Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	63891
Gene name	Ring finger protein 123
Gene symbol	RNF123
Synonyms (NCBI Gene)	FP1477KPC1
Chromosome	3
Chromosome location	3p21.31
Summary	The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein

132

Show/Hide all (132)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006102	hsa-miR-155-5p	ELISALuciferase reporter assayqRT-PCRWestern blot	21355095
MIRT006102	hsa-miR-155-5p	ELISALuciferase reporter assayqRT-PCRWestern blot	21355095
MIRT006102	hsa-miR-155-5p	ELISALuciferase reporter assayqRT-PCRWestern blot	21355095
MIRT049325	hsa-miR-92a-3p	CLASH	23622248
MIRT047567	hsa-miR-10a-5p	CLASH	23622248
MIRT006102	hsa-miR-155-5p	ImmunofluorescenceImmunohistochemistryNext Generation Sequencing (NGS)qRT-PCRWestern blotReverse-phase protein array	28389511
MIRT006102	hsa-miR-155-5p	ImmunofluorescenceImmunohistochemistryNext Generation Sequencing (NGS)qRT-PCRWestern blotReverse-phase protein array	28389511
MIRT1309760	hsa-miR-183	CLIP-seq
MIRT1309761	hsa-miR-2392	CLIP-seq
MIRT1309762	hsa-miR-4438	CLIP-seq
MIRT1309763	hsa-miR-665	CLIP-seq
MIRT1309760	hsa-miR-183	CLIP-seq
MIRT1309761	hsa-miR-2392	CLIP-seq
MIRT2393807	hsa-miR-3689d	CLIP-seq
MIRT1309762	hsa-miR-4438	CLIP-seq
MIRT2393808	hsa-miR-4514	CLIP-seq
MIRT2393809	hsa-miR-4692	CLIP-seq
MIRT2393810	hsa-miR-4742-5p	CLIP-seq
MIRT1309763	hsa-miR-665	CLIP-seq
MIRT2458318	hsa-miR-1185	CLIP-seq
MIRT2458319	hsa-miR-1224-3p	CLIP-seq
MIRT2458320	hsa-miR-1260	CLIP-seq
MIRT2458321	hsa-miR-1260b	CLIP-seq
MIRT2458322	hsa-miR-1280	CLIP-seq
MIRT2458323	hsa-miR-1296	CLIP-seq
MIRT2458324	hsa-miR-2909	CLIP-seq
MIRT2458325	hsa-miR-3173-3p	CLIP-seq
MIRT2458326	hsa-miR-3605-5p	CLIP-seq
MIRT2458327	hsa-miR-3652	CLIP-seq
MIRT2458328	hsa-miR-3679-5p	CLIP-seq
MIRT2458329	hsa-miR-378g	CLIP-seq
MIRT2458330	hsa-miR-4269	CLIP-seq
MIRT2458331	hsa-miR-4430	CLIP-seq
MIRT2458332	hsa-miR-4437	CLIP-seq
MIRT1309762	hsa-miR-4438	CLIP-seq
MIRT2458333	hsa-miR-4505	CLIP-seq
MIRT2458334	hsa-miR-4512	CLIP-seq
MIRT2393808	hsa-miR-4514	CLIP-seq
MIRT2458335	hsa-miR-4674	CLIP-seq
MIRT2393809	hsa-miR-4692	CLIP-seq
MIRT2393810	hsa-miR-4742-5p	CLIP-seq
MIRT2458336	hsa-miR-5095	CLIP-seq
MIRT2458337	hsa-miR-532-3p	CLIP-seq
MIRT2458338	hsa-miR-940	CLIP-seq
MIRT2458319	hsa-miR-1224-3p	CLIP-seq
MIRT2458320	hsa-miR-1260	CLIP-seq
MIRT2458321	hsa-miR-1260b	CLIP-seq
MIRT2458322	hsa-miR-1280	CLIP-seq
MIRT2458323	hsa-miR-1296	CLIP-seq
MIRT2458324	hsa-miR-2909	CLIP-seq
MIRT2458327	hsa-miR-3652	CLIP-seq
MIRT2458329	hsa-miR-378g	CLIP-seq
MIRT2458330	hsa-miR-4269	CLIP-seq
MIRT2458331	hsa-miR-4430	CLIP-seq
MIRT2458332	hsa-miR-4437	CLIP-seq
MIRT2458333	hsa-miR-4505	CLIP-seq
MIRT2458334	hsa-miR-4512	CLIP-seq
MIRT2393808	hsa-miR-4514	CLIP-seq
MIRT2458335	hsa-miR-4674	CLIP-seq
MIRT2393809	hsa-miR-4692	CLIP-seq
MIRT2393810	hsa-miR-4742-5p	CLIP-seq
MIRT2458337	hsa-miR-532-3p	CLIP-seq
MIRT2458318	hsa-miR-1185	CLIP-seq
MIRT2458319	hsa-miR-1224-3p	CLIP-seq
MIRT2458320	hsa-miR-1260	CLIP-seq
MIRT2458321	hsa-miR-1260b	CLIP-seq
MIRT2458322	hsa-miR-1280	CLIP-seq
MIRT2458323	hsa-miR-1296	CLIP-seq
MIRT2458324	hsa-miR-2909	CLIP-seq
MIRT2458325	hsa-miR-3173-3p	CLIP-seq
MIRT2612548	hsa-miR-323-5p	CLIP-seq
MIRT2458326	hsa-miR-3605-5p	CLIP-seq
MIRT2612549	hsa-miR-3650	CLIP-seq
MIRT2458327	hsa-miR-3652	CLIP-seq
MIRT2458328	hsa-miR-3679-5p	CLIP-seq
MIRT2458329	hsa-miR-378g	CLIP-seq
MIRT2458330	hsa-miR-4269	CLIP-seq
MIRT2458331	hsa-miR-4430	CLIP-seq
MIRT2458332	hsa-miR-4437	CLIP-seq
MIRT1309762	hsa-miR-4438	CLIP-seq
MIRT2458333	hsa-miR-4505	CLIP-seq
MIRT2458334	hsa-miR-4512	CLIP-seq
MIRT2393808	hsa-miR-4514	CLIP-seq
MIRT2612550	hsa-miR-4648	CLIP-seq
MIRT2612551	hsa-miR-4654	CLIP-seq
MIRT2458335	hsa-miR-4674	CLIP-seq
MIRT2393809	hsa-miR-4692	CLIP-seq
MIRT2612552	hsa-miR-4700-3p	CLIP-seq
MIRT2393810	hsa-miR-4742-5p	CLIP-seq
MIRT2612553	hsa-miR-4764-5p	CLIP-seq
MIRT2612554	hsa-miR-4769-5p	CLIP-seq
MIRT2458336	hsa-miR-5095	CLIP-seq
MIRT2458337	hsa-miR-532-3p	CLIP-seq
MIRT2612555	hsa-miR-876-3p	CLIP-seq
MIRT2458338	hsa-miR-940	CLIP-seq
MIRT2458318	hsa-miR-1185	CLIP-seq
MIRT2458319	hsa-miR-1224-3p	CLIP-seq
MIRT2458320	hsa-miR-1260	CLIP-seq
MIRT2458321	hsa-miR-1260b	CLIP-seq
MIRT2458322	hsa-miR-1280	CLIP-seq
MIRT2458323	hsa-miR-1296	CLIP-seq
MIRT2458324	hsa-miR-2909	CLIP-seq
MIRT2689793	hsa-miR-3154	CLIP-seq
MIRT2458325	hsa-miR-3173-3p	CLIP-seq
MIRT2612548	hsa-miR-323-5p	CLIP-seq
MIRT2458326	hsa-miR-3605-5p	CLIP-seq
MIRT2612549	hsa-miR-3650	CLIP-seq
MIRT2458327	hsa-miR-3652	CLIP-seq
MIRT2458328	hsa-miR-3679-5p	CLIP-seq
MIRT2458329	hsa-miR-378g	CLIP-seq
MIRT2458330	hsa-miR-4269	CLIP-seq
MIRT2458331	hsa-miR-4430	CLIP-seq
MIRT2689794	hsa-miR-4434	CLIP-seq
MIRT2458332	hsa-miR-4437	CLIP-seq
MIRT1309762	hsa-miR-4438	CLIP-seq
MIRT2458333	hsa-miR-4505	CLIP-seq
MIRT2458334	hsa-miR-4512	CLIP-seq
MIRT2393808	hsa-miR-4514	CLIP-seq
MIRT2689795	hsa-miR-4516	CLIP-seq
MIRT2612550	hsa-miR-4648	CLIP-seq
MIRT2612551	hsa-miR-4654	CLIP-seq
MIRT2458335	hsa-miR-4674	CLIP-seq
MIRT2393809	hsa-miR-4692	CLIP-seq
MIRT2612552	hsa-miR-4700-3p	CLIP-seq
MIRT2393810	hsa-miR-4742-5p	CLIP-seq
MIRT2612553	hsa-miR-4764-5p	CLIP-seq
MIRT2689796	hsa-miR-4768-3p	CLIP-seq
MIRT2612554	hsa-miR-4769-5p	CLIP-seq
MIRT2458336	hsa-miR-5095	CLIP-seq
MIRT2458337	hsa-miR-532-3p	CLIP-seq
MIRT2612555	hsa-miR-876-3p	CLIP-seq
MIRT2458338	hsa-miR-940	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IDA	25860612
GO:0004842	Function	Ubiquitin-protein transferase activity	IBA
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15531880, 27312109
GO:0005737	Component	Cytoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	15531880, 16227581
GO:0007249	Process	Canonical NF-kappaB signal transduction	IDA	34721373
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030163	Process	Protein catabolic process	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0046872	Function	Metal ion binding	IEA
GO:0051603	Process	Proteolysis involved in protein catabolic process	IBA
GO:0051604	Process	Protein maturation	IDA	25860612
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	15531880, 16227581, 25860612
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

MIM	HGNC	e!Ensembl
614472	21148	ENSG00000164068

Q5XPI4

Protein name

E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123)

Protein function

Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase (PubMed:15531880, PubMed:16227581, PubMed:25860612). Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inh

PDB

2MA6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00622	SPRY	134 → 252	SPRY domain	Family
PF13920	zf-C3HC4_3	1250 → 1298		Domain

Sequence

MASKGAGMSFSRKSYRLTSDAEKSRVTGIVQEKLLNDYLNRIFSSSEHAPPAATSRKPLN
FQNLPEHLDQLLQVDNEEEESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSN
FGTIRSTTCVYKGKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRK
WNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLS
FKESVAFNFGSRPLRYPVAGYRPLQDPPSADLVRAQRLLGCFRAVLSVELDPVEGRLLDK
ESSKWRLRGQPTVLLTLAHIFHHFAPLLRKVYLVEAVLMSFLLGIVEKGTPTQAQSVVHQ
VLDLLWLFMEDYEVQDCLKQLMMSLLRLYRFSPIVPDLGLQIHYLRLTIAILRHEKSRKF
LLSNVLFDVLRSVVFFYIKSPLRVEEAGLQELIPTTWWPHCSSREGKESTEMKEETAEER
LRRRAYERGCQRLRKRIEVVEELQVQILKLLLDNKDDNGGEASRYIFLTKFRKFLQENAS
GRGNMPMLCPPEYMVCFLHRLISALRYYWDEYKASNPHASFSEEAYIPPQVFYNGKVDYF
DLQRLGGLLSHLRKTLKDDLASKANIVIDPLELQSTAMDDLDEDEEPAPAMAQRPMQALA
VGGPLPLPRPGWLSSPTLGRANRFLSTAAVSLMTPRRPLSTSEKVKVRTLSVEQRTREDI
EGSHWNEGLLLGRPPEEPEQPLTENSLLEVLDGAVMMYNLSVHQQLGKMVGVSDDVNEYA
MALRDTEDKLRRCPKRRKDILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYW
LLRVCLRTIEHGDRTGSLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRL
AAILAKHFADARIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQ
RPWAQTNWILVRLWRGCGFGYRYTRLPHLLKTKLEDANLPSLQKPCPSTLLQQHMADLLQ
QGPDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVS
LLRVLEMTITLVPEIFLDWTRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGL
ESVDHYPILVAVTGILVQLLVRGPASEREQATSVLLADPCFQLRSICYLLGQPEPPAPGT
ALPAPDRKRFSLQSYADYISADELAQVEQMLAHLTSASAQAAAASLPTSEEDLCPICYAH
PISAVFQPCGHKSCKACINQHLMNNKDCFFCKTTIVSVEDWEKGANTSTTSSAA

Sequence length

1314

Interactions

View interactions

	Reactome
			Ub-specific processing proteases Antigen processing: Ubiquitination & Proteasome degradation

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Hypertrophic cardiomyopathy	Uncertain significance	rs61743872	RCV001199398

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenoma	Associate	34232602
Angelman Syndrome	Associate	23671107
Canavan Disease	Associate	19737927
Cholangiocarcinoma	Associate	36476255
Chronic Pain	Associate	33926923
Depressive Disorder Major	Associate	21982424
Heart Defects Congenital	Associate	19737927
Laminopathies	Associate	29676528
Melanoma	Inhibit	28389511
Neoplasms	Associate	28489605, 36476255
Neoplasms	Inhibit	34873064, 36476255
Retinal Telangiectasis	Associate	19737927
Sezary Syndrome	Associate	28489605

RNF123 (ring finger protein 123)