Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	63898
Gene name	SH2 domain containing 4A
Gene symbol	SH2D4A
Synonyms (NCBI Gene)	PPP1R38SH2A
Chromosome	8
Chromosome location	8p21.3

144

Show/Hide all (144)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002747	hsa-miR-1-3p	Microarray	15685193
MIRT649407	hsa-miR-4461	HITS-CLIP	23824327
MIRT649406	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT649404	hsa-miR-4469	HITS-CLIP	23824327
MIRT649405	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT649403	hsa-miR-4287	HITS-CLIP	23824327
MIRT649402	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT649401	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT649400	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT649399	hsa-miR-4468	HITS-CLIP	23824327
MIRT649398	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT649397	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT649396	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT649395	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT649394	hsa-miR-3672	HITS-CLIP	23824327
MIRT649393	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT649392	hsa-miR-8055	HITS-CLIP	23824327
MIRT649407	hsa-miR-4461	HITS-CLIP	23824327
MIRT649406	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT649404	hsa-miR-4469	HITS-CLIP	23824327
MIRT649405	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT649403	hsa-miR-4287	HITS-CLIP	23824327
MIRT649402	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT649401	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT649400	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT649399	hsa-miR-4468	HITS-CLIP	23824327
MIRT649398	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT649397	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT649396	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT649395	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT649394	hsa-miR-3672	HITS-CLIP	23824327
MIRT649393	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT649392	hsa-miR-8055	HITS-CLIP	23824327
MIRT1344262	hsa-miR-1224-5p	CLIP-seq
MIRT1344263	hsa-miR-1294	CLIP-seq
MIRT1344264	hsa-miR-145	CLIP-seq
MIRT1344265	hsa-miR-1972	CLIP-seq
MIRT1344266	hsa-miR-198	CLIP-seq
MIRT1344267	hsa-miR-2113	CLIP-seq
MIRT1344268	hsa-miR-2355-3p	CLIP-seq
MIRT1344269	hsa-miR-298	CLIP-seq
MIRT1344270	hsa-miR-3153	CLIP-seq
MIRT1344271	hsa-miR-3189-5p	CLIP-seq
MIRT1344272	hsa-miR-3194-3p	CLIP-seq
MIRT1344273	hsa-miR-3194-5p	CLIP-seq
MIRT1344274	hsa-miR-338-5p	CLIP-seq
MIRT1344275	hsa-miR-3650	CLIP-seq
MIRT1344276	hsa-miR-383	CLIP-seq
MIRT1344277	hsa-miR-3944-5p	CLIP-seq
MIRT1344278	hsa-miR-432	CLIP-seq
MIRT1344279	hsa-miR-4503	CLIP-seq
MIRT1344280	hsa-miR-4646-3p	CLIP-seq
MIRT1344281	hsa-miR-4659a-3p	CLIP-seq
MIRT1344282	hsa-miR-4659b-3p	CLIP-seq
MIRT1344283	hsa-miR-4685-5p	CLIP-seq
MIRT1344284	hsa-miR-4707-5p	CLIP-seq
MIRT1344285	hsa-miR-4712-5p	CLIP-seq
MIRT1344286	hsa-miR-4751	CLIP-seq
MIRT1344287	hsa-miR-4755-3p	CLIP-seq
MIRT1344288	hsa-miR-4772-5p	CLIP-seq
MIRT1344289	hsa-miR-490-5p	CLIP-seq
MIRT1344290	hsa-miR-495	CLIP-seq
MIRT1344291	hsa-miR-512-5p	CLIP-seq
MIRT1344292	hsa-miR-561	CLIP-seq
MIRT1344293	hsa-miR-570	CLIP-seq
MIRT1344294	hsa-miR-579	CLIP-seq
MIRT1344295	hsa-miR-583	CLIP-seq
MIRT1344296	hsa-miR-587	CLIP-seq
MIRT1344297	hsa-miR-593	CLIP-seq
MIRT1344298	hsa-miR-654-3p	CLIP-seq
MIRT1344299	hsa-miR-760	CLIP-seq
MIRT1344300	hsa-miR-770-5p	CLIP-seq
MIRT2326169	hsa-miR-1205	CLIP-seq
MIRT2326170	hsa-miR-1256	CLIP-seq
MIRT2326171	hsa-miR-1269	CLIP-seq
MIRT2326172	hsa-miR-1269b	CLIP-seq
MIRT2326173	hsa-miR-1288	CLIP-seq
MIRT2326174	hsa-miR-1909	CLIP-seq
MIRT1344272	hsa-miR-3194-3p	CLIP-seq
MIRT2326175	hsa-miR-3199	CLIP-seq
MIRT2326176	hsa-miR-3654	CLIP-seq
MIRT2326177	hsa-miR-377	CLIP-seq
MIRT2326178	hsa-miR-378	CLIP-seq
MIRT2326179	hsa-miR-378b	CLIP-seq
MIRT2326180	hsa-miR-378c	CLIP-seq
MIRT2326181	hsa-miR-378d	CLIP-seq
MIRT2326182	hsa-miR-378e	CLIP-seq
MIRT2326183	hsa-miR-378f	CLIP-seq
MIRT2326184	hsa-miR-378h	CLIP-seq
MIRT2326185	hsa-miR-378i	CLIP-seq
MIRT1344276	hsa-miR-383	CLIP-seq
MIRT2326186	hsa-miR-409-3p	CLIP-seq
MIRT2326187	hsa-miR-422a	CLIP-seq
MIRT2326188	hsa-miR-4257	CLIP-seq
MIRT2326189	hsa-miR-4260	CLIP-seq
MIRT2326190	hsa-miR-4263	CLIP-seq
MIRT2326191	hsa-miR-4515	CLIP-seq
MIRT2326192	hsa-miR-4680-5p	CLIP-seq
MIRT2326193	hsa-miR-4684-3p	CLIP-seq
MIRT2326194	hsa-miR-4740-5p	CLIP-seq
MIRT1344288	hsa-miR-4772-5p	CLIP-seq
MIRT2326195	hsa-miR-4789-3p	CLIP-seq
MIRT1344291	hsa-miR-512-5p	CLIP-seq
MIRT1344299	hsa-miR-760	CLIP-seq
MIRT2621867	hsa-miR-1257	CLIP-seq
MIRT2326171	hsa-miR-1269	CLIP-seq
MIRT2326172	hsa-miR-1269b	CLIP-seq
MIRT2621868	hsa-miR-1285	CLIP-seq
MIRT2326173	hsa-miR-1288	CLIP-seq
MIRT2621869	hsa-miR-1289	CLIP-seq
MIRT2621870	hsa-miR-1299	CLIP-seq
MIRT1344264	hsa-miR-145	CLIP-seq
MIRT2621871	hsa-miR-3165	CLIP-seq
MIRT2621872	hsa-miR-3187-5p	CLIP-seq
MIRT2621873	hsa-miR-3198	CLIP-seq
MIRT2621874	hsa-miR-4277	CLIP-seq
MIRT2621875	hsa-miR-4294	CLIP-seq
MIRT2621876	hsa-miR-4309	CLIP-seq
MIRT2326191	hsa-miR-4515	CLIP-seq
MIRT2621877	hsa-miR-4519	CLIP-seq
MIRT2326194	hsa-miR-4740-5p	CLIP-seq
MIRT2621878	hsa-miR-4782-5p	CLIP-seq
MIRT2621879	hsa-miR-4790-3p	CLIP-seq
MIRT2621880	hsa-miR-516b	CLIP-seq
MIRT2621881	hsa-miR-612	CLIP-seq
MIRT2621882	hsa-miR-875-3p	CLIP-seq
MIRT2621867	hsa-miR-1257	CLIP-seq
MIRT2326171	hsa-miR-1269	CLIP-seq
MIRT2326172	hsa-miR-1269b	CLIP-seq
MIRT2621868	hsa-miR-1285	CLIP-seq
MIRT2326173	hsa-miR-1288	CLIP-seq
MIRT1344265	hsa-miR-1972	CLIP-seq
MIRT2621871	hsa-miR-3165	CLIP-seq
MIRT2621872	hsa-miR-3187-5p	CLIP-seq
MIRT1344271	hsa-miR-3189-5p	CLIP-seq
MIRT1344273	hsa-miR-3194-5p	CLIP-seq
MIRT2326191	hsa-miR-4515	CLIP-seq
MIRT2621877	hsa-miR-4519	CLIP-seq
MIRT1344283	hsa-miR-4685-5p	CLIP-seq
MIRT1344284	hsa-miR-4707-5p	CLIP-seq
MIRT2326194	hsa-miR-4740-5p	CLIP-seq
MIRT1344287	hsa-miR-4755-3p	CLIP-seq
MIRT2621879	hsa-miR-4790-3p	CLIP-seq
MIRT2621881	hsa-miR-612	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 19389623, 20936779, 25416956, 26496610, 27107012, 27173435, 27880917, 28330616, 28514442, 29892012, 31515488, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0019902	Function	Phosphatase binding	IBA
GO:0019902	Function	Phosphatase binding	IDA	19389623

MIM	HGNC	e!Ensembl
614968	26102	ENSG00000104611

Q9H788

Protein name

SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)

Protein function

Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00017	SH2	347 → 423	SH2 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Aberrantly expressed in some cancers. {ECO:0000269|PubMed:12476414}.

Sequence

MLKQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREAAMERKESLPVKPRPKK
ENGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHSEE
FTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSRNI
QQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQICKSWKEDSEWQASLRKSK
AADEKRRSLAKQAREDYKRLSLGAQKGRGGERLQSPLRVPQKPERPPLPPKPQFLNSGAY
PQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANEL
LLSTGMPGSFLIRVSERIKGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLV
EYHKEEPITSLGKELLLYPCGQQDQLPDYLELFE

Sequence length

454

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALUNION FRACTURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMOOTH SURFACE DENTAL CARIES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	34893760	★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma	Associate	34893760	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	34893760	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chromosomal Instability	Inhibit	34893760	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	34893760	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Inhibit	38043670	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Associate	37698534	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	34893760	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	38043670	★★★★★ ★☆☆☆☆ Found in Text Mining only

SH2D4A (SH2 domain containing 4A)