Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	63876
Gene name Gene Name - the full gene name approved by the HGNC.	PBX/knotted 1 homeobox 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PKNOX2
Synonyms (NCBI Gene) Gene synonyms aliases	PREP2
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q24.2
Summary Summary of gene provided in NCBI Entrez Gene.	Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class

Show/Hide all(97)

miRTarBase ID	miRNA	Experiments	Reference
MIRT655040	hsa-miR-665	HITS-CLIP	23824327
MIRT655039	hsa-miR-5193	HITS-CLIP	23824327
MIRT655038	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT655037	hsa-miR-2114-3p	HITS-CLIP	23824327
MIRT655035	hsa-miR-6823-3p	HITS-CLIP	23824327
MIRT655036	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT655034	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT655033	hsa-miR-185-5p	HITS-CLIP	23824327
MIRT655032	hsa-miR-4306	HITS-CLIP	23824327
MIRT655031	hsa-miR-4644	HITS-CLIP	23824327
MIRT655030	hsa-miR-5192	HITS-CLIP	23824327
MIRT490209	hsa-miR-4323	PAR-CLIP	23592263
MIRT490208	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT490207	hsa-miR-671-5p	PAR-CLIP	23592263
MIRT490206	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT490204	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT490205	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT490203	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT490202	hsa-miR-4271	PAR-CLIP	23592263
MIRT490201	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT490200	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT490199	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT490198	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT490197	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT490196	hsa-miR-5698	PAR-CLIP	23592263
MIRT490195	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT490194	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT490193	hsa-miR-4525	PAR-CLIP	23592263
MIRT490192	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT490191	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT490190	hsa-miR-4447	PAR-CLIP	23592263
MIRT490188	hsa-miR-4472	PAR-CLIP	23592263
MIRT490189	hsa-miR-1275	PAR-CLIP	23592263
MIRT490187	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT439957	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT439957	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT655040	hsa-miR-665	HITS-CLIP	23824327
MIRT655039	hsa-miR-5193	HITS-CLIP	23824327
MIRT655038	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT655037	hsa-miR-2114-3p	HITS-CLIP	23824327
MIRT655035	hsa-miR-6823-3p	HITS-CLIP	23824327
MIRT655036	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT655034	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT655033	hsa-miR-185-5p	HITS-CLIP	23824327
MIRT655032	hsa-miR-4306	HITS-CLIP	23824327
MIRT655031	hsa-miR-4644	HITS-CLIP	23824327
MIRT655030	hsa-miR-5192	HITS-CLIP	23824327
MIRT490209	hsa-miR-4323	PAR-CLIP	23592263
MIRT490208	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT490207	hsa-miR-671-5p	PAR-CLIP	23592263
MIRT490206	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT490204	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT490205	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT490203	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT490202	hsa-miR-4271	PAR-CLIP	23592263
MIRT490201	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT490200	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT490199	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT490198	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT490197	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT490196	hsa-miR-5698	PAR-CLIP	23592263
MIRT490195	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT490194	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT490193	hsa-miR-4525	PAR-CLIP	23592263
MIRT490192	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT490191	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT490190	hsa-miR-4447	PAR-CLIP	23592263
MIRT490188	hsa-miR-4472	PAR-CLIP	23592263
MIRT490189	hsa-miR-1275	PAR-CLIP	23592263
MIRT490187	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT1238007	hsa-miR-2682	CLIP-seq
MIRT1238008	hsa-miR-27a	CLIP-seq
MIRT1238009	hsa-miR-27b	CLIP-seq
MIRT1238010	hsa-miR-3184	CLIP-seq
MIRT1238011	hsa-miR-3665	CLIP-seq
MIRT1238012	hsa-miR-423-5p	CLIP-seq
MIRT1238013	hsa-miR-4421	CLIP-seq
MIRT1238014	hsa-miR-4423-3p	CLIP-seq
MIRT1238015	hsa-miR-449c	CLIP-seq
MIRT1238016	hsa-miR-4656	CLIP-seq
MIRT1238017	hsa-miR-4736	CLIP-seq
MIRT1238018	hsa-miR-490-3p	CLIP-seq
MIRT1238019	hsa-miR-5096	CLIP-seq
MIRT1238020	hsa-miR-513a-5p	CLIP-seq
MIRT1238021	hsa-miR-616	CLIP-seq
MIRT1238022	hsa-miR-649	CLIP-seq
MIRT1238023	hsa-miR-940	CLIP-seq
MIRT2069995	hsa-miR-4757-5p	CLIP-seq
MIRT2069996	hsa-miR-663b	CLIP-seq
MIRT2297284	hsa-miR-1238	CLIP-seq
MIRT2297285	hsa-miR-183	CLIP-seq
MIRT2297286	hsa-miR-2276	CLIP-seq
MIRT2297287	hsa-miR-3924	CLIP-seq
MIRT2297288	hsa-miR-4642	CLIP-seq
MIRT2297289	hsa-miR-4696	CLIP-seq
MIRT2297290	hsa-miR-4762-3p	CLIP-seq
MIRT2297291	hsa-miR-4772-3p	CLIP-seq

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0003785	Function	Actin monomer binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0015630	Component	Microtubule cytoskeleton	IEA
GO:0045171	Component	Intercellular bridge	IDA
GO:0051015	Function	Actin filament binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
613066	16714	ENSG00000165495

Protein

UniProt ID

Q96KN3

Protein name

Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16493	Meis_PKNOX_N	96 → 181	N-terminal of Homeobox Meis and PKNOX1	Family
PF05920	Homeobox_KN	306 → 345	Homeobox KN domain	Family

Sequence

MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAP
IDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEH
KPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDL
GGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSG
GALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHAT
NIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAP
KAKKIKSQHRPTQRFWPNSIAAGVLQQQGGAPGTNPDGSINLDNLQSLSSDSATMAMQQA
MMAAHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEHSDSLE

Sequence length

472

Interactions

View interactions

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Prostate cancer	Prostate carcinoma, Prostate cancer, familial	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29892016
Prostate cancer, hereditary	PROSTATE CANCER, HEREDITARY, 1	rs387906327, rs193929331, rs74315365, rs397516896, rs794729219, rs121913349, rs587782641, rs1114167673, rs1597371666, rs2073394466	29892016
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	22648509

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	Source
Unknown
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Testicular Germ Cell Tumor	Testicular Germ Cell Tumor		GWAS
Diabetes	Diabetes		GWAS

PKNOX2 (PBX/knotted 1 homeobox 2)