Gene Gene information from NCBI Gene database.
Entrez ID 639
Gene name PR/SET domain 1
Gene symbol PRDM1
Synonyms (NCBI Gene)
BLIMP-1BLIMP1PRDI-BF1
Chromosome 6
Chromosome location 6q21
Summary This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induc
miRNA miRNA information provided by mirtarbase database.
327
miRTarBase ID miRNA Experiments Reference
MIRT001937 hsa-miR-9-5p Luciferase reporter assay 18583325
MIRT001937 hsa-miR-9-5p Luciferase reporter assay 18583325
MIRT001937 hsa-miR-9-5p Luciferase reporter assay 18583325
MIRT001936 hsa-let-7a-5p Luciferase reporter assay 18583325
MIRT004279 hsa-miR-127-3p qRT-PCRLuciferase reporter assayWestern blot 19530237
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
CEBPB Activation 19717648
PAX5 Repression 17682124;22593617
STAT3 Activation 1702555
STAT3 Unknown 12953803
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
68
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 1851123
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS 1851123
GO:0000976 Function Transcription cis-regulatory region binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603423 9346 ENSG00000057657
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75626
Protein name PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1)
Protein function Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negativ
PDB 3DAL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00856 SET 68 201 SET domain Family
PF00096 zf-C2H2 575 597 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 603 625 Zinc finger, C2H2 type Domain
PF13912 zf-C2H2_6 631 656 Domain
Sequence
MLDICLEKRVGTTLAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTY
IVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEI
YTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGM
NIYFYTIKPIPANQELLVWYC
RDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCP
KNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYP
IRAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTV
SPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNAHYPKFLLPPYGM
NCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQ
PEHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAA
PSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGE
RPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQ
CKVCPAKFTQFVHLKLHKRLHTRERPHKCSQCHKNYIHLCSLKVHLKGNCAAAPAPGLPL
EDLTRINEEIEKFDISDNADRLEDVEDDISVISVVEKEILAVVRKEKEETGLKVSLQRNM
GNGLLSSGCSLYESSDLPLMKLPPSNPLPLVPVKVKQETVEPMDP
Sequence length 825
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Regulation of TP53 Expression
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
PRDM1-related disorder Likely benign; Uncertain significance rs138916112, rs202200155, rs2114661844 RCV003944694
RCV003966899
RCV003972112
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arthralgia Stimulate 29720240
Arthritis Stimulate 29720240
Arthritis Rheumatoid Associate 19898481
Arthritis Rheumatoid Stimulate 29720240
Breast Neoplasms Associate 19433448, 34907035
Burkitt Lymphoma Associate 25382611
Carcinogenesis Inhibit 28468592
Carcinoma Embryonal Inhibit 18992153
Carcinoma Hepatocellular Associate 35382824
Carcinoma Non Small Cell Lung Associate 25635434