Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	63928
Gene name	Calcineurin like EF-hand protein 2
Gene symbol	CHP2
Synonyms (NCBI Gene)	-
Chromosome	16
Chromosome location	16p12.2
Summary	This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase acti

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miRTarBase ID	miRNA	Experiments
MIRT891056	hsa-miR-106a	CLIP-seq
MIRT891057	hsa-miR-106b	CLIP-seq
MIRT891058	hsa-miR-1208	CLIP-seq
MIRT891059	hsa-miR-1249	CLIP-seq
MIRT891060	hsa-miR-1266	CLIP-seq
MIRT891061	hsa-miR-1286	CLIP-seq
MIRT891062	hsa-miR-1288	CLIP-seq
MIRT891063	hsa-miR-142-5p	CLIP-seq
MIRT891064	hsa-miR-149	CLIP-seq
MIRT891065	hsa-miR-150	CLIP-seq
MIRT891066	hsa-miR-17	CLIP-seq
MIRT891067	hsa-miR-20a	CLIP-seq
MIRT891068	hsa-miR-20b	CLIP-seq
MIRT891069	hsa-miR-2110	CLIP-seq
MIRT891070	hsa-miR-3127-3p	CLIP-seq
MIRT891071	hsa-miR-3127-5p	CLIP-seq
MIRT891072	hsa-miR-3144-5p	CLIP-seq
MIRT891073	hsa-miR-3150a-3p	CLIP-seq
MIRT891074	hsa-miR-3173-5p	CLIP-seq
MIRT891075	hsa-miR-3191	CLIP-seq
MIRT891076	hsa-miR-3193	CLIP-seq
MIRT891077	hsa-miR-3199	CLIP-seq
MIRT891078	hsa-miR-3609	CLIP-seq
MIRT891079	hsa-miR-3679-3p	CLIP-seq
MIRT891080	hsa-miR-3682-3p	CLIP-seq
MIRT891081	hsa-miR-3918	CLIP-seq
MIRT891082	hsa-miR-425	CLIP-seq
MIRT891083	hsa-miR-4518	CLIP-seq
MIRT891084	hsa-miR-4652-5p	CLIP-seq
MIRT891085	hsa-miR-4663	CLIP-seq
MIRT891086	hsa-miR-4713-5p	CLIP-seq
MIRT891087	hsa-miR-4722-5p	CLIP-seq
MIRT891088	hsa-miR-4778-5p	CLIP-seq
MIRT891089	hsa-miR-4796-3p	CLIP-seq
MIRT891090	hsa-miR-519a	CLIP-seq
MIRT891091	hsa-miR-519b-3p	CLIP-seq
MIRT891092	hsa-miR-519c-3p	CLIP-seq
MIRT891093	hsa-miR-519d	CLIP-seq
MIRT891094	hsa-miR-532-3p	CLIP-seq
MIRT891095	hsa-miR-548ah	CLIP-seq
MIRT891096	hsa-miR-570	CLIP-seq
MIRT891097	hsa-miR-582-5p	CLIP-seq
MIRT891098	hsa-miR-610	CLIP-seq
MIRT891099	hsa-miR-668	CLIP-seq
MIRT891100	hsa-miR-760	CLIP-seq
MIRT891101	hsa-miR-93	CLIP-seq
MIRT891062	hsa-miR-1288	CLIP-seq
MIRT891069	hsa-miR-2110	CLIP-seq
MIRT1964128	hsa-miR-219-1-3p	CLIP-seq
MIRT891072	hsa-miR-3144-5p	CLIP-seq
MIRT891073	hsa-miR-3150a-3p	CLIP-seq
MIRT891075	hsa-miR-3191	CLIP-seq
MIRT891077	hsa-miR-3199	CLIP-seq
MIRT1964129	hsa-miR-323-3p	CLIP-seq
MIRT1964130	hsa-miR-4527	CLIP-seq
MIRT1964131	hsa-miR-4528	CLIP-seq
MIRT891084	hsa-miR-4652-5p	CLIP-seq
MIRT891085	hsa-miR-4663	CLIP-seq
MIRT1964132	hsa-miR-4710	CLIP-seq
MIRT1964133	hsa-miR-4712-3p	CLIP-seq
MIRT1964134	hsa-miR-4792	CLIP-seq
MIRT1964135	hsa-miR-483-3p	CLIP-seq
MIRT1964136	hsa-miR-568	CLIP-seq
MIRT1964137	hsa-miR-571	CLIP-seq
MIRT1964138	hsa-miR-580	CLIP-seq
MIRT1964139	hsa-miR-584	CLIP-seq
MIRT891098	hsa-miR-610	CLIP-seq
MIRT1964140	hsa-miR-944	CLIP-seq
MIRT891056	hsa-miR-106a	CLIP-seq
MIRT891057	hsa-miR-106b	CLIP-seq
MIRT891058	hsa-miR-1208	CLIP-seq
MIRT891062	hsa-miR-1288	CLIP-seq
MIRT891063	hsa-miR-142-5p	CLIP-seq
MIRT891065	hsa-miR-150	CLIP-seq
MIRT891066	hsa-miR-17	CLIP-seq
MIRT891067	hsa-miR-20a	CLIP-seq
MIRT891068	hsa-miR-20b	CLIP-seq
MIRT891069	hsa-miR-2110	CLIP-seq
MIRT2200329	hsa-miR-3117-5p	CLIP-seq
MIRT891072	hsa-miR-3144-5p	CLIP-seq
MIRT891073	hsa-miR-3150a-3p	CLIP-seq
MIRT891075	hsa-miR-3191	CLIP-seq
MIRT2200330	hsa-miR-3194-3p	CLIP-seq
MIRT891077	hsa-miR-3199	CLIP-seq
MIRT2200331	hsa-miR-323-5p	CLIP-seq
MIRT891078	hsa-miR-3609	CLIP-seq
MIRT2200332	hsa-miR-3614-5p	CLIP-seq
MIRT2200333	hsa-miR-3670	CLIP-seq
MIRT2200334	hsa-miR-3673	CLIP-seq
MIRT2200335	hsa-miR-380	CLIP-seq
MIRT2200336	hsa-miR-4421	CLIP-seq
MIRT2200337	hsa-miR-4436b-5p	CLIP-seq
MIRT2200338	hsa-miR-4639-3p	CLIP-seq
MIRT891084	hsa-miR-4652-5p	CLIP-seq
MIRT891085	hsa-miR-4663	CLIP-seq
MIRT891086	hsa-miR-4713-5p	CLIP-seq
MIRT891089	hsa-miR-4796-3p	CLIP-seq
MIRT1964135	hsa-miR-483-3p	CLIP-seq
MIRT891090	hsa-miR-519a	CLIP-seq
MIRT891091	hsa-miR-519b-3p	CLIP-seq
MIRT891092	hsa-miR-519c-3p	CLIP-seq
MIRT891093	hsa-miR-519d	CLIP-seq
MIRT891094	hsa-miR-532-3p	CLIP-seq
MIRT891095	hsa-miR-548ah	CLIP-seq
MIRT891098	hsa-miR-610	CLIP-seq
MIRT891099	hsa-miR-668	CLIP-seq
MIRT2200339	hsa-miR-876-3p	CLIP-seq
MIRT2200340	hsa-miR-890	CLIP-seq
MIRT891101	hsa-miR-93	CLIP-seq
MIRT1964140	hsa-miR-944	CLIP-seq
MIRT1964128	hsa-miR-219-1-3p	CLIP-seq
MIRT1964129	hsa-miR-323-3p	CLIP-seq
MIRT1964132	hsa-miR-4710	CLIP-seq
MIRT1964134	hsa-miR-4792	CLIP-seq
MIRT1964136	hsa-miR-568	CLIP-seq
MIRT1964137	hsa-miR-571	CLIP-seq
MIRT1964139	hsa-miR-584	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IDA	21392185
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	16710297, 21392185, 31912575, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	21392185
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	21392185
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	21392185
GO:0005886	Component	Plasma membrane	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	18815128, 21392185
GO:0010922	Process	Positive regulation of phosphatase activity	IDA	18815128
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0042306	Process	Regulation of protein import into nucleus	IEA
GO:0042307	Process	Positive regulation of protein import into nucleus	IDA	18815128
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	18815128
GO:0046872	Function	Metal ion binding	IEA
GO:0070884	Process	Regulation of calcineurin-NFAT signaling cascade	IEA
GO:0070886	Process	Positive regulation of calcineurin-NFAT signaling cascade	IBA
GO:0070886	Process	Positive regulation of calcineurin-NFAT signaling cascade	IDA	18815128
GO:0071277	Process	Cellular response to calcium ion	IDA	18815128

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

O43745

Protein name

Calcineurin B homologous protein 2 (Hepatocellular carcinoma-associated antigen 520)

Protein function

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum depriv

PDB

2BEC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13202	EF-hand_5	31 → 54	EF hand	Domain
PF00036	EF-hand_1	115 → 143	EF hand	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in malignantly transformed cells but not detected in normal tissues. {ECO:0000269|PubMed:12097419, ECO:0000269|PubMed:12226101}.

Sequence

MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVN
PLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAF
QLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKS
LEKMDVEQKMSIRILK

Sequence length

196

Interactions

View interactions

CHP2 (calcineurin like EF-hand protein 2)