Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	63935
Gene name	Phosphorylated CTD interacting factor 1
Gene symbol	PCIF1
Synonyms (NCBI Gene)	C20orf67CAPAMMT-A70PPP1R121hCAPAMhPCIF1
Chromosome	20
Chromosome location	20q13.12

Show/Hide all (75)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052546	hsa-let-7a-5p	CLASH	23622248
MIRT1217742	hsa-miR-1275	CLIP-seq
MIRT1217743	hsa-miR-1908	CLIP-seq
MIRT1217744	hsa-miR-3180	CLIP-seq
MIRT1217745	hsa-miR-3180-3p	CLIP-seq
MIRT1217746	hsa-miR-3184	CLIP-seq
MIRT1217747	hsa-miR-3196	CLIP-seq
MIRT1217748	hsa-miR-3199	CLIP-seq
MIRT1217749	hsa-miR-3686	CLIP-seq
MIRT1217750	hsa-miR-3688-5p	CLIP-seq
MIRT1217751	hsa-miR-3910	CLIP-seq
MIRT1217752	hsa-miR-423-5p	CLIP-seq
MIRT1217753	hsa-miR-4425	CLIP-seq
MIRT1217754	hsa-miR-4436a	CLIP-seq
MIRT1217755	hsa-miR-4652-3p	CLIP-seq
MIRT1217756	hsa-miR-4665-5p	CLIP-seq
MIRT1217757	hsa-miR-4710	CLIP-seq
MIRT1217758	hsa-miR-4711-5p	CLIP-seq
MIRT1217759	hsa-miR-4742-3p	CLIP-seq
MIRT1217760	hsa-miR-4747-5p	CLIP-seq
MIRT1217761	hsa-miR-4802-3p	CLIP-seq
MIRT1217762	hsa-miR-635	CLIP-seq
MIRT1217763	hsa-miR-663	CLIP-seq
MIRT1217764	hsa-miR-890	CLIP-seq
MIRT1217748	hsa-miR-3199	CLIP-seq
MIRT2062949	hsa-miR-3201	CLIP-seq
MIRT2062950	hsa-miR-3646	CLIP-seq
MIRT1217751	hsa-miR-3910	CLIP-seq
MIRT2062951	hsa-miR-4268	CLIP-seq
MIRT2062952	hsa-miR-4283	CLIP-seq
MIRT2062953	hsa-miR-432	CLIP-seq
MIRT1217753	hsa-miR-4425	CLIP-seq
MIRT1217754	hsa-miR-4436a	CLIP-seq
MIRT2062954	hsa-miR-4443	CLIP-seq
MIRT2062955	hsa-miR-4489	CLIP-seq
MIRT1217758	hsa-miR-4711-5p	CLIP-seq
MIRT1217759	hsa-miR-4742-3p	CLIP-seq
MIRT1217760	hsa-miR-4747-5p	CLIP-seq
MIRT2062956	hsa-miR-4791	CLIP-seq
MIRT1217761	hsa-miR-4802-3p	CLIP-seq
MIRT2062957	hsa-miR-494	CLIP-seq
MIRT2062958	hsa-miR-520d-5p	CLIP-seq
MIRT2062959	hsa-miR-524-5p	CLIP-seq
MIRT2062960	hsa-miR-624	CLIP-seq
MIRT1217764	hsa-miR-890	CLIP-seq
MIRT2291363	hsa-miR-1207-5p	CLIP-seq
MIRT2291364	hsa-miR-1321	CLIP-seq
MIRT2291365	hsa-miR-3144-5p	CLIP-seq
MIRT2291366	hsa-miR-3191	CLIP-seq
MIRT1217751	hsa-miR-3910	CLIP-seq
MIRT2291367	hsa-miR-4270	CLIP-seq
MIRT1217754	hsa-miR-4436a	CLIP-seq
MIRT2291368	hsa-miR-4441	CLIP-seq
MIRT2291369	hsa-miR-4514	CLIP-seq
MIRT2291370	hsa-miR-4652-5p	CLIP-seq
MIRT2291371	hsa-miR-4692	CLIP-seq
MIRT1217758	hsa-miR-4711-5p	CLIP-seq
MIRT2291372	hsa-miR-4728-5p	CLIP-seq
MIRT2291373	hsa-miR-4739	CLIP-seq
MIRT2291374	hsa-miR-4756-5p	CLIP-seq
MIRT2291375	hsa-miR-4763-3p	CLIP-seq
MIRT2291376	hsa-miR-939	CLIP-seq
MIRT2291377	hsa-miR-940	CLIP-seq
MIRT1217743	hsa-miR-1908	CLIP-seq
MIRT1217744	hsa-miR-3180	CLIP-seq
MIRT1217745	hsa-miR-3180-3p	CLIP-seq
MIRT1217746	hsa-miR-3184	CLIP-seq
MIRT1217747	hsa-miR-3196	CLIP-seq
MIRT1217750	hsa-miR-3688-5p	CLIP-seq
MIRT1217752	hsa-miR-423-5p	CLIP-seq
MIRT1217753	hsa-miR-4425	CLIP-seq
MIRT1217757	hsa-miR-4710	CLIP-seq
MIRT2588887	hsa-miR-4761-5p	CLIP-seq
MIRT2062960	hsa-miR-624	CLIP-seq
MIRT1217763	hsa-miR-663	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	18294453, 31279659
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006397	Process	MRNA processing	IDA	30467178, 30487554, 31279658, 31279659, 33428944
GO:0006417	Process	Regulation of translation	IDA	31279658
GO:0008168	Function	Methyltransferase activity	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016422	Function	MRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	IDA	30467178, 30487554, 31279658, 31279659, 32814042, 33428944
GO:0016422	Function	MRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0017148	Process	Negative regulation of translation	IDA	31279659
GO:0032259	Process	Methylation	IEA
GO:0045171	Component	Intercellular bridge	IDA
GO:0045727	Process	Positive regulation of translation	IMP	30467178
GO:0099122	Function	RNA polymerase II C-terminal domain binding	IDA	18294453, 30467178
GO:0099122	Function	RNA polymerase II C-terminal domain binding	IEA
GO:1904047	Function	S-adenosyl-L-methionine binding	IDA	30467178
GO:1990269	Function	RNA polymerase II C-terminal domain phosphoserine binding	IDA	32814042

MIM	HGNC	e!Ensembl
618626	16200	ENSG00000100982

Q9H4Z3

Protein name

mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121)

Protein function

Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, Pub

PDB

2JX8 , 6IRV , 6IRW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00397	WW	45 → 75	WW domain	Domain
PF12237	PCIF1_WW	446 → 621	Phosphorylated CTD interacting factor 1 WW domain	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:12565871}.

Sequence

MANENHGSPREEASLLSHSPGTSNQSQPCSPKPIRLVQDLPEELVHAGWEKCWSRRENRP
YYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPPAENKPRKRQLSEEQP
SGNGVKKPKIEIPVTPTGQSVPSSPSIPGTPTLKMWGTSPEDKQQAALLRPTEVYWDLDI
QTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLER
KVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIE
SRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGI
CSKIYHISLEYVKRIREKHLAILKENNISEEVEAPEVEPRLVYCYPVRLAVSAPPMPSVE
MHMENNVVCIRYKGEMVKVSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFG
VGLYEGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPC
LDFAPLSGSFEANPPFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRME
QSRFKRHQLILPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERL
QELSAAYRQSGRSHSSGSSSSSSSEAKDRDSGREQGPSREPHPT

Sequence length

704

Interactions

View interactions

PCIF1 (phosphorylated CTD interacting factor 1)