Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
639
Gene name Gene Name - the full gene name approved by the HGNC.
PR/SET domain 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRDM1
Synonyms (NCBI Gene) Gene synonyms aliases
BLIMP-1, BLIMP1, PRDI-BF1
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induc
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001937 hsa-miR-9-5p Luciferase reporter assay 18583325
MIRT001937 hsa-miR-9-5p Luciferase reporter assay 18583325
MIRT001937 hsa-miR-9-5p Luciferase reporter assay 18583325
MIRT001936 hsa-let-7a-5p Luciferase reporter assay 18583325
MIRT004279 hsa-miR-127-3p qRT-PCR, Luciferase reporter assay, Western blot 19530237
Transcription factors
Transcription factor Regulation Reference
CEBPB Activation 19717648
PAX5 Repression 17682124;22593617
STAT3 Activation 1702555
STAT3 Unknown 12953803
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 1851123
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS 1851123
GO:0000976 Function Transcription cis-regulatory region binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603423 9346 ENSG00000057657
Protein
UniProt ID O75626
Protein name PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1)
Protein function Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negativ
PDB 3DAL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00856 SET 68 201 SET domain Family
PF00096 zf-C2H2 575 597 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 603 625 Zinc finger, C2H2 type Domain
PF13912 zf-C2H2_6 631 656 Domain
Sequence
MLDICLEKRVGTTLAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTY
IVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEI
YTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGM
NIYFYTIKPIPANQELLVWYC
RDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCP
KNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYP
IRAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTV
SPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNAHYPKFLLPPYGM
NCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQ
PEHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAA
PSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGE
RPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQ
CKVCPAKFTQFVHLKLHKRLHTRERPHKCSQCHKNYIHLCSLKVHLKGNCAAAPAPGLPL
EDLTRINEEIEKFDISDNADRLEDVEDDISVISVVEKEILAVVRKEKEETGLKVSLQRNM
GNGLLSSGCSLYESSDLPLMKLPPSNPLPLVPVKVKQETVEPMDP
Sequence length 825
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Regulation of TP53 Expression
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Acne acne vulgaris N/A N/A GWAS
Colorectal Cancer Colorectal cancer N/A N/A GWAS
Crohn Disease Crohn's disease N/A N/A GWAS
Inflammatory Bowel Disease Inflammatory bowel disease, Inflammatory bowel disease (MTAG) N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Arthralgia Stimulate 29720240
Arthritis Stimulate 29720240
Arthritis Rheumatoid Associate 19898481
Arthritis Rheumatoid Stimulate 29720240
Breast Neoplasms Associate 19433448, 34907035
Burkitt Lymphoma Associate 25382611
Carcinogenesis Inhibit 28468592
Carcinoma Embryonal Inhibit 18992153
Carcinoma Hepatocellular Associate 35382824
Carcinoma Non Small Cell Lung Associate 25635434