PKNOX2 (PBX/knotted 1 homeobox 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
63876
Gene name Gene Name - the full gene name approved by the HGNC.
PBX/knotted 1 homeobox 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PKNOX2
Synonyms (NCBI Gene) Gene synonyms aliases
PREP2
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q24.2
Summary Summary of gene provided in NCBI Entrez Gene.
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(97)
miRTarBase ID miRNA Experiments Reference
MIRT655040 hsa-miR-665 HITS-CLIP 23824327
MIRT655039 hsa-miR-5193 HITS-CLIP 23824327
MIRT655038 hsa-miR-6734-3p HITS-CLIP 23824327
MIRT655037 hsa-miR-2114-3p HITS-CLIP 23824327
MIRT655035 hsa-miR-6823-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(15)
GO ID Ontology Definition Evidence Reference
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
GO:0003677 Function DNA binding IEA
GO:0003785 Function Actin monomer binding IEA
GO:0005515 Function Protein binding IPI 20211142, 32296183, 33961781
GO:0005634 Component Nucleus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
613066 16714 ENSG00000165495
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q96KN3
Protein name Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16493 Meis_PKNOX_N 96 → 181 N-terminal of Homeobox Meis and PKNOX1 Family
PF05920 Homeobox_KN 306 → 345 Homeobox KN domain Family
Sequence 
MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAP
IDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEH
KPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDL
GGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSG
GALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHAT
NIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAP
KAKKIKSQHRPTQRFWPNSIAAGVLQQQGGAPGTNPDGSINLDNLQSLSSDSATMAMQQA
MMAAHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEHSDSLE
Sequence length 472
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast Cancer Breast cancer (survival) N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Prostate cancer Prostate cancer N/A N/A GWAS
Testicular Germ Cell Tumor Testicular germ cell tumor N/A N/A GWAS