CLSPN (claspin)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 63967 |
| Gene name | Claspin |
| Gene symbol | CLSPN |
| Synonyms (NCBI Gene) |
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| Chromosome | 1 |
| Chromosome location | 1p34.3 |
| Summary | The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a norm |
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miRNA
miRNA information provided by mirtarbase database.
661
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9HAW4 | |
| Protein name | Claspin (hClaspin) | |
| Protein function | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein wh | |
| PDB | 7AKO , 7PFO , 7PLO , 8B9D | |
| Family and domains | ||
| Sequence |
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| Sequence length | 1339 | |
| Interactions | View interactions | |
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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