV003899537 RCV003899655 RCV003892304 RCV003913984 RCV003934548 RCV003951926 RCV003951949 RCV003959516 RCV003971900 RCV003971973 RCV003931693 RCV003949795 RCV003914601 RCV003939360 RCV003951418 RCV003922267 RCV003922300 RCV003917350 RCV003934213 RCV003934317 RCV003934600 RCV003934640 RCV003954430 RCV003976840 RCV003957185 RCV003947272 RCV003957371 RCV003954837 RCV003969667 RCV003969675 RCV003969730 RCV003969739 RCV003969798 RCV003969833 RCV003969845 RCV003969118 RCV004747418 RCV004747419 RCV003975573 RCV003933022

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	39232098
Breast Neoplasms	Associate	26784191
Calcinosis Cutis	Inhibit	20388805
Carcinogenesis	Associate	26722466, 30696738, 32297576, 39232098
Carcinoma Adenoid Cystic	Associate	28961428
Colorectal Neoplasms	Associate	25193853, 33109776
Colorectal Neoplasms	Inhibit	26722466
Disease	Inhibit	31215376
Endometrial Neoplasms	Inhibit	21933904
Endometrial Neoplasms	Associate	31215376, 32297576
Esophageal Squamous Cell Carcinoma	Inhibit	32441221
Fatty Liver	Associate	38034016
Hemangioma capillary infantile	Inhibit	26086095
Hirschsprung Disease	Associate	30663199
Hypoxia	Associate	19177200, 21610314
Idiopathic Hypogonadotropic Hypogonadism	Associate	33495532
Lung Neoplasms	Associate	10702410, 12845630
Lung Neoplasms	Inhibit	19177200
Lymphatic Metastasis	Associate	32441221
Lymphoma	Associate	25068647
Megacolon	Associate	30663199
Neoplasm Metastasis	Inhibit	20388805, 21610314, 26722466
Neoplasm Metastasis	Associate	21933904, 28961428
Neoplasms	Associate	12845630, 20388805, 21610314, 21933904, 32297576
Neoplasms	Inhibit	19177200, 26722466, 28052040, 31215376, 32441221
Ovarian Neoplasms	Associate	20124444
Parkinson Disease	Associate	38203854
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	25068647
Small Cell Lung Carcinoma	Associate	8633026
Stomach Neoplasms	Associate	28052040
Thyroid Neoplasms	Associate	36737753
Uterine Cervicitis	Associate	30696738

SEMA3F (semaphorin 3F)