Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6391
Gene name	Succinate dehydrogenase complex subunit C
Gene symbol	SDHC
Synonyms (NCBI Gene)	CYB560CYBLPGL3PPGL3QPS1SDH3
Chromosome	1
Chromosome location	1q23.3
Summary	This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein

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SNP ID	Visualize variation	Clinical significance	Consequence
rs200375156	A>G,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Missense variant, coding sequence variant, non coding transcript variant
rs201286421	C>T	Pathogenic	Intron variant, coding sequence variant, stop gained, non coding transcript variant
rs587776652	G>A	Pathogenic	Initiator codon variant, missense variant, non coding transcript variant
rs587776653	G>A,C,T	Likely-pathogenic, pathogenic	Splice donor variant, intron variant
rs587778661	C>T	Uncertain-significance, likely-pathogenic, not-provided	Coding sequence variant, non coding transcript variant, missense variant, intron variant
rs748440817	G>A,T	Likely-pathogenic	Splice donor variant
rs755235380	A>G,T	Pathogenic, likely-pathogenic	Initiator codon variant, missense variant, non coding transcript variant
rs756676111	C>T	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs764575966	C>T	Pathogenic	Stop gained, non coding transcript variant, intron variant, coding sequence variant
rs786202080	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant, intron variant, non coding transcript variant
rs786202200	G>A,T	Likely-pathogenic	Splice acceptor variant, intron variant
rs786203457	A>G	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant, intron variant, non coding transcript variant
rs786205146	T>-	Pathogenic, likely-pathogenic	Coding sequence variant, frameshift variant, non coding transcript variant
rs786205147	G>A,T	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant, non coding transcript variant
rs794727791	A>G	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant, synonymous variant, non coding transcript variant
rs867966048	G>A,C	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs876658301	->T	Pathogenic	Coding sequence variant, intron variant, frameshift variant, non coding transcript variant
rs898854295	A>G	Likely-pathogenic, uncertain-significance, pathogenic	Intron variant, coding sequence variant, non coding transcript variant, missense variant
rs981049067	G>A,C	Pathogenic, likely-pathogenic, uncertain-significance	Stop gained, coding sequence variant, non coding transcript variant, intron variant, missense variant
rs1057517818	G>C	Likely-pathogenic	Splice donor variant, intron variant
rs1131691062	A>G	Likely-pathogenic	Intron variant, splice acceptor variant
rs1553260596	->TG	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs1553261757	CAGAC>-	Likely-pathogenic	Intron variant, coding sequence variant, splice acceptor variant, non coding transcript variant
rs1553264218	G>-	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs1553265817	TATCATACCTGGAATG>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant, non coding transcript variant
rs1553266474	TGTGGGACCTAGGAAAAGGCCTGAAGATTCCCCAGCTATACCAGTCTGGAGTGGTTGTCCTGGTTCTTACTGTGTTGTCCTCTATGGGGCTGGCAGCCATGTGAA>-	Pathogenic	Inframe indel, non coding transcript variant, coding sequence variant, stop lost, 3 prime UTR variant, terminator codon variant
rs1558164647	G>A	Likely-pathogenic	Intron variant, splice donor variant
rs1558182956	G>-	Likely-pathogenic	Intron variant, coding sequence variant, non coding transcript variant, splice donor variant
rs1571869304	->T	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs1571889991	CTTT>-	Pathogenic	Intron variant, coding sequence variant, non coding transcript variant, frameshift variant

317

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025841	hsa-miR-7-5p	Microarray	19073608
MIRT044536	hsa-miR-320a	CLASH	23622248
MIRT040069	hsa-miR-615-3p	CLASH	23622248
MIRT036997	hsa-miR-877-3p	CLASH	23622248
MIRT498304	hsa-miR-8084	PAR-CLIP	22291592
MIRT498303	hsa-miR-9-3p	PAR-CLIP	22291592
MIRT733619	hsa-miR-145-5p	Microarray	34012635
MIRT733620	hsa-miR-185-5p	Microarray	34012635
MIRT498304	hsa-miR-8084	PAR-CLIP	22291592
MIRT498303	hsa-miR-9-3p	PAR-CLIP	22291592
MIRT1331832	hsa-miR-1252	CLIP-seq
MIRT1331833	hsa-miR-1299	CLIP-seq
MIRT1331834	hsa-miR-142-5p	CLIP-seq
MIRT1331835	hsa-miR-3119	CLIP-seq
MIRT1331836	hsa-miR-3133	CLIP-seq
MIRT1331837	hsa-miR-3163	CLIP-seq
MIRT1331838	hsa-miR-3188	CLIP-seq
MIRT1331839	hsa-miR-323-3p	CLIP-seq
MIRT1331840	hsa-miR-3545-3p	CLIP-seq
MIRT1331841	hsa-miR-3662	CLIP-seq
MIRT1331842	hsa-miR-3682-5p	CLIP-seq
MIRT1331843	hsa-miR-3973	CLIP-seq
MIRT1331844	hsa-miR-4266	CLIP-seq
MIRT1331845	hsa-miR-4282	CLIP-seq
MIRT1331846	hsa-miR-4328	CLIP-seq
MIRT1331847	hsa-miR-4422	CLIP-seq
MIRT1331848	hsa-miR-4428	CLIP-seq
MIRT1331849	hsa-miR-4434	CLIP-seq
MIRT1331850	hsa-miR-4476	CLIP-seq
MIRT1331851	hsa-miR-4516	CLIP-seq
MIRT1331852	hsa-miR-4539	CLIP-seq
MIRT1331853	hsa-miR-4668-5p	CLIP-seq
MIRT1331854	hsa-miR-4683	CLIP-seq
MIRT1331855	hsa-miR-4760-3p	CLIP-seq
MIRT1331856	hsa-miR-4782-5p	CLIP-seq
MIRT1331857	hsa-miR-496	CLIP-seq
MIRT1331858	hsa-miR-516b	CLIP-seq
MIRT1331859	hsa-miR-539	CLIP-seq
MIRT1331860	hsa-miR-548a-5p	CLIP-seq
MIRT1331861	hsa-miR-548aa	CLIP-seq
MIRT1331862	hsa-miR-548ab	CLIP-seq
MIRT1331863	hsa-miR-548ak	CLIP-seq
MIRT1331864	hsa-miR-548b-5p	CLIP-seq
MIRT1331865	hsa-miR-548c-5p	CLIP-seq
MIRT1331866	hsa-miR-548d-5p	CLIP-seq
MIRT1331867	hsa-miR-548h	CLIP-seq
MIRT1331868	hsa-miR-548i	CLIP-seq
MIRT1331869	hsa-miR-548j	CLIP-seq
MIRT1331870	hsa-miR-548k	CLIP-seq
MIRT1331871	hsa-miR-548l	CLIP-seq
MIRT1331872	hsa-miR-548w	CLIP-seq
MIRT1331873	hsa-miR-548y	CLIP-seq
MIRT1331874	hsa-miR-559	CLIP-seq
MIRT1331875	hsa-miR-577	CLIP-seq
MIRT1331876	hsa-miR-628-5p	CLIP-seq
MIRT1331877	hsa-miR-875-3p	CLIP-seq
MIRT1331878	hsa-miR-124	CLIP-seq
MIRT1331879	hsa-miR-1290	CLIP-seq
MIRT1331880	hsa-miR-129-5p	CLIP-seq
MIRT1331881	hsa-miR-1301	CLIP-seq
MIRT1331882	hsa-miR-3613-3p	CLIP-seq
MIRT1331883	hsa-miR-3714	CLIP-seq
MIRT1331884	hsa-miR-3910	CLIP-seq
MIRT1331885	hsa-miR-4477b	CLIP-seq
MIRT1331886	hsa-miR-4506	CLIP-seq
MIRT1331887	hsa-miR-450b-5p	CLIP-seq
MIRT1331853	hsa-miR-4668-5p	CLIP-seq
MIRT1331888	hsa-miR-4691-3p	CLIP-seq
MIRT1331889	hsa-miR-495	CLIP-seq
MIRT1331890	hsa-miR-5047	CLIP-seq
MIRT1331891	hsa-miR-506	CLIP-seq
MIRT1331892	hsa-miR-507	CLIP-seq
MIRT1331893	hsa-miR-557	CLIP-seq
MIRT2098052	hsa-miR-1273d	CLIP-seq
MIRT1331879	hsa-miR-1290	CLIP-seq
MIRT2098053	hsa-miR-185	CLIP-seq
MIRT2098054	hsa-miR-3065-3p	CLIP-seq
MIRT2098055	hsa-miR-3123	CLIP-seq
MIRT2098056	hsa-miR-330-3p	CLIP-seq
MIRT2098057	hsa-miR-3692	CLIP-seq
MIRT1331843	hsa-miR-3973	CLIP-seq
MIRT2098058	hsa-miR-4279	CLIP-seq
MIRT2098059	hsa-miR-4306	CLIP-seq
MIRT1331848	hsa-miR-4428	CLIP-seq
MIRT2098060	hsa-miR-4436b-5p	CLIP-seq
MIRT2098061	hsa-miR-4644	CLIP-seq
MIRT1331854	hsa-miR-4683	CLIP-seq
MIRT2098062	hsa-miR-4719	CLIP-seq
MIRT2098063	hsa-miR-4725-5p	CLIP-seq
MIRT2098064	hsa-miR-4802-5p	CLIP-seq
MIRT2098065	hsa-miR-504	CLIP-seq
MIRT2098066	hsa-miR-548m	CLIP-seq
MIRT2098067	hsa-miR-584	CLIP-seq
MIRT2098068	hsa-miR-3647-3p	CLIP-seq
MIRT2322736	hsa-miR-1238	CLIP-seq
MIRT2322737	hsa-miR-1251	CLIP-seq
MIRT2322738	hsa-miR-1256	CLIP-seq
MIRT1331880	hsa-miR-129-5p	CLIP-seq
MIRT1331881	hsa-miR-1301	CLIP-seq
MIRT2322739	hsa-miR-1302	CLIP-seq
MIRT2322740	hsa-miR-141	CLIP-seq
MIRT2322741	hsa-miR-187	CLIP-seq
MIRT2322742	hsa-miR-200a	CLIP-seq
MIRT2322743	hsa-miR-2053	CLIP-seq
MIRT2322744	hsa-miR-219-2-3p	CLIP-seq
MIRT2322745	hsa-miR-2355-3p	CLIP-seq
MIRT2322746	hsa-miR-2682	CLIP-seq
MIRT2322747	hsa-miR-298	CLIP-seq
MIRT2322748	hsa-miR-3064-5p	CLIP-seq
MIRT2098054	hsa-miR-3065-3p	CLIP-seq
MIRT2098055	hsa-miR-3123	CLIP-seq
MIRT2322749	hsa-miR-320b	CLIP-seq
MIRT2322750	hsa-miR-320c	CLIP-seq
MIRT2322751	hsa-miR-320d	CLIP-seq
MIRT2098056	hsa-miR-330-3p	CLIP-seq
MIRT2322752	hsa-miR-34a	CLIP-seq
MIRT2322753	hsa-miR-34c-5p	CLIP-seq
MIRT1331882	hsa-miR-3613-3p	CLIP-seq
MIRT2098068	hsa-miR-3647-3p	CLIP-seq
MIRT2098057	hsa-miR-3692	CLIP-seq
MIRT2322754	hsa-miR-3909	CLIP-seq
MIRT2322755	hsa-miR-4265	CLIP-seq
MIRT2322756	hsa-miR-4287	CLIP-seq
MIRT2322757	hsa-miR-4296	CLIP-seq
MIRT2322758	hsa-miR-4298	CLIP-seq
MIRT2322759	hsa-miR-4322	CLIP-seq
MIRT2322760	hsa-miR-4417	CLIP-seq
MIRT1331848	hsa-miR-4428	CLIP-seq
MIRT2322761	hsa-miR-4429	CLIP-seq
MIRT2322762	hsa-miR-4436b-3p	CLIP-seq
MIRT2098060	hsa-miR-4436b-5p	CLIP-seq
MIRT2322763	hsa-miR-4469	CLIP-seq
MIRT2322764	hsa-miR-4487	CLIP-seq
MIRT2322765	hsa-miR-449a	CLIP-seq
MIRT2322766	hsa-miR-449b	CLIP-seq
MIRT2322767	hsa-miR-449c	CLIP-seq
MIRT2322768	hsa-miR-4503	CLIP-seq
MIRT1331887	hsa-miR-450b-5p	CLIP-seq
MIRT2322769	hsa-miR-4514	CLIP-seq
MIRT1331854	hsa-miR-4683	CLIP-seq
MIRT2322770	hsa-miR-4685-3p	CLIP-seq
MIRT1331888	hsa-miR-4691-3p	CLIP-seq
MIRT2322771	hsa-miR-4692	CLIP-seq
MIRT2098062	hsa-miR-4719	CLIP-seq
MIRT2322772	hsa-miR-4720-5p	CLIP-seq
MIRT2098063	hsa-miR-4725-5p	CLIP-seq
MIRT2322773	hsa-miR-4749-3p	CLIP-seq
MIRT2322774	hsa-miR-4766-5p	CLIP-seq
MIRT2322775	hsa-miR-4775	CLIP-seq
MIRT2322776	hsa-miR-4777-5p	CLIP-seq
MIRT2322777	hsa-miR-4786-3p	CLIP-seq
MIRT2322778	hsa-miR-4799-3p	CLIP-seq
MIRT2322779	hsa-miR-498	CLIP-seq
MIRT2098065	hsa-miR-504	CLIP-seq
MIRT1331890	hsa-miR-5047	CLIP-seq
MIRT1331892	hsa-miR-507	CLIP-seq
MIRT2322780	hsa-miR-518d-5p	CLIP-seq
MIRT2322781	hsa-miR-519b-5p	CLIP-seq
MIRT2322782	hsa-miR-519c-5p	CLIP-seq
MIRT2322783	hsa-miR-520c-5p	CLIP-seq
MIRT2322784	hsa-miR-526a	CLIP-seq
MIRT1331893	hsa-miR-557	CLIP-seq
MIRT2322785	hsa-miR-569	CLIP-seq
MIRT2098067	hsa-miR-584	CLIP-seq
MIRT2322786	hsa-miR-590-3p	CLIP-seq
MIRT2322787	hsa-miR-601	CLIP-seq
MIRT2322788	hsa-miR-642a	CLIP-seq
MIRT2322789	hsa-miR-676	CLIP-seq
MIRT2322790	hsa-miR-892b	CLIP-seq
MIRT1331848	hsa-miR-4428	CLIP-seq
MIRT2322739	hsa-miR-1302	CLIP-seq
MIRT2322758	hsa-miR-4298	CLIP-seq
MIRT2618801	hsa-miR-1229	CLIP-seq
MIRT2322738	hsa-miR-1256	CLIP-seq
MIRT2618802	hsa-miR-1266	CLIP-seq
MIRT2618803	hsa-miR-1295	CLIP-seq
MIRT1331880	hsa-miR-129-5p	CLIP-seq
MIRT1331881	hsa-miR-1301	CLIP-seq
MIRT2322740	hsa-miR-141	CLIP-seq
MIRT2098053	hsa-miR-185	CLIP-seq
MIRT2618804	hsa-miR-1915	CLIP-seq
MIRT2322742	hsa-miR-200a	CLIP-seq
MIRT2322743	hsa-miR-2053	CLIP-seq
MIRT2322744	hsa-miR-219-2-3p	CLIP-seq
MIRT2322745	hsa-miR-2355-3p	CLIP-seq
MIRT2618805	hsa-miR-2355-5p	CLIP-seq
MIRT2322746	hsa-miR-2682	CLIP-seq
MIRT2322747	hsa-miR-298	CLIP-seq
MIRT2098054	hsa-miR-3065-3p	CLIP-seq
MIRT2098055	hsa-miR-3123	CLIP-seq
MIRT2618806	hsa-miR-3185	CLIP-seq
MIRT2322749	hsa-miR-320b	CLIP-seq
MIRT2322750	hsa-miR-320c	CLIP-seq
MIRT2322751	hsa-miR-320d	CLIP-seq
MIRT2098056	hsa-miR-330-3p	CLIP-seq
MIRT2322752	hsa-miR-34a	CLIP-seq
MIRT2322753	hsa-miR-34c-5p	CLIP-seq
MIRT1331882	hsa-miR-3613-3p	CLIP-seq
MIRT2618807	hsa-miR-3664-3p	CLIP-seq
MIRT2098057	hsa-miR-3692	CLIP-seq
MIRT2618808	hsa-miR-378g	CLIP-seq
MIRT2322755	hsa-miR-4265	CLIP-seq
MIRT2322757	hsa-miR-4296	CLIP-seq
MIRT2098059	hsa-miR-4306	CLIP-seq
MIRT2322759	hsa-miR-4322	CLIP-seq
MIRT2322760	hsa-miR-4417	CLIP-seq
MIRT2322761	hsa-miR-4429	CLIP-seq
MIRT2322762	hsa-miR-4436b-3p	CLIP-seq
MIRT2098060	hsa-miR-4436b-5p	CLIP-seq
MIRT2618809	hsa-miR-4437	CLIP-seq
MIRT2322764	hsa-miR-4487	CLIP-seq
MIRT2322765	hsa-miR-449a	CLIP-seq
MIRT2322766	hsa-miR-449b	CLIP-seq
MIRT2322767	hsa-miR-449c	CLIP-seq
MIRT2322768	hsa-miR-4503	CLIP-seq
MIRT1331887	hsa-miR-450b-5p	CLIP-seq
MIRT2322769	hsa-miR-4514	CLIP-seq
MIRT2618810	hsa-miR-4518	CLIP-seq
MIRT2098061	hsa-miR-4644	CLIP-seq
MIRT1331853	hsa-miR-4668-5p	CLIP-seq
MIRT2618811	hsa-miR-4674	CLIP-seq
MIRT2618812	hsa-miR-4685-5p	CLIP-seq
MIRT1331888	hsa-miR-4691-3p	CLIP-seq
MIRT2322771	hsa-miR-4692	CLIP-seq
MIRT2618813	hsa-miR-4694-5p	CLIP-seq
MIRT2618814	hsa-miR-4709-3p	CLIP-seq
MIRT2098062	hsa-miR-4719	CLIP-seq
MIRT2322772	hsa-miR-4720-5p	CLIP-seq
MIRT2098063	hsa-miR-4725-5p	CLIP-seq
MIRT2322777	hsa-miR-4786-3p	CLIP-seq
MIRT2322778	hsa-miR-4799-3p	CLIP-seq
MIRT2098064	hsa-miR-4802-5p	CLIP-seq
MIRT2098065	hsa-miR-504	CLIP-seq
MIRT1331890	hsa-miR-5047	CLIP-seq
MIRT1331892	hsa-miR-507	CLIP-seq
MIRT1331893	hsa-miR-557	CLIP-seq
MIRT2322785	hsa-miR-569	CLIP-seq
MIRT2098067	hsa-miR-584	CLIP-seq
MIRT2618815	hsa-miR-645	CLIP-seq
MIRT2618816	hsa-miR-661	CLIP-seq
MIRT2322789	hsa-miR-676	CLIP-seq
MIRT2618817	hsa-miR-873	CLIP-seq
MIRT2618818	hsa-miR-892a	CLIP-seq
MIRT2618819	hsa-miR-941	CLIP-seq
MIRT2618801	hsa-miR-1229	CLIP-seq
MIRT2322738	hsa-miR-1256	CLIP-seq
MIRT2618802	hsa-miR-1266	CLIP-seq
MIRT2618803	hsa-miR-1295	CLIP-seq
MIRT1331880	hsa-miR-129-5p	CLIP-seq
MIRT1331881	hsa-miR-1301	CLIP-seq
MIRT2322740	hsa-miR-141	CLIP-seq
MIRT2098053	hsa-miR-185	CLIP-seq
MIRT2618804	hsa-miR-1915	CLIP-seq
MIRT2322742	hsa-miR-200a	CLIP-seq
MIRT2322743	hsa-miR-2053	CLIP-seq
MIRT2322744	hsa-miR-219-2-3p	CLIP-seq
MIRT2322745	hsa-miR-2355-3p	CLIP-seq
MIRT2618805	hsa-miR-2355-5p	CLIP-seq
MIRT2322746	hsa-miR-2682	CLIP-seq
MIRT2322747	hsa-miR-298	CLIP-seq
MIRT2098054	hsa-miR-3065-3p	CLIP-seq
MIRT2098055	hsa-miR-3123	CLIP-seq
MIRT2618806	hsa-miR-3185	CLIP-seq
MIRT2322749	hsa-miR-320b	CLIP-seq
MIRT2322750	hsa-miR-320c	CLIP-seq
MIRT2322751	hsa-miR-320d	CLIP-seq
MIRT2098056	hsa-miR-330-3p	CLIP-seq
MIRT2322752	hsa-miR-34a	CLIP-seq
MIRT2322753	hsa-miR-34c-5p	CLIP-seq
MIRT1331882	hsa-miR-3613-3p	CLIP-seq
MIRT2618807	hsa-miR-3664-3p	CLIP-seq
MIRT2098057	hsa-miR-3692	CLIP-seq
MIRT2618808	hsa-miR-378g	CLIP-seq
MIRT2322755	hsa-miR-4265	CLIP-seq
MIRT2322757	hsa-miR-4296	CLIP-seq
MIRT2098059	hsa-miR-4306	CLIP-seq
MIRT2322759	hsa-miR-4322	CLIP-seq
MIRT2322760	hsa-miR-4417	CLIP-seq
MIRT2322761	hsa-miR-4429	CLIP-seq
MIRT2322762	hsa-miR-4436b-3p	CLIP-seq
MIRT2098060	hsa-miR-4436b-5p	CLIP-seq
MIRT2618809	hsa-miR-4437	CLIP-seq
MIRT2322764	hsa-miR-4487	CLIP-seq
MIRT2322765	hsa-miR-449a	CLIP-seq
MIRT2322766	hsa-miR-449b	CLIP-seq
MIRT2322767	hsa-miR-449c	CLIP-seq
MIRT2322768	hsa-miR-4503	CLIP-seq
MIRT1331887	hsa-miR-450b-5p	CLIP-seq
MIRT2322769	hsa-miR-4514	CLIP-seq
MIRT2618810	hsa-miR-4518	CLIP-seq
MIRT2098061	hsa-miR-4644	CLIP-seq
MIRT1331853	hsa-miR-4668-5p	CLIP-seq
MIRT2618811	hsa-miR-4674	CLIP-seq
MIRT2618812	hsa-miR-4685-5p	CLIP-seq
MIRT1331888	hsa-miR-4691-3p	CLIP-seq
MIRT2322771	hsa-miR-4692	CLIP-seq
MIRT2618813	hsa-miR-4694-5p	CLIP-seq
MIRT2618814	hsa-miR-4709-3p	CLIP-seq
MIRT2098062	hsa-miR-4719	CLIP-seq
MIRT2322772	hsa-miR-4720-5p	CLIP-seq
MIRT2098063	hsa-miR-4725-5p	CLIP-seq
MIRT2322777	hsa-miR-4786-3p	CLIP-seq
MIRT2322778	hsa-miR-4799-3p	CLIP-seq
MIRT2098064	hsa-miR-4802-5p	CLIP-seq
MIRT2098065	hsa-miR-504	CLIP-seq
MIRT1331890	hsa-miR-5047	CLIP-seq
MIRT1331892	hsa-miR-507	CLIP-seq
MIRT1331893	hsa-miR-557	CLIP-seq
MIRT2322785	hsa-miR-569	CLIP-seq
MIRT2098067	hsa-miR-584	CLIP-seq
MIRT2322787	hsa-miR-601	CLIP-seq
MIRT2618815	hsa-miR-645	CLIP-seq
MIRT2618816	hsa-miR-661	CLIP-seq
MIRT2322789	hsa-miR-676	CLIP-seq
MIRT2618817	hsa-miR-873	CLIP-seq
MIRT2618818	hsa-miR-892a	CLIP-seq
MIRT2618819	hsa-miR-941	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	TAS	2302193
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	ISS
GO:0005743	Component	Mitochondrial inner membrane	NAS	30030361
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006099	Process	Tricarboxylic acid cycle	NAS	30030361
GO:0006099	Process	Tricarboxylic acid cycle	TAS	9533030
GO:0006121	Process	Mitochondrial electron transport, succinate to ubiquinone	IBA
GO:0006121	Process	Mitochondrial electron transport, succinate to ubiquinone	NAS	30030361
GO:0009055	Function	Electron transfer activity	IEA
GO:0009060	Process	Aerobic respiration	TAS	9533030
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9533030
GO:0020037	Function	Heme binding	ISS
GO:0042776	Process	Proton motive force-driven mitochondrial ATP synthesis	NAS	30030361
GO:0045273	Component	Respiratory chain complex II (succinate dehydrogenase)	IBA
GO:0045273	Component	Respiratory chain complex II (succinate dehydrogenase)	IDA	37098072
GO:0045273	Component	Respiratory chain complex II (succinate dehydrogenase)	ISS
GO:0045273	Component	Respiratory chain complex II (succinate dehydrogenase)	TAS	9533030
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
602413	10682	ENSG00000143252

Q99643

Protein name

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (Malate dehydrogenase [quinone] cytochrome b560 subunit) (QPs-1) (QPs1) (Succinate dehydrogenase complex subunit C) (Succinate-ubiquinone oxidoreductase cytoc

Protein function

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:9533030). SD

PDB

8GS8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01127	Sdh_cyt	47 → 166	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	Family

Sequence

MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYS
WSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFAL
VFPLMYHTWNGIRHLMWDLGKGLKIPQLYQSGVVVLVLTVLSSMGLAAM

Sequence length

169

Interactions

View interactions

	KEGG		Reactome
	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways Carbon metabolism Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy		Citric acid cycle (TCA cycle)

2047

Show/Hide Causal Diseases (9)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Carney triad	Pathogenic; Likely pathogenic	rs786205146, rs786205147, rs587776653	RCV000170331 RCV000170332 RCV000170333
Carney-Stratakis syndrome	Pathogenic; Likely pathogenic	rs764575966, rs587776653, rs898854295, rs201286421, rs756676111	RCV001329019 RCV000007666 RCV005398713 RCV004819210 RCV004796320
Gastrointestinal stromal tumor	Likely pathogenic; Pathogenic	rs1249046874, rs2102307803, rs2102370242, rs1483039185, rs1363265634, rs1057517818, rs587778661, rs2102336244, rs2102271857, rs2102307538, rs2526364684, rs786202200, rs786203457, rs764575966, rs786205147 View all (33 more)	RCV001378182 RCV001385231 RCV001380966 RCV001384853 RCV002028731 RCV001975845 RCV000641913 RCV001953500 RCV002044863 RCV003775007 RCV005227623 RCV005222790 RCV000641906 RCV000232178 RCV000688261 RCV002797062 RCV002881906 RCV002899357 RCV002933132 RCV000812224 RCV000641917 RCV000023194 RCV003777290 RCV003800158 RCV003801879 RCV003802140 RCV003813266 RCV003810540 RCV005220918 RCV001047084 RCV000791400 RCV000462244 RCV001240954 RCV000551177 RCV001380749 RCV000641918 RCV001386659 RCV000627763 RCV000641911 RCV000641907 RCV003767891 RCV000691372 RCV000809572 RCV000809817 RCV001382560 RCV001221046 RCV001064681 RCV001055954 RCV001058295 RCV001036663 RCV001217901 RCV001202377 RCV001233063 RCV001244070 RCV001232924 RCV001243668 RCV001879958
Hereditary cancer-predisposing syndrome	Pathogenic; Likely pathogenic	rs2102370242, rs1483039185, rs1363265634, rs587778661, rs2102271857, rs2526572703, rs2526364684, rs786202200, rs786203457, rs764575966, rs2526364101, rs748440817, rs2102370188, rs786205146, rs786205147 View all (18 more)	RCV003375274 RCV005271228 RCV002407277 RCV000492504 RCV004656677 RCV002339996 RCV002342914 RCV000164903 RCV000166772 RCV000162467 RCV002376670 RCV002450329 RCV002459803 RCV000492519 RCV000564191 RCV000574152 RCV005480316 RCV000215996 RCV004246162 RCV004508382 RCV000492312 RCV000492170 RCV002429493 RCV000492770 RCV000492617 RCV000492239 RCV000492714 RCV000574696 RCV000565535 RCV000569757 RCV000128874 RCV003380656 RCV004669129 RCV002424897 RCV001015229 RCV001015731 RCV001026732 RCV001015445 RCV002354978 RCV004671305
Hereditary pheochromocytoma and paraganglioma	Likely pathogenic; Pathogenic	rs1249046874, rs587778661, rs786203457, rs764575966, rs587776653, rs2102370242, rs1057517818, rs778582853, rs898854295, rs981049067, rs1553266474, rs1553261757, rs201286421, rs786202200	RCV004803676 RCV000826184 RCV003995530 RCV000505285 RCV003996080 RCV000505371 RCV003404850 RCV003323526 RCV004000756 RCV000505370 RCV004802098 RCV000505297 RCV000612576 RCV000505325 RCV004802320
Inherited phaeochromocytoma and paraganglioma excluding NF1	Likely pathogenic; Pathogenic	rs786203457, rs898854295, rs201286421	RCV005865260 RCV005865324 RCV005865209
Pheochromocytoma/paraganglioma syndrome 3	Likely pathogenic; Pathogenic	rs1249046874, rs2102307803, rs2102370242, rs1483039185, rs1363265634, rs1057517818, rs587778661, rs2102336244, rs2102271857, rs2102307538, rs2526364684, rs786202200, rs786203457, rs764575966, rs2526364101 View all (40 more)	RCV001378182 RCV001385231 RCV001380966 RCV001384853 RCV002028731 RCV001975845 RCV000641913 RCV001953500 RCV002044863 RCV003775007 RCV003316865 RCV005222790 RCV000641906 RCV000232178 RCV005248682 RCV000688261 RCV002797062 RCV002881906 RCV002899357 RCV002933132 RCV000007663 RCV000007664 RCV001201884 RCV003149093 RCV003149096 RCV003316923 RCV003316970 RCV003316997 RCV003800158 RCV003801879 RCV003802140 RCV003813266 RCV003810540 RCV004442524 RCV004442587 RCV005220918 RCV004589328 RCV001047084 RCV000467345 RCV000462244 RCV001240954 RCV000551177 RCV001380749 RCV000641918 RCV001386659 RCV000034695 RCV000641911 RCV000641907 RCV003767891 RCV000691372 RCV000809572 RCV000809817 RCV001382560 RCV001221046 RCV001064681 RCV001055954 RCV001058295 RCV001036663 RCV001217901 RCV001202377 RCV001233063 RCV001244070 RCV001232924 RCV001243668 RCV001256199
Rhabdomyosarcoma	Likely pathogenic; Pathogenic	rs1672294906	RCV001257556
SDHC-related disorder	Likely pathogenic; Pathogenic	rs898854295, rs201286421	RCV003419827 RCV004751234

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cowden syndrome	Benign; Likely benign; Conflicting classifications of pathogenicity	rs61733156, rs1277488324	RCV005359321 RCV005357589
Lung cancer	Uncertain significance	rs760572684	RCV005900646
Malignant tumor of breast	Conflicting classifications of pathogenicity	rs200375156	RCV001269363
Malignant tumor of urinary bladder	Uncertain significance	rs2102336404	RCV005924034
Neuroblastoma	Uncertain significance	rs760572684	RCV003445918
Ovarian cancer	Conflicting classifications of pathogenicity	rs200375156	RCV003153438
Ovarian serous cystadenocarcinoma	Uncertain significance	rs2102384860	RCV005930292
Pheochromocytoma	Uncertain significance; Conflicting classifications of pathogenicity; Likely benign; Benign	rs142139022, rs759481419, rs375109418, rs376293449, rs191417790, rs886045489, rs886045491, rs886045495, rs569588829, rs886045485, rs886045490, rs886045492, rs886045496, rs752685687, rs886045481 View all (11 more)	RCV000148872 RCV000313704 RCV000299067 RCV000335179 RCV000363683 RCV000271389 RCV000275038 RCV000342735 RCV000293423 RCV000281236 RCV000310077 RCV000389237 RCV000403425 RCV000319172 RCV000353963 RCV000328424 RCV000306956 RCV000316841 RCV000377337 RCV000292734 RCV000329756 RCV000341850 RCV000396733 RCV000293942 RCV000301880 RCV000211525

Show/Hide Text Mining Associations (37)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abdominal Injuries	Associate	17557926, 29878124
Breast Neoplasms	Associate	33560870
Carcinogenesis	Associate	24859990
Carcinoma Ductal Breast	Associate	32156290
Carcinoma Hepatocellular	Associate	25894340, 36308411
Carcinoma Intraductal Noninfiltrating	Associate	32156290
Carcinoma Renal Cell	Associate	23083876, 24625421, 34014604, 34558728, 36455002
Carney Complex	Associate	19522821
Carney Stratakis Syndrome	Associate	19522821, 23282968
Carney Triad	Associate	24859990, 25540324
Carotid Body Tumor	Associate	21106325
Colonic Neoplasms	Associate	36949947
Colorectal Neoplasms	Associate	26377099
Disease	Associate	23083876
Ganglioneuroma	Associate	26173966
Gastrointestinal Stromal Tumors	Associate	19522821, 21173220, 22955521, 23109135, 23174939, 23612575, 23743927, 24625421, 25540324, 26415883, 31308404, 34558728
Head and Neck Neoplasms	Associate	16405730, 19906784, 21106325, 21224366, 27700540, 34558728
Hypertension	Associate	17557926
Hypoxia	Associate	34021238
Leukemia Myeloid Acute	Associate	36245043
Mediastinitis	Associate	24758179
Mitochondrial Complex II Deficiency	Associate	27011036, 31308404
Multiple Myeloma	Associate	32144272
Neoplasm Invasiveness	Associate	32152520
Neoplasms	Inhibit	16288654, 16405730, 19368708, 20890271, 32156290
Neoplasms	Associate	22955521, 24859990, 25540324, 26173966, 31308404, 32152520, 32195970, 32677196, 33854214, 34021238, 36178902, 37899663
Neoplastic Syndromes Hereditary	Associate	11404820, 11897817, 14685938, 16405730, 19368708, 20484225, 20505258, 21455202, 24758179, 28099933, 29878124
Obesity	Associate	29107296, 30782949
Ovarian Neoplasms	Associate	33560870
Paraganglioma	Associate	11897817, 16080474, 16405730, 17557926, 18826997, 19269919, 19522821, 19576851, 20418362, 20505258, 20890271, 20980436, 21106325, 21173220, 21455202 View all (11 more)
Paraganglioma Extra Adrenal	Associate	34558728
Paragangliomas 3	Associate	17557926, 19269919, 20890271, 24758179, 29878124
Pheochromocytoma	Associate	16098460, 16288654, 16405730, 19368708, 20484225, 20505258, 20890271, 20980436, 21455202, 22573489, 23174939, 23512077, 24466223, 24625421, 26173966, 28099933 View all (1 more)
Pituitary Neoplasms	Associate	25494863
Polypoidal Choroidal Vasculopathy	Associate	32677196
Spinocerebellar Degenerations	Associate	17487275
Uterine Cervical Neoplasms	Associate	37899663

SDHC (succinate dehydrogenase complex subunit C)