SELL (selectin L)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6402
Gene name Selectin L
Gene symbol SELL
Synonyms (NCBI Gene)
CD62LLAM1LECAM1LEU8LNHRLSELLYAM1PLNHRTQ1
Chromosome 1
Chromosome location 1q24.2
Summary This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeat
miRNA miRNA information provided by mirtarbase database.
35
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (35)
miRTarBase ID miRNA Experiments Reference
MIRT1334276 hsa-miR-1179 CLIP-seq
MIRT1334277 hsa-miR-1252 CLIP-seq
MIRT1334278 hsa-miR-1261 CLIP-seq
MIRT1334279 hsa-miR-204 CLIP-seq
MIRT1334280 hsa-miR-211 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (1)
Transcription factor Regulation Reference
KLF2 Unknown 20146713
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (30)
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IPI 17548643
GO:0005509 Function Calcium ion binding IDA 28011641
GO:0005515 Function Protein binding IPI 18606703, 32296183
GO:0005615 Component Extracellular space IBA
GO:0005886 Component Plasma membrane IDA 2663882, 28011641
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
153240 10720 ENSG00000188404
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P14151
Protein name L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Protein function Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28011641, PubMed:28489325). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in
PDB 2LGF , 3CFW , 5VC1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00059 Lectin_C 46 → 157 Lectin C-type domain Domain
PF00084 Sushi 197 → 254 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 259 → 316 Sushi repeat (SCR repeat) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in B-cell lines and T-lymphocytes. {ECO:0000269|PubMed:2473156}.
Sequence
Sequence length 372
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Cell adhesion molecules   Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Neutrophil degranulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Colon adenocarcinoma Benign rs2229568 RCV005907403
Nonpapillary renal cell carcinoma Benign rs2229568 RCV005907404
Show/Hide Text Mining Associations (212)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acne Vulgaris Associate 24399259
Acquired Immunodeficiency Syndrome Inhibit 10444267
Acute Disease Associate 30949182
Acute Kidney Injury Stimulate 36333626
Adenocarcinoma Associate 27513329
Adenocarcinoma Mucinous Associate 11726653
Adenocarcinoma of Lung Associate 27513329, 35918384
Alzheimer Disease Associate 25197660
Anemia Sickle Cell Associate 11895759, 24191245
Aneurysm Associate 9290560